Clinical trials: Pervasive Development Disorders
Child Development Disorders, Pervasive
RUPP PI PDD: Drug and Behavioral Therapy for Children With Pervasive Developmental Disorders
This 24-week study will compare the safety and effectiveness of medication treatment alone (risperidone or aripiprazole) to medication treatment in combination with a parent management training program.
- Trial name
- NCT00080145
- Testing
- Risperidone, Behavior Therapy
- Where
- 3 sites in United States
- Volunteers
- 124 people
- Sponsor
- Yale University
Autistic Disorder
An Evaluation of Low Level Laser Light Therapy for Autistic Disorder
The purpose of this study is to determine whether the Erchonia HLS Laser is effective in the treatment of irritability associated with autistic disorder in children and adolescents aged five (5) to seventeen (17) years.
- Trial name
- NCT03379662
- Testing
- Erchonia HLS Laser
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Erchonia Corporation
Autism Spectrum Disorders
Investigating Phenotypic Profiles of Children and Adolescents With ASD
The purpose of this study is to provide a detailed description of language and cognitive profiles found among children and adolescents diagnosed with autism spectrum disorders (ASD).
- Trial name
- Phenotyping (NCT02700113)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Boston University Charles River Campus
FOXP1, Mental Retardation With Language Impairment and With or Without Autistic Features
FOXP1 Syndrome: The Seaver Autism Center for Research and Treatment is Characterizing FOXP1-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.
FOXP1, also known as Forkhead-box Protein P1, is a transcription factor protein belonging to the FOX gene family. Disruptions in the FOXP1 gene cause a phenotype characterized by global developmental delay, speech deficits, mild…
- Conditions
- FOXP1, Mental Retardation With Language Impairment and With or Without Autistic Features, Autism Spectrum Disorder
- Trial name
- NCT03718923
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Specific Phobia, Social Anxiety Disorder
Virtual Reality for Youth Phobias
The purpose of this study is to examine the effectiveness of virtual reality (VR) delivered exposure therapy for youth with phobias or social anxiety, with and without autism spectrum disorder.
- Conditions
- Specific Phobia, Social Anxiety Disorder, Autism Spectrum Disorder
- Trial name
- NCT05839431
- Testing
- Virtual Reality for Youth Phobias
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Miami
Autism
Clinical and Genetic Study of Autism Spectrum Disorder
The purpose of this study is to prepare instruments for Autism Spectrum Disorder (ASD), to collect clinical, neuropsychological, and genetic data of ASD probands and their family, and to identify the genetic variants close to…
- Trial name
- NCT00494754
- Where
- 4 sites in Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder, Siblings
Screening for Neurodevelopmental Disorders in Siblings of Children With Autism Diagnosed in Tertiary Centers
In this study, a selective and multi-stages screening for neurodevelopmental disorders (NDD) in siblings of children with a confirmed ASD is done.
- Conditions
- Autism Spectrum Disorder, Siblings, Neurodevelopmental Disorders
- Trial name
- FRATSA (NCT05512637)
- Testing
- Step 1 - Screening ; Step 2 - Clinical interview
- Where
- France
- Volunteers
- 384 people
- Sponsor
- University Hospital, Montpellier
Rett Syndrome
Treatment of Rett Syndrome With Recombinant Human IGF-1
Investigators are recruiting children for a clinical trial using the medication recombinant human IGF-1 (a.k.a. mecasermin or INCRELEX) to see if it improves the health of children with Rett syndrome (RTT).
- Trial name
- NCT01777542
- Testing
- Recombinant Human Insulin Growth Factor 1 (rhIGF-1)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
Autonomic Nervous System Diseases, Sleep
Sleep, Autonomic Nervous System and Cardiorespiratory Capacity in Autism Spectrum Disorders Children (APAUTRES)
Autism Spectrum Disorders (ASD) is a neurodevelopmental disorder which involves social and behavioural impairments. Autonomic dysfunctions and disturbed sleep were often associated to ASD.
- Trial name
- APAUTRES (NCT02830022)
- Testing
- physiological explorations
- Where
- France
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Speech, Autism Spectrum Disorder (ASD)
Research on Speech Development Trajectories and Predictive Models in Children With Autism Spectrum Disorder
Recent studies indicate that children with ASD have a significantly higher risk of co-occurring speech sound disorders than typically developing children.
- Trial name
- NCT07472829
- Testing
- Approaches to ASD social intervention
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Chongqing Medical University
CTNNB1 Gene Mutation
Genotype-phenotype Correlations in Children and Adults With CTNNB1 Mutation
The aim of this study is to explore and define the correlations between genotype and phenotype in patients with CTNNB1 mutations as well as monitor and survey the natural history of the CTNNB1 syndrome.
- Trial name
- Gen-Phe CTNNB1 (NCT04812119)
- Testing
- The Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F), The Autism Spectrum Quotient-Children's Version (AQ-Child), The Autism-Spectrum Quotient (AQ)-Adolescent Version (AQ-Adolescent)
- Where
- 3 sites in Australia, Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Autism Spectrum Disorder, Neurodevelopmental Disorders
Combined Human Milk Oligosaccharides (HMOs) and Probiotics Intervention for Children With Autism
This research project will investigate if a supplement containing a unique combination of prebiotics and probiotics can influence behaviour in children diagnosed with autism spectrum disorder.
- Conditions
- Autism Spectrum Disorder, Neurodevelopmental Disorders, Anxiety
- Trial name
- NCT05151601
- Testing
- Experimental
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- The University of Queensland
Autism Spectrum Disorder
A Study of Bumetanide for the Treatment of Autism Spectrum Disorders
The investigators are going to carry out a randomized double-blind placebo-controlled trial to study the efficiency and mechanism of bumetanide on the treatment of children with Autism Spectrum Disorder.
- Trial name
- NCT03156153
- Testing
- Bumetanide
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Autism Spectrum Disorders
Genetics, Brain Structure and Thinking Skills in Autism
The purpose of this research is to better understand the genetic, biochemical, cognitive and behavioral symptom abnormalities that contribute to autism spectrum disorders.
- Trial name
- NCT01451983
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Autism Spectrum Disorder
Early Neurodivergent Developmental Trajectories in Autism and in Response to the ESDM Intervention
Early support is thought to be key to ensure a better quality of life for young children on the autism spectrum. Among early support, different evidence-based approaches have combined the principles of developmental and…
- Trial name
- NCT06494605
- Testing
- Early Start Denver Model (ESDM)
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Neurodevelopmental Disorders, Intellectual Disability
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
LEOPARD is a multicenter study aimed at improving the genetic diagnosis of patients with neurodevelopmental disorders (NDDs) of unknown etiology, particularly those with moderate-to-severe intellectual disability.
- Conditions
- Neurodevelopmental Disorders, Intellectual Disability, Autism Spectrum Disorder, Genetic Diseases, Inborn
- Trial name
- LEOPARD (NCT07884227)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini
Autism Spectrum Disorder, Autism
Parent Telehealth Intervention for Children With Autism
As a result of the COVID-19 pandemic, telecoaching/telepractice models are of urgent importance. Given this, parents in the study will receive parent coaching through weekly video calls.
- Trial name
- NCT04501588
- Testing
- Responsive training with no video feedback, Responsive training with video feedback
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Mental Health Wellness 1, Parent-Child Relations
BRIGHT Coaching Program for Families
Children with, or at elevated risk for, brain-based developmental disabilities can experience lifelong consequences and challenges throughout their development.
- Conditions
- Mental Health Wellness 1, Parent-Child Relations, Child Developmental Delay, Parenting
- Trial name
- NCT03880383
- Testing
- Coaching, Online parent education, Online peer support
- Where
- 4 sites in Canada
- Volunteers
- 306 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders
Multi-observational Study for the Early Identification of Autism Spectrum Disorder (ASD) and Other Neurodevelopmental Disorders (NDD) in At-risk Populations
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects about 78 million people worldwide. Its prevalence and degree of impact on individuals and families place it among disorders of global importance.
- Trial name
- BABY@NET (NCT06915805)
- Where
- 5 sites in Italy
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Istituto Superiore di Sanità
Autism Spectrum Disorder
Evaluation of Some Inflammatory Markers in Autism Spectrum Disorders
Evaluate some Inflammatory markers [IL-6, IL-8, TNF_alpha] in children with autism spectrum disorder
- Trial name
- NCT05803005
- Testing
- inflammatory marker in autism spectrum disorder
- Volunteers
- 100 people
- Sponsor
- Assiut University
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