Clinical trials: Pervasive Development Disorders
Circadian Rhythm Sleep Disorders, Non-24 Hour Sleep-Wake Disorder
Study of the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents
Open-label Study to Investigate the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents.
- Conditions
- Circadian Rhythm Sleep Disorders, Non-24 Hour Sleep-Wake Disorder, Autism Spectrum Disorder, Smith-Magenis Syndrome
- Trial name
- NCT02776215
- Testing
- tasimelteon
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Vanda Pharmaceuticals
Autism Spectrum Disorder (ASD, Prospective Study
Prospective Clinical Study on Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Childhood Autism
This clinical study aims to evaluate whether a nasal spray containing exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSC-EXOs) can safely and effectively improve core symptoms in children aged 3-7 years…
- Trial name
- EXO-ASD (NCT07243561)
- Testing
- hUC-MSC-Exos Nasal Spray
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Dongfang People's Hospital
Autism Spectrum Disorder, Mental Health Issue
Access to Tailored Autism Integrated Care Pilot Study
Children with autism spectrum disorder (ASD) represent a rapidly growing, high-priority clinical population highlighted by the NIMH and Interagency Autism Coordinating Committee due, in part, because they have multiple service…
- Trial name
- ATTAIN (NCT04293627)
- Testing
- ATTAIN
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Autistic Disorder
Open-Label Extension Study of Kuvan for Autism
This is an open-label extension study available only to subjects who completed an earlier double-blind, placebo-controlled study of sapropterin in children with autism.
- Trial name
- NCT00943579
- Testing
- Kuvan®
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- The Children's Health Council
Autism Spectrum Disorder
Dietetic Pattern in Children With Autism Spectrum Disorders
To date, it is well documented that the gut microbiota (GM) influences numerous physiological processes in the healthy "host". The alteration of the composition and function of the intestinal microbiota, commonly referred to as…
- Trial name
- NCT04719923
- Testing
- Children with autism spectrum disorders
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Autism
Folate Rechallenge
New evidence suggests that autistic disorder (AD) may be associated with abnormalities in folate metabolism, which is a process that affects genetic expression by facilitating the formation of methyl donors for DNA methylation.
- Trial name
- NCT00672360
- Testing
- Folic acid
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor College of Medicine
Autism, Childhood Autism
Galantamine Versus Placebo in Childhood Autism
Autism is a severe neurodevelopmental disorder that affects up to 16 in 10,000 individuals. It is a pervasive developmental disorder affecting social, communicative, and compulsive/repetitive behaviors characterized by…
- Trial name
- NCT00252603
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Joint Engagement + Enhanced Milieu Training, Joint Engagement + Enhanced Milieu Training+Augmentative Communication (AAC)
Developmental and Augmented Intervention for Facilitating Expressive Language
This study will contrast two experimental treatment conditions by testing whether joint attention/joint engagement intervention using spoken communication (JAE-EMT) results in better outcomes than joint attention/joint engagement…
- Trial name
- CCNIA (NCT01013545)
- Testing
- JAE Intervention
- Where
- 3 sites in United States
- Volunteers
- 96 people
- Sponsor
- Autism Speaks
Autism Spectrum Disorder
ASD-specific Induced Pluripotent Stem Cells for Disease Modeling
Specific Aims: 1. To generate induced-pluripotent stem cells (iPSCs) from peripheral blood mononuclear cells (PBMCs) isolated from whole blood of ASD probands and healthy controls. 2.
- Trial name
- NCT02720939
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder
Group Based Parent Training for Children With Autism and Disruptive Behaviors
The goal of the study is to providing parents of children diagnosed with autism spectrum disorders (ASD) and disruptive behaviors essential skills to manage their children's behaviors using an evidence based parent training…
- Trial name
- NCT04097457
- Testing
- "Parent training for disruptive behaviors" manual (Bearss, Johnson, Handen, Butter, Lecavalier, Smith & Scahill, 2018)
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hebrew University of Jerusalem
Autistic Disorder, Pervasive Developmental Disorder
Placebo-Controlled Pilot Trial of Mecamylamine for Treatment of Autism Spectrum Disorders
The purpose of this study is to examine the safety and efficacy of mecamylamine for the core symptoms of autism.
- Trial name
- NCT00773812
- Testing
- mecamylamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ohio State University
Autism Spectrum Disorder
Integrated Life Skill Training and Executive Function Strategies in Children With ASD
The goal of this clinical trial is to test if using what is called executive function strategies like strategies for improving self-regulation ,strategies for improving planning and problem solving work well when applied within…
- Trial name
- ASD (NCT05829577)
- Testing
- Executive Function Strategies and Training, Daily Life skill training, Sensory Integration /Processing training
- Where
- Qatar
- Volunteers
- 92 people
- Sponsor
- Hamad General Hospital
Autism, Emotion Regulation Difficulties
Enhancing Emotion Regulation in Children With Autism Through Extended Reality
Pilot study on the development of an Extended Reality (XR) application to support emotion regulation in children with Autism Spectrum Disorder (ASD) (random assignment to an experimental group, N = 10, and a control group, N =…
- Trial name
- ERAC-XR (NCT07838272)
- Testing
- Extended Reality, Emotion regulation coaching
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Johannes Kepler University of Linz
Autism Spectrum Disorder, Intellectual Disability
Vagus Nerve Stimulator for Autism and Other Developmental Disorders
The goal of this flexible single-subject design vagus nerve stimulation (VNS) study is to examine the behavioral, cognitive, and biorhythmic effects of VNS in children and adults with autism and developmental disabilities.
- Conditions
- Autism Spectrum Disorder, Intellectual Disability, Autonomic Nervous System, Developmental Disability
- Trial name
- VNS (NCT06259201)
- Testing
- Vagus Nerve Stimulation
- Where
- 2 sites in United States
- Sponsor
- New York State Institute for Basic Research
Autism Spectrum Disorder
Trial of Autism Parent Navigator Program
To address the dual needs of parents for support in navigating Autistic Spectrum Disorder (ASD) services and maintaining positive family functioning, the investigators propose to test Autism Parent Navigators (APN), an innovative…
- Trial name
- APN (NCT04744428)
- Testing
- Autism Parent Navigators, Peer mentoring
- Where
- United States
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Penn State University
Autism Spectrum Disorder
Micronutrient Supplementation in Children With ASD
An open-label examination of changes in metabolites with use of micronutrients in children with autism spectrum disorder (ASD). Investigators will also measure behavioral measures monthly at school with teachers and parents…
- Trial name
- NCT05268744
- Testing
- Micronutrient
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Sensory Processing Disorder, Autism Spectrum Disorder
Telehealth Parent Coaching to Improve Activity Participation for Young Children With ASD and SPD
This clinical trial aims to develop parent-child interaction strategy coaching and sensory processing strategy coaching via Telehealth and examine the feasibility and efficacy of the interventions in young children with autism…
- Trial name
- NCT06079632
- Testing
- parent coaching via telehealth, weekly self-learning materials and group discussion session
- Volunteers
- 68 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder
Gut to Brain Interaction in Autism. Role of Probiotics on Clinical, Biochemical and Neurophysiological Parameters
The purpose of this study is to assess the effects of a 6-months supplementation with probiotic Vivomixx® on inflammatory and gastrointestinal (GI) biomarkers, gastrointestinal disturbances, behavioral and developmental profiles…
- Trial name
- NCT02708901
- Testing
- Vivomixx®
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- IRCCS Fondazione Stella Maris
Child Development Disorders, Pervasive
A Prospective Study Comparing the Mifne Approach of Treating Childhood Autism With Routine Standard Treatment
The current study aims at comparing outcomes achieved using the Mifne approach of treating autistic children with results obtained when routine standard treatment is used.
- Trial name
- NCT00445471
- Testing
- Mifne Approach to PDD, Treatment as usual
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Rabin Medical Center
Developmental Coordination Disorder, Autism Spectrum Disorder
An Explorative RVA of the Motor Development of Children With DCD <2y
This study compares motor development in three groups of infants (controls, DCD, DCD+ASD) before the age of 2 years using retrospective video analysis of infants in home video contexts.
- Trial name
- RVA_DCD (NCT04126395)
- Testing
- Movement Assessment Battery for Children 2(M-ABC-2), Developmental Coordination Disorder - Questionnaire (DCD-Q), Social Responsiveness Scale 2 (SRS-2)
- Where
- 2 sites in Belgium, Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Ghent
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