Clinical trials: Physical Function
Cystic Fibrosis
Retrospective Observational Study to Compare Cystic Fibrosis Patients in Two Decades Before and After 2000
The purpose of this study is to describe two cohorts of cystic fibrosis patients treated in 2 different decades in terms of FEV1 (Forced Expiratory Volume in one second) maintenance.
- Trial name
- MAESTRALE (NCT01651455)
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Kidney Transplant
The Study of Long-term Deterioration of Kidney Transplants.
This study is being done to create a kidney transplant database with information from many transplant centers for the purpose of studying ways to help improve transplant outcomes and the care of transplant recipients.
- Trial name
- NCT00217126
- Where
- United States
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Muscular Atrophy, Spinal
Safety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA) (OFELIA)
This was a phase IV Open-label, single-arm, single-dose, multicenter study, to evaluate the safety, tolerability and efficacy of intravenous administration of OAV101 (AVXS-101) in patients with SMA with bi-allelic mutations in…
- Trial name
- OFELIA (NCT05073133)
- Testing
- OAV101
- Where
- 5 sites in Argentina, Brazil
- Volunteers
- 16 people
- Sponsor
- Novartis Pharmaceuticals
Diet Habit, Cognitive Control
Correlational and Intervention Effects of Egg Consumption on Macular Carotenoids, Cognition, and Achievement During Childhood
The aim of this study is to examine the correlational and intervention effects of egg consumption on macular carotenoids, cognition, and achievement during childhood.
- Trial name
- SHELL (NCT03521349)
- Testing
- Whole Egg Intervention, Egg White Control
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Cardiac Failure, Extracorporeal Membrane Oxygenation Complication
Echocardiographic Assessment of Function During ECMO Support
The purpose of this study is to evaluate echocardiographic markers of cardiac function to assess the ability of patients to successfully end VA-ECMO support.
- Trial name
- NCT01551849
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Nationwide Children's Hospital
Type 1 Diabetes
Beta Cell Function in (Pre) Type 1 Diabetes
This study will establish criteria indicating short-term loss of beta cell mass and therefore accelerated progression towards type 1 diabetes.
- Trial name
- NCT00800085
- Testing
- glucose 20%
- Where
- 4 sites in Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Type1 Diabetes Mellitus, Diabetes Mellitus, Type 1
MEtabolic and Renal Effects of AutoMAted Insulin Delivery Systems in Youth With Type 1 Diabetes Mellitus
In type 1 diabetes (T1DM), automated insulin delivery (AID) systems such as the hybrid closed loop artificial pancreas (HCL AP) combine the use of an insulin pump, continuous blood sugar monitor, and control algorithm to adjust…
- Conditions
- Type1 Diabetes Mellitus, Diabetes Mellitus, Type 1, Autoimmune Diabetes, Juvenile Diabetes
- Trial name
- MERMAID-T1D (NCT03945747)
- Testing
- Blood draw, Urine sample collection, DXA scan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Phenylketonuria
Phase 2 Study of Glycomacropeptide Versus Amino Acid Diet for Management of Phenylketonuria
For individuals with Phenylketonuria (PKU), the investigators hypothesize that glycomacropeptide will provide an acceptable form of low-phenylalanine dietary protein that will improve dietary compliance, blood phenylalanine…
- Trial name
- PKU (NCT01428258)
- Testing
- GMP Diet/GMP Medical Foods, AA Diet/AA Medical Foods
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Wisconsin, Madison
Physical Activity, Sedentary Behavior
B4B Evolution Type II Hybrid Effectiveness-Implementation Trial
Break4Brain Evolution is a school-based programme designed to help teachers incorporate brief, safe and inclusive movement activities into normal classroom routines.
- Conditions
- Physical Activity, Sedentary Behavior, Cognition, Academic Acheivement
- Trial name
- B4B Evolution (NCT07726732)
- Testing
- Break4Brain Evolution
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Cystic Fibrosis
Respiratory Function at Preschool Age of Children Detected of Cystic Fibrosis in Neonatal Period
The widespread neonatal detection of cystic fibrosis in France since 2002 permits to treat children from birth. New treatments used for young children involve to assess efficacy criteria specific to this population.
- Trial name
- REVOLMUCO (NCT02358798)
- Testing
- 3 years-assessment of respiratory function
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Brain Injuries, Focal
VR Versus Task-Oriented Circuit Training on UL Sensorimotor in Children With Immature Brain Injury
To investigate and compare the effect of virtual reality and task-oriented circuit training on pinch grip and quality of life in children with with immature brain injury.
- Trial name
- NCT07827365
- Testing
- Virtual reality, Task-oriented circuit training
- Volunteers
- 44 people
- Sponsor
- October 6 University
Concussion, Brain, Athletic Injuries
Longitudinal Brain Health in Youth Tackle Football Players
The purpose of this study is to determine the neurologic and cognitive effects of playing tackle football in grade school and high school.
- Trial name
- NCT03104244
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- More Foundation
Cognitive Function
Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function
Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time.
- Trial name
- NCT06004687
- Testing
- acetaminophen mannitol, Normal saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Affiliated Hospital of Nantong University
Cystic Fibrosis
Safety and Efficacy of Recombinant Adeno-Associated Virus Containing the CFTR Gene in the Treatment of Cystic Fibrosis
The purpose of this study is to confirm the improvement in pulmonary function and cytokine levels observed in the recently completed multidose aerosol study for the treatment of Cystic Fibrosis (CF).
- Trial name
- NCT00073463
- Testing
- tgAAVCF
- Where
- 11 sites in United States
- Volunteers
- 100 people
- Sponsor
- Targeted Genetics Corporation
Joint Hypermobility, Femoral Anteversion
The Effect of Lower Extremity Rotational Profile on Postural Control, Muscle Strength, Functional Capacity and Lower Extremity Function in Children With Generalized Joint Hypermobility
Generalized joint hypermobility is when the range of motion in synovial joints exceeds its physiological limits. The aim of this investigation is to investigate the effect of lower extremity rotational profile on postural…
- Conditions
- Joint Hypermobility, Femoral Anteversion, Postural Control, Lower Extremity Muscle Strength
- Trial name
- NCT06998563
- Testing
- Rotational Profile- Hip Internal and External Rotation Measurement, Rotational Profile- Craig's Test Measurement, Rotational Profile- Foot/Thigh Angle Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Ocular Albinism (OA), Oculocutaneous Albinism (OCA)
The Effects of Lutein and Zeaxanthin Supplementation on Vision in Patients With Albinism
The LUVIA study is a randomized placebo-controlled trial designed to investigate the effects of lutein and zeaxanthin supplementation on macular pigment and visual function in ocular or oculocutaneous albinism.
- Trial name
- LUVIA (NCT02200263)
- Testing
- Lutein plus Zeaxanthin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
ADHD
Executive Function in Learning in Children With Attention Deficit Hyperactivity Disorder (ADHD) Receiving Medical Treatment Alone Compared to Children Receiving Additional Treatment to Improve Learning Strategies
The purpose of this study is to determine whether there is a difference in executive function in learning in children with ADHD receiving medical treatment alone to the executive function in children receiving, in addition to…
- Trial name
- NCT01531127
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hillel Yaffe Medical Center
Cerebral Palsy
Impact of an Education Program for Parents of Children With Cerebral Palsy
The Physical Therapy for children with Cerebral Palsy is of great complexity, in addition to improving the neuromotor components at the level of structure and body function, must empower them to carry out their activities and…
- Trial name
- NCT02490462
- Testing
- Education + Conventional PhysicalTherapy, Conventional Physical Therapy
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Bahia
Autism Spectrum Disorder, Attention Deficit-Hyperactivity Disorder
Community Based Intervention for Children With ADHD and ASD
The purpose of this study is to determine whether a new treatment, Unstuck and On Target (UOT), works better, worse, or the same as the best treatment that is available now, Contingency Behavioral Management (CBM), for low income…
- Conditions
- Autism Spectrum Disorder, Attention Deficit-Hyperactivity Disorder, Executive Function
- Trial name
- NCT03003286
- Testing
- Unstuck and on Target (UOT), Parents and Teachers Supporting Students (PATSS)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Lauren Kenworthy
Hepatocyte Nuclear Factor 1-beta
Long Term Follow up of a Cohort of Children With TCF2 Mutation:Evolution of Endocrine and Renal Function
Anomalies of renal development are well know for patients treated for MODY-5 diabetes due to TCF2 mutation.A recent study confirms the existence of pediatric patients having TCF2 mutation but presenting renal anomalies…
- Trial name
- TCF2 (NCT00760331)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Limoges
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