Clinical trials: Pigmentation Disorder
Vitiligo, Repigmentation
Topical Bimatoprost Solution 0.03%in Stable Vitiligo
Vitiligo is an acquired depigmentation disorder of great cosmetic importance, affecting 1-4% of the world's population. Phototherapy and topical agents such as corticosteroids, calcineurin inhibitors, and vitamin-D derivatives…
- Trial name
- NCT01202513
- Testing
- Bimatoprost 0.03% topical ophthalmic solution
- Volunteers
- 20 people
- Sponsor
- Gian Sagar Medical College and Hospital
Vitiligo
Effect of Early Systemic Stabilization Therapy on Recent Onset Vitiligo
Vitiligo is a distressing disorder of depigmentation. In spite of multiple successful therapeutic regimens, disease relapse remains a challenge to patients and physicians.
- Trial name
- NCT05037981
- Volunteers
- 25 people
- Sponsor
- Cairo University
Pulse Oximetry, Disparities
Beyond Race: Objectively Assessed Skin Color and Its Association With Pulse Oximeter Bias in Critically Ill Infants
The overall objective of this proposal is to quantify the bias in pulse oximeter reported oxygen saturation (SpO2) by evaluating its measures compared to the gold standard blood gas measured arterial oxygen saturation (SaO2)…
- Conditions
- Pulse Oximetry, Disparities, Infants
- Trial name
- NCT05994417
- Volunteers
- 200 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Vitiligo
Microneedling Combined With Topical Crisaborole 2 % Ointment in Treatment of Vitiligo.
The goal of this clinical trial is to learn if topical crisaborole ointment works to treat vitiligo. It will also learn about the safety of the drug.
- Trial name
- NCT07088276
- Testing
- microneedling with topical crisaborole
- Volunteers
- 20 people
- Sponsor
- Tanta University
Skin Pigmentation Over Contour Deformities of Face, Trauma, Rhomberg Disease
Long Term Effects on Skin Hyper Pigmentation With and Without Mesenchymal Stem Cell Enriched Adipose Tissue Grafting for "Contour Deformities With Pigmentary Changes on Face"
MSCs one injected along with fat, regulate pigmentation over the contour defects of face
- Trial name
- MSCs (NCT03564808)
- Testing
- MSC
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Retinitis Pigmentosa, Usher Syndromes
Prospective Open Clinical and Genetic Study of Patients With Retinitis Pigmentosa
This study is aimed to characterize Russian population of Retinitis Pigmentosa
- Trial name
- RU-RP (NCT03901391)
- Testing
- Whole Exome Sequencing
- Where
- 2 sites in Russia
- Volunteers
- 130 people
- Sponsor
- Sensor Technology for Deafblind
Acanthosis Nigricans
Systemic and Topical Metformin Versus Glycolic Acid Peel for the Treatment of Acanthosis Nigricans
Acanthosis nigricans (AN) is a common dermatologic condition associated with insulin resistance and obesity. Existing treatment options often provide inconsistent results.
- Trial name
- MET-AN (NCT07751549)
- Testing
- systemic metformin, topical intervention, glycolic acid 70% peeling
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Tanta University
Vitiligo
A Phase III Clinical Study to Evaluate the Efficacy and Safety of MH004 Ointment in Non-segmental Vitiligo
This is a randomized, double-blind, multicenter, placebo-controlled clinical study intended to evaluate the efficacy, safety and population pharmacokinetic profiles of MH004 ointment in eligible participants with NSV.
- Trial name
- NCT07682506
- Testing
- MH004 1.0% Ointment
- Where
- China
- Volunteers
- 405 people
- Sponsor
- Minghui Pharmaceutical (Hangzhou) Ltd
Hermansky Pudlak Syndrome
A Longitudinal Study of Hermansky-Pudlak Syndrome Pulmonary Fibrosis
Hermansky-Pudlak Syndrome (HPS) is a rare genetic disease that is associated with oculocutaneous albinism, bleeding, granulomatous colitis, and pulmonary fibrosis in some subtypes, including HPS-1, HPS-2, and HPS-4.
- Trial name
- NCT02368340
- Testing
- Pulmonary function test, Chest CT, Sample collection
- Where
- 5 sites in United States
- Volunteers
- 55 people
- Sponsor
- Vanderbilt University
RAS Mutation, Neurofibromatosis 1
RASopathy Biorepository
The RASopathies are a group of developmental disorders caused by genetic changes in the genes that compose the Ras/mitogen activated protein kinase (MAPK) pathway. New RASopathies are being diagnosed frequently.
- Conditions
- RAS Mutation, Neurofibromatosis 1, Noonan Syndrome, Noonan Syndrome With Multiple Lentigines
- Trial name
- NCT04395495
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Leber Congenital Amaurosis
Safety Study in Subjects With Leber Congenital Amaurosis
The purpose of this study is to determine whether gene transfer will be safe and effective in the treatment of Leber Congenital Amaurosis (LCA).
- Trial name
- NCT00516477
- Testing
- voretigene neparvovec-rzyl
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Spark Therapeutics, Inc.
Infectious Disease, Bacterial Overgrowth
Infectious Pseudochromdrosis Caused by Bacillus Cereus
Twelve patients with blue sweat (infectious pseudochromhidrosis) caused by Bacillus cereus.
- Conditions
- Infectious Disease, Bacterial Overgrowth, Pigment Deposition
- Trial name
- Blue sweat (NCT05507086)
- Testing
- Antimicrobial therapy
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Oslo University Hospital
Pressure Injuries, Pressure Ulcers, Bedsores, Decubitus Ulcer
Prevention of Pressure Injury (PI) in Hospitalised Infants, Children, and Young People (CYP) (Aged 0-19 Years)
What is the problem? Children and young people admitted to hospital can sometimes be harmed by what is called a pressure injury. Pressure injuries are sores (ulcers) that happen on areas of the skin that are under pressure.
- Trial name
- CYPPI (NCT07303569)
- Where
- United Kingdom
- Volunteers
- 542 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Melasma
Efficacy of New Trio Combination for Melasma
The goal of this clinical trial is to learn if the drug New Trio Combination (0.1% isobutylamido-thiazolyl-resorcinol, 0.1% retinoic acid and 0.1% dexamethasone) works to treat melasma.
- Trial name
- NCT07676994
- Testing
- New trio combination, Kligman's formula (trio)
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Ghurki Trust and Teaching Hospital
Albinism, Ocular
NGS Panel of Incomplete Forms of Ocular Albinism
Implementation of a next-generation sequencing panel of genes to identify deleterious variants in patients with incomplete forms of albinism.
- Trial name
- DIA (NCT04495218)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 53 people
- Sponsor
- University Hospital, Bordeaux
CHD - Congenital Heart Disease, Single Ventricle Heart Disease
PRecision Integrated Saturation Monitor
The purpose of this study is to find out if an abdominal pulse oximeter device is as accurate as a conventional fingertip pulse oximeter in pediatric patients.
- Trial name
- PRISM (NCT07686341)
- Testing
- vital sign monitoring
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Le Bonheur Children's Hospital
Port Wine Stains
The Effects of Aldara as an Adjunct to Laser Treatment
The primary objective is to determine the effects of Aldara on the cosmetic outcome of laser treatment of vascular malformations.
- Trial name
- NCT00979550
- Testing
- Imiquimod, non-medicated petroleum cream
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Henry Vasconez
Pigment Dispersion, Mosaicism
Characterize Metzker Pigmentary Disorders
Metzker pigmentary disorders are frequent cause of consultation in pediatric dermatology. The investigators can describe 4 patterns.
- Trial name
- NCT04966533
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Montpellier
Vitiligo
Oral Mini Pulse Dexamethasone in Pediatric Vitiligo
The goal of this clinical trial is to learn if oral mini pulse (OMP) dexamethasone works to treat active vitiligo in children and also learn about the safety of this drug within this age group the main questions it aims to answer…
- Trial name
- NCT07353801
- Testing
- Dexamethasone (0.1 mg/kg)
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Cairo University
Vitiligo Vulgaris
The Effect of Fractional Co2 Laser Either With Tacrolimus, Calcipotriol or NB-UVB in Stable Generalized Vitiligo
Vitiligo is an acquired disorder of the skin and mucous membranes characterized by well circumscribed depigmented macules and patches that occur secondary to selective destruction of melanocytes (Zhang et al., 2009).
- Trial name
- NCT03234673
- Testing
- Tacrolimus ointment, calcipotriol ointment, NB-UVB
- Volunteers
- 30 people
- Sponsor
- Assiut University