Clinical trials: Pleural Empyema
Pleural Effusion, Pleurisy
Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy
This is a prospective study to assess the efficacy and safety of a single dose of cefazolin 2g IV for the prophylaxis of surgical site and pleural space infections in patients undergoing medical thoracoscopy.
- Conditions
- Pleural Effusion, Pleurisy, Empyema
- Trial name
- APT (NCT02446782)
- Testing
- Cefazolin, saline
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Empyema
Empyema Treated With tPA & DNAse
The objective of this study is to scientifically evaluate a new substrate for fibrinolysis compared to our standard tPA. The hypothesis, driven by a recent prospective trial, is that tPA may benefit from the addition of DNAse.
- Trial name
- NCT01862458
- Testing
- tPA alone, tPA plus dornase
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City
Pleural Empyema, Tuberculosis (TB)
The Role of Decortication in Complex Empyema Cases: Multidrug Resistance and Tuberculosis at the Forefront
Empyema is a problem that thoracic surgeons deal in everyday practice. The main goal of treatment is evacuating the pus and fibrin deposits in the thoracic cavity for complete lung expansion.
- Conditions
- Pleural Empyema, Tuberculosis (TB), Bacterial Sepsis
- Trial name
- NCT07167823
- Testing
- Decortication
- Where
- Pakistan
- Volunteers
- 350 people
- Sponsor
- University of Health Sciences Lahore
Second Stage Empyema
Comparative Study Between Outcome of ICT Drainage and VATS in Management of Second Stage Empyema
The goal of this clinical trial is to compare between outcome of inter-costal tube drainage and video assisted thoracoscopic surgery in management of patients with second stage empyema.
- Trial name
- ICT and VATS (NCT06680024)
- Testing
- Intercostal tube, Video assisted thoracoscope
- Volunteers
- 40 people
- Sponsor
- Sohag University
Pyothorax, Fungal Infection Lungs
Fungal Empyema Thoracis
Background: Fungal empyema thoracis is a rare but life-threatening pleural infection caused by fungal organisms such as Aspergillus and Candida species.
- Conditions
- Pyothorax, Fungal Infection Lungs, Pleural Empyema
- Trial name
- NCT07337993
- Testing
- pleural lavage followed by surgery, Decortication, Conservative Arm
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Health Sciences Lahore
Mesothelioma, Lung Neoplasms
Chest Wall Motion Analysis in Disease
Breathing movements, called chest wall motion, are very complex. The investigators are studying how movement of the abdomen, ribs and diaphragm contribute to breathing and how this differs with different diseases in the chest.
- Conditions
- Mesothelioma, Lung Neoplasms, Surgery, Cystic Fibrosis
- Trial name
- CWM (NCT02958683)
- Testing
- Chest wall motion analysis
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Heart of England NHS Trust
Empyema
Thoracoscopy Versus Fibrinolysis in Children With Empyema
The null hypothesis is that patients receiving either thoracoscopy or fibrinolysis for empyema recover in the same amount of time.
- Trial name
- NCT00323531
- Testing
- Chest tube with tPA infusion for 3 days, VATS decortication
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Children's Mercy Hospital Kansas City
Complicated Pleural Effusion/ Empyema
Efficacy of Fibrinolytic Agents in Complicated Pleural Effusion
Intrapleural administration of fibrinolytic therapy, urokinase in parapneumonic effusion and empyema has been shown to decrease the need for surgical intervention and length of hospital stay.
- Trial name
- NCT03716375
- Testing
- Intrapleural Medications
- Volunteers
- 80 people
- Sponsor
- Beijing Children's Hospital
Empyema, Pleural
Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema
To evaluate the impact of using different antibiotic regimens including single and combined agents as the empirical therapy and evaluate the clinical outcomes regarding safety, efficacy, and pharmacodynamics parameters.
- Trial name
- NCT06787885
- Testing
- Levofloxacin + clindamycin, Levofloxacin + cefipime
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Fayoum University
Pleural Empyema
Dornase Alfa and Urokinase for Kids With Pleural Empyema
The purpose of this study is to determine whether intrapleural treatment with Dornase alfa plus Urokinase improves clinical outcome compared to Urokinase alone in children with complicated parapneumonic effusions
- Trial name
- DUKE (NCT00502632)
- Testing
- Urokinase and Dornase alfa, Urokinase
- Where
- 3 sites in Italy
- Volunteers
- 94 people
- Sponsor
- Azienda Ospedaliera di Padova
Empyema, Pneumonia
Urokinase Versus Video-assisted Thoracoscopic to Treat Complicated Parapneumonic Empyema in Childhood
A great controversy exists about which is the best method to perform the evacuation of the collection. The purpose of this study is to evaluate which is the best initial treatment to drain complicated parapneumonic empyema…
- Trial name
- NCT00798278
- Testing
- Urokinase, Video-Assisted Thoracoscopic
- Where
- 6 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Spanish Society of Pediatric Surgery
Acute Cholecystitis, Empyema of Gallbladder
Effects of Drainage in Laparoscopic Cholecystectomy
During laparoscopic surgery for an acutely inflamed gallbladder, most surgeons routinely insert a drain. However, no consensus has been reached regarding the need for drainage in these cases, and the use of a drain remains…
- Conditions
- Acute Cholecystitis, Empyema of Gallbladder, Abscess of Gallbladder
- Trial name
- NCT02027402
- Testing
- Laparoscopic cholecystectomy with drain insertion
- Where
- South Korea
- Volunteers
- 198 people
- Sponsor
- Seoul St. Mary's Hospital
Empyema, Pleural
Comparison of Intrapleural Urokinase and Video-Assisted Thorascopic Surgery in the Treatment of Parapneumonic Pleural Effusion in Children
Despite the improvement in the technology available for diagnosing and treating empyema, the management of empyema in children remains controversial.
- Trial name
- UROVATS (NCT02165891)
- Testing
- insertion of a chest drain with urokinase instillation, primary video-assisted thorascopic surgery
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Queen Fabiola Children's University Hospital
Acute Calculous Cholecystitis, Gallbladder Empyema
Role of Intra-Operative Aspiration in Distended GB in LC
Laparoscopic cholecystectomy (LC) is a standard procedure for gallstones and the standard surgical approach for acute calcular cholecystitis, superseding open cholecystectomy for gallbladder (GB) pathologies.
- Conditions
- Acute Calculous Cholecystitis, Gallbladder Empyema, Gallbladder Mucocele
- Trial name
- NCT07378410
- Testing
- Laparoscopic needle
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Aswan University
Pleural Empyema
Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial)
Bacterial pneumonia can be complicated by the development of excess fluid and pus (pleural empyema) around the lungs in children. The incidence of pleural empyema in children has increased significantly in the last 10 years.
- Trial name
- NCT01717742
- Testing
- TPA (Tissue Plasminogen Activator), DNase
- Where
- 6 sites in Canada
- Volunteers
- 97 people
- Sponsor
- The Hospital for Sick Children
Empyema
Clinical Feature and Microbiology Characteristics of Empyema in Children
The study is designed to clarify the clinical characteristics and reversion of children with empyema, observe the effect of streptococcus vaccine application on serotype of streptococcus, and to explore the susceptibility factors…
- Trial name
- NCT04695275
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Children's Hospital
Empyema
Is Intercostal Tube Enough in Management of Empyema
Is intercostal tube enough in management of empyema ?
- Trial name
- NCT06235359
- Testing
- intercostal tube
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Parapneumonic Pleural Effusion, Empyema
Clinical Trial Corticoids For Empyema And Pleural Effusion In Children
STUDY JUSTIFICATION 1. Scientific evidence of the usefulness of corticosteroid use for infectious diseases: Corticosteroids along with antibiotic use improve survival in some infectious processes provide long term benefits and…
- Trial name
- CORTEEC (NCT01261546)
- Testing
- Dexamethasone
- Where
- 8 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Infanta Sofia
Thoracic Empyema
Pediatric Video Assisted Thoracoscopic Surgery (VATS) in Management of Empyema
Thoracic surgeons have developed a thoracoscopic procedure which is less intrusive method allows complete evacuation and washing of the debris from the pleural cavity.
- Trial name
- VATS (NCT06424457)
- Testing
- video assisted thoracoscopy (VATS), open thoracotomy
- Where
- Egypt
- Volunteers
- 73 people
- Sponsor
- Assiut University
Empyema Thoracis in Children
Early Results of Empyema Thoracis Treatment in Children by Video-assisted Thoracoscopic Surgery
The aim of study is to assess early results of Empyema Thoracis treatment in Children by Video-assisted Thoracoscopic Surgery
- Trial name
- NCT04177550
- Where
- Vietnam
- Volunteers
- 44 people
- Sponsor
- Nhan Pham Nguyen Hien