Clinical trials: Pleurodesis
Primary Spontaneous Pneumothorax
Autologous Blood Patch for Primary Spontaneous Pneumothorax
The purpose of this study is to show that treatment with prophylactic autologous blood patch (ABP) after management of primary spontaneous pneumothorax (PSP) is feasible, reduces the incidence of prolonged air leaks, and reduces…
- Trial name
- NCT06088901
- Testing
- Autologous Blood Patch
- Where
- United States
- Sponsor
- Rush University Medical Center
Malignant Pleural Effusion, Thoracic Cancer
Video Assisted Thoracoscopic Surgery (VATS) - Surgical Pleurodesis vs Tube Drainage in Management of Malignant Pleural Effusion (MPE)
Malignant Pleural Effusion (MPE) is considered to be a common presentation at malignant tumors representing 15% of all cancer cases. It carries a burden on our patients with dyspnea being the most common symptom in most of cases.
- Trial name
- NCT05872126
- Testing
- VATS-Surgical pleurodesis, Tube Drainage
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pneumothorax
Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax
To test if additional minocycline pleurodesis after thoracoscopic procedures can reduce the rates of ipsilateral recurrence for patients with primary spontaneous pneumothorax.
- Trial name
- NCT00154895
- Testing
- intrapleural minocycline instillation
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Pleural Effusion
Comparison of Thoracoscopic Talc Pleurodesis by Thoracic Epidural or General Anesthesia
Video-assisted thoracoscopic surgery (VATS) talc pleurodesis is often carried out in patients with malignant recurrent pleural effusion to relieve symptoms and prevent recurrence.
- Trial name
- NCT01469728
- Testing
- Non-awake VATS talc pleurodesis, Awake VATS talc pleurodesis
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Rome Tor Vergata
Primary Spontaneous Pneumothorax
Efficacy of the Additional Mechanical Pleurodesis for Surgical Management of Primary Spontaneous Pneumothorax
For the definite treatment of primary spontaneous pneumothorax(PSP), thoracoscopic bleb obliteration with pleural adhesive procedure is generally accepted as a standard.
- Trial name
- NCT00615849
- Testing
- thoracoscopic surgery
- Where
- South Korea
- Volunteers
- 1,440 people
- Sponsor
- Seoul National University Bundang Hospital
Pneumothorax
Pleural Abrasion Plus Minocycline Versus Apical Pleurectomy for Primary Spontaneous Pneumothorax
Optimal surgical management of primary spontaneous pneumothorax has been a matter of devate, especially regarding the method of pleurodesis.
- Trial name
- NCT00270751
- Testing
- 1 apical pleurectomy, 2 pleural abrasion + minocycline pleurodesis
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Pneumothorax
Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax
The estimated recurrence rate of primary spontaneous pneumothorax is 23-50% after the first episode, and the optimal treatment remains unknown.
- Trial name
- NCT00418392
- Testing
- Simple aspiration with minocycline pleurodesis, simple aspiration
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Thoracic Surgical Procedures
Thoracoscopic Bullectomy Versus Thoracoscopic Bullectomy With Pleurodesis in Primary Spontaneous Pneumothorax
The exact pathogenesis of PSP is controversial. A few theories has been proposed contributing to the pathogenesity of the PSP as emphysematous like changes (ELCs) which lead to the formation and rupture of the lung bullae or…
- Trial name
- NCT03943069
- Testing
- Thoracoscopic bullectomy alone, Thoracoscopic bullectomy with pleurodesis
- Where
- Saudi Arabia
- Volunteers
- 232 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Safety of Intervention, Efficacy of Intervention
Video-assisted Hyperthermic Pleural Chemoperfusion vs Talc Pleurodesis for Refractory Malignant Pleural Effusions.
Aim of this study is to compare two methods of pleurodesis for refractory malignant pleural effusions, in terms of safety and efficacy.
- Conditions
- Safety of Intervention, Efficacy of Intervention, Cost Effectiveness
- Trial name
- NCT01409551
- Testing
- VATS hyperthermic chemoperfusion, Bedside talc slurry pleurodesis
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Theagenio Cancer Hospital
Pneumothorax
A Prospective Randomised Study of Efficacy, Safety and Costs of Talc Pleurodesis Under Medical Thoracoscopy and Pleurodesis Under Video-assisted Thoracoscopy Surgery for Recurrent Primary Spontaneous Pneumothorax
Treatment of recurrent primary spontaneous pneumothorax remains controversial and many therapeutic options exist. The aim of this study is to compare pleural symphysis by talc poudrage during medical thoracoscopy and surgical…
- Trial name
- NCT00767962
- Testing
- talc pleurodesis under medical thoracoscopy, pleurodesis under video-assisted thoracoscopy surgery
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pneumothorax
Intrapleural Minocycline Following Simple Aspiration for Primary Spontaneous Pneumothorax
The optimal initial management of primary spontaneous pneumothorax (PSP) remains controversial. This study was conducted to evaluate the safety and efficacy of additional minocycline pleurodesis after successful aspiration of the…
- Trial name
- NCT00520221
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan University Hospital
Spontaneous Pneumothorax, Surgery
Absorbable Mesh Pleurodesis in Thoracoscopic Treatment of Spontaneous Pneumothorax
Primary spontaneous pneumothorax usually occurs in young, lean male without underlying lung disease. In most cases, the cause of pneumothorax is rupture of blebs at the apex of the lung.
- Trial name
- NCT01848860
- Testing
- Thoracoscopic bullectomy and pleural abrasion, Mesh coverage of the staple line
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- National Taiwan University Hospital
Malignant Pleural Effusions, Recurrent Pleural Effusions
A Comparative Study of the Safety and Efficacy of Face Talc Slurry and Iodopovidone for Pleurodesis
Pleurodesis is a technique used to fuse the two layers of the lining over the lung. This is done to get rid of collections of fluid or air in this space.
- Conditions
- Malignant Pleural Effusions, Recurrent Pleural Effusions, Primary Spontaneous Pneumothorax, Secondary Spontaneous Pneumothorax
- Trial name
- NCT00430664
- Testing
- Pleurodesis with either talc or iodopovidone
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary
Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis
Pleural effusion is characterized by the accumulation of fluid in the pleural space, which typically contains about 10-20 mL of pleural fluid that is crucial for the movement of the lungs against the chest wall.
- Conditions
- Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary, Pleural Effusion, Malignant, Pleurodesis
- Trial name
- NCT07167992
- Testing
- Pleurodesis
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- University of Health Sciences Lahore
Primary and Secondary Spontaneous Pneumothorax
Does Non-Steroidal Anti-inflammatory Drugs Decrease the Quality of Pleurodesis After Mechanical Pleural Abrasion/Pleurectomy for Treatment of Pneumothorax?
Investigators aim to assess if NSAIDs affect the quality of pleurodesis resulting from mechanical pleurodesis (open surgery or VATS) regarding : Primary outcome: Recurrence of pneumothorax in 6 monthes.
- Trial name
- NCT06467318
- Testing
- Paracetamol, NSAID, Paracetamol
- Where
- Egypt
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Effect of Patient Rotation on Pleurodesis Success and Patient Comfort, Malignant Pleural Effusion
Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound
chemical pleurodesis using doxycycline is an acceptable and commonly employed palliation for malignant pleural effusion. Rotation of patient during pleurodesis using the powder from doxycycline capsule is still practiced in some…
- Conditions
- Effect of Patient Rotation on Pleurodesis Success and Patient Comfort, Malignant Pleural Effusion, Pleurodesis
- Trial name
- NCT07147270
- Testing
- side to side and front to back rotation 30 minutes each
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Pneumothorax, Pleurodesis
Improving Primary Spontaneous Pneumothorax (PSP) Treatment Techniques in VATS
The purpose of this study is to: 1. Evaluate the validity of using abnormal characteristics of the pneumothorax line, as evaluated from chest X-ray film, as the operative indications for video-assisted thoracic surgery (VATS) on…
- Trial name
- NCT01463553
- Testing
- VATS pleurodesis
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Beijing Haidian Hospital
Malignant Pleural Effusions (Mpe)
The Outcome of Inserting Intercostal Tube or Pleurodesis for Malignant Pleural Effusion
Approximately half of all patients with metastatic cancer develop a malignant pleural effusion which is likely to lead to a significant reduction in quality of life secondary to symptoms such as dyspnoea and cough.
- Trial name
- NCT06742099
- Testing
- Intercostal chest tube, Pleurodesis
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Primary Spontaneous Pneumothorax
Which is Better Between Single Chest Tube and Multiple Tubes Drainage in Primary Spontaneous Pneumothorax
There was no evidence that the number of chest tube do effect to the recurrence of pneumothorax, which placed after thoracoscopic wedge resection together with mechanical pleurodesis.This study evaluates the efficacy of single…
- Trial name
- NCT04831554
- Testing
- single chest tube drainage
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital