Clinical trials: Pleurodesis
Prolonged Air Leak, Persistent Air Leak
Comparison of 40% Glucose Solution and Autologous Blood Patch Pleurodesis for Postoperative Air Leak After Lung Resections
Prolonged or persistent air leak (PAL) is one of the most common complications in patients after surgery on the lung parenchyma.
- Trial name
- GLUC-PAL (NCT06936969)
- Testing
- Autologous blood patch pleurodesis, 40% glucose solution pleurodesis
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Wielkopolskie Centrum Pulmonologii i Torakochirurgii
Primary Spontaneous Pneumothorax
Which is Better Between Single Chest Tube and Multiple Tubes Drainage in Primary Spontaneous Pneumothorax
There was no evidence that the number of chest tube do effect to the recurrence of pneumothorax, which placed after thoracoscopic wedge resection together with mechanical pleurodesis.This study evaluates the efficacy of single…
- Trial name
- NCT04831554
- Testing
- single chest tube drainage
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Pleural Effusion, Malignant
Multicentre Study Comparing Indwelling Pleural Catheter With Talc Pleurodesis for Malignant Pleural Effusion Management
Malignant pleural effusion (MPE) accounts for 50% of all pleural effusions and affects about 300,000 patients annually (UK and USA).
- Trial name
- NCT02045121
- Testing
- Indwelling Pleural Catheter, Talc Pleurodesis
- Where
- Singapore
- Volunteers
- 160 people
- Sponsor
- National University Hospital, Singapore
Lung Cancer
Cervical Video Assisted Thoracoscopic Surgery (C-VATS)
Although thoracic NOTES may not be ready for human trials, a new minimally invasive technique to access the pleural cavity and perform pleural, pulmonary and mediastinal procedures would be possible.
- Trial name
- CT0030 (NCT01440244)
- Testing
- Cervical mediastinoscopy
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Mesothelioma, Malignant
11C-Methionine PET/CT Imaging in Patients Affected by Malignant Pleural Mesothelioma (MPM)
Prospective exploratory study specifically investigating the role of 11C-Methionine PET/CT imaging in patients affected by Malignant Pleural Mesothelioma (MPM) and candidate to pleurodesis.
- Trial name
- NCT02519049
- Testing
- No intervention
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas
PCL Pleurodesis
PCL (Poly-ε-caprolactone) Mesh Pleurodesis
Recent advances in thoracoscopic surgery have made it a commonly used technique for treating spontaneous pneumothoraces and preventing recurrence.
- Trial name
- NCT03227978
- Testing
- PCL mesh pleurodesis
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Pleural Effusion, Malignant
Relationship Between Pleural Elastance and Effectiveness of Pleurodesis on Recurrent Malignant Pleural Effusion
The objective of this study is to analyze the correlation between pleural elastance and the radiological effectiveness (measured by chest tomography) of pleurodesis performed via catheters in patients with RMPE.
- Trial name
- NCT01819363
- Testing
- Pleural elastance
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Grupo de Pesquisa em Pleura e Oncologia Toracica
Postoperative Air Leak
The Efficacy of OK-432 Pleurodesis on Postoperative Air Leak
The purpose of this study is (1) The success rate of OK-432 pleurodesis after thoracic surgery that air leak over 48 hours (2)The side effects and treatments of OK-432 pleurodesis.
- Trial name
- NCT02502643
- Testing
- OK-432 pleurodesis, normal saline pleurodesis
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Pneumothorax
Intrapleural Minocycline Following Simple Aspiration for Primary Spontaneous Pneumothorax
The optimal initial management of primary spontaneous pneumothorax (PSP) remains controversial. This study was conducted to evaluate the safety and efficacy of additional minocycline pleurodesis after successful aspiration of the…
- Trial name
- NCT00520221
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan University Hospital
Pleural Effusion, Malignant
Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion
Iodopovidone is safe when using as a pleurodesis sclerosing agent for malignant pleural effusion, with minimal adverse events, especially reducing dose.
- Trial name
- NCT01670786
- Testing
- pleurodesis
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Grupo de Pesquisa em Pleura e Oncologia Toracica
Postoperative Air Leak
Pleurodesis Using Hypertonic Glucose to Treat Post-operative Air Leaks
The investigators will define the most appropriate safe dose of D50 to heal air leaks in patients that have undergone lung resection surgery
- Trial name
- PLUG-I (NCT03905408)
- Testing
- 50 mL of 50% Glucose, 100 mL of 50% Glucose, 150 mL of 50% Glucose
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Malignant Pleural Effusion, Respiratory Disease
AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion
The purpose of this study is to determine if an indwelling catheter is more effective than surgical pleurodosis in treating malignant pleural effusion.
- Conditions
- Malignant Pleural Effusion, Respiratory Disease, Cancer
- Trial name
- AMPLE-3 (NCT04322136)
- Testing
- Pleurodesis via Video-assisted thoracoscopic surgery, Indwelling pleural catheter (with talc pleurodesis if suitable)
- Where
- Australia
- Volunteers
- 158 people
- Sponsor
- The University of Western Australia
Malignant Pleural Effusion, Malignancy
Feasibility of Ambulatory Talc. Pleurodesis
Patients with malignant pleural disease often experience a significant symptom burden and a short life expectancy. The cornerstone of their treatment is relieving breathlessness by draining fluid from around the lungs and…
- Conditions
- Malignant Pleural Effusion, Malignancy, Palliative Care
- Trial name
- NCT06682936
- Testing
- ambulatory chest drain and talc pleurodesis
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- David Rollins
Pneumothorax, Pleurodesis
Improving Primary Spontaneous Pneumothorax (PSP) Treatment Techniques in VATS
The purpose of this study is to: 1. Evaluate the validity of using abnormal characteristics of the pneumothorax line, as evaluated from chest X-ray film, as the operative indications for video-assisted thoracic surgery (VATS) on…
- Trial name
- NCT01463553
- Testing
- VATS pleurodesis
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Beijing Haidian Hospital
Malignant Pleural Effusions
Biomarker Levels During Indwelling Pleural cAtheter Sample Testing
Some patients that have a tunneled pleural catheter will not have the pleural fluid (water around the lung) return after some time (pleurodesis).
- Trial name
- BLAST (NCT02092155)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Johns Hopkins University
Malignant Pleural Effusions (Mpe)
The Outcome of Inserting Intercostal Tube or Pleurodesis for Malignant Pleural Effusion
Approximately half of all patients with metastatic cancer develop a malignant pleural effusion which is likely to lead to a significant reduction in quality of life secondary to symptoms such as dyspnoea and cough.
- Trial name
- NCT06742099
- Testing
- Intercostal chest tube, Pleurodesis
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Advanced Cancer, Pleural Effusion
Intrapleural Catheter Daily Versus Three Times a Week Drainage
The goal of this clinical research study is to learn if draining the IPC every day is better at than draining it 3 times a week.
- Trial name
- NCT00761618
- Testing
- Intrapleural catheter (IPC) drained, IPC Placement, Chest X-Ray
- Where
- United States
- Volunteers
- 257 people
- Sponsor
- M.D. Anderson Cancer Center
Air Leak From Lung
Pleurodesis Using Hypertonic Glucose
Air leaks from unhealed lung tissue following lung resection for benign or malignant lesions are one of the most common complications following thoracic surgery, occurring after 10% of major lung resections.
- Trial name
- PLUG-II (NCT06293885)
- Testing
- Dextrose 50, Standard of Care - No Dextrose 50
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Recurrent Malignant Pleural Effusion.
Talc Pleurodesis in Patients With Recurrent Malignant Pleural Effusion
The purpose of this study is to analyze and compare radiological lung expansion after talc pleurodesis performed either by videothoracoscopy or chest tube and correlate it with clinical outcome.
- Trial name
- NCT00789087
- Testing
- Videothoracoscopic talc poudrage (VT)., Talc slurry through a chest tube (DT).
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Metastatic Cancer
Ibuprofen or Morphine in Treating Pain in Patients Undergoing Pleurodesis for Malignant Pleural Effusion
RATIONALE: Morphine and ibuprofen help lessen pain caused by pleurodesis. It is not yet known whether one drug is more effective than the other in lessening pleurodesis-related pain or whether the size of the chest drain tube…
- Trial name
- NCT00644319
- Testing
- ibuprofen, morphine sulfate, management of therapy complications
- Where
- United Kingdom
- Volunteers
- 320 people
- Sponsor
- Oxford University Hospitals NHS Trust