Clinical trials: Pneumoperitoneum
Pain, Inflammatory, Pain Management
Reduced-pressure Pneumoperitoneum and Intraperitoneal Saline Washout to Alleviate Pain Following vNOTES Hysterectomy
vNOTES, initially employed for cholecystectomy, appendectomy, and nephrectomy, made its debut in the field of gynecologic surgery in 2012.
- Trial name
- Vnotes (NCT06944015)
- Testing
- normal saline
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Surgery, Pneumoperitoneum
Intra-Abdominal Pressure Effect on Intra-Abdominal Volume and Airway Pressures During Laparoscopy
During pneumoperitoneum insufflation the insufflated gas increase intra-abdominal pressure. The generated pressure can lead to a different increase in volume depending on the abdominal cavity and patients' characteristics.
- Conditions
- Surgery, Pneumoperitoneum, Intra Abdominal Pressure
- Trial name
- NCT04468698
- Testing
- Peritoneum insufflation
- Where
- Spain
- Volunteers
- 204 people
- Sponsor
- Hospital Universitario La Fe
Shoulder Pain
Pneumoperitoneum Management With SurgiQuest AirSeal® at Low vs. Higher Pressure
A prospective, randomized, controlled single-center clinical Study designed to evaluate Physician Preference related to the use of the SurgiQuest AirSeal® Insufflation System (AIS) at low vs.
- Trial name
- PRESSURE (NCT02837601)
- Testing
- AirSeal® Insufflation System (AIS)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Akron Children's Hospital
Laparoscopy, Pneumoperitoneum
The Turbine-based CO2 Insufflator Pediatric Feasibility Study
A novel CO2 insufflator, the Turbine-based insufflator, has been developed to improve minimally invasive surgery. Turbine technology permits accurate pressure control resulting in an intra-abdominal volume that is dynamically…
- Trial name
- TuBa (NCT07715968)
- Testing
- Turbine-based insufflator
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Erasmus Medical Center
Anesthesia, Intravenous, Hemodynamic Stability
Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery
This single-center study at CHA Ilsan Medical Center compares intraoperative hemodynamics between remimazolam- and propofol-based total intravenous anesthesia (TIVA) in patients undergoing robot-assisted gynecologic surgery…
- Conditions
- Anesthesia, Intravenous, Hemodynamic Stability, Gynecologic Surgery
- Trial name
- By_HD (NCT07251101)
- Testing
- Remimazolam, Propofol
- Where
- 2 sites in South Korea
- Volunteers
- 58 people
- Sponsor
- Ilsan Cha hospital
Hemodynamic Response, Acute Appendicitis
Lidocaine VS Hemodynamic, Metabolic and Hormonal Response
Intravenous lidocaine - a potent local anesthetic with analgesic and anti- inflammatory properties has been shown to be an effective adjunct that reduces intra and postoperative opioid consumption and facilitates pain management…
- Conditions
- Hemodynamic Response, Acute Appendicitis, Complication of Treatment, Opioid Consumption
- Trial name
- NCT05238506
- Testing
- Intravenous lidocaine, Normal saline infusion
- Where
- Poland
- Volunteers
- 132 people
- Sponsor
- Medical University of Warsaw
Laparoscopic Hysterectomy
Clearance Rate of Peritoneal Fluid After Full Conditioning Pneumoperitoneum
Measurement of residual peritoneal fluid after laparoscopic surgery
- Trial name
- NCT01344499
- Testing
- Carbon dioxide, full conditioning, Adept
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Pneumoperitoneum
CO2 Absorption During Laparoscopy
CO2 absorption from the pneumoperitoneum increases over time during laparoscopic procedures. Adding 4% of oxygen to the carbon dioxide was shown in rabbits to decrease CO2 resorbtion through prevention of mesothelial hypoxia.
- Trial name
- NCT01340989
- Testing
- alteration of the insufflation gas, full conditioning, standard pneumoperitoneum
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Intracranial Pressure
The Effect of Pneumoperitoneum on Intracranial Pressure in Pediatric Laparoscopic Surgery: Ultrasonographic Measurement of Optic Nerve Sheath Diameter
The pneumoperitoneum during laparoscopic surgery in pediatrics has the potential to cause an increase of intracranial pressure (ICP).
- Trial name
- NCT01840267
- Testing
- ultrasonographic measurement of optic nerve sheath diameter
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Yonsei University
Pneumoperitoneum, Pain
Effect of Low-pressure Pneumoperitoneum on Pain and Inflammation Post Laparoscopic Cholecystectomy
The purpose of this study is to assess the effect of low-pressure pneumoperitoneum on post operative pain and inflammation in patients undergoing elective laparoscopic cholecystectomy by comparing it to standard practice.
- Conditions
- Pneumoperitoneum, Pain, Inflammation
- Trial name
- NCT04779515
- Testing
- low-pressure pneumoperitoneum, standard-pressure pneumoperitoneum
- Where
- Jordan
- Volunteers
- 100 people
- Sponsor
- University of Jordan
Cholecystectomy, Pneumoperitoneum
Comparison Between Low Pressure Pneumoperitoneum with High Pressure Pneumoperitoneum in Post-operative Pain, Shoulder Tip Pain and Common Bile Duct Injuries in Patients Undergoing Laparoscopic Cholecystectomy
This study aims to address the existing gap in knowledge by conducting a comprehensive comparison of the incidence of pain and common bile duct injuries in patients undergoing laparoscopic cholecystectomy using Low pressure…
- Conditions
- Cholecystectomy, Pneumoperitoneum, Pain, Postoperative
- Trial name
- NCT06447545
- Testing
- Changing pressure of Pneumoperitoneum to 6-10 mmHg, Changing pressure of Pneumoperitoneum to 12-15 mmHg
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- Gulab Devi Hospital
Pneumoperitoneum
Comparing Nitrous Oxide and Carbon Dioxide for Laparoscopic Cholecystectomy
There is no general agreement about the ideal gas for pneumoperitoneum. CO2, now in common use, has not compared to N2O sufficiently to disclose which one has minimal "physiological" invasiveness characters.
- Trial name
- NCT01512511
- Testing
- nitrous oxide use for pneumoperitoneum creation
- Where
- Iran
- Volunteers
- 64 people
- Sponsor
- Ahvaz Jundishapur University of Medical Sciences
Appendicitis Acute
Low vs Medium Pressure Pneumoperitoneum
The purpose of this study is to asses whether the pressure used for the pneumoperitoneum during laparoscopic surgery in children affects their postoperative pain levels.
- Trial name
- LoMePneu (NCT04949659)
- Testing
- Laparoscopic appendectomy
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University Children's Hospital, Zurich
Pneumoperitoneum
Comparison of Intraoperative Hemodynamic Parameters and Arterial-blood Gas Changes at Two Different Pneumoperitoneal Pressure Values
Clinic and metabolic consequences of pneumoperitoneum, achieved by insufflation of gas carbon dioxide, are still debated. Cardiovascular system suffering due to the compression of intra-abdominal venous structures can cause…
- Trial name
- NCT05367557
- Testing
- laparoscopic cholecystectomy
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Eva Intagliata
Kidney Transplantation
Intraperative Assessment of Renal Perfusion Using Infrared Imaging
Current assessment of organ tissue viability by surgeons in the operating room is limited to crude estimates such as overt physical examination, measurement of laboratory values and physical measurements of vascular flow and…
- Trial name
- NCT00595179
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Bradyarrhythmia, Cardiac Arrest
Glycopyrrolate Prophylaxis for Prevention of Bradyarrhythmia During Laparoscopic Cholecystectomy
The goal of this clinical trial is to evaluate the incidence of bradycardia during laparoscopic cholecystectomy. The main question[s] it aims to answer are: Does bradycardia really occurs during pneumoperitoneum/laparoscopic…
- Conditions
- Bradyarrhythmia, Cardiac Arrest, Tachycardia, Asystole
- Trial name
- NCT05997004
- Testing
- Normal Saline, Glycopyrrolate
- Where
- Nepal
- Volunteers
- 62 people
- Sponsor
- National Academy of Medical Sciences, Nepal
Prostate Cancer, Robotic Surgery
Effect of Dexmedetomidine on Heart-rate Corrected QT(QTc) Interval Prolongation During Robotic-assisted Laparoscopic Radical Prostatectomy -Randomized Blind Clinical Trial-
Sympathetic activity could be increased during robot-assisted laparoscopic radical prostatectomy, which is performed in a steep trendelenburg position under CO2 pneumoperitoneum.
- Trial name
- NCT02536014
- Testing
- Dexmedetomidine, Saline
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Cholelithiasis
Comparison Between Low Pressure Versus High Pressure Laparoscopic Cholecystectomy
The physiological changes and postoperative pain are directly related with the degree of intra-abdominal pressure kept during the laparoscopy.
- Trial name
- NCT00606762
- Testing
- Laparoscopic cholecystectomy
- Where
- India
- Volunteers
- 26 people
- Sponsor
- Sterling Hospital
Hypertension, Laparoscopic Cholecystectomy
Hemodynamic Stability of Dexmedetomidine in Hypertensive Patients Undergoing Laparoscopic Cholecystectomy
Dexmedetomidine provides better hemodynamic stability to the patients with hypertension undergoing laparoscopic cholecystectomy.
- Trial name
- NCT04646317
- Testing
- Dexmedetomidine injection, Normal Saline
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Dr. Ruth K.M. Pfau Civil Hospital, Karachi
Atelectasis
Effects of Pneumoperitoneum on Dynamic Alveolar Stress-strain in Anesthetized Pediatric Patients
General anesthesia is associated with loss of pulmonary functional residual capacity and consequent developement of atelectasis and closure of the small airway.
- Trial name
- NCT04183309
- Testing
- Measure the transpulmonary pressure in pediatric patients
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata