Clinical trials: Polypharmacy
HIV
Polypharmacy and Clinically Significant Drug Interactions Among HIV-Infected Patients Receiving Antiretroviral Therapy
This will be a cross-sectional population-based study carried out in the region of Madrid (6,468,322 inhabitants according to current census) to quantify the number of Co-meds in HIV-infected individuals on ART in the region of…
- Trial name
- PODIUM (NCT03123575)
- Volunteers
- 1,000 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Polypharmacy, Inappropriate Prescribing
Opportunities and Limits to Deprescribing in Nursing Homes:Quality Circle Deprescribing Module
Older people residing in nursing homes (NH) are frequently polymedicated and often prescribed potentially inappropriate medications.
- Trial name
- OLD-NH-QC-DeMo (NCT03688542)
- Testing
- Quality Circle Deprescribing Module
- Where
- Switzerland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Anne Niquille
Medication-related Problems
Clinical Pharmacist-Led Bundled Care Model on Preventable Polypharmacy and Cost Avoidance
This study aims to evaluate whether a clinical pharmacist-led bundled care model can improve medication use and health outcomes in hospitalized adult patients with preventable polypharmacy.
- Trial name
- NCT07719907
- Testing
- Clinical Pharmacist-Led Bundled Care, Control Arm (Usual Care)
- Volunteers
- 260 people
- Sponsor
- Sultan Qaboos University
Inappropriate Prescribing, Primary Health Care
Deprescribing in Primary Health Care
Medications can help older adults but can also harm them. Frail older adults tend to have many health problems that require treatment, but are also at risk of harm from the medications prescribed.
- Conditions
- Inappropriate Prescribing, Primary Health Care, Polypharmacy
- Trial name
- NCT03903484
- Testing
- Deprescribing toolbox and intervention
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Child, Only, Disabilities Multiple
Pediatric Medication Therapy Management Trial
The purpose of this study is to evaluate whether an intervention called Pediatric Medication Therapy Management (pMTM) improves the identification and management of medication-related problems among children with medical…
- Conditions
- Child, Only, Disabilities Multiple, Medication Interaction, Medication Compliance
- Trial name
- pMTM (NCT05761847)
- Testing
- Pediatric Medication Therapy Management (pMTM)
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- University of Colorado, Denver
Adverse Drug Event
Improving Wisely - Polypharmacy
This is a randomized controlled trial that uses an audit and feedback intervention to alert primary care physicians who are outliers in one or more metrics related to high risk prescribing of participants' outlier status.
- Trial name
- NCT03857100
- Testing
- Audit and feedback - letter and report
- Where
- United States
- Volunteers
- 11,000 people
- Sponsor
- Johns Hopkins University
Polypharmacy
Physician-initiated Medication Review in a Type 2 Diabetes Outpatient Clinic
Aiming to reduce polypharmacy in patients with type 2 diabetes by using physician-initiated medication reviews.
- Trial name
- NCT05501223
- Testing
- Medication review, Standard care
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Bispebjerg Hospital
Polypharmacy
Feasibility Study of a Systematic Approach for Deprescribing of Statins and PPI's.
Deprescribing, the process of safely reducing or discontinuing unnecessary or harmful medication, has the potential to decrease polypharmacy and improve health outcomes.
- Trial name
- FeDeS+P (NCT04204590)
- Testing
- Deprescribing algorithm
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Zuyderland Medisch Centrum
Polypharmacy Because of Multimorbidity in Geriatric Nursing Home Residents
Discontinuing Inappropriate Medication in Nursing Home Residents
Nursing home residents are among the frailest patient groups with a high number of co-morbidities and a high use of medicines. Inappropriate polypharmacy (i.e.
- Trial name
- NCT01876095
- Testing
- Multidisciplinary medication review
- Where
- Netherlands
- Volunteers
- 992 people
- Sponsor
- University of Groningen
Psychotropic Drugs, Psychiatric Drugs
Decreasing Harms and Improving Child Health
The investigators are doing this study because they know from research and talking with caregivers that kids can be on a bunch of medications, and it's hard to keep track of what the medications are for and whether or not they…
- Conditions
- Psychotropic Drugs, Psychiatric Drugs, Children, Shared Decision Making
- Trial name
- NCT07392489
- Testing
- AWARE Shared Decision Making Medication Review
- Where
- 4 sites in United States
- Volunteers
- 31 people
- Sponsor
- Glyn Jones-Elwyn
Neurologic Disorder, Chronic Disease
Parent-Reported Symptom Assessments in Children Taking Multiple Medications
This study plans to learn about how to measure symptoms (like tiredness or rash) in children with special healthcare needs who take 5 or more medications. Sometimes symptoms change in severity over time or new symptoms develop.
- Conditions
- Neurologic Disorder, Chronic Disease, Pediatric Disorder
- Trial name
- PRSA (NCT03849066)
- Testing
- Parent-Reported Symptom Assessment
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Colorado, Denver
Delirium, Age-Related Cognitive Decline
Acute Care for Elders (ACE) Program at OHSU Hospital
The purpose of this investigation is to assess the effectiveness of a multi-disciplinary Acute Care for Elders (ACE) program dedicated to the care of patients age 70 and older admitted to Oregon Health \& Science University's…
- Conditions
- Delirium, Age-Related Cognitive Decline, Frail Elderly, Hospital Acquired Pressure Ulcer
- Trial name
- NCT02119078
- Testing
- Acute Care of Elders focused geriatric care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Oregon Health and Science University
Age 65 and Older, Polypharmacy
Effect of Longitudinal Care in Primary Health Care: An Analysis From the Patient's Perspective
Objective To explore and describe the opinions of Primary Health Care chronically ill users regarding being cared for over time by the same reference professional.
- Conditions
- Age 65 and Older, Polypharmacy, Cronic Lung Disease, Mental Disorder
- Trial name
- CUALIPRIM (NCT07320053)
- Where
- 2 sites in Spain
- Volunteers
- 26 people
- Sponsor
- IBS Granada
Polypharmacy, Adverse Drug Reaction
Deprescribing of Symptomatic Medications in Rehabilitative or Subacute Care Patients
Deprescribing is a systematic method of withdrawing potentially inappropriate or unnecessary medications and is warranted in the elderly due to the high prevalence of polypharmacy.
- Trial name
- NCT03354845
- Testing
- Deprescribing intervention
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bright Vision Hospital
Systemic Lupus Erythematosus
Evaluation of Belimumab Impact on a BLyS Activity Signature Test in the Absence of Confounding Polypharmacy
This will be an open label, non-randomized trial of belimumab in at least 20 subjects to test the feasibility of belimumab as a single agent and to capitalize on simplified background treatment regimens to determine immunologic…
- Trial name
- BLAST (NCT02270970)
- Testing
- belimumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oklahoma Medical Research Foundation
Polypharmacy, Insomnia
MIDAS Cluster Randomized Controlled Trial of Implementation Strategies to Optimize Use of Medications in VA Clinical Settings
Scientific advances are constantly leading to better treatments. However, it is quite challenging for healthcare systems, including VA, to ask very busy providers to change the way they practice.
- Conditions
- Polypharmacy, Insomnia, Anticoagulants
- Trial name
- MIDAS cRCT (NCT05065502)
- Testing
- Academic Detailing (AD), LEAP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development
Hyponatremia, SIADH
Hyponatraemia and Mortality in Schizophrenic and Bipolar Patients: Protocol for a Bayesian Causal Inference Study
This study seeks to investigate if hyponatraemia be a direct contributor to death in schizophrenic and bipolar patients, and gauge the potential role of somatic comorbidity and psychotropic polypharmacy, with emphasis on…
- Trial name
- NCT04409626
- Testing
- Plasma sodium level (continuous variables)
- Volunteers
- 31,740 people
- Sponsor
- Zealand University Hospital
Delirium
Polypharmacy-related Adverse Events in Critically Ill Children
The purpose of this study is to learn how 2 medications (fentanyl and dexmedetomidine) affect how sick children think and interact with their environments.
- Trial name
- NCT03293927
- Testing
- Fentanyl, Dexmedetomidine
- Where
- United States
- Sponsor
- Duke University