Clinical trials: Polypharmacy
Polypharmacy
Improving Medication Management in World Trade Center Responders
By 2030, the majority of World Trade Center (WTC) rescue and recovery workers (responders) will be aged 65 and over and at risk for aging-related conditions and consequences including the concurrent use of five or more…
- Trial name
- NCT07022990
- Testing
- Educational brochure for deprescribing
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Deprescriptions, Aged
Impact of Medications Review on Potentially Inappropriate Medications and Clinical Outcomes Among Hospitalized Older Adults
The goal of this randomized controlled trial is to assess the effectiveness of a pharmacist-led medication review using the locally developed Malaysian Potentially Inappropriate Prescribing Screening tool in Older Adults…
- Conditions
- Deprescriptions, Aged, Inappropriate Prescribing, Potentially Inappropriate Medications
- Trial name
- NCT05875623
- Testing
- MALPIP criteria
- Where
- Malaysia
- Volunteers
- 500 people
- Sponsor
- Monash University
Older Adults (65 Years and Older), Polypharmacy (People Under Treatment With 5 or More Drugs)
Impact of Pharmacotherapy Optimization in Polymedicated Lebanese Older Adults in Primary Health Care Centers
Why are the researchers doing this study? Many older adults take five or more medicines every day. Some of these medicines may no longer help them. Some may even cause harm, such as falls, confusion or tiredness.
- Conditions
- Older Adults (65 Years and Older), Polypharmacy (People Under Treatment With 5 or More Drugs), Primary Health Care, Social Determinants of Health (SDOH)
- Trial name
- PHARMACT-PHC (NCT07866677)
- Testing
- Structured pharmacotherapy optimization, Usual Care
- Where
- Lebanon
- Volunteers
- 452 people
- Sponsor
- National Institute of Public Health, Clinical Epidemiology, and Toxicology-Lebanon (INSPECT-LB)
Adverse Drug Reaction (ADR), Polypharmacy Patients
IPGx PILOT Whole Genome Sequencing Extension Cohort
The investigator's primary aim is to evaluate polypharmacy-associated adverse drug reactions (ADR) in a pilot study of at-risk patients using state-of-the-art pharmacogenomic technology and to use this information to make…
- Trial name
- NCT06766071
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Texas A&M University
Polypharmacy
A Digital Tool to Help Doctors and Pharmacists Prescribe Medicines More Safely for Older Adults in Oman
This is a prospective, multi-phase interventional study evaluating the clinical utility and efficacy of POLYMED-a bilingual (Arabic/English) web-based, explainable-AI medication risk calculator-on optimizing geriatric medication…
- Trial name
- POLYMED (NCT07840222)
- Testing
- OPIP Score Calculator (Oman Potentially Inappropriate Prescribing Risk Score)
- Volunteers
- 400 people
- Sponsor
- Oman Ministry of Health
Polypharmacy (Individuals Treated With 4 or More Medications)
THE EFFECTS OF MULTIPLE DRUG USE ON BALANCE, FALL RISK, AND COGNITIVE STATUS
This study aims to evaluate the effects of polypharmacy on balance, fall risk, cognitive status, vestibular function, and hearing among individuals living in nursing homes.
- Trial name
- NCT07816276
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Polypharmacy
Evaluation of the Impact of a Collaboration Between Hospital and Community Pharmacists at Hospital Discharge
The aim of this study is to evaluate the impact of an enhanced collaboration between a hospital pharmacist and a community pharmacist during hospital discharge.
- Trial name
- NCT06902779
- Testing
- Support of the hospital pharmacist for the medication management at hospital discharge
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- Pharmacie des Hopitaux de l'Est Lemanique
Polypharmacy
Empowering Patients to Improve Safety in Polymedication
Rationale: In current clinical practice, polypharmacy and patient empowerment are critical yet often overlooked. Polypharmacy, the chronic use of five or more drugs, poses risks such as adverse drug reactions and decreased…
- Trial name
- EmpaSafe (NCT06956820)
- Testing
- Medication Management Center
- Where
- 4 sites in Germany, Greece and 1 more
- Volunteers
- 132 people
- Sponsor
- Leiden University Medical Center
Older Adults (65 Years and Older), Living Alone
Home-based Monitoring & Enabled Medication Independence With New Digital Tools
This clinical trial is studying an online tool that may help older adults safely manage their medications at home. The study focuses on older adults who live alone and have memory concerns or mild changes in thinking.
- Conditions
- Older Adults (65 Years and Older), Living Alone, Mild Cognitive Decline, Polypharmacy (People Under Treatment With 5 or More Drugs)
- Trial name
- HOME-MIND (NCT07659548)
- Testing
- HOME-MIND
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Polypharmacy, Alzheimer's Disease and Related Dementias
ALIGN: Aligning Medications With What Matters Most (Demonstration)
The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners.
- Conditions
- Polypharmacy, Alzheimer's Disease and Related Dementias, Mild Cognitive Impairment
- Trial name
- NCT06335953
- Testing
- Pharmacist-led deprescribing intervention
- Where
- United States
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Polypharmacy, Medication Review
Less Is More: Optimized Pharmacotherapy With Improved coNtinuity of CarE in hospitaLized oLder peOple
The goal of this cluster randomized controlled trial is to compare transitional multidisciplinary pharmacotherapeutic care (TMPC) with usual care in patients aged 70 years or older with polypharmacy, admitted to the hospital via…
- Trial name
- LIMONCELLO (NCT05899114)
- Testing
- Transitional Multidisciplinary Pharmacotherapeutic Care
- Where
- 16 sites in Netherlands
- Volunteers
- 1,241 people
- Sponsor
- Radboud University Medical Center
Polypharmacy, Alzheimer Disease and Related Dementias
Aligning Medications With What Matters Most
The Aligning Medications with What Matters Most (ALIGN) study will assess the feasibility and preliminary efficacy of a deprescribing intervention to reduce medication regimen complexity and treatment burden for people living…
- Trial name
- ALIGN (NCT04938648)
- Testing
- Pharmacist-led deprescribing intervention
- Where
- 2 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Polypharmacy, Pharmacogenomic Testing
Preemptive Pharmacogenomics Testing Among Geriatric Patients
The primary goal of this study is to conduct pharmacogenomics testing (a type of DNA test) within an aging population and measure the impact of this test on medication selection, dosing, and costs of care.
- Trial name
- NCT05091879
- Testing
- Multigene pharmacogenomics test
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Geisinger Clinic
Chronic Kidney Diseases, Polypharmacy
Effectiveness of Health Literacy Program for Polypharmacy Patients (HLP-CKD)
This study aims to evaluate the effectiveness of a health literacy promotion program in preventing chronic kidney disease (CKD) among patients who use multiple medications (polypharmacy).
- Conditions
- Chronic Kidney Diseases, Polypharmacy, Health Literacy
- Trial name
- HLP-CKD (NCT07622134)
- Testing
- Health Literacy Promotion Program (HLP-CKD)
- Where
- Thailand
- Volunteers
- 104 people
- Sponsor
- Nakhon Pathom Rajabhat University
Polypharmacy (People Under Treatment With 5 or More Drugs), Polypharmacy, Decision-making
Factors Determining the Rate of Adoption of Pharmaceutical Recommendations by Patients in Primary Care Following a Medication Review by a Pharmacist
Polypharmacy is a growing public health concern associated with adverse drug events, drug interactions, and hospitalizations. Medication reviews (MedRev) are structured evaluations of patients' medications aiming to optimize…
- Conditions
- Polypharmacy (People Under Treatment With 5 or More Drugs), Polypharmacy, Decision-making, Medication Review
- Trial name
- REVMedAdopt (NCT07606716)
- Testing
- medication review and deprescribing
- Where
- Belgium
- Volunteers
- 123 people
- Sponsor
- Université Catholique de Louvain
Polypharmacy
Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges R01 Trial
High-risk polypharmacy is common among older adults in the United States, is particularly dangerous for individuals with dementia or cognitive impairment, and is associated with harms such as adverse drug reactions, falls, and…
- Trial name
- HRPP (NCT05656560)
- Testing
- Clinical decision support (CDS)-Commitment nudge, Clinician education, Clinical decision support (CDS)-Justification nudge
- Where
- 2 sites in United States
- Volunteers
- 786 people
- Sponsor
- Northwestern University
Medication Review, Polypharmacy
The Effect of a Medication Coordinator on the Quality of Patients Medication Treatment
To examine the effect of a Medication Coordinator, who facilitates medication reviews in close collaboration with patients using My Medication Plan to reduce the risk of post-hospital inappropriate medication usage.
- Conditions
- Medication Review, Polypharmacy, Potentially Inappropriate Medication, Quality of Life
- Trial name
- MEDCOOR (NCT06383364)
- Testing
- Medication Coordinator
- Where
- Denmark
- Volunteers
- 141 people
- Sponsor
- University of Southern Denmark
Polypharmacy, Inappropriate Prescribing
SPIDER: A Research & QI Collaboration Supporting Practices in Improving Care for Complex Elderly Patients
Elders living with multiple chronic conditions often take many drugs (polypharmacy); some of the drugs may not benefit them or may be harmful.
- Conditions
- Polypharmacy, Inappropriate Prescribing, Aged, Primary Health Care
- Trial name
- SPIDER (NCT03689049)
- Testing
- SPIDER, Usual Care
- Where
- 9 sites in Canada
- Volunteers
- 104 people
- Sponsor
- University of Toronto Practice Based Research Network
Medication Review, Polypharmacy
Prioritising Patient Medication Review: Hospitals Reaching Out
To examine the effect of a cross-sectoral medication review intervention to admitted multi-morbid, polypharmacy patients aged 65+ at SHS in two settings; an acute admission unit (typical admission time < 48 hours) and a medical…
- Conditions
- Medication Review, Polypharmacy, General Practitioners, Interdisciplinary Communication
- Trial name
- PriPMed (NCT06451692)
- Testing
- Clinical pharmacist
- Where
- Denmark
- Volunteers
- 800 people
- Sponsor
- University of Southern Denmark
Nonadherence, Patient, Polypharmacy
Pharmacist Intervention to Reduce Post-Hospitalization Utilization
This is a randomized trial testing a peri- and post-discharge pharmacist-led medication management intervention on post-discharge utilization, including both readmissions and emergency department visits within 30 days of…
- Conditions
- Nonadherence, Patient, Polypharmacy, Readmission
- Trial name
- NCT04071951
- Testing
- Pharmacist-led Hospital Discharge Care Intervention
- Where
- 2 sites in United States
- Volunteers
- 6,478 people
- Sponsor
- Cedars-Sinai Medical Center