Clinical trials: Postoperative Disease Recurrence
Cervical Cancer, Endometrial Cancer
Epidural Analgesia or Patient-Controlled Analgesia in Treating Patients Who Have Undergone Surgery for Gynecologic Cancer
RATIONALE: Giving pain medication into the space between the wall of the spinal canal and the covering of the spinal cord or giving it into a vein may help lessen pain caused by cancer surgery.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00295945
- Testing
- fentanyl citrate, hydromorphone hydrochloride, ropivacaine hydrochloride
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Otitis Media in Children, Chronic Otitis Media With Effusion
Posterior vs. Anterior Tympanostomy Tube Placement
The goal of this randomized clinical trial is to compare the results of ear tube placement in two different parts of the ear drum. The ear drum can be divided into four parts (called quadrants).
- Conditions
- Otitis Media in Children, Chronic Otitis Media With Effusion, Recurrent Acute Otitis Media
- Trial name
- NCT06191562
- Testing
- Tympanostomy tube
- Where
- 2 sites in United States
- Volunteers
- 386 people
- Sponsor
- David Chi, MD
Tracheal Stenosis
Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients
tracheal stenosis is the result of abnormal wound-healing processes leading to hypertrophic scar formation and obstruction of the airway lumen by excess granulation tissue.
- Trial name
- NCT02855502
- Testing
- Prednisolone
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- National Research Institute of Tuberculosis and Lung Disease, Iran
Melanoma (Skin)
High-Dose or Low-Dose Interferon Alfa Compared With No Further Therapy Following Surgery in Treating Patients With Stage III Melanoma
RATIONALE: Interferon alfa may interfere with the growth of cancer cells. It is not known whether giving high-dose or low-dose interferon alfa is more effective than no further therapy in treating patients with stage III…
- Trial name
- NCT00002763
- Testing
- recombinant interferon alfa
- Where
- 86 sites in Austria, Belgium and 19 more
- Volunteers
- 1,000 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Lumbar Pain Syndrome
Evaluation and Timing in an ERAS-like Structured Rehabilitation Program After Lumbar Spine Surgery
The goal of this clinical trial is to investigate the safety of early inpatient rehabilitation after lumbar spine surgery. Participants are assigned to therapy groups C (low) - A (high) intensity and receive standardized…
- Trial name
- NCT05937997
- Testing
- high intensity physiotherapy, moderate intensity physiotherapy, low intensity physiotherapy
- Where
- Germany
- Volunteers
- 245 people
- Sponsor
- Median
Crohn Disease
Prediction and Close Monitoring of Postoperative Recurrence by Intestinal Ultrasound After Ileocecal Resection in Crohn's Disease Patients
Crohn's disease (CD) is an inflammatory bowel disease causing chronic transmural inflammation followed by intestinal complications including strictures and penetrating lesions such as fistulas and abscesses.
- Trial name
- INSIGHT (NCT05713409)
- Testing
- Intestinal ultrasound
- Where
- 5 sites in Germany, Italy and 2 more
- Volunteers
- 120 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Relapse, Quality of Life
Ingrown Toenails : Surgery Only Versus Surgery + Chemical Cauterization With TCA
Ingrown toenail is a very common disease in the general population that touches young adults. There are lots of treatments from local care of pedicure to surgery with matricectomy.
- Conditions
- Relapse, Quality of Life, Complication, Pain, Postoperative
- Trial name
- NCT04921540
- Testing
- Ingrown toenails with surgery with chemical cauterisation, Ingrown toenails with only surgery
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Otitis Media
Postoperative Effects of Intranasal Fentanyl, IV and IM Morphine in Children Undergoing Myringotomy
The purpose of this study is to compare the difference in effect of three clinically common methods of providing pain medication during surgery for ventilating tubes placed for recurring ear infections.The methods are fentanyl…
- Trial name
- NCT01244126
- Testing
- Intranasal fentanyl, morphine IM, IV morphine
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Baylor College of Medicine
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Gastric Cancer (GC)
Recurrence and Prognosis Prediction Model for Gastric Cancer
This study, utilizing a large-scale multicenter Eastern database, has established a Deep Learning-based predictive model for recurrence following gastric cancer surgery, which demonstrates robust discriminatory power for early…
- Trial name
- NCT07243847
- Testing
- surgery and/or chemo
- Volunteers
- 5,000 people
- Sponsor
- Fudan University
Atrial Fibrillation, Coronary Artery Disease
Management of New-Onset Postoperative Atrial Fibrillation
One common occurrence following open heart surgery is an irregular rhythm from the top chambers of the heart known as atrial fibrillation (afib or AF).
- Conditions
- Atrial Fibrillation, Coronary Artery Disease, Post Operative Arrythmia
- Trial name
- Monitor-AF (NCT01395836)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Emory University
Gastrointestinal Stromal Tumors
Preoperative and Postoperative Imatinib Mesylate Study in Patients With c-Kit Positive GIST
Primary objectives 1. To determine whether induction of apoptosis or inhibition of angiogenesis are involved in the antitumor activity of (Gleevec, Formerly STI-571) in patients with gastrointestinal stromal tumors (GIST) as…
- Trial name
- NCT00500188
- Testing
- Imatinib Mesylate (Gleevec)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Mesothelioma
Pemetrexed Disodium and Cisplatin Followed By Surgery and Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma
RATIONALE: Drugs used in chemotherapy, such as pemetrexed disodium and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00227630
- Testing
- cisplatin, pemetrexed disodium, adjuvant therapy
- Where
- 8 sites in Belgium, Italy and 2 more
- Volunteers
- 59 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Esophageal Squamous Cell Carcinoma
Individualized Tumor-Informed CtDNA Analysis for Monitoring Postoperative Recurrence in ESCC (NEOCRTEC2401)
The goal of this observational study or is to explore the correlation between dynamic changes in postoperative circulating tumor DNA (ctDNA) and recurrence risk using a novel, tumor-informed ctDNA detection technique, thus laying…
- Trial name
- NCT06561178
- Testing
- molecular residual disease detection
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-Sen University Cancer Center
Spontaneous Pneumothorax, Recurrence
Most Preventable Surgical Option to Reduce Primary Spontaneous Pneumothorax Patients' Postoperative Recurrence: A Prospective Cohort Study
To investigate the most preventable option to reduce primary spontaneous postoperative recurrence.
- Conditions
- Spontaneous Pneumothorax, Recurrence, Surgery
- Trial name
- NCT04758143
- Where
- Japan
- Volunteers
- 450 people
- Sponsor
- Yuka Kadomatsu
Skin Cancer, Complication
Complications and Recurrences After Mohs Micrographic Surgery and Slow Mohs
Mohs micro-graphic surgery (Mohs) is a tissue-sparing, surgical treatment for different types of skin cancer (e.g. basal cell carcinoma, squamous cell carcinoma, lentigo maligna (melanoma).
- Conditions
- Skin Cancer, Complication, Complication of Surgical Procedure, Complication,Postoperative
- Trial name
- NCT06014619
- Testing
- Mohs surgery, Slow Mohs surgery
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Maastricht University Medical Center
Pelvic Organ Prolapse
Do Patients With Early Post Operative Recurrence of Pelvic Organ Prolapse Have a Genetic Predisposition?
The objective is to explore the genetic predisposition to early pelvic organ prolapse after adequate surgical repair by exploring the association between pelvic organ prolapse recurrences and certain polymorphisms.
- Trial name
- NCT01614587
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Atlantic Health System
Gastrointestinal Stromal Tumors, Minimal Residual Disease
Prediction of Postoperative Treatment Efficacy and Recurrence Risk of High-risk GIST Based on Liquid Biopsy MRD
So far, MRD assessment by liquid biopsy (ctDNA) has not been used to predict postoperative treatment efficacy and recurrence risk of GIST patients because of special disease characteristics and technological limitations.
- Trial name
- NCT05408897
- Testing
- liquid biopsy
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Peking University People's Hospital
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Lung Carcinoma
Predictive Value of CEA and ctDNA in Lung Cancer Recurrence
The study aims to investigate the predictive value of CEA levels for postoperative recurrence in the highly sensitive CEA lung cancer patients and to explore whether the dynamic changes of postoperative CEA and MRD in this…
- Trial name
- NCT07170046
- Volunteers
- 100 people
- Sponsor
- Guangdong Provincial People's Hospital