Clinical trials: Pragmatic Randomized Controlled Trial
Laceration
Virtual Reality vs. Standard-of-Care for Comfort During Laceration Repair
Lacerations are a common reason for presentation to the Emergency Department and children needing laceration repair with sutures are experiencing pain and anxiety.
- Trial name
- NCT03681717
- Testing
- Virtual Reality
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of British Columbia
Vaccines, Vaccines Adverse Reaction
A Multifaceted Intervention on Reducing Immunization Errors
The goal of this trial is to reduce the general error related to vaccines and immunizations (composited on secondary endpoint), after 11 moths of folow-up after cluster randomization and stepped wedge on primary care on brazilian…
- Conditions
- Vaccines, Vaccines Adverse Reaction, Vaccine Practice
- Trial name
- THEIA (NCT06745635)
- Testing
- Usual Care, Multifaceted intervention
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
Sedentary Behavior, Physical Activity
Teen Mom Study: A Confirmatory Pragmatic Cluster RCT
The goal of this clinical trial is to test the effectiveness of #BabyLetsMove - a 24-week mobile Health and peer health coaching intervention paired with the Special Supplemental Nutrition Program for Women, Infants, and Children…
- Conditions
- Sedentary Behavior, Physical Activity, Gestational Weight Gain, Arterial Pressure
- Trial name
- NCT06216925
- Testing
- #BabyLetsMove, WIC Antenatal Care
- Volunteers
- 144 people
- Sponsor
- University of Mississippi Medical Center
Mental Health Wellness 1, COVID
Telepsychoeducation for the Prevention of Emotional Distress in Professionals and Students From Essential Services in the Context of COVID-19
A pragmatic superiority randomized controlled trial comparing Telepsychoeducation plus personalized videos vs. Telepsychoeducation without personalized videos for the prevention of future emotional distress in professionals and…
- Conditions
- Mental Health Wellness 1, COVID, Emotional Distress, Depressive Symptoms
- Trial name
- NCT04632082
- Testing
- Telepsychoeducation with personalized videos, Telepsychoeducation without personalized videos
- Where
- Brazil
- Volunteers
- 2,200 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Severe Bronchiolitis, Pediatric Respiratory Distress
NIV-NAVA in Infants With Severe Bronchiolitis, a Pilot Multicenter Randomized Controlled Trial
Severe bronchiolitis is a common lung infection in babies that can cause serious breathing problems and often leads to hospitalization in pediatric intensive care units (PICUs).
- Trial name
- NAVIGATE (NCT07834723)
- Testing
- NIV NAVA
- Where
- 4 sites in Canada
- Volunteers
- 90 people
- Sponsor
- St. Justine's Hospital
Postmenopausal Symptoms, Hot Flashes
WHAT (Women, Hot-flashes, Activity, Trial) - Physical Activity for Treatment of Hot Flushes Among Postmenopausal Women
More than 60 % of women experience hot-flashes during postmenopausal and 20 % have serious symptoms. Use of combined estrogen/progesterone therapy reduces hot-flashes effectively.
- Trial name
- WHAT (NCT01282320)
- Testing
- Physical activity intervention program
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Intravenous Catheterization
Virtual Reality vs Standard-of-Care for Comfort During Intravenous Catheterization
Children often need an intravenous catheter placement for delivery of fluids and medications, a procedure associated with pain and anxiety. In the Emergency Department topical anesthetics are frequently used.
- Trial name
- NCT03681730
- Testing
- Virtual Reality
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of British Columbia
Tracheal Intubation, Videolaryngoscopy
Video Versus Direct Laryngoscopy for Tracheal Intubation in Pediatric Surgery
Tracheal intubation in paediatric patients is a high-risk procedure in which failure to achieve successful intubation on the first attempt is associated with an increased risk of complications, including hypoxaemia and airway…
- Conditions
- Tracheal Intubation, Videolaryngoscopy, General Anesthesia, Difficult Airway Intubation
- Trial name
- VIDEOKIDS (NCT07495436)
- Testing
- Videolaryngoscope, Direct Laryngoscope
- Where
- Spain
- Volunteers
- 5,562 people
- Sponsor
- Hospital Clinico Universitario de Santiago
Lower Respiratory Infection, LRTI
Effectiveness of Point-of-care Lung Ultrasound for the Management of Childhood Lower Respiratory Infections
The goal of this clinical trial is to evaluate the effectiveness of point-of-care lung ultrasound versus chest X-ray for the management of childhood lower respiratory infections in a low-resource setting.
- Conditions
- Lower Respiratory Infection, LRTI, Pneumonia, Bronchiolitis
- Trial name
- ELUS (NCT05921526)
- Testing
- Point-of-care lung ultrasound, Chest X-ray (digital images)
- Where
- Nepal
- Volunteers
- 616 people
- Sponsor
- Nagasaki University
Utilization, Laboratory, Hospital
Effect of Norms on Laboratory and Imaging Testing (ENLITen)
Studies suggest that some laboratory tests ordered for hospitalized patients are duplicative or have limited value. This study will evaluate a normative feedback intervention to reduce overuse of laboratory tests for hospitalized…
- Trial name
- ENLITen (NCT02330289)
- Testing
- Normative report card
- Volunteers
- 154 people
- Sponsor
- University of Pennsylvania
Distal Forearm Fracture, Distal Radius Fracture
Is Casting of Displaced Pediatric Distal Forearm Fractures Non-inferior to Reduction in General Anesthesia?
Treatment of displaced distal forearm fractures (DFF) in children have traditionally been closed reduction and pin fixation, although they might heal and remodel without manipulation, with no functional impairment.
- Trial name
- CASTING (NCT05736068)
- Testing
- Non-surgical treatment, Surgical treatment
- Where
- 4 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Zealand University Hospital
Post Partum Hemorrhage
A Pragmatic Randomized Controlled Trial to Predict Postpartum Hemorrhage
This research project aims to enhance the safety of childbirth by using advanced computer models to predict the risk of postpartum hemorrhage (PPH). PPH is a significant concern for mothers during and after delivery.
- Trial name
- NCT06513351
- Testing
- Novel PPH Risk Prediction Model - Comparator Arm B
- Where
- United States
- Volunteers
- 12,500 people
- Sponsor
- Holly Ende
Neurodevelopmental Disorders
NeuroN-QI: An Intervention to Promote Preterm Infants' Neurodevelopment
NeuroN-QI aims to evaluate the effects of an intervention consisting of periods of: 1) parents/preterm infants skin-to-skin contact and auditory stimulation by the parents's voice and 2) calm without manipulation with olfactory…
- Trial name
- NCT06087744
- Testing
- NeuroN-QI, SSC alone
- Where
- 2 sites in Canada
- Volunteers
- 124 people
- Sponsor
- St. Justine's Hospital
Myocardial Injury After Noncardiac Surgery (MINS)
SecondarY Prevention and maNagement of Myocardial Injury aftER Noncardiac surGerY (SYNERGY) Pilot Trial
Cardiac complications, particularly myocardial injury after noncardiac surgery (MINS), significantly contribute to 30-day mortality, affecting about 1 in 10 patients after noncardiac surgery.
- Trial name
- NCT06768034
- Testing
- Intervention Group
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Trauma Injury
Reducing Low-value Care for Trauma Admissions
In Canada, injury leads to more potential years of life lost and to greater costs than heart and stroke diseases combined. Furthermore, more than 50% of patients hospitalised following injury do not receive optimal care, 20% of…
- Trial name
- NCT05744154
- Testing
- Audit & feedback with educational outreach and facilitation, Simple audit & feedback (usual practice)
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Laval University
Latent Tuberculosis Infection
Risk of SDRs Under 3HP and 1HP Regimen for LTBI
Successful implement of preventive therapy for subjects with latent tuberculosis infection (LTBI) is the critical step for elimination of tuberculosis (TB).
- Trial name
- NCT04094012
- Testing
- isoniazid and rifapentine
- Where
- Taiwan
- Volunteers
- 490 people
- Sponsor
- National Taiwan University Hospital
Atopic Dermatitis
The Effectiveness of Antibacterial Therapeutic Clothing Based on Silver or Chitosan as Compared With Non-antibacterial Therapeutic Clothing in Patients With Moderate to Severe Atopic Dermatitis
Since 2000 therapeutic clothing or functional textiles based on silver or chitosan as antibacterial agents were introduced as therapeutics of atopic dermatitis (AD).
- Trial name
- ABC project (NCT04297215)
- Testing
- DermaCura® Chitosan based antimicrobial therapeutic clothing, Binamed® silver based antimicrobial therapeutic clothing, Binamed® therapeutic clothing without antimicrobial agents
- Where
- Netherlands
- Volunteers
- 165 people
- Sponsor
- Erasmus Medical Center
Dermatitis, Atopic
Atopic Dermatitis in Atopy Predisposed Infants
The primary objective of this study is to investigate the effectiveness of a standardized skin care regimen using a milk lotion once daily and a bathing addendum as needed during the first 52 weeks of life on the development of…
- Trial name
- ADAPI (NCT02906475)
- Testing
- standardized skin care regimen
- Where
- Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- HiPP GmbH & Co. Vertrieb KG
Depression
Study of Whether Educational Visits to Primary Care Professionals Improves the Quality of Care They Provide.
The purpose of this study is to find out whether educational visits by Pharmacists, who are already employed as advisers in health organisations, improve the prescribing habits of primary care doctors.
- Trial name
- NCT00393536
- Testing
- Educational outreach visiting
- Where
- United Kingdom
- Volunteers
- 73 people
- Sponsor
- Newcastle University
Crohn Disease
The Vitamin D in Pediatric Crohn's Disease ( ViDiPeC-2 )
The purpose of this study is to determine if vitamin D as an adjuvant therapy can improve the outcome (i.e. fewer relapses) and the quality of life, including levels of physical activity, in children diagnosed Crohn's disease…
- Trial name
- ViDiPeC-2 (NCT03999580)
- Testing
- vitamin D3
- Where
- 7 sites in Canada
- Volunteers
- 55 people
- Sponsor
- Jantchou Prevost