Clinical trials: Pre-eclampsia
Preeclampsia, Preterm Birth
The Effect of Prematurity and Hypertensive Disorders of Pregnancy on Offspring Cardiovascular Health
The purpose of this study is to investigate whether exposure to hypertensive disorders of pregnancy and/or a preterm birth results in alterations in the cardiovascular system during infancy.
- Trial name
- EPOCH (NCT01888770)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Oxford
Pre-Eclampsia, Premature Birth
PREPARE, Prematurity Reduction by Pre-eclampsia Care
Investigators will test a novel system of integrated care, to promote the use of the WORLD HEALTH ORGANIZATION Guidelines for the management of pre-eclampsia and initiate the use of a structured risk assessment strategy to reduce…
- Trial name
- PREPARE (NCT03073317)
- Testing
- FullPIERS and sFlit/PLGF (Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio)
- Where
- 8 sites in Brazil
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Instituto Fernandes Figueira
Pre-Eclampsia, Obesity; Endocrine
C1q/TNF-related Protein 9 (CTRP 9) Level in Preeclamptic Obese and Non-obese Pregnancies
The complement C1q tumor necrosis factor-associated protein-9 (CTRP-9), which is responsible for regulating cardiovascular and metabolic functions, increases vascular relaxation by pathway dependent on AMPK / endothelial nitric…
- Trial name
- CTRP (NCT03650790)
- Testing
- Blood test
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Diyarbakir Women's and Children's Diseases Hospital
Preeclampsia
Antioxidant Supplementation in Pregnant Women With Low Antioxidant Status
The purpose of this study is to investigate antioxidants supplementation in pregnant women with low antioxidant status at 10-12 weeks gestation age in relation to adverse pregnancy outcome in randomized prospective study.
- Trial name
- NCT00388856
- Testing
- Vitamin C 1000mg and E 400IU
- Where
- Indonesia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Showa University
Severe Preeclampsia, Antiphospholipid Syndrome
Antiphospholipid Antibodies and Early Severe Preeclampsia.
The Antiphospholipid Syndrome is an immune disease where the presence of antibodies directed against cell membrane phospholipids (antiphospholipid antibodies) can cause an hypercoagulable state that causes thrombosis and…
- Trial name
- NCT01538121
- Where
- Panama
- Volunteers
- 310 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia
sFlt-1:PlGF Ratio in Diagnosing Superimposed Preeclampsia
Preeclampsia: associated with poor placentation, incomplete uteroplacental spiral arteries remodeling. Result: ischemia, re-perfusion injury, oxidative stress.
- Trial name
- NCT03441711
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Tennessee
Pre-eclampsia, Intrauterine Growth Retardation
A Modernized Approach to Prenatal Care in Low Risk Women
The investigators plan to identify 80 pregnant women at low risk for obstetrical complications and replace 4-5 routine third trimester visits with a structured program of home weight, blood pressure and urine protein monitoring…
- Trial name
- NCT01606774
- Testing
- Modernized prenatal care
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hypertension, Pregnancy Induced, Hydralazine Adverse Reaction
Randomized Controlled Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients.
Severe Hypertension in pregnancy demands urgent treatment because of high mortality \& morbidity in obstetric patients. Hydralazine, the most commonly used agent, causes sudden hypo tension and tachycardia.
- Conditions
- Hypertension, Pregnancy Induced, Hydralazine Adverse Reaction, Pre-eclampsia, Pre-eclampsia Superimposed Pre-existing Hypertension
- Trial name
- NCT02050529
- Testing
- Labetalol, Hydralazine
- Where
- Pakistan
- Volunteers
- 190 people
- Sponsor
- Dow University of Health Sciences
Pre-eclampsia
Efficacy Study of Digibind for Treatment of Severe Preeclampsia
The purpose of this study is to determine whether a commercially available anti-digoxin antibody, Digibind, can delay delivery in patients with severe pre-eclampsia.
- Trial name
- NCT00158743
- Testing
- Anti-digoxin antibody (FAB fragment), sodium chloride
- Where
- 8 sites in United States
- Volunteers
- 51 people
- Sponsor
- BTG International Inc.
Pre-Eclampsia
CA-125 and Severity of Pre-Eclampsia
The Aim of this study is to determine the relationship between serum concentrations of cancer antigen-125 (CA-125) and pre-eclampsia severity.
- Trial name
- NCT02704676
- Testing
- marker(CA-125)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Preeclampsia, Gestational Hypertension
Exploring the Effect of Discharge Education, Blood Pressure Cuffs, and Postpartum Bracelets to Improve Health Among Newly Diagnosed Gestational Hypertension and Preeclampsia Patients During the Postpartum Period.
This pilot, exploratory qualitative, descriptive study will examine whether standard postpartum discharge education, a free home blood pressure cuff, and an "At-Risk Postpartum" bracelet support self-management among postpartum…
- Conditions
- Preeclampsia, Gestational Hypertension, Postpartum
- Trial name
- NCT07807098
- Testing
- Education, Blood Pressure Cuff, and Visual Cue Bracelet
- Volunteers
- 40 people
- Sponsor
- Memorial Hermann Health System
Fetal Growth Retardation
Fetal Cardiac Function
The aim of our study is to evaluate the effect of PE and FGR on fetal cardiac function. Pregnancies with preeclampsia and FGR, and preeclampsia with normal fetal growth are evaluated by echocardiography and compared with…
- Trial name
- NCT06381258
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
Vitamin D Deficiency, Pre Eclampsia
Evaluation of the Effectiveness of Vitamin D Supplementation to Pregnant Women and Their Infants in Pakistan.
Vitamin D deficiency is wide spread in South Asian population and is contributing to burden of disease in this region including Pakistan.
- Conditions
- Vitamin D Deficiency, Pre Eclampsia, Stillbirths, Low Birth Weight
- Trial name
- NCT01229189
- Testing
- Vitamin D
- Where
- Pakistan
- Volunteers
- 460 people
- Sponsor
- Aga Khan University
High-Risk Pregnancy
Longitudinal Measures of Leptin in Pregnant Women Who Developed Preeclampsia
Background: Obesity in pregnancy is increasing and is a risk factor for metabolic pathology such as preeclampsia. Leptin is an adipokine which has a direct relationship to obesity.
- Trial name
- NCT01649167
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Materno-Perinatal Hospital of the State of Mexico
Severe Preeclampsia
The Association Between Different Markers With Development of Maternal and Neonatal Complications in Women With Severe Preeclampsia
pregnant women diagnosed with severe preeclampsia were subjected to • Full history taking including a detailed history of the hypertension state during the current pregnancy (onset, course, current medication, and whether the…
- Trial name
- NCT07125599
- Where
- Egypt
- Volunteers
- 284 people
- Sponsor
- Cairo University
Pre-Eclampsia, Eclampsia
Postpartum Uterine Curettage in the Recovery From Preeclampsia/Eclampsia
Use of Postpartum uterine curettage in reducing hospitalization time or in improving the clinical evolution of the patient with preeclampsia/eclampsia.
- Trial name
- NCT03028194
- Testing
- Curettage
- Where
- 2 sites in Panama
- Volunteers
- 442 people
- Sponsor
- Saint Thomas Hospital, Panama
Cardiovascular Diseases, Heart Diseases
Angiotensinogen Variants and Adverse Pregnancy Outcomes
To examine angiotensinogen genetic variants and adverse pregnancy outcomes.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Pre-Eclampsia
- Trial name
- NCT00005400
- Sponsor
- University of Utah
Offspring of Pre-eclamptic Mothers
Cardiovascular Risk in Infants Exposed to Pre-eclampsia in Utero
An increasing number of scientific publications show that high blood pressure is being described in younger and younger children of African ancestry.
- Trial name
- NCT05091827
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Walter Sisulu University
Hypertension in Pregnancy
Perinatal Outcomes in Patients With Elevated sFlt-1/PlGF Ratio
Retrospective cohort study that evaluated 190 subjects admitted with diagnosis of hypertensive disorder of pregnancy, between 24 and 36 6/7 weeks, with an sFlt-1/PlGF index greater than or equal to 110.
- Trial name
- NCT06403722
- Testing
- Standard of care
- Where
- Panama
- Volunteers
- 190 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia
162 mg of Aspirin for Prevention of Preeclampsia
This is a study to assess if 162 mg of aspirin will decrease rates of preeclampsia in pregnant patients compared to 81 mg of aspirin.
- Trial name
- NCT05221164
- Testing
- Aspirin 162 mg
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Methodist Medical Center of Illinois