Clinical trials: Precision Medicine
ARDS, Human, Covid19
Associations Between COVID-19 ARDS Treatment, Clinical Trajectories and Liberation From Mechanical Ventilator - an Analysis of the NorthCARDS Dataset
The mortality rates associated with COVID-19 related ARDS (COVIDARDS) have varied from observational reports from around the world.
- Trial name
- NorthCARDS (NCT04729075)
- Testing
- ARDS and COVID19 treatments
- Where
- United States
- Volunteers
- 1,800 people
- Sponsor
- Northwell Health
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
The Patient Cohort of the National Center for Precision Medicine in Leukemia
If for years the treatment strategy of leukemia and related disorders (LRDs, including acute leukemias and predisposition syndromes) has been based solely on whether the patient could receive or not intensive chemotherapy and…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, High-risk Myelodysplastic Syndrome, Secondary Myelofibrosis in Myeloproliferative Disease
- Trial name
- eTHEMA (NCT05326919)
- Testing
- Biobanking
- Where
- 3 sites in France
- Volunteers
- 3,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Psychosis
CLinical Utility of Early Intervention Including the 5-Step Precision Medicine (5SPM) Method in First-episode Psychosis: The CLUMP Project
CLUMP is a project of translational research that intends to bridge the gap between what we already know about pharmacogenetics of antipsychotic drugs and what we still do to treat patients with first-episode psychosis (FEP).
- Trial name
- CLUMP (NCT06453174)
- Testing
- Adherence to the first prescribed antipsychotic medication
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Epilepsy
The Role of Genetic Factors in the Development of Epilepsy in the Kazakh Population
This is a GWAS study that aims to identify possible candidate genes associate to epilepsy by exploring single nucleotide polymorphism (SNP) in a group of epilepsy, in the Kazakh population.
- Trial name
- NCT05088499
- Testing
- DNA analysis
- Where
- Kazakhstan
- Volunteers
- 600 people
- Sponsor
- Asfendiyarov Kazakh National Medical University
Rehabilitation, Pain, Shoulder
Precision Medicine for Nociception, Sngception and Proprioception.
Precision medicine is defined as "an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person" by the Precision Medicine…
- Conditions
- Rehabilitation, Pain, Shoulder, Pain, Chronic, Idiopathic Scoliosis
- Trial name
- NCT06161038
- Testing
- LASER, Ultrasound, Prolotherapy
- Where
- Taiwan
- Volunteers
- 160 people
- Sponsor
- National Taiwan University Hospital
Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia
Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling
Functional precision medicine (FPM) is a relatively new approach to cancer therapy based on direct exposure of patient- isolated tumor cells to clinically approved drugs and integrates ex vivo drug sensitivity testing (DST) and…
- Conditions
- Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood Large Cell Lymphoma, Refractory Childhood Acute Lymphoblastic Leukemia
- Trial name
- NCT05857969
- Testing
- Functional Precision Medicine
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Florida International University
Asthma
A Pilot Study of Personalized Medicine for Pediatric Asthma
A pilot study to test the feasibility of a personalized asthma care intervention.
- Trial name
- NCT01681732
- Testing
- Personalized Care Plan, Control Standard Care
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Milton S. Hershey Medical Center
Medication Adherence, Medication Reaction
Taste of Medicines in Children
Some but not all children will refuse to take medicine because of its taste, which can lead to substantial worsening of disease, antibiotic resistance, increased health care costs, and even death.
- Trial name
- NCT04220918
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Children's Hospital of Philadelphia
Major Depressive Disorder
Precision Medicine for the Prediction of Treatment (PROMPT) Response (PROMPT)
Major depressive disorder (MDD) is the most common psychiatric disease worldwide with a huge socio-economic impact. Pharmacotherapy represents the first-line treatment choice; however, only about one third of patients respond to…
- Trial name
- PROMPT (NCT05537558)
- Testing
- Antidepressant
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Muenster
Bladder Cancer, Kidney Cancer
Ex VIvo DEtermiNed Cancer Therapy
EVIDENT's aim is to test if ex vivo drug screening can predict whether patients with solid cancers will respond, or not respond, to standard care treatments.
- Conditions
- Bladder Cancer, Kidney Cancer, Melanoma, Sarcoma
- Trial name
- EVIDENT (NCT05231655)
- Testing
- Functional drug screen
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Obstructive Sleep Apnea (OSA), Down Syndrome
Endotype DIrected Treatment for OSA in Down Syndrome
Down syndrome is the most common genetic cause of intellectual disability. People with Down syndrome often have obstructive sleep apnea (OSA), a condition where people have difficulties with breathing while asleep.
- Trial name
- EDIT OSA (NCT07280468)
- Testing
- ato-oxy, Oxygen
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Arizona
Neuroblastoma, Diffuse Intrinsic Pontine Glioma
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
A Phase I open-label, multicenter study, to evaluate the safety, feasibility, and maximum tolerated dose (MTD) of treating children with newly diagnosed DIPG or recurrent neuroblastoma with molecular targeted therapy in…
- Trial name
- PEACH (NCT04837547)
- Testing
- Tumor-specific ex vivo expanded autologous lymphocyte transfer (TTRNA-xALT)
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Chronic Illnesses, Multiple
FLIGHT Study for Childhood Chronic Illness
The FLIGHT study is an open-label, single-arm, pilot and feasibility study of a personalized and multimodality intervention focusing upon modifiable lifestyle factors, environmental modifications, and transdisciplinary clinical…
- Trial name
- NCT06377384
- Testing
- FLIGHT Intervention
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Documenting Hope Project
Personalized Medicine in Type 1 Diabetes
Measuring and Predicting Glycemic Response to Food in Patients With Type 1 Diabetes
Personalized medicine methods in the management of type 1 diabetes
- Trial name
- NCT02919839
- Testing
- non-Interventional
- Volunteers
- 200 people
- Sponsor
- Dr. Orit Hamiel
Rhabdomyosarcoma, Non-Rhabdo. Soft Tissue Sarcoma
Molecular-Functional Imaging of Hypoxia in Childhood Sarcomas
This study will test the feasibility of using novel/existing imaging technologies focused on hypoxia measurements to determine "response to therapy" in pediatric soft tissue sarcomas as a pilot study.
- Trial name
- NCT03054792
- Testing
- Blood Oxygen Level Dependent [BOLD] MRI, Diffusion-Weighted [DW] MRI, Magnetic Resonance Spectroscopy [MRS]
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- The Hospital for Sick Children
Breast Cancer, Prostate Cancer
Tempus Priority Study: A Pan-tumor Observational Study
Observational study that will be collecting clinical and molecular health information from cancer patients who have received comprehensive genomic profiling and meet the specific eligibility criteria outlined for each cohort with…
- Conditions
- Breast Cancer, Prostate Cancer, Bladder Cancer, Lung Cancer
- Trial name
- NCT05179824
- Testing
- Observation
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Tempus AI
Cancer, Neoplams
xDRIVE for Florida-based Cancer Patients
Through this study funded by the Florida Cancer Innovation Fund, First Ascent will demonstrate state-wide feasibility of providing xDRIVE Functional Precision Medicine + Artificial Intelligence platform by assessing patient…
- Conditions
- Cancer, Neoplams, Refractory, Recurrence
- Trial name
- NCT07167381
- Testing
- xDRIVE Tumor Profiling
- Where
- 2 sites in United States
- Volunteers
- 210 people
- Sponsor
- First Ascent Biomedical Inc.
Ovarian Cancer, Quality of Life
Patient Preferences for Precision Medicine: Determining Optimal Patient Quality of Life Using PARPi's
Patients with ovarian cancer with defective DNA repair mechanisms derive substantial benefit from PARP inhibitor (PARPi) maintenance therapy.
- Trial name
- 4PDQ (NCT06751303)
- Testing
- Patients that are HRP are given a decision aid for PARPi use
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Saskatchewan
Pediatric Disorder, Genetic Predisposition
Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy
This study looks at how a medicine called trihexyphenidyl works in children with dystonic cerebral palsy. The study aims to understand how trihexyphenidyl is broken down and used in the body of pediatric patients and whether this…
- Conditions
- Pediatric Disorder, Genetic Predisposition, Dystonia, Secondary, Dystonia
- Trial name
- TRIKE2 (NCT06554288)
- Testing
- Trihexyphenidyl
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Maturity-onset Diabetes of the Young, Monogenic Diabetes
Identifying Maturity-onset Diabetes of the Young in Emirati Patients
Diabetes Mellitus is a disease that affects nearly 1 in 5 people in United Arab Emirates and is one of leading causes of death and disability.
- Conditions
- Maturity-onset Diabetes of the Young, Monogenic Diabetes, MODY
- Trial name
- NCT05586594
- Testing
- Genetic testing for 4 MODY genes (GCK, HNF1A, HNF4A, HNF1B)
- Volunteers
- 150 people
- Sponsor
- United Arab Emirates University