Clinical trials: Precision Medicine
Psoriasis (PsO), Psoriasis Arthritis
Molecular Inflammation Board at the Center for Personalized Medicine
Molecular Inflammation Board at the Center for Personalized Medicine
- Conditions
- Psoriasis (PsO), Psoriasis Arthritis, Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Spondylarthropathies
- Trial name
- MEB@ZPM (NCT07132333)
- Testing
- Biologic Agent
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- University Hospital Tuebingen
Hypertension
H-Type Hypertension Precision Medicine Trial
This is a multicenter, randomized, double-blind, controlled clinical trial. It aims to investigate the effects of different doses of folic acid on lowering homocysteine (Hcy) in patients with hypertension with different genotypes…
- Trial name
- NCT03472508
- Testing
- Folic Acid, Enalapril Maleate and Folic Acid Tablets (Yiye), Enalapril
- Where
- 5 sites in China
- Volunteers
- 3,600 people
- Sponsor
- Shenzhen Ausa Pharmed Co.,Ltd
Non-Small Cell Lung Cancer
Precision Medicine Randomized Clinical Trial Comparing Molecular Tumor Board Assisted Care to Usual Care
This trial will compare Molecular Tumor Board (MTB) assisted care to usual care for patients who have newly diagnosed histologically or cytologically confirmed stage IIb-IV Non-Small Cell Lung Cancer (NSCLC) and are planning to…
- Trial name
- PRiMAL (NCT05254795)
- Testing
- Molecular tumor board assisted care
- Where
- United States
- Volunteers
- 659 people
- Sponsor
- Timothy Mullett
Depressive Disorder, Treatment-Resistant
Personalized rTMS for Resistant Depression
The investigators hypothesize that personalizing the rTMS targets using functional MRI will increase its efficacy. The most dysfunctional regions or the most dysfunctional network will be stimulated homogeneously.
- Trial name
- NCT02863380
- Testing
- Functional magnetic resonance imaging used to individualize rTMS protocol, Individualized rTMS (transcranial magnetic stimulation), Classical rTMS (transcranial magnetic stimulation)
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Strasbourg, France
Health Behavior, Health Knowledge, Attitudes, Practice
Survey on Precision Medicine and Digital Health
The investigators have created an anonymous online survey that queries current topics in precision medicine.
- Conditions
- Health Behavior, Health Knowledge, Attitudes, Practice, Health Attitude
- Trial name
- precisionmed (NCT03543631)
- Testing
- Survey
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Gastrointestinal Cancers
DPD Guided 5-FU Precision Treatment in Gastro-intestinal Cancer Patients
Rationale: Fluorouracil (5-FU) are broadly used in chemotherapeutic regimens for the treatment of cancers. Dihydropyrimidine dehydrogenase (DPD) is a major enzyme in the 5-FU metabolism pathway.
- Trial name
- COMBIGaPP (NCT06782022)
- Testing
- 5-Fluoro-Uracil
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Jan Gerard Maring
Parkinson Disease
Analysis of the Prognostic Role of Epigenetic Biomarkers in Relation to the Motor Decline in Parkinson's Disease
BioGenParkinson is an observational, prospective cohort study evaluating biomarkers of Parkinson's Disease (PD) progression in community-dwelling subjects aged 65 years or more, consecutively referring to INRCA outpatient clinic…
- Trial name
- BioGenPark (NCT05384522)
- Testing
- blood samples collection
- Volunteers
- 103 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Fibromyalgia (FM), tDCS
Home-based Transcranial Direct Current Stimulation (tDCS) Compared to Duloxetine: Non-inferiority Clinical Trial (FIBROSTIM)
Fibromyalgia is characterized by widespread pain, fatigue, non-restorative sleep, and psychocognitive alterations, compromising quality of life and leading to absenteeism and early retirement.
- Conditions
- Fibromyalgia (FM), tDCS, Duloxetine, BDNF
- Trial name
- FIBROSTIM (NCT07203339)
- Testing
- Duloxetine (60 mg) once daily, Home-based transcranial direct current stimulation, Duloxetine 60 mg
- Where
- Brazil
- Volunteers
- 610 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Metastatic Colorectal Cancer
Genotyping of Metastatic Colorectal Cancer Patients for Precision Medicine Clinical Trials
The goal of delivering the right drug to the right cancer patient (precision medicine) requires a detailed understanding of how genomic alterations are linked to drug response.
- Trial name
- FUNNEL (NCT03350412)
- Where
- 5 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Pancreas Cancer
Genetic, Microenvironmental, and Immunological Factors in Unresectable Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) complexity, where genetic, stromal, and immunological factors all interact with each other, is responsible for the overall poor response of PDAC to chemotherapeutic agents, making this a…
- Trial name
- NCT05248750
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Catholic University of the Sacred Heart
Pancreas Cancer
Pancreatic Cancer Molecular Sub-classification Using Endoscopic Ultrasound Tissue Core Biopsy Samples
This study evaluated the feasibility and reliability of PDAC molecular subtyping on tissue core biopsies samples acquired under EUS guidance.
- Trial name
- NCT04246710
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Catholic University of the Sacred Heart
Asthma
Phenotyping Responses to Systemic Corticosteroids in the Management of Asthma Attacks
This observational study compares the phenotypic variability (clinical and biological) in treatment response to systemic corticosteroids according to the blood eosinophil count and FeNO in physician-diagnosed ≥12-year-old…
- Trial name
- PRISMA (NCT05870215)
- Testing
- Visit 1: Clinical exam and questionnaires, Visit 1: Respiratory physiology, Visit 1: Inflammometry
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Depressive Disorder, Major, Inflammation
Treating Immuno-metabolic Depression With Anti-inflammatory Drugs
As the role of (neuro)inflammation in depression is emerging, augmentation of antidepressant treatments with anti-inflammatory drugs such as celecoxib has shown encouraging preliminary results.
- Trial name
- INFLAMED (NCT05415397)
- Testing
- Celecoxib 400mg
- Where
- Netherlands
- Volunteers
- 94 people
- Sponsor
- Amsterdam UMC, location VUmc
Head and Neck Cancer
Personalised Postoperative Radiochemotherapy in Patients With Head and Neck Cancer
The current trial is evaluating the integration of a pretherapeutical FDG-PET/MRI in the adjuvant radiochemotherapy in patients with head and neck cancer.
- Trial name
- NCT02666885
- Testing
- Integration of PET/MRI in radiotherapy
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- University Hospital Tuebingen
Kidney Stone, Nephrolithiasis
Prediction of Recurrence and Complications of Nephrolithiasis Using a Precision Medicine Approach
Nephrolithiasis is a disease caused by the formation of kidney stones in the urinary tract which can then partially or completely obstruct the latter causing an extremely sharp pain called renal colic.
- Trial name
- PRECILITH (NCT05237063)
- Testing
- Blood and urine samples
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Coronary Artery Disease, Angina Pectoris
Clinician Utilization of Corus CAD (or ASGES) in Primary Care Provider Decision Making
This retrospective study will investigate clinician behavior in diagnosing patients with possible obstructive coronary artery disease who received a Corus CAD (Age/Sex/Gene Expression score - ASGES) result compared to patients…
- Conditions
- Coronary Artery Disease, Angina Pectoris, Chest Pain, Cardiovascular Diseases
- Trial name
- CU-PCP (NCT02158754)
- Testing
- Corus CAD (ASGES)
- Where
- 9 sites in United States
- Sponsor
- CardioDx
Biliary Tract Cancer (BTC)
The Registry of Genetic Alterations of Taiwan Biliary Tract Cancer
Recent progress in comprehensive genomic profiling for advanced BTC has helped to clarify tumorigenesis and facilitate the coming era of precision medicine.
- Trial name
- NCT05036486
- Testing
- next-generation sequencing
- Where
- 13 sites in Taiwan
- Volunteers
- 480 people
- Sponsor
- National Health Research Institutes, Taiwan
Knee Arthritis
The Efficacy of Collaborative Patient Education on Total Knee Arthroplasty
This project is about the integrated rehabilitation program for the patients receiving total knee arthroplasty. The investigators are monitoring the WOMAC(Western Ontario and Mcmaster University Arthritis Index)/ Pain…
- Trial name
- NCT05346822
- Testing
- integrated rehabilitation (the collaborative patient education)
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
NAFLD, Precision Medicine
The Liver BIoBank Lombardia of Fatty Liver
NAFLD is most frequently linked to excess adiposity, insulin resistance and cardiometabolic risk factors, it has become the leading cause of liver disease worldwide, and is associated with increased mortality due to multiple…
- Conditions
- NAFLD, Precision Medicine, Cardiovascular Diseases
- Trial name
- NCT06566105
- Testing
- precision medicine approach
- Where
- Italy
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Observation, Postoperative
Proteomics and Physiological Parameters Predicting Complications After Colorectal Cancer Surgery
Study combines physiological data from wearables, continuous glucose montiors and proteomics to better assess risk of complications after colorectal surgery
- Trial name
- ProComp (NCT07494669)
- Testing
- Risk stratification with proteomics and data from wearables and CGMs
- Volunteers
- 210 people
- Sponsor
- Region Skane