Clinical trials: Preterm
Infant, Extremely Premature, Erythrocyte Transfusion
Red Blood Cells From Umbilical Cord for Transfusion of Preterm Infants
This study has been designed to demonstrate that red blood cell from umbilical cord blood (UCB-RBC) is a safe and available product for extremely preterm infants (EPI) transfusion and that transfusion of UCB-RBC is non-less…
- Conditions
- Infant, Extremely Premature, Erythrocyte Transfusion, Umbilical Cord Issue
- Trial name
- NCT05612919
- Testing
- Red blood cell from umbilical cord blood, Red blood cell from adult donor
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Hospital Clinic of Barcelona
Infant, Premature, Anticoagulants
Heparin Versus no Heparin on Duration of Peripherally Inserted Central Catheter (PICC) Patency in Neonates
Background: Heparin is an anticoagulant commonly used in the neonatal population as a means to prevent catheter related occlusion and malfunction by thrombosis (clot).
- Conditions
- Infant, Premature, Anticoagulants, Thrombosis
- Trial name
- NCT00879957
- Testing
- heparin, No heparin
- Where
- United States
- Sponsor
- The University of Texas Health Science Center at San Antonio
Gastro Esophageal Reflux
Effect of Right Lateral Position on Ventilated Preterm Neonates
Objective: to evaluate the effect of right lateral positioning in comparison with supine positioning on tracheal aspirate pepsin levels as a marker of aspiration of gastric contents in ventilated preterm neonates.
- Trial name
- NCT03258528
- Testing
- positioning
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Spastic Diplegia, Periventricular Leukomalacia
Randomized Controlled Trial of Early Intensive Leg Exercise to Improve Walking in Children With Diplegia
This is a randomized controlled trial, comparing 3 months of intensive leg exercise to standard physiotherapy care for the improvement of gross motor function in young children with spastic diplegia.
- Trial name
- NCT03672877
- Testing
- Intensive exercise
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Intrauterine Growth Retardation (IUGR), Lung Function Tests
Early Lung Function Trajectories: Comparison Between Infants With and Without Intrauterine Growth Restriction.
During intrauterine life, some babies are smaller or grow less than expected. This fetal growth abnormality, called fetal growth restriction (FGR), can be diagnosed by ultrasound.
- Conditions
- Intrauterine Growth Retardation (IUGR), Lung Function Tests, Preterm Infant, Respiratory Monitoring
- Trial name
- ELFIGO (NCT06919757)
- Testing
- fetal ultrasound to assess lungs, heart and diaphragm
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Oxygen Saturation, Heart Rate
The Effect of Elastic Sac on Feeding
The study will be conducted using the crossover randomized controlled method. Preterm infants who began oral feeding from the neonatal intensive care unit will be divided into two groups through randomization in the computer…
- Conditions
- Oxygen Saturation, Heart Rate, Nutritional Status
- Trial name
- NCT05154357
- Testing
- Elastic Sac, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Apnea of Prematurity
Stochastic Resonance Mattress (Physiological Interventions) and Biomarkers for Enhancing Neonatal Health
The purpose of this study is to explore physiological interventions and biomarkers for Apnea of Prematurity in newborn infants.
- Trial name
- NCT01643057
- Testing
- Stochastic Resonance Mattress
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Wyss Institute at Harvard University
Testosterone, Angiographic Complexity
Serum Testosterone Level on Angiographic Complexity of Coronary Lesions in Premature Ischemic Egyptian Males
This study aims to investigate the association between serum testosterone levels and the angiographic complexity of coronary artery lesions in male patients under 45 years of age presenting with premature ischemic heart disease.
- Conditions
- Testosterone, Angiographic Complexity, Coronary Lesion, Premature Ischemia
- Trial name
- NCT07076771
- Testing
- Coronary Angiography, Syntax Score
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Cancer, Risk of Premature Ovarian Failure
Cryopreservation of Ovarian Tissue
The study hopes to contribute to the development of technologies of ovarian tissue freezing-thawing and in vitro maturation of immature eggs such that a person at risk for premature ovarian failure might be able to conceive a…
- Conditions
- Cancer, Risk of Premature Ovarian Failure, Fertility Preservation
- Trial name
- NCT01558544
- Testing
- surgery to remove ovaries or high dose chemotherapy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Weill Medical College of Cornell University
Neurophysiologic Maturation
Neurophysiological Maturation Correlate With Clinical Milestones
To examine the association of early measures of heart rate variability and amplitude-integrated electroencephalography with time to wean to crib and to achieve full oral feeds among moderate and late preterm infants.
- Trial name
- NEMO (NCT03722901)
- Where
- 2 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Infant, Premature, Diseases
Measurement of Neonatal Microvascular Hemodynamics Using Non-invasive Optical Technologies
Alterations to microvascular blood flow in premature infants, are known to contribute to several major disease entities. The optically-measured tissue blood flow, to determine tissue perfusion that can be use to detect blood loss.
- Trial name
- NCT01982357
- Testing
- Laser Speckle Imaging and Diffuse Optical Spectroscopy
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Prematurity, Feeding Disorder Neonatal
Preterm Infants May Better Tolerate Warmer Feeds
Feeding intolerance is frequent among preterm infants in neonatal intensive care units (NICUs). Although there are many studies about enteral nutrition strategies and content in preterm infants, no evidence-based standards exist…
- Trial name
- Prematurity (NCT03743207)
- Testing
- Room temperature, Warmer temperature
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ege University
Infant, Extremely Premature
Description of Practices Implemented in the Birth of Living Children Before 24 Weeks of Amenorrhea
Every year, at the Nice University Hospital, about sixty deliveries take place before 24 weeks of amenorrhea. The child is not viable because of his extreme immaturity.
- Trial name
- NCT03403894
- Testing
- Asking caregivers in their practice
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Preterm, Chronobiology
The Effect of Oral Feeding Model With a Chronobiological Approach in Neonates
The ideal food for healthy term babies as well as preterm babies and sick term babies is breast milk. There are many studies showing that the composition of breast milk can vary from mother to mother, according to the baby's…
- Conditions
- Preterm, Chronobiology, Human Milk/Breastfeeding, Bottle Feeding
- Trial name
- NCT06821672
- Testing
- Chronobiological Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Bilgi University
Hypertriglyceridemia
Fat Tolerance From Lipid Emulsion Infusion Packaged in Glass or Plastic
This will be a prospective, randomized trial to determine if differences exist in the tolerance of lipid injectable emulsions in the neonatal intensive care unit (NICU).
- Trial name
- NCT00278928
- Testing
- Liposyn III 20% (lipid infusion), Intralipid 20% (lipid infusion)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Beth Israel Deaconess Medical Center
Method of Contraception, Preterm Birth Recurrence
Optimizing Postpartum Contraception in Women With Preterm Births
The purpose of this study is to examine the effectiveness of focused family planning counseling on the uptake and continuation of highly effective contraceptive methods (defined as the intrauterine device, implant, and both male…
- Trial name
- NCT01864629
- Testing
- Focused contraception counseling
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Utah
Premature Coronary Heart Disease
Correlation Between the Severity of Coronary Artery Disease and Peripheral Arterial Stiffness in Patients With Premature Coronary Heart Disease
Premature coronary heart disease (CHD) refers to the onset of myocardial infarction in men < 55 years old, women < 65 years old.
- Trial name
- NCT04578522
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chongqing Medical University
Prematurity, Bronchopulmonary Dysplasia
Inhaled Nitric Oxide and Neuroprotection in Premature Infants
The purpose of this study is to determine whether inhaled nitric oxide improves the neurological outcome for premature infants.
- Conditions
- Prematurity, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage, Periventricular Leukomalacia
- Trial name
- NOVA2 (NCT00515281)
- Testing
- inhaled nitric oxide, oxygen
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- University of Chicago
Preterm Birth, Complication of Prematurity
Single Dose Antenatal Corticosteroids (SNACS) for Women at Risk of Preterm Birth
Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities, such as respiratory distress syndrome, in preterm infants.
- Conditions
- Preterm Birth, Complication of Prematurity, Obstetric Labor, Premature, Obstetric Labor Complications
- Trial name
- SNACS Pilot (NCT04494529)
- Testing
- 24 mg betamethasone
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Respiratory Distress Syndrome in Premature Infants
First In Human Study on Synthetic Surfactant CHF 5633 in Respiratory Distress Syndrome
The aim of this study is to investigate the safety and tolerability of intratracheal administration of two different single doses of CHF 5633 in preterm neonates with RDS in terms of adverse events, adverse drug reactions…
- Trial name
- NCT01651637
- Testing
- synthetic surfactant (CHF5633)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
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