Clinical trials: Preterm
Breastfeeding, Exclusive, Breastfeeding
Donor Breast Milk and Breastfeeding Rates
The purpose of this pilot study is to determine if a randomized controlled study comparing a human milk diet versus a formula supplemented diet in late preterm and term infants in the neonatal intensive care unit (NICU) is…
- Trial name
- NCT04572581
- Testing
- Donor Breast Milk
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of California, Los Angeles
Cholestasis of Parenteral Nutrition
Ursodeoxycholic Acid Prevents Total Parenteral Nutrition Cholestasis
This study aims to confirm whether the preventive use of ursodeoxycholic acid on the 5th day after birth in preterm infants who started parenteral nutrition therapy can reduce the occurrence of enteral nutrition-related…
- Trial name
- UDACPPNAC (NCT05043194)
- Testing
- Ursodeoxycholic Acid 250 Mg Oral Capsule
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Wei Liu
Cardiovascular Diseases, Defect, Congenital Heart
Management of Patent Ductus in Premature Infants
To evaluate the effects (up to one year of age) of indomethacin on the clinical course of patent ductus arteriosus (PDA) in premature infants (24 hours old or less) and to assess the relative merits of indomethacin and surgery in…
- Conditions
- Cardiovascular Diseases, Defect, Congenital Heart, Ductus Arteriosus, Patent, Heart Diseases
- Trial name
- NCT00000494
- Testing
- indomethacin, surgery, cardiovascular
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Empowerment, Competence
COPE Program , Mental Health, Mother- Infant Interaction, Sense of Competence
The aim of the study is to: Evaluate the effect of creating opportunities for parent empowerment program on maternal sense of competence, mental health outcome and mother-infant interaction.
- Conditions
- Empowerment, Competence, Outcome, Interaction
- Trial name
- NCT06502730
- Testing
- Creating Opportunities for Parent Empowerment (COPE) Program
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Matrouh University
Respiratory Distress Syndrome, Newborn
Comparison of Methods of Weaning From Nasal CPAP in Preterm Infants: A Randomized Controlled Trial
This study aimed to determine the efficacy of different NCPAP weaning strategies in pre-term infants presenting with respiratory distress, and ultimately establishing the best method to withdraw from NCPAP.
- Trial name
- NCT07009366
- Testing
- Sudden weaning of NCPAP, Gradual weaning with increasing the time off NCPAP, Pressure weaning of NCPAP
- Where
- Pakistan
- Volunteers
- 75 people
- Sponsor
- RESnTEC, Institute of Research
Premature Birth
Influence of Physical Treatments of Human Milk on the Kinetics of Gastric Lipolysis in Preterm Newborns
The optimization of newborns nutrition is a challenge especially for preterm newborns for whom nutrition plays a crucial part in cerebral and global development. Human milk is considered as the best food for newborns.
- Trial name
- ARCHILACT (NCT02112331)
- Testing
- Raw human milk, Pasteurized human milk, Pasteurized-homogenized human milk
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Rennes University Hospital
Infant, Premature, Neonatal Respiratory Distress
Maintaining Optimal HVNI Delivery Using Automatic Titration of Oxygen in Preterm Infants
Oxygen treatment is common in management of preterm babies requiring intensive care. Delivery of too much or too little oxygen increase the risk of damage to eyes and lungs, and contributes to death and disability.
- Conditions
- Infant, Premature, Neonatal Respiratory Distress, Oxygen Saturation, Bronchopulmonary Dysplasia
- Trial name
- MODERATION Neo (NCT05030012)
- Testing
- Automated Control, Manual Control
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Vapotherm, Inc.
Acute Kidney Injury
Acute Kidney Injury in Premature Infants
Our first Aim is to describe how common a sudden decrease in renal function happens in premature infants in a neonatal intensive care unit. We also want to see how a sudden loss of renal function affects survival.
- Trial name
- NCT00573079
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- University of Alabama at Birmingham
Birth Weight, Miscarriage
Micronutrient Supplementation Before and During 1st Pregnancy to Improve Birth Outcomes (JiVitA-5)
The purpose of this cluster-randomized trial is to evaluate the efficacy of daily, multiple micronutrient (MM) supplement versus identical placebo use among nulligravid, recently married women, starting preconceptionally through…
- Conditions
- Birth Weight, Miscarriage, Small-for-gestational Age, Preterm Birth
- Trial name
- JiVitA-5 (NCT03921177)
- Testing
- Multiple micronutrient supplement
- Where
- Bangladesh
- Volunteers
- 9,859 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Retinopathy of Prematurity
Effect of Benoxinate Hydrochloride Eye Drops on The Premature Infant Pain Profile Score During Retinopathy of Prematurity Screening
Aims: To evaluate the effects of topical Benoxinate HCL eye drops on the Premature Infant Pain Profile (PIPP) scores in infants undergoing Retinopathy of Prematurity (ROP) screening.
- Trial name
- NCT06461975
- Testing
- Benoxinate Hydrochloride, artificial tear (Sodium Hyaluronate 2 mg/ml) eye drops.
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Alexandria University
Neonatal Sepsis
Outcomes and Predictors of Mortality Among Preterm Infants With Neonatal Sepsis
A prospective cross-sectional study of outcomes and predictors of mortality among preterm infants with neonatal sepsis admitted in NICU of Assiut University Children's Hospital
- Trial name
- NCT06113653
- Testing
- Prospective study
- Volunteers
- 50 people
- Sponsor
- Assiut University
Infant, Premature, Diseases, Infant Nutrition Disorders
Early Nutrition and Neurological Development of Very Preterm Infants
The main goal of this study is to determine the association between: the quantity of mother's milk and duration of breastfeeding the intake of polyunsaturated fatty acids and iron during hospitalization and the development of…
- Conditions
- Infant, Premature, Diseases, Infant Nutrition Disorders, Development; Delayed, Mental
- Trial name
- EPINUTRI (NCT01486173)
- Where
- France
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Lapillonne, Alexandre, M.D.
Acute Kidney Injury, Premature Infant
NIRS Monitoring to Detect AKI in Preterm Infants
This study will examine the relationship of oxygen levels, using Near-infrared spectroscopy (NIRS) monitoring, and kidney injury in infants born prematurely.
- Trial name
- nNIRS-AKI (NCT03384173)
- Testing
- Near Infrared Spectroscopy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Wisconsin, Madison
Postnatal Growth Disorder, Neurodevelopment
Individualized Fortification of Breast Milk
The proposed research will investigate individualized fortification of breast milk based on daily milk analysis of carbohydrate, protein, and fat content in a randomized double blind controlled trial.
- Trial name
- IFO (NCT01609894)
- Testing
- Individualized fortification of breast milk, Routine fortification of breast milk
- Where
- Canada
- Volunteers
- 112 people
- Sponsor
- McMaster Children's Hospital
Children Born Very Prematurely in Relation to Structural Brain Abnormalities
Magnetic Resonance Spectroscopy at Term-equivalent Age and Executive Functions at 5 Years of Age Corrected in Very Preterm Infants
EPIRMEX is a complementary study to the national cohort EPIPAGE 2 the INSERM Unit 953 is responsible. The objective of this study is to evaluate at the age of 5 years corrected executive functions in children born very…
- Trial name
- EPIRMEX (NCT02851537)
- Testing
- an advanced technique as magnetic resonance spectroscopy (MRS)
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Neonatal Oxygen Desaturation, Premature
Non-Invasive Neurally Adjusted Ventilatory Assist (NAVA) Prone vs Supine in Premature Infants
This research study is being done to investigate the effect of changing an infant's body position on how hard the baby works to breathe, the baby's oxygen level, the baby's carbon dioxide level, the baby's lung volume, the baby's…
- Conditions
- Neonatal Oxygen Desaturation, Premature, Ventilator Lung; Newborn, Apnea of Prematurity
- Trial name
- NCT05968586
- Testing
- Body positioning
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Milton S. Hershey Medical Center
Premature Lungs, Respiratory Distress Syndrome
Early Caffeine and LISA Compared to Caffeine and CPAP in Preterm Infants
This study is being conducted to determine whether prophylactic administration of surfactant by the Less Invasive Surfactant Administration (LISA) method reduces the need for mechanical ventilation in the first 72 hours of life…
- Conditions
- Premature Lungs, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
- Trial name
- CaLI (NCT04209946)
- Testing
- Less Invasive Surfactant Administration LISA, Continuous Positive Airway Pressure CPAP
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Sharp HealthCare
Premature Birth
Preterm Functional Early Enteral Development (FEED) Trial on Respiratory Support
The purpose of this study is to demonstrate that allowing infants that require high flow nasal cannula (HFNC)/Continuous positive airway pressure (CPAP) to orally feed if demonstrating oral cues will achieve full oral feeds…
- Trial name
- NCT04531566
- Testing
- Oral Feed, Usual care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Infant, Very Low Birth Weight
Liquid Preterm Formula Versus Powdered Human Milk Fortifier in VLBW Infants
This study aims to compare the short-term effects on growth and feeding tolerance of a liquid high calorie formula added to human milk versus powdered human milk fortifier in small preterm infants.
- Trial name
- NCT00760942
- Testing
- Similac special care 30, Similac human milk fortifier
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Oklahoma
Breast Feeding, Premature Birth
Meditation for NICU Moms
This project explores whether meditation increases breastmilk supply in mothers who are pumping milk for infants in the NICU. Mothers will be randomly assigned to daily meditation while pumping using an app designed for…
- Conditions
- Breast Feeding, Premature Birth, Stress, Depression, Postpartum
- Trial name
- NCT03574766
- Testing
- Meditation
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- St. Louis University
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