Clinical trials: Preterm
Duchenne Muscular Dystrophy
Study of Ataluren in Previously Treated Participants With Nonsense Mutation Dystrophinopathy (nmDBMD)
The objective of this study is to assess the safety and tolerability of 10, 10, 20 milligrams per kilogram (mg/kg) ataluren in participants with nmDBMD who had prior exposure to ataluren in a PTC sponsored clinical trial or…
- Trial name
- NCT01247207
- Testing
- Ataluren
- Where
- 34 sites in United States, Canada
- Volunteers
- 265 people
- Sponsor
- PTC Therapeutics
Gastritis of Newborn, Other Vomiting of Newborn
Effect of Gastric Lavage in Preventing Feeding Problems in Babies Born With Meconium Stained Amniotic Fluid
The purpose of the study is to evaluate the role of gastric lavage in preventing feeding problems in babies born through meconium stained amniotic fluid.
- Conditions
- Gastritis of Newborn, Other Vomiting of Newborn, Meconium in Amniotic Fluid
- Trial name
- GLAM (NCT01306500)
- Testing
- Gastric lavage
- Where
- India
- Volunteers
- 538 people
- Sponsor
- Lady Hardinge Medical College
Birth Weight, Miscarriage
Micronutrient Supplementation Before and During 1st Pregnancy to Improve Birth Outcomes (JiVitA-5)
The purpose of this cluster-randomized trial is to evaluate the efficacy of daily, multiple micronutrient (MM) supplement versus identical placebo use among nulligravid, recently married women, starting preconceptionally through…
- Conditions
- Birth Weight, Miscarriage, Small-for-gestational Age, Preterm Birth
- Trial name
- JiVitA-5 (NCT03921177)
- Testing
- Multiple micronutrient supplement
- Where
- Bangladesh
- Volunteers
- 9,859 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
NRDS
Impact of Delayed Cord Clamping and Minimally Invasive Surfactant Administration on Outcomes in Premature Infants Less Than 30 Weeks Gestation
Background: Preventing early exposure to invasive mechanical ventilation in premature infants is crucial for reducing the incidence of bronchopulmonary dysplasia (BPD) and improving overall outcomes.
- Trial name
- NCT07092319
- Testing
- deferred cord clamping
- Where
- China
- Volunteers
- 518 people
- Sponsor
- Peking University Third Hospital
Neonates, Respiratory Distress
Non-invasive Secondary Respiratory Support in Late Preterm and Term Infants
The aim of the present work is to compare between various modes of non-invasive respiratory support (including NCPAP, NIPPV, and NHFOV) as secondary respiratory support modes in late preterm and term neonates as regards the need…
- Conditions
- Neonates, Respiratory Distress, Non- Invasive Ventilation
- Trial name
- NCT07000071
- Testing
- NCPAP, NIPPV, NHFOV
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Maternal Infection During Pregnancy (Diagnosis), Neonatal Infection
Immediate Versus Delayed Induction in Term-PROM Using or Not Antibiotic Prophylaxis
The primary aim of this study is to determine if antibiotics combined with immediate induction can significantly reduce the rate of maternal and neonatal infection compared with immediate induction alone in women presenting with…
- Trial name
- NCT02985086
- Testing
- Cefoxitin, oxytocin/misoprostol
- Where
- 2 sites in Portugal
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- Hospital de Santa Maria, Portugal
Infant, Premature
The Effects of Family Centered Intervention Program on Preterm Infants
Infant born preterm have an increased risk of adverse long-term developmental outcomes.The risk associated with preterm birth increase as gestational age decreases, and vulnerability remains in moderate and early preterm (<34…
- Trial name
- NCT03146351
- Testing
- Family based early intervention program (NDT-Bobath based)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Gazi University
Full Enteral Nutrition, the Day and Night Cycle
The Effect of Day-Night Cycle on the Transition Time to Full Enteral Feeding in Preterm Newborns Receiving Oropharyngeal Colostrum
The aim of this study was to examine the effect of the day-night cycle on the transition time to full enteral nutrition in premature infants receiving oropharyngeal colostrum.
- Trial name
- PRETERM (NCT06883903)
- Testing
- day-night cycle application, routine practice
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Biruni University
Prematurity
Maternal Stress, Milk Composition, and Preterm Neurodevelopment
This study explores the associations between maternal stress, breastmilk composition, and feeding and neurodevelopment for preterm infants in the NICU and at 4 months corrected age.
- Trial name
- NCT05537454
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Minnesota
Premature Birth
Parental Involvement in Enteral Nutrition in Neonatal Units
Hypothesis : Bolus feeding of the newborn with a syringe under parents' visual control increases parental presence when compared to enteral feeding with a syringe pump.
- Trial name
- PREMALIM (NCT05272956)
- Testing
- enteral feeding with pushed syringe by the parents
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Limoges
Stress, Psychological, Father-Child Relations
Hair Cortisol as Marker of Chronic Stress in Preterm and Term Fathers - Fathair-study
The goal of this observational study is to compare the paternal hair cortisol as a marker for chronic stress in prematurely born children to maturely born children.
- Conditions
- Stress, Psychological, Father-Child Relations, Premature Birth
- Trial name
- NCT05969431
- Testing
- measurement of cortisol level
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Cologne
Space Maintenance
The Effectiveness of Combined Design Nance/Transpalatal Arch Appliance in Maintaining Arch Dimensions After Premature Extraction of Primary Molars
This study will evaluate the effectiveness of N-TPA appliance compared to Nance SM in maintaining the arch dimensions after bilateral premature extraction of primary molars in children.
- Trial name
- NCT05514145
- Testing
- Nance/Transpalatal arch space maintainer, Nance space maintainer
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Intermittent Hypoxemia, Apnea of Prematurity
Influence of Oxygen Target Range on Intermittent Hypoxemia in Preterm Infants
In this randomized crossover trial, preterm infants with intermittent hypoxemia and need for supplemental oxygen will be randomized to either Sequence of two different oxygen target ranges (low: 85-89%; high: 91-95%) for a total…
- Trial name
- NCT02743988
- Testing
- Oxygen
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- University of Ulm
Premature Birth, Brain Injury
Melatonin As A Novel Neuroprotectant In Preterm Infants- Dosage Study
Preterm babies are at risk of brain injury. Melatonin, a naturally occurring hormone, may reduce this risk. The unborn baby receives melatonin from the mother but following premature delivery there maybe a period of prolonged…
- Trial name
- MIND (NCT00649961)
- Testing
- Melatonin injection
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- Imperial College London
Premature; Infant, Light-for-dates, Breastfeeding
Probiotics and Early Microbial Contact in Preterm Neonates
Probiotics are live microbes which, when administered in sufficient amounts, confer a health benefit to the host. According to recent clinical trials, administration of probiotics to very low birth weight infants significantly…
- Trial name
- ProPre (NCT01454661)
- Testing
- LGG, LGG+Bb-12
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Preterm Infants
Comparison of Instillation and Packing in Mydriasis for Premature Infants
The purpose of this study is to compare the mydriatic effect of 2.5% phenylephrine and 1% tropicamide by conventional instillation and lower conjunctival fornix packing in premature infants.
- Trial name
- NCT00877175
- Testing
- 1% tropicamide and 2.5% phenylephrine
- Where
- Thailand
- Volunteers
- 25 people
- Sponsor
- Khon Kaen University
Infant Respiratory Distress Syndrome, Respiratory Insufficiency
Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study
The purpose of this study is to test whether application of high frequency ventilation through a nasal tube can lower blood carbon dioxide levels in stable preterm infants.
- Conditions
- Infant Respiratory Distress Syndrome, Respiratory Insufficiency, Apnea of Prematurity
- Trial name
- NCT00296231
- Testing
- Nasal high frequency ventilation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Tarah T Colaizy
Intensive Care, Neonatal, Analgesia
Clonidine for Analgesia to Preterm Infants During Neonatal Intensive Care
A prospective pharmacokinetic (PK), pharmacodynamic (PD) and pharmacogenetic (PG) observation study, including the PK/PD/PG relationship, in clonidine administered for analgesia and sedation to preterm newborn infants receiving…
- Conditions
- Intensive Care, Neonatal, Analgesia, Hypnotics and Sedatives
- Trial name
- NCT04928651
- Testing
- Clonidine
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Premature Birth
Single-center Retrospective Study : Developmental Trajectories of Children Born Prematurely Before 32 Weeks Assessed With the Revised Brunet Lézine Scale at 1, 2 and 3 Years
This study will assess professionals in the CHI Créteil neonatal department and the Val de Marne perinatal network to gain a better understanding of the developmental trajectories of children hospitalized at the CHI Créteil, with…
- Trial name
- NCT06731686
- Testing
- Retrospective study
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Hypothermia
Neonatal Warming to Prevent Hypothermia
Researchers are proposing a pilot randomized controlled trial evaluating the benefit of immediately warming preterm babies using a warming mattress and a plastic wrap, while delaying clamping the umbilical cord at the time of…
- Trial name
- NCT04827394
- Testing
- Neonatal warming mattress, Sterile polyethylene wrap
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Oklahoma
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