Clinical trials: Preterm Delivery
Preterm Birth
Trial of the Use of Antenatal Corticosteroids in Developing Countries
Multi-country two-arm, parallel cluster randomized controlled trial to reduce neonatal mortality through increasing the rate of antenatal corticosteroid administration to eligible women.
- Trial name
- ACT (NCT01084096)
- Testing
- Increasing use of Antenatal Corticosteroids (ACS)
- Where
- 7 sites in Argentina, Guatemala and 4 more
- Volunteers
- 103,117 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Infant, Premature
Nasogastric Tube vs. Orogastric Feeding Tube in Preterm Infants: Which is Best?
The purpose of this study is to find out which method (nasogastric vs. orogastric) of feeding tube for premature infants results in earlier only oral feeding.
- Trial name
- NCT00365703
- Testing
- Feeding tube insertion
- Where
- Israel
- Volunteers
- 115 people
- Sponsor
- Hillel Yaffe Medical Center
Persistent Ductus Arteriosus, Complication of Prematurity
The Preterm Infants' Paracetamol Study
Present randomized, controlled, double-blind trial investigates the efficacy and safety of early (<24 h) intravenous paracetamol therapy for pain medication in very small premature infants.
- Conditions
- Persistent Ductus Arteriosus, Complication of Prematurity, Pain or Discomfort in Intensive Care of Preterm Infants
- Trial name
- PreParaS (NCT01938261)
- Testing
- paracetamol, 0.45 % saline solution
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- University of Oulu
Preterm Infants
Single-Session Physiotherapy Versus Massage in Premature Infants
This study investigates the effects of a single-session physiotherapy intervention compared to massage in premature infants hospitalized in the neonatal intensive care unit.
- Trial name
- SPIM-Preterm (NCT07207161)
- Testing
- Infant Massage, Physiotherapy (Moyer-Mileur Protocol)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Necmettin Erbakan University
Premature Birth of Newborn, Critically Ill
The Use of Methadone in Newborn Infants
This proposed investigation will test the following hypotheses: 1) Enzymatic activity of CYP2B6 characterized by the formation clearance of methadone to EDDP (CLf,EDDP), is directly related to both gestational and postnatal age…
- Trial name
- Methadone (NCT01327079)
- Testing
- Methadone
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- John van den Anker
Brain Development, Behavior Disorders, Child
The Brain Mechanism of Social Emotion and Communication in Infants Aged 0 to 6 Years
This study explores the relationship between brain development and infants' social emotion and communication ability, as well as the role of genetic factors and maternal exposure during pregnancy (e.g., environmental exposures…
- Conditions
- Brain Development, Behavior Disorders, Child, Intellectual Developmental Disorders
- Trial name
- NCT05040542
- Testing
- maternal exposure during pregnancy
- Where
- China
- Volunteers
- 3,001 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Nasogastric Tube, Orogastric Tube
Effects of Intermittent Feeding Methods With Nasogastric and Orogastric Tubes in Preterm Infants
The study is a randomized controlled, prospective, double-blind trial planned to compare the effects of intermittent feeding methods using nasogastric and orogastric tubes on the growth, nutrition, and physiological parameters of…
- Trial name
- NCT06765720
- Testing
- Intermittent feeding method with nasogastric tube, Intermittent feeding method with orogastric tube
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- İstanbul Yeni Yüzyıl Üniversitesi
Prematurity, Respiratory Distress Neonatal
Effect of Automated Oxygen Control on Early-childhood Lung Mechanics
Preterm infants are at higher risk of long-term respiratory problems and abnormal lung function in childhood. Respiratory support including mechanical ventilation, that is the use of a machine to move air into and out of the…
- Conditions
- Prematurity, Respiratory Distress Neonatal, Oxygen Delivery
- Trial name
- NCT07866820
- Testing
- Forced oscillometry technique
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust
Preterm Infants
Perenteral Nutrition and Oxidative Stress in Preterm Infants
In an effort to decrease the load of peroxides in TPN solutions, multiple studies examined different strategies such as photo-protection, adding multivitamins to the lipid emulsion rather than to the dextrose-amino acid…
- Trial name
- NCT00611546
- Testing
- Photo-protection, Photo-exposure
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Newborn Care, Pain Management
The Effect of Breast Milk, 10% and 20% Dextrose on Pain and Physiological Variables During Heel Puncture in Infants
Pain, defined by the International Association for the Study of Pain as a subjective, sensory, and emotional experience, differs from nociception, which is merely a neural activity.
- Conditions
- Newborn Care, Pain Management, Physiological Parameters During Newborn Care İn Newborn's, Breast Milk
- Trial name
- NCT07716813
- Testing
- Administering oral breast milk in a supportive position, Administering oral 10% dextrose in a supportive position, Administering oral 20% dextrose in a supportive position
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Mersin University
Preterm Birth, Respiratory Distress Syndrome
Sustained Lung Inflation and Pulmonary Mechanics in Preterm Infant
Lung protection should start in the delivery room where, from the first breaths, the preterm infant can be helped to clear the lung fluid and to recruit alveolar spaces and establish the functional residual capacity (FRC).
- Conditions
- Preterm Birth, Respiratory Distress Syndrome, Lung Diseases
- Trial name
- NCT02493920
- Testing
- Sustained lung inflation, mask using a T-piece system (Fabian,Acutronic Medical Systems AG, Switzerland).
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Respiratory Distress Syndrome, Lung Ultrasonography Score
The Role of Lung Ultrasonography Score in Predicting Prognosis in Term and Late Preterm Newborns With Postnatal Respiratory Distress
Respiratory distress in term and late preterm infants in the first hour after birth is a prevalent condition. This situation may occur due to different reasons such as minimal respiratory stress, transient tachypnea of newborn…
- Trial name
- TeLaPLUS (NCT06031324)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa City Hospital
Premature, Placental Transfusion
Evaluation of Placental Transfusion Techniques in Prevention of Prematurity Related Complications and Effect on Their Hematological Profile
The objective of this study is to evaluate the general course and prognosis associated with different methods of placental transfusion (Intact umbilical cord milking, cut- umbilical cord milking and delayed cord clamping) in…
- Trial name
- NCT06812507
- Testing
- intact umbilical milking, cut umbilical milking, Delayed cord clamping
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Shock
Dobutamine in the Treatment of Haemodynamic Insufficiency in the Immediate Postnatal Period
Haemodynamic insufficiency after birth is seen commonly in babies born prematurely and is associated with adverse outcomes. In current clinical practice, a combination of blood pressure and clinical signs is used to guide…
- Trial name
- NeoCirc-001 (NCT03311178)
- Testing
- Dobutamine
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
Premature Birth, Neonatal Hypoxic Conditions
Effects of Vanilla on Hypoxic Intermittent Events in Premature Infants
The purpose of this study is to evaluate the effect of vanilla odor on hypoxic intermittent events in premature infants born between 32.0 and 33.6 weeks of gestational age.
- Trial name
- Vanilla (NCT02630147)
- Testing
- Vanilla scent
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- Université de Sherbrooke
Premature Infants
Kangaroo Care an EffectonTransitionTime From Gavage Feeding
Objectives: Kangaroo care is a safe and effective alternative method to conventional neonatal care for newborn babies. The aim of this study was to evaluate the effect of kangaroo care on the transition time to full oral feeding…
- Trial name
- KangarooCare (NCT05492747)
- Testing
- Kangaroo Care an Effect
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Firat University
Premature Birth, Obstetric Labor, Premature
Family Nurture Intervention in the NICU at The Valley Hospital
The purpose of this study is to compare neurodevelopment and activity in infants born preterm (25 to 34 1/7 weeks gestational age (GA)) receiving Standard Care (SC) or Family Nurture Intervention (FNI) in the neonatal intensive…
- Trial name
- NCT03267043
- Testing
- Family Nurture Intervention (FNI), Standard Care
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Columbia University
Premature Birth
2-Brain Regulation to Achieve Improved Neuroprotection During Early Development
Each year 15 million infants are born preterm (PT). Even without severe comorbidities, they are exposed to sensory stress during the Neonatal Intensive Care Unit (NICU) stay and are at greater risk of neurodevelopmental problems…
- Trial name
- 2-BRAINED (NCT06659809)
- Testing
- Tele-care video-feedback intervention (TVFI)
- Where
- 2 sites in Italy
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Infant, Premature, Brain Injuries
Structural Brain Abnormalities in Children Born Prematurely: New Detection Methods and Clinical-Pathological Correlates
The purpose of the study is to detect structural brain changes using MRI and to correlate these findings with neurodevelopmental assessments in two-year old children previously enrolled in the NIH sponsored trial of inhaled…
- Trial name
- NCT00153855
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Early Skin-to-skin Contact, Psychological Distress
Effects of the Couplet Care in Neonatal Intensive Care Unit
This is a quasi-experimental before and after intervention study taking place in the level III NICU of Turku University Hospital in Finland to evaluate the effects of the Couplet Care, a care model which provides maternal and…
- Conditions
- Early Skin-to-skin Contact, Psychological Distress, Parenting, Preterm Infant
- Trial name
- NCT05655104
- Testing
- Couplet Care
- Volunteers
- 30 people
- Sponsor
- Turku University Hospital
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