Clinical trials: Preterm Neonates
Bacillus Cereus Infection
Contamination of Bacillus Species Sepsis.
Bacillus species are ubiquitous gram-positive spore-forming organisms. They rarely cause disease in the immunocompetent and are more frequently isolated as a culture contaminant.
- Trial name
- BACILLUS (NCT03377530)
- Testing
- Ways to prevent these infections.
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Hôpital NOVO
Premature Birth
Development of a Digital Tool for the Individualization of Speech Therapy Care for Premature Newborns
The study concerns the creation and implementation of a digital tool presenting the various orofacial stimuli that can be offered to premature newborns.
- Trial name
- NEORTHO (NCT05992181)
- Testing
- NEORTHO
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Sud Francilien
Patent Ductus Arteriosus
An Escalating Dose Indomethacin for the Treatment of Persistent Patent Ductus Arteriosus (PDA) In Preterm Infants
A large patent ductus arteriosus (PDA) is associated with congestive heart failure, pulmonary hemorrhage, chronic lung disease (CLD), necrotizing enterocolitis (NEC) and intraventricular bleeding.
- Trial name
- NCT00750581
- Testing
- Indomethacin
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Fetal Membranes, Premature Rupture
Perinatal Outcome After Premature Rupture of Membranes
Premature rupture of membranes is an important cause of neonatal morbidity and mortality, mainly because of the complications associated with this pathology (oligohydramnios, cord compression or prolapse, infection).
- Trial name
- NCT01538030
- Where
- Panama
- Volunteers
- 80 people
- Sponsor
- Saint Thomas Hospital, Panama
Patent Ductus Arteriosus, Preterm
Precision Dosing of Oral Ibuprofen for PDA, A Pilot RCT
Newborns born early are at risk for a serious health problem called patent ductus arteriosus (PDA). PDA is a passageway between heart and lung that can cause life-threatening complications such as bleeding in the brain or even…
- Trial name
- MIPD-PDA (NCT07143201)
- Testing
- Standard Dose - Ibuprofen oral suspension, Precision Dose - Ibuprofen oral suspension
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Hamilton Health Sciences Corporation
Infant, Premature, Diseases
Electromyographic Activity of Preterm Newborns Submitted to Hammock Positioning
To compare and analyze the effects on the electromyographic activity of preterm newborns placed in the hammock position with the activity of newborns not placed in this position.
- Trial name
- NCT02668107
- Testing
- Hammock positioning
- Where
- Brazil
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Temperature, Preterm
Body Temperature in Preterm Neonates: Creating a Data Model
The aim of this study is to examine the relationship between the characteristics, medical history, interventions performed within the first six hours, and follow-up findings of preterm newborns receiving respiratory support and…
- Trial name
- NCT07176364
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Impact of Kangroo on Neonates
Effect of Kangaroo Mother Care on Energy Utilization in Preterm Neonates
This study aims to assess the impact of kangaroo mother care on energy utilization in preterm neonates by measuring urinary levels of xanthine, uric acid, and malondialdehyde.
- Trial name
- NCT07548229
- Testing
- kangroo mother care, routine incubation care
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Preterm Infant, Physical Therapy
Early Physical Therapy Intervention in Preterm Infants
The hypothesis of this study is that early physical therapy intervention, initiated during the NICU stay and up to 2 months corrected age, based on the family-centered model, could promote preterm infants motor development in…
- Conditions
- Preterm Infant, Physical Therapy, Early Intervention, NICU
- Trial name
- NCT03313427
- Testing
- Physical Therapy Early Intervention, Usual Care
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Vic - Central University of Catalonia
Pregnancy, Pregnancy Complications
AI-POCUS for Maternal and Neonatal Health in Ethiopia
Maternal and neonatal health remains one of the most pressing global health challenges, particularly in low- and middle-income countries (LMICs).
- Conditions
- Pregnancy, Pregnancy Complications, Preterm Birth, Fetal Growth Restriction
- Trial name
- AIM-ETH (NCT07171086)
- Testing
- AI-POCUS (BabyChecker, Delft Imaging), AI-POCUS (Edan, China)
- Where
- Ethiopia
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Premature Birth, Infant, Newborn
Orofacial Development of Preterm and Low Birthweight Infants Versus Term Infants
Preterm infants account for 6 % of all live-births in western societies. Scientific evidence can be found for altered palatal morphology in the short term among preterm children.
- Conditions
- Premature Birth, Infant, Newborn, Pregnancy
- Trial name
- NCT00408746
- Testing
- palatal development
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Neonatal Late Onset Sepsis
Pentoxifylline Dose Optimization in Neonatal Sepsis
Sepsis is a very important cause of death and morbidity in preterm infants. There are strong indications that preterm neonates with sepsis could benefit, next to antibiotics, from treatment with pentoxifylline (PTX).
- Trial name
- NCT04152980
- Testing
- Pentoxifylline
- Where
- 2 sites in Netherlands, Poland
- Volunteers
- 30 people
- Sponsor
- Erasmus Medical Center
Gastroesophageal Reflux, Apnea
Study of Erythromycin in GER-Associated Apnea of the Newborn
To evaluate the relationship of reflux and apnea and to determine whether the administration of erythromycin improves the incidence of GER and GER-associated apnea, bradycardic and/or desaturation events in a prospective…
- Conditions
- Gastroesophageal Reflux, Apnea, Bradycardia
- Trial name
- SEGAN (NCT01825473)
- Testing
- Erythromycin, Multi-channel intra-luminal impedance (MII) pH monitoring
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Gastroesophageal Reflux
Esophageal Bolus Transit in Newborns With Gastroesophageal Reflux Disease
Esophageal dysmotility due to immaturity could promote impaired bolus transit during esophageal swallow events,thus influencing gastroesophageal reflux (GER) clearance.
- Trial name
- NCT02167984
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- University of Turin, Italy
Infant, Premature, Diseases
Efficacy of an Oral Stimulation Protocol in Preterm Infants to Shorten the Period Between Enteral and Oral Nutrition
Oral feeding in the neonatal period requires an accurate coordination between suction, swallowing and breathing. In premature new-borns and, depending on their gestational age, the coordinated work of those processes becomes…
- Trial name
- NCT03016767
- Testing
- Manual oral stimulation protocol
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Fundacion Para La Investigacion Hospital La Fe
Premature Birth, Growth Failure
Predictors of Postnatal Growth Failure in Preterm Infants
This prospective observational study aims to identify the clinical and nutritional predictors of postnatal growth failure among preterm infants admitted to the Neonatal Intensive Care Unit of Assiut University Children's Hospital.
- Conditions
- Premature Birth, Growth Failure, Very Low Birth Weight Infant
- Trial name
- NCT07818681
- Volunteers
- 120 people
- Sponsor
- Assiut University
Retinopathy of Prematurity
European Disease Registry on Retinopathy of Prematurity (ROP)
The EU-ROP registry is a European wide multicenter non-interventional observational registry study intended to run open-ended in as many countries as possible including infants treated for retinopathy of prematurity irrespective…
- Trial name
- EU-ROP (NCT04939571)
- Testing
- Registry of preterm born infants with treatment-requiring ROP
- Where
- 59 sites in Austria, Bulgaria and 10 more
- Volunteers
- 3,000 people
- Sponsor
- University Medicine Greifswald
Malaria
Congenital and Neonatal Malaria in Mali
This study will look at blood samples taken from 300 preterm babies and newborns admitted for inpatient care at Hopital Gabriel Toure in Bamako, Mali, and to gather information that will help the investigators verify the role of…
- Trial name
- NCT00384267
- Where
- Mali
- Volunteers
- 44 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Infant, Newborn, Infant, Low Birth Weight
Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity
The purpose of this trial was to determine the efficacy and safety of supplemental therapeutic oxygen for infants with prethreshold retinopathy of prematurity (ROP) to reduce the probability of progression to threshold ROP and…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- STOP-ROP (NCT01203436)
- Testing
- Supplemental Oxygen Management, Conventional Oxygen Management
- Where
- 9 sites in United States
- Volunteers
- 649 people
- Sponsor
- NICHD Neonatal Research Network
Late Onset Neonatal Sepsis, Necrotizing Enterocolitis
Effects of Oral Probiotic Supplementation on the Clinical Status of Very-low-birth-weight Preterm Neonates.
The purpose of this study was to evaluate the safety of a probiotic foodstuff and its influence on emergence and development of natural intestinal flora and the clinical status of premature very low birth weight neonates.
- Conditions
- Late Onset Neonatal Sepsis, Necrotizing Enterocolitis, Infant, Very Low Birth Weight
- Trial name
- NCT02073214
- Testing
- Probiotic
- Volunteers
- 182 people
- Sponsor
- IBSS Biomed S.A.
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