Clinical trials: Primaquine
Malaria, Vivax, G6PD Deficiency
Operational Feasibility of Appropriate Plasmodium Vivax Radical Cure After G6PD Testing in Thailand
The purpose of this prospective, observational study is to assess the operational feasibility of appropriate radical cure treatment for P.
- Trial name
- ARCTIC (NCT05753150)
- Testing
- Tafenoquine, Primaquine
- Where
- 9 sites in Thailand
- Volunteers
- 187 people
- Sponsor
- Dr. Prayuth Sudathip
Malaria
Phase 2 Efficacy Study of Primaquine and Methylene Blue
The purpose of this study is to determine the most efficacious transmission blocking drug regimen for seasonal malaria chemoprophylaxis in Mali.
- Trial name
- NCT02831023
- Testing
- Sulphadoxine-pyrimethamine, 0.25 mg/kg primaquine, Dihydroartemisinin-piperaquine
- Where
- Mali
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
P Vivax, Malaria, Vivax
Efficacy of 3 Regimens of Chloroquine and Primaquine for Treatment of P. Vivax Malaria, Cruzeiro do Sul, Acre, Brazil
We plan to assess the efficacy of 3 different regimens of chloroquine and primaquine for the treatment of P. vivax infections in Cruzeiro do Sul, Acre, Brazil.
- Trial name
- NCT03610399
- Testing
- Primaquine
- Where
- Brazil
- Volunteers
- 257 people
- Sponsor
- Centers for Disease Control and Prevention
Vivax Malaria, G6PD Deficiency
Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients
A clinical study to assess the safety and efficacy of alternative regimens of primaquine for radical cure of vivax malaria in glucose 6-phosphate dehydrogenase (G6PD) deficient. G6PD deficient patients with P.
- Trial name
- NCT03529396
- Testing
- Chloroquine, Primaquine
- Where
- 2 sites in Brazil
- Volunteers
- 106 people
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Malaria
A Trial on Supervised Primaquine Use in Ethiopia
This is a randomized, controlled, open label trial to assess the effectiveness of unsupervised versus supervised primaquine treatment in patients with uncomplicated malaria. In co-endemic regions, the risk of P.
- Trial name
- SPRUE (NCT02793388)
- Testing
- Supervised primaquine treatment, Unsupervised primaquine treatment
- Sponsor
- Menzies School of Health Research
Vivax Malaria
Safety and Efficacy of Chloroquine and Primaquine for Vivax Malaria in Bhutan
This research is intended to study the efficacy of chloroquine (CQ) and primaquine (PQ) for Plasmodium vivax (P.vivax) infection, and also to study the recurrence rate among patients with P.vivax malaria on standard doses of CQ…
- Trial name
- NCT01716260
- Testing
- Chloroquine, Primaquine
- Where
- Bhutan
- Volunteers
- 24 people
- Sponsor
- Menzies School of Health Research
Plasmodium Falciparum Malaria
Targeted Chemo-elimination (TCE) of Malaria
The overall aim of this study is two fold: 1. to pilot targeted chemo-elimination of plasmodium falciparum malaria in known areas of artemisinin resistance in South East Asia. 2.
- Trial name
- TME (NCT01872702)
- Testing
- malaria elimination using DP and low-dose primaquine
- Where
- 5 sites in Burma, Cambodia and 3 more
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Vivax Malaria
G6PD Assessment Before Primaquine for Radical Treatment of Vivax Malaria
This will be a single-arm observational cohort study. Malaria patients with Plasmodium vivax and meeting study inclusion criteria, who give consent to be enrolled in the study, will have their G6PD status measured by the…
- Trial name
- GAP (NCT02876549)
- Testing
- Chloroquine, Primaquine 0.25 mg/kg/day, Primaquine 0.75 mg/kg weekly
- Where
- Afghanistan
- Volunteers
- 1,000 people
- Sponsor
- University of Oxford
Malaria
Impact of Dihydroartemisinin-piperaquine Plus Primaquine on Malaria Transmission in Lampung Province, Sumatra
Artemisinin-based combination therapy (ACT) has been known to be controversial for stopping malaria transmission. The addition of primaquine (PQ) - the only drug commercially available that kills mature transmission stage - to…
- Trial name
- NCT01389557
- Testing
- Dihydroartemisinin-piperaquine with primaquine
- Where
- Indonesia
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Pneumonia, Pneumocystis Carinii, HIV Infections
The Safety and Efficacy of Clindamycin and Primaquine in the Treatment of Mild - Moderate Pneumocystis Carinii Pneumonia in Patients With AIDS
To determine the safety and effectiveness of clindamycin and primaquine in the treatment of mild Pneumocystis carinii pneumonia (PCP) in AIDS patients.
- Trial name
- NCT00000717
- Testing
- Primaquine, Clindamycin
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Uncomplicated Falciparum Malaria
Trial of Artesunate Combination Therapy in Pakistan
This study is an evaluation of the benefit of adding artesunate to existing first and second line antimalarial therapies in Pakistan.
- Trial name
- NCT00959517
- Testing
- artesunate (AS), sulphadoxine-pyrimethamine (SP), Chloroquine (CQ)
- Where
- Pakistan
- Volunteers
- 588 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Falciparum
Methylene Blue Against Falciparum Malaria in Burkina Faso
Safety of artesunate-amodiaquine combined with methylene blue or primaquine for falciparum malaria treatment in African children: A randomised controlled trial Elimination has become the goal of malaria programmes in an…
- Trial name
- BlueACTn (NCT02851108)
- Testing
- Methylene Blue, Primaquine
- Where
- Burkina Faso
- Volunteers
- 100 people
- Sponsor
- Heidelberg University
Malaria, Vivax
Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria
This is a prospective, double-blind, double-dummy, multicenter, comparative study. A total of 300 subjects will be randomized to treatment on Day 1, of which a minimum of 50 female subjects must be enrolled that display moderate…
- Trial name
- NCT02216123
- Testing
- Tafenoquine, Chloroquine, Primaquine
- Where
- 10 sites in Brazil, Colombia and 4 more
- Volunteers
- 251 people
- Sponsor
- GlaxoSmithKline
Malaria Vivax
Efficacy of Chloroquine-Primaquine Treatment for Uncomplicated Plasmodium Vivax Malaria
The study was designed to evaluate the current efficacy of this combination therapy against P. vivax, given the possibility of misuse or inadequate adherence to the regimen due to its lengthy treatment duration, in one of a…
- Trial name
- CQ-PQ (NCT07753967)
- Testing
- CQ-PQ
- Where
- Ethiopia
- Volunteers
- 192 people
- Sponsor
- Jimma University
Vivax Malaria
Comparison Between 7 and 14 Day Primaquine Combined With Dihydroartemisinin-piperaquine or 3 Day Chloroquine Radical Cure of P. Vivax (BPD)
In Southeast Asia, Plasmodium vivax (Pv) infection reaches 50-80% and bears a greater burden of disease than Plasmodium falciparum (Pf).
- Trial name
- NCT01640574
- Testing
- Dihydroartemisinin-Piperaquine, Chloroquine
- Where
- Thailand
- Volunteers
- 680 people
- Sponsor
- University of Oxford
Malaria
Dihydroartemisinin-piperaquine and Primaquine for Uncomplicated Plasmodium Falciparum Cases
Artemisinin-based combination therapy (ACT) has been known to be controversial for stopping malaria transmission.The addition of primaquine (PQ) - the only drug commercially available that kills mature transmission stage - to…
- Trial name
- DHP+PQ (NCT01392014)
- Testing
- dihydroartemisinin-piperaquine, dihydroartemisinin-piperaquine + primaquine
- Where
- Indonesia
- Volunteers
- 374 people
- Sponsor
- Universitas Indonesia
Malaria, Vivax, Relapse
Primaquine Double Dose for Radical Cure of Plasmodium Vivax in Colombia
Primaquine (PQ) is the only widely available treatment to prevent P. vivax relapses. World Health Organization recommends increased PQ doses in East Asia and Oceania, frequently relapsing strains.
- Trial name
- NCT05232227
- Testing
- Primaquine double dose over 14 days, Primaquine single dose over 14 days
- Sponsor
- University of California, San Francisco
Plasmodium Falciparum Malaria
Efficacy and Safety of Artesunate + Amodiaquine With SLD of Primaquine for Treatment of Falciparum Malaria in Zanzibar
The general objective of this study is to assess the therapeutic efficacy and safety of artesunate + amodiaquine combined with a single low dose of primaquine (0.25 mg/kg) for the treatment of uncomplicated P.
- Trial name
- AcoV (NCT03773536)
- Testing
- Artesunate-amodiaquine given with single low dose primaquine
- Where
- Tanzania
- Volunteers
- 146 people
- Sponsor
- Professor Anders Björkman
Plasmodium Vivax Malaria, Malaria
FocaL Mass Drug Administration for Vivax Malaria Elimination
FLAME is an open-label cluster-randomized controlled trial that aims to determine the effectiveness of focal mass drug administration (fMDA) to reduce the incidence of Plasmodium vivax malaria in the Loreto Department in Peru.
- Trial name
- FLAME (NCT05690841)
- Testing
- Focal Mass Drug Administration (fMDA)
- Where
- Peru
- Volunteers
- 7,530 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Plasmodium Vivax
Investigation of Short Course, High Dose Primaquine Treatment for Liver Stages of Plasmodium Vivax Infection
This study specifically seeks to provide data on the safety, tolerability and pilot efficacy of short course, high dose primaquine treatment in Papua New Guinean children aged 5-10 years, in a cross-sectional study design.
- Trial name
- NCT02364583
- Testing
- Primaquine
- Where
- Papua New Guinea
- Volunteers
- 150 people
- Sponsor
- Papua New Guinea Institute of Medical Research