Clinical trials: Procedural Sedation
Cardiac Surgical Procedures
Pharmacokinetics and Pharmacodynamics of Pentobarbital in Neonates, Infants, and Children Following Open Heart Surgery
This medication is used for procedural sedation and sedation for diagnostic imaging. The purpose of this study is to find out what happens to pentobarbital in the body after it is given to children who have had heart surgery.
- Trial name
- NCT00577434
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Children's Hospital of Philadelphia
Conscious Sedation
Procedural Sedation And Analgesia in Children in the Emergency Department: The Role of Adjunct Therapies
The role of Adjunct therapies such as Child Life therapy and Music listening during Procedural Sedation and Analgesia(PSA) for children during painful procedures has not been studied in the Emergency Department (ED).
- Trial name
- NCT02518919
- Testing
- Child life intervention, Music listening
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Children's Hospital of Michigan
Anesthesia, Sedation
EEG Signal Correlates During Anesthesia and Sedation in Adults and Children
This prospective, multicenter, non-interventional observational study investigates the correlates between electroencephalographic (EEG) signals and pharmacological/clinical parameters during general anesthesia and procedural…
- Conditions
- Anesthesia, Sedation, Consciousness Monitors
- Trial name
- SPECTRALADUPED (NCT07460414)
- Where
- 2 sites in France
- Volunteers
- 330 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sialorrhea
Effectiveness of Atropine and Glycopyrrolate to Reduce Hyper Salivation With Ketamine Sedation
The purpose of this study is to determine if the antisialagogues (anti-salivary agents), Atropine and Glycopyrrolate, are effective in reducing hypersalivation when sedating patients with Ketamine for procedural sedation in the…
- Trial name
- NCT01191398
- Testing
- Atropine (0.01mg/kg), Glycopyrrolate (0.01mg/kg), Normal saline 0.9%
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Craig J. Huang
Trauma
The Effects of the Anesthetic Ketamine in Young Children Undergoing Procedural Sedation
In the emergency department (ED), ketamine is a popular anesthetic agent during sedation of children for painful and other short procedures.
- Trial name
- NCT02650154
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- The Hospital for Sick Children
Procedural Sedation, EEG
Factors Associated With Successful Completion of MRI in Children Undergoing a Vigil Sedation With Dexmedetomidin
This is a retrospective cohort study aiming to determine whether the use of Dexmedetomidine (DEX) to sedate children prior to MRI scanning is more or less effective in children with autism spectrum disorders or other…
- Conditions
- Procedural Sedation, EEG, MRI
- Trial name
- RIDEX (NCT06203522)
- Testing
- Data collection of successful completion of MRI
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Informed Consent Process
A Parental Educational Intervention to Facilitate Informed Consent for Pediatric Procedural Sedation in the Emergency Department
This study is planning to develop the computed-assisted information program and determine whether the computed-assisted information program are superior to routine discussion for informing parents in the emergency department (ED)…
- Trial name
- NCT01850329
- Testing
- computed-assisted information program
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Pain
Decreasing Propofol Injection Pain by Pre-Treatment With Lidocaine in Pediatric Procedural Sedation
This is a double blind, randomized, controlled study. The sedationist performing the sedation procedure will inject the appropriate amount of either a 1% Lidocaine solution or a placebo before the administration of Propofol.
- Trial name
- NCT02512783
- Testing
- Lidocaine, Normal Saline, Propofol
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Pain, Procedural, Procedural Anxiety
Evaluating the Feasibility of VR for Pediatric Renal Biopsies
The purpose of this study is to assess the use of virtual reality (VR) as an adjunct or alternative to pharmacologic sedation in pediatric patients undergoing renal biopsy.
- Conditions
- Pain, Procedural, Procedural Anxiety, Sedation Complication
- Trial name
- NCT05267704
- Testing
- Oculus Go Virtual Reality Headset
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sedation
Dexmedetomidine Versus Pentobarbital for Pediatric Procedural Sedation
The investigators believe dexmedetomidine will provide superior sedation with reduced side effects and reduced time to discharge compared with pentobarbital.
- Trial name
- NCT00878345
- Testing
- dexmedetomidine sedation protocol, pentobarbital sedation protocol
- Where
- United States
- Sponsor
- Washington University School of Medicine
Procedural Sedation, Intra-nasal Delevery Device
Intranasal Midazolam for Pediatric Pre-procedural Sedation and Pre-procedural Anti-anxiety Using sipNose Device - a Randomized Controlled Study
A Three-arm, Randomized Controlled Trial for Pediatric Pre-procedural Sedation and Pre-procedural Anti-anxiety: Intranasal Midazolam by SipNose versus MAD Versus oral administration
- Trial name
- NCT03635398
- Testing
- Sipnose device, MAD (Mucosal Atomization Device), midazolam
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Rabin Medical Center
Ambulatory Surgery
REducing Anxiety in CHildren Undergoing Procedures
This is a small pilot, feasibility study designed as a quality improvement project. The purpose is to identify anxiety in children aged 4-12 years who will receive a sedated procedure and to see if the use of an iPad as a focused…
- Trial name
- REACH-UP! (NCT03054077)
- Testing
- iPad with downloaded games
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Emergence Delirium in Pediatric Anesthesia
The Effect of Dormicum-Ketamine Versus Dexmedetomidine on Emergence Delirium During Deep Sedation in Paediatric Burn Patients
The aim of this study is to compare the effects of dormicum-ketamine versus dexmedetomidine on postoperative emergence delirium in pediatric patients undergoing deep sedation for burn-related procedures
- Trial name
- NCT07519863
- Testing
- Midazolam + Ketamine, Dexmedetomidine (DEX)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Procedural Pain
Pharmacogenetics of Ketamine in Children
The need to treat the children with painful diagnostic-therapeutic procedures has increased in the last years. There is evidence from a wide scientific literature that drugs available in the setting of procedural sedation and…
- Trial name
- NCT05796232
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Burlo Garofolo
MRI Sedation
Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans
This is a randomized, double-blind, dose-ranging study of the efficacy and safety of dexmedetomidine (DEX) when used with propofol as needed, for procedural sedation of pediatric subjects ≥1 month to <17 years of age undergoing…
- Trial name
- NCT04237792
- Testing
- dexmedetomidine, propofol
- Where
- 23 sites in United States, Japan
- Volunteers
- 128 people
- Sponsor
- Pfizer
Procedural Sedation, Propofol
Safety and Efficacy of Propofol Only Sedation in Oral and Maxillofacial Surgery
The purpose of this study is to determine if the use of propofol only to achieve procedural sedation for the removal of third molars is both safe and effective.
- Trial name
- NCT01227174
- Testing
- Propofol
- Where
- Canada
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Atlantic Center for Oral and Maxillofacial Surgery
Fracture, Dislocation
Intranasal Dexmedetomidine Plus Ketamine for Procedural Sedation
Orthopedic injuries comprise more than 10% of ED visits in children and 25 to 50% of children will sustain a fracture before age 16 years.
- Trial name
- Ketodex (NCT04195256)
- Testing
- IN Ketodex (D4K2), IN Ketodex (D3K3), IN Ketodex (D2K4)
- Where
- 6 sites in Canada
- Volunteers
- 400 people
- Sponsor
- Naveen Poonai
Pain
Analgesia During Pediatric Digestive Endoscopy: a Comparison of Two Protocols for Procedural Sedation
The purpose of this study is to determine whether ketamine, midazolam, and meperidine are more effective than midazolam and meperidine alone for procedural sedation and analgesia in pediatric digestive endoscopy.
- Trial name
- NCT01168492
- Testing
- ketamine
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Université de Montréal
Bone Fractures, Dislocations
Intranasal Ketamine for Procedural Sedation
This study will examine the effectiveness of intranasal (IN) ketamine compared to standard intravenous (IV) ketamine administration for simple reductions of orthopaedic injuries in the paediatric population.
- Trial name
- INK (NCT02828566)
- Testing
- IN ketamine, IV ketamine, IN saline 0.9%
- Volunteers
- 470 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conscious Sedation Failure During Procedure, Analgesia
Lidocaine as Local Anesthetics in Children Under Ketamine Sedation
Ketamine seems an obvious choice in the setting of an emergency department in laceration repair. Lidocaine is the local anesthetics widespread used. Ketamine leads to dissociative amnesia.
- Conditions
- Conscious Sedation Failure During Procedure, Analgesia, Anesthesia
- Trial name
- NCT02205502
- Testing
- Lidocaine, Normal saline
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital