Clinical trials: Prognostic Biomarkers
Carcinoma Ex Pleomorphic Adenoma of Salivary Glands, Pleomorphic Adenoma of Salivary Glands
Diagnostic and Prognostic Accuracy of Gold Nanoparticles in Salivary Gland Tumours
Nano-based diagnostic tool can provide promising highly sensitive, specific biomarker for early detection and treatment of salivary gland tumours compared to non-conjugated biomarkers and in turn improves patient prognosis and…
- Trial name
- NCT04907422
- Testing
- CD24-Gold Nanocomposite expression using Real-time quantitative polymerase chain reaction, non-conjugated CD24 expression using Real-time quantitative polymerase chain reaction
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Amina Fouad Farag
Endometrial Cancers
Screening of Biomarkers on Endometrial Cancers
Ovarian cancer is the first mortality rate of gynecologic malignancies. The incidence of ovarian cancer increased in recent 10 years and it has become the ninth cause of malignancies in the women in Taiwan.
- Trial name
- NCT00674349
- Testing
- surgery
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Triage, Risk Stratification With Biomarker
Risk Stratification in Acute Care: The Meaning of suPAR Measurement in Triage
Will clinical outcome for patients be improved if triage in Acute wards and Emergency rooms is supplemented with a prognostic biomarker?
- Trial name
- suPAR (NCT02643459)
- Testing
- suPAR measurement
- Where
- Denmark
- Volunteers
- 20,000 people
- Sponsor
- Herlev Hospital
Anal Cancer, Anal Squamous Intraepithelial Neoplasia
Anal Intraepithelial Neoplasia and Anal Squamous Cell Carcinoma
This is a study involving exome sequencing and immune profiling of matched tissue and blood samples from patients with both high-grade squamous intraepithelial lesions and anal squamous cell carcinoma.
- Trial name
- NCT05835960
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London
Lung Adenocarcinoma, Surgery
DNA Methylation Biomarkers to Predict Survival After Surgery for Lung Adenocarcinoma
This study is designed to assess DNA 5-methylcytosine (5mC) methylation modifications in lung adenocarcinoma (LUAD) samples and develop a prognosis-predictive model for LUAD based on cancer tissue DNA 5mC levels.
- Conditions
- Lung Adenocarcinoma, Surgery, Prognostic Cancer Model
- Trial name
- NCT06477211
- Where
- China
- Volunteers
- 292 people
- Sponsor
- Nanjing University
Discriminate Obese Children at Risk for Diabetes.
Circulating microRNAs for Discriminating Obese Preschoolers at Risk of Diabetes
Childhood obesity certainly increases susceptibility to type 2 diabetes (T2D) in adulthood. Recently, microRNAs (miRNAs) are closely related to various diseases and have been suggested as valuable biomarkers.
- Trial name
- NCT02843139
- Where
- China
- Volunteers
- 535 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Pancreas Adenocarcinoma
Verification of Predictive Biomarkers for Pancreatic Cancer Treatment Using Multicenter Liquid Biopsy
This study is for verification of predictive biomarkers for pancreatic cancer treatment using multi-center liquid biopsy.
- Trial name
- NCT04241367
- Where
- South Korea
- Volunteers
- 420 people
- Sponsor
- National Cancer Center, Korea
Kidney Scarring Post-Febrile UTI
Urinary Cytokine Levels as a Prognostic Marker for Kidney Scarring After Pyelonephritis
The prevalence of kidney scarring after UTI is approximately 5-57%. UTIs are caused mainly by bacteria that cause local and systemic immunological reaction that are accompanied by cytokines.
- Trial name
- NCT00868270
- Where
- Israel
- Volunteers
- 35 people
- Sponsor
- Hillel Yaffe Medical Center
Stroke, Transient Ischemic Attack
The "COSMOS"-Study (Copeptin in Osmoregulation and Stress Assessment)
Sodium imbalance is common and an adverse prognostic factor in hospitalized patients. However, identifying the causes of sodium imbalance is challenging in clinical practice.
- Trial name
- NCT00390962
- Where
- Switzerland
- Volunteers
- 469 people
- Sponsor
- University Hospital, Basel, Switzerland
Triple Negative Breast Cancer, HER2-positive Breast Cancer
Exosome as the Prognostic and Predictive Biomarker in EBC Patients
This study is the experimental study for serial ctDNA and exosome evaluation in EBC patients
- Trial name
- NCT05955521
- Testing
- exosome and ctDNA evaluation
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Cervical Cancer
Studying Biomarkers in Blood Samples From Patients With Invasive Cervical Cancer
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT01074424
- Testing
- proteomic profiling, laboratory biomarker analysis
- Volunteers
- 84 people
- Sponsor
- Gynecologic Oncology Group
Role of Neurofilment in Diagnosis of Multiple Sclerosis
Neurofilament Light Chain as Diagnostic and Prognostic Marker in naïve Multiple Sclerosis Patients
Neurofilament protein detected in the serum appears to be a good marker for the extent of active neurodegeneration. Chitinase may also be a good marker reflecting the degree of astrocyte activation, or damage in active lesions…
- Trial name
- NFLMS (NCT06197841)
- Where
- Egypt
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Assiut University
Heart Failure
Surfactant Derived Protocol in Heart Failure
Pulmonary surfactant is a highly surface-active lipoprotein complex that lines the alveoli and terminal airways, reducing surface tension and preventing alveolar collapse at the end of expiration.
- Trial name
- (SPB) (NCT06896461)
- Testing
- Cardiopulmonary exercise test, Lung function, Biomarkers evaluation
- Where
- Italy
- Volunteers
- 471 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
Legionella
Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease
Legionnaires' disease (LD) is a relatively common pneumonia in France (1200 cases/year), 98% of cases are hospitalized and 40% require intensive care unit (ICU) admission.
- Trial name
- Proglegio (NCT03064737)
- Testing
- Skin biopsy for genetic analyze
- Where
- 19 sites in France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Intervertebral Disc Degeneration, Discogenic Pain
Identification of Biomarkers and Molecular Targets Involved on Intervertebral Disc Degeneration and Discogenic Pain
Low back pain, associated with intrinsic disorders of the spine, is a very frequent clinical condition that is accompanied by high morbidity with effects both on psychosocial aspects, and health care system.
- Conditions
- Intervertebral Disc Degeneration, Discogenic Pain, Discogenic Disease
- Trial name
- NCT06349226
- Testing
- cell isolation from intervertebral disc tissue and biomarker investigation
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Gliomas
Location-Molecular Integrated Outcomes in 450 Cerebellar Glioma Microsurgical Cases
The goal of this observational study is to learn if refined anatomical location-combined with molecular biomarkers-can predict surgical success and long-term survival in 450 adults and children with cerebellar gliomas who…
- Trial name
- NCT07342699
- Where
- China
- Volunteers
- 450 people
- Sponsor
- West China Hospital
Traumatic Brain Injury
Transforming Research and Clinical Knowledge in TBI Pilot
The global aim of this proposal is to test and refine Common Data Elements (CDEs), neuroimaging standards, and best practices for genetics and proteomics in Traumatic Brain Injury (TBI) studies.
- Trial name
- NCT01565551
- Testing
- N/A (Observational Study)
- Where
- 4 sites in United States
- Volunteers
- 650 people
- Sponsor
- University of California, San Francisco
Pneumonia in Children
Roles of Some Non-classic Biomarkers in Pediatric Pneumonia
The current work aims to: 1. Measure the levels of Neutrophil CD64 Receptor, Monocyte Human Leukocyte Antigen-DR (mHLA-DR), and Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) in children suffering from pneumonia. 2.
- Trial name
- NCT05701605
- Volunteers
- 120 people
- Sponsor
- Assiut University
Neuroblastoma, Ewing Sarcoma
Β3-adrenoreceptor As Prognostic Marker in Neuroblastoma and Ewing Sarcoma
This study on biological samples of patients affected by neuroblastoma and Ewing sarcoma aims at validating the beta3-adrenoreceptor as prognostic biomarker.
- Trial name
- NCT06851221
- Testing
- beta3 expression
- Where
- Italy
- Volunteers
- 95 people
- Sponsor
- Meyer Children's Hospital IRCCS
Amblyopia
Plasma Biomarker in Amblyopia Patients
This prospective study aims to observe the predictive effect of peripheral blood plasma biomarker on the outcome of treatment in children with different types of amblyopia.
- Trial name
- NCT05705778
- Testing
- standard amblyopia treatment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University