Clinical trials: Prognostic Biomarkers
Aortic Stenosis, Amyloid
Atrial Amyloid May Influence Outcomes in Patients Undergoing Surgical Aortic Valve Replacement
Background (Context): Some older adults who undergo surgery to replace a narrowed heart valve (called aortic stenosis) may also have small protein deposits in their heart.
- Trial name
- AORTICMARKER (NCT07105501)
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Germans Trias i Pujol Hospital
COPD, Idiopathic Pulmonary Fibrosis (IPF)
Identification of Diagnostic and Prognostic Biomarkers in the Pathological Continuum of Bronco Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis and Pulmonary Neoplasia
Primary Objective: To evaluate the association between inflammatory, immunological, genetic, and epigenetic biomarkers measured at enrollment and the clinical, functional, and phenotypic characteristics of patients with chronic…
- Conditions
- COPD, Idiopathic Pulmonary Fibrosis (IPF), Lung Cancer
- Trial name
- RESPIRO (NCT07707245)
- Testing
- Peripheral Blood Collection
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Coronary Artery Occlusive Disease
Role of High Mobility Group Box 1 as a Prognostic Biomarker in Patients Undergoing Off-pump Coronary Artery Bypass Graft
High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein, and has recently been identified as a cytokine mediator of systemic inflammation.
- Trial name
- NCT02206412
- Where
- South Korea
- Volunteers
- 255 people
- Sponsor
- Yonsei University
Multiple Sclerosis
SPINCOMS Biomarker Study
To determine if biomarker-based CSF testing is reliably detecting differences between patients with Multiple Sclerosis (MS), different MS-subtypes, and other central nervous system (CNS) diseases.
- Trial name
- SPINCOMS (NCT04496830)
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- Washington University School of Medicine
Carcinoma Ex Pleomorphic Adenoma of Salivary Glands, Pleomorphic Adenoma of Salivary Glands
Diagnostic and Prognostic Accuracy of Gold Nanoparticles in Salivary Gland Tumours
Nano-based diagnostic tool can provide promising highly sensitive, specific biomarker for early detection and treatment of salivary gland tumours compared to non-conjugated biomarkers and in turn improves patient prognosis and…
- Trial name
- NCT04907422
- Testing
- CD24-Gold Nanocomposite expression using Real-time quantitative polymerase chain reaction, non-conjugated CD24 expression using Real-time quantitative polymerase chain reaction
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Amina Fouad Farag
Endometrial Cancers
Screening of Biomarkers on Endometrial Cancers
Ovarian cancer is the first mortality rate of gynecologic malignancies. The incidence of ovarian cancer increased in recent 10 years and it has become the ninth cause of malignancies in the women in Taiwan.
- Trial name
- NCT00674349
- Testing
- surgery
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury
Acute Post-cardiac Surgery Renal Failure: Prevention Through Individualized Intensive Hemodynamic Management
BACKGROUND: The incidence of acute kidney injury (AKI) in patients undergoing cardiac surgery can reach 35% and between 2 and 5% require kidney replacement therapy during the AKI episode.
- Trial name
- PrevHemAKI (NCT04005105)
- Testing
- Intensive management
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Hospital Clinic of Barcelona
Prostate Cancer
Care of the Prostate Cancer Patient and Prospective Procurement of Prostate Cancer Tissue
Background: Prostate cancer is the most common noncutaneous cancer among men in the U.S. Researchers want to study blood, tissue, and fluid samples of people with prostate cancer.
- Trial name
- NCT02594202
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- National Cancer Institute (NCI)
Low-Flow, Low-Gradient Aortic Stenosis
Anatomic Stenosis Severity as a Prognostic Marker in Patients With Low-Flow Low-Gradient Aortic Stenosis Undergoing TAVI
The ATLAS TAVI Registry is a retrospective, investigator-initiated, multicenter registry including patients, who underwent Transcatheter Aortic Valve Implantation (TAVI) for classical or paradoxical low-flow, low-gradient aortic…
- Trial name
- ATLAS TAVI (NCT04914481)
- Where
- 11 sites in Canada, Denmark and 5 more
- Volunteers
- 1,500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pregnancy, Fertility
Prognostic Value of PIF Detection in Embryo Culture Media Correlation With Pregnancy Outcome
PIF: biomarker of successful implantation To overcome the poor reproductive potential of embryos generated during in vitro fertilization cycles and the lack of markers enabling the identification of the most competent ones, it is…
- Trial name
- PIF-SET1 (NCT01803893)
- Where
- 5 sites in United States, France and 1 more
- Volunteers
- 500 people
- Sponsor
- BioIncept LLC
Lung Cancer, Lung Adenocarcinoma
Identify Prognostic Biomarkers of Lung Cancer
Multi-omics and Clinical Data Analysis is potential to predict the prognosis of lung cancer patients.
- Conditions
- Lung Cancer, Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Non Small Cell Lung Cancer
- Trial name
- NCT05010330
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Traumatic Brain INjury
Prognostic Potential of Prehospital Biomarkers in TBI Patients
The PreTBI III study aims to investigate the prognostic potential of prehospital and repeated in-hospital S100B, NSE and GFAP measurements as predictors of neurological outcome in patients suffering severe TBI.
- Trial name
- PreTBI III (NCT03062566)
- Testing
- Blood sampling
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- University of Aarhus
Non-small Cell Lung Cancer (NSCLC)
Analysis of Whole Exome and Transcriptome Sequencing to Identify Prognostic Biomarkers in Patients With Non-Small Cell Lung Cancer (NSCLC)
This is a non-interventional translational research study aiming to comprehensively characterize the genomic and transcriptomic landscape of patients with non-small cell lung cancer (NSCLC).
- Trial name
- EXPLORE (NCT07900581)
- Where
- 20 sites in Cyprus, Greece
- Volunteers
- 300 people
- Sponsor
- Hellenic Cooperative Oncology Group
Pancreatic Tumor
Prognostic and Predictive Biomarkers of Therapeutic Response in Pancreatic Tumors
Pancreatic cancer is among the most serious human neoplasia and the most difficult to treat. Most patients present at diagnosis a non resectable, locally advanced or metastatic disease, with a median survival of 12 month.
- Trial name
- PACAomics (NCT01692873)
- Testing
- suspected pancreatic tumor
- Where
- France
- Volunteers
- 274 people
- Sponsor
- Institut Paoli-Calmettes
Asthma, Cough
Smartphone Enabled Detection of Nocturnal Cough Rate and Sleep Quality as a Prognostic Marker for Asthma Control
The purpose of the study is to explore the value which cough rate might provide for asthma self-management. In this study, the focus will be specifically on nocturnal cough rate.
- Trial name
- NCT03635710
- Testing
- The patient will undergo no intervention
- Where
- 3 sites in Switzerland
- Volunteers
- 94 people
- Sponsor
- Cantonal Hospital of St. Gallen
Triage, Risk Stratification With Biomarker
Risk Stratification in Acute Care: The Meaning of suPAR Measurement in Triage
Will clinical outcome for patients be improved if triage in Acute wards and Emergency rooms is supplemented with a prognostic biomarker?
- Trial name
- suPAR (NCT02643459)
- Testing
- suPAR measurement
- Where
- Denmark
- Volunteers
- 20,000 people
- Sponsor
- Herlev Hospital
Sepsis, Shock
Studies of Blood DNA in Patients With Severe Infection DYNAMICS
Severe sepsis (ie. life-threatening infections) is triggered by harmful microorganisms or their toxins in the blood or tissues. These harmful agents damage the lining of blood vessels which can lead to inflammation, blood clot…
- Conditions
- Sepsis, Shock, Trauma
- Trial name
- DYNAMICS (NCT01355042)
- Where
- 6 sites in Canada
- Volunteers
- 792 people
- Sponsor
- Alison Fox-Robichaud
Soft-tissue Sarcomas
CINSARC Signature and Correlation With Hemotherapy Efficacy in Soft-tissue Sarcomas. A Biomarker Study.
This is a prospective observational biomarker study including patients with non-metastatic, soft-tissue sarcomas (STS) for whom neoadjuvant chemotherapy is considered as the best option by the multidisciplinary sarcoma team of…
- Trial name
- NEOSarcomics (NCT02789384)
- Testing
- Procedure/Surgery
- Where
- 10 sites in France
- Volunteers
- 205 people
- Sponsor
- Institut Bergonié
Prostate Cancer
Predictive and Prognostic Markers for Treatment Outcomes in Prostate Cancer Patients
The study aims to identify potential urine marker metabolites as predictive or prognostic markers for treatment outcomes in patients with prostate cancer.
- Trial name
- NCT03237026
- Testing
- No intervention required
- Where
- Taiwan
- Volunteers
- 360 people
- Sponsor
- National Taiwan University Hospital
Anal Cancer, Anal Squamous Intraepithelial Neoplasia
Anal Intraepithelial Neoplasia and Anal Squamous Cell Carcinoma
This is a study involving exome sequencing and immune profiling of matched tissue and blood samples from patients with both high-grade squamous intraepithelial lesions and anal squamous cell carcinoma.
- Trial name
- NCT05835960
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London