Clinical trials: Prophylactic
Scoliosis
Effectiveness of Bracing in Preventing Scoliosis in Children With Spinal Cord Injury
The purpose of this study is to determine whether full-time high dose prophylactic bracing (23 hours or more per day) is more effective than low dose bracing (12 hours or less per day) in preventing or delaying spinal curve…
- Trial name
- NCT00256672
- Testing
- Thoraco-Lumbar-Sacral-Orthoses (TLSO) / Flex-Foam
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- Shriners Hospitals for Children
Heart Diseases
Heart-health Promotion
The researchers intend to use the Expanded Health Belief Model in enhancing heart-health preventive behaviors among high school female students
- Trial name
- NCT05949892
- Testing
- Expanded Health Belief Model-Based Intervention
- Where
- Iraq
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Cleft Palates
Preventing Complications in Cleft Palate Repair With Antibiotics
The primary objective of this study is to determine the efficacy of administering a single dose of preoperative antibiotics to prevent complications in patients undergoing primary closure of a cleft secondary palate.
- Trial name
- NCT00760006
- Testing
- Unasyn, saline solution
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Joseph Losee
Healthy, Adolescent
GumChucks vs Interdental Brushes in Plaque Removal.
This study compared two ways of cleaning between the teeth, Gumchucks (a new handled dental flossing system) and interdental brushes, in Lebanese adolescents aged 10-15 years.
- Conditions
- Healthy, Adolescent, Dental Plaque, Gingivitis
- Trial name
- NCT07140068
- Testing
- Handled dental flossing system (GumChucks®), Interdental Brush
- Where
- Lebanon
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beirut Arab University
Postoperative Bile Leak, Focal Liver Lesions
Prevention of Bile Leakage After Liver Resection in Children
Bile leakage is a clinically important complication after liver resection in children and may require prolonged drainage, additional radiological or endoscopic procedures, or repeat surgery.
- Trial name
- NCT07867522
- Testing
- prophylactic extrahepatic biliary drainage during liver resection
- Where
- Russia
- Volunteers
- 12 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Soil-Transmitted Helminths
Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and Effectiveness
An open-label, randomized by school, two-arm pragmatic trial, will be conducted involving two study sites in Sub-Saharan-Africa (SSA), Ghana and Kenya, to evaluate safety and effectiveness of the newly developed fixed dose…
- Trial name
- NCT06282315
- Testing
- Pre-screening Phase, Screenig Phase, Randomization
- Where
- 2 sites in Ghana, Kenya
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
HIV Infections
A Study of Zidovudine in the Prevention of HIV Infection in Individuals Exposed to the Virus
To prevent individuals who have had a massive accidental exposure to HIV from becoming infected with HIV and possibly developing AIDS, by treating them with zidovudine (AZT).
- Trial name
- NCT00000993
- Testing
- Zidovudine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mental Disorder
VIA Family 4 Year Follow-up of a Family-based Preventive Intervention
This study aims to investigate the long-term effects (2.5 years after post-intervention) of a preventive family-based intervention (VIA Family) compared with treatment as usual (TAU) for children of parents with a severe mental…
- Trial name
- NCT06218693
- Testing
- VIA Family, Treatment As Usual (TAU)
- Where
- Denmark
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Myelodysplastic Syndrome
Reduced-intensity Conditioning Allogeneic Hematopoietic Cell Transplantation
The purpose of this study is to evaluate the feasibility and efficacy of reduced-intensity conditioning allogeneic HCT followed by prophylactic dose-escalating DLIs in patients with higher risk MDS.
- Trial name
- RICandDLI (NCT01252784)
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Cooperative Study Group A for Hematology
Caries Prevention
Comparison of the Efficacy of Three Preventive Methods to Reduce the Incidence of Coronal Caries in Schoolchildren
The objective of this clinical trial is to compare the efficacy of three preventive methods in reducing the incidence of coronal caries in the first permanent molars of Mexican schoolchildren.
- Trial name
- NCT07131358
- Testing
- Glass ionomer pit and fissure sealant plus fluoride varnish, Pit and fissure sealant with Giomer® technology, Fluoride varnish
- Where
- 3 sites in Mexico
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Latent Tuberculosis Infection (LTBI), Tuberculosis (TB)
Latent Infection Freshmen Tracking for Tuberculosis
The goal of this study is to learn whether taking short-course preventive treatment in high school and college freshmen with strong positive tuberculosis (TB) skin tests can safely and effectively protect them from developing…
- Trial name
- LIFT-TB (NCT07811518)
- Testing
- tuberculosis preventive treatment
- Where
- 2 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nantong University
Cesarean Section
Ondansetron Prior Spinal Anaesthesia
Since Ondansetron is commonly used during cesarean deliveries to treat nausea and vomiting, this study will observe the correlation between ondansetron administration and effect on hemodynamics in order to confirm that the use of…
- Trial name
- Ondansetron (NCT06431568)
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Assiut University
Melanoma
The Impact of a Prevention Program on Sun Risks in Primary School in Tropical French Region
Sun exposure during childhood can cause the development of skin cancer in later years, in particular melanoma, which is the most lethal.The worldwide incidence of melanoma is on the rise, with nearly 290,000 new cases diagnosed…
- Trial name
- PRESOLRE (NCT05367180)
- Testing
- MISOLRE prevention program on sun risks, "Vivre avec le Soleil" prevention program on sun risks, Sun protection equipment
- Where
- Reunion
- Volunteers
- 1,452 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Bite, Wound
The Use of Prophylactic Antibiotics In the Management of Dog Bites
This double blinded RCT will help to ascertain the usefulness of prophylactic antibiotics in the management of uncomplicated dog bites, utilizing currently best available antibiotics (Augmentin) and an important clinical outcome…
- Conditions
- Bite, Wound, Infection
- Trial name
- NCT00185939
- Testing
- Augmentin
- Where
- 3 sites in United States
- Volunteers
- 125 people
- Sponsor
- Stanford University
Breast Cancer
A Pilot Study to Evaluate Nipple-Areolar Complex (NAC) Sparing Mastectomy
The goal of this study is to study nipple-areolar complex (NAC) sparing mastectomy as an alternative procedure to the standard skin-sparing mastectomy for women who have breast cancer or are at high-risk for developing breast…
- Trial name
- NCT00539227
- Testing
- NAC Sparing Mastectomy, Questionnaire
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- M.D. Anderson Cancer Center
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Nilotinib and Imatinib Mesylate After Donor Stem Cell Transplant in Treating Patients With ALL or CML
This phase I/II trial is studying the side effects and best way to give nilotinib when given alone or sequentially after imatinib mesylate after donor stem cell transplant in treating patients with acute lymphoblastic leukemia or…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Blastic Phase Chronic Myelogenous Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission
- Trial name
- NCT00702403
- Testing
- nilotinib, imatinib mesylate, pharmacological study
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Fred Hutchinson Cancer Center
HIV, HIV Infections
Preventative Misconception Intervention
This study will carry out a preliminary "proof of concept" to evaluate two types of supplemental information that would serve as an adjunct to the traditional informed consent in a Human Immunodeficiency Virus (HIV) vaccine…
- Trial name
- NCT01049139
- Testing
- 1-sided messages, 2-sided messages
- Where
- 4 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pregnancy, Malaria
Efficacy of Intermittent Screening and Treatment or Intermittent Preventive Treatment (IPT) With Dihydroartemisinin-Piperaquine, Versus IPT With Sulfadoxine-Pyrimethamine for the Control of Malaria in Pregnancy in Kenya
Malaria in pregnancy (MiP) due to Plasmodium falciparum infection is a major cause of maternal morbidity and poor birth outcomes.
- Trial name
- STOP MiP KENYA (NCT01669941)
- Testing
- IPTp-SP, IPTp-DP, ISTp-DP
- Where
- 4 sites in Kenya
- Volunteers
- 1,546 people
- Sponsor
- Kenya Medical Research Institute
Abortion, Dilation and Evacuation
Effect of Prophylactic Tranexamic Acid on Bleeding Outcomes for Dilation and Evacuation
Prophylactic tranexamic acid has shown been shown to reduce maternal mortality from postpartum hemorrhage with no adverse effects, but has not been studied to reduce bleeding complications with dilation and evacuation (D\&E).
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Blood Loss
- Trial name
- NCT04651166
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Nosocomial Infection, Diarrhea, Infantile
Effect and Tolerability of Lactobacillus Rhamnosus GG LA801 for the Preventive Nutritional Care of Nosocomial Diarrhea in Children
One of the most common infections acquired in hospital, also known as nosocomial infections, is intestinal infections. These infections can lead to the development of nosocomial diarrhea which can have serious consequences in…
- Trial name
- EPISODE (NCT04628819)
- Where
- 2 sites in France
- Volunteers
- 61 people
- Sponsor
- PiLeJe