Clinical trials: Prophylactic
Dental Caries, Early Childhood Caries
Cohort Zero Caries
The purpose of this study is to compare the effectiveness of a traditional oral health educational program and a program based on the theories of the Motivational Interview directed to the child's mothers/fathers/responsible…
- Trial name
- CZC (NCT02578966)
- Testing
- Motivational Interview, Traditional health education
- Volunteers
- 650 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Liver Cirrhosis, Upper Gastrointestinal Bleeding
Prophylactic Antibiotics in Prevention of Spontaneous Bacterial Peritonitis in Compensated Liver Cirrhosis
timely short-term antibiotic prophylaxis is an essential step in the management of these patients . Prophylaxis must be instituted as early as variceal hemorrhage is suspected, and timely administration has been associated with a…
- Trial name
- NCT04711122
- Testing
- Third generation cephalosporin antibiotics
- Volunteers
- 80 people
- Sponsor
- Assiut University
HIV
Harnessing the Power of Text Messaging to Invigorate AMSM HIV Preventive Behavior
The purpose of this study is to examine whether Guy2Guy (G2G), a text messaging-based healthy sexuality and human immunodeficiency virus (HIV) prevention program intervention for 14-18 year gay, bisexual and queer men, is…
- Trial name
- G2G (NCT02113956)
- Testing
- Guy2Guy (G2G)
- Where
- 2 sites in United States
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Center for Innovative Public Health Research
Hypospadias
Prophylactic Antibiotics or Placebo After Hypospadias Repair
The primary purpose of this study is to determine if routine use of prophylactic (preventive) antibiotics after repair of mid-to-distal hypospadias is beneficial.
- Trial name
- PROPHY (NCT02096159)
- Testing
- trimethoprim-sulfamethoxazole
- Where
- 2 sites in United States, Canada
- Volunteers
- 93 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Prostate Cancer, Erectile Dysfunction
Study of Sildenafil Citrate During and After Radiotherapy/Hormone Therapy for Erectile Function Versus Radiotherapy/Hormone Therapy for Prostate Cancer
Radiation sometimes affects the ability for a person to have a normal erection. Complete loss of erections after radiation treatment can happen in 40-50% of treated patients.
- Trial name
- NCT00142506
- Testing
- sildenafil citrate and questionaires
- Where
- 5 sites in United States
- Volunteers
- 290 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Lung Disease
The Anti-inflammatory Effect of Prophylactic Macrolides on Children With Chronic Lung Disease
The purpose of this study is to determine if the prophylactic use of azithromycin will reduce the total number of days when unscheduled treatment is given outside of the home in a clinic, urgent care, emergency room or hospital…
- Trial name
- NCT02544984
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center, Houston
Bronchial Asthma, Genome Wide Association Studies
The Role of Genetic Factors in the Development of Bronchial Asthma in the Kazakh Population
To research for a genetic marker of bronchial asthma, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with bronchial asthma and normal control will be performed.
- Trial name
- NCT05088512
- Testing
- SNP analysis of the DNA
- Where
- Kazakhstan
- Volunteers
- 300 people
- Sponsor
- Asfendiyarov Kazakh National Medical University
Vaccine, Human Papiloma Virus Vaccine
State Immunization Information Systems to Improve HPV Vaccination Rates
The overarching goal of this study is to evaluate the effectiveness, cost-effectiveness and sustainability of utilizing statewide Immunization Information Systems (IIS) to conduct centralized reminder/recall (R/R) to improve…
- Conditions
- Vaccine, Human Papiloma Virus Vaccine, HPV Vaccine, Immunization
- Trial name
- NCT02993965
- Testing
- Vaccine Reminder/Recall
- Where
- United States
- Volunteers
- 77,716 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Neonatal Jaundice
Role of Fenofibrate in Neonatal Jaundice
Fenofibrate appears to be an effective and safe drug for the treatment of neonatal hyperbilirubinemia. It has been proven that it decreases the duration of phototherapy and thus shortens the length of hospital stay.
- Trial name
- NCT06451900
- Testing
- Fenofibrate
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Invasive Candidiases
Efficacy of Prophylactic Fluconazole Therapy in Preterm and Very Low Birth Weight Neonates in Preventing Invasive Fungal Infection.
Invasive fungal infection is detecting candida species in blood, cerebrospinal fluid, or urine. Clinical signs of invasive candidiasis may include lethargy, temperature instability, feeding intolerance, apnea, hypotension…
- Trial name
- NCT05848492
- Testing
- Fluconazole, Saline
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Psychological Well-Being
Impact of Preventive Mental Health Programme on Social/Emotional Functioning and Resilience in Children in South Africa
The goal of this clinical trial is to test the effectiveness of a mental health prevention and promotion programme delivered to children (ages 8 to 13) living in under-resourced communities in South Africa.
- Trial name
- NCT06445777
- Testing
- Mental Health Prevention and Promotion
- Where
- South Africa
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Little Lions Child Coaching
Colostomy, Hirschsprung Disease - Pull Through
Bowel Preparation in Elective Pediatric Colorectal Surgery
Infections after elective intestinal surgery remain a significant burden for patients and for the health care system. The cost of treating a single surgical site infection is estimated at approximately $27,000.
- Conditions
- Colostomy, Hirschsprung Disease - Pull Through, Necrotizing Enterocolitis, Inflammatory Bowel Diseases
- Trial name
- NCT03593252
- Testing
- Senna, Sodium Picosulfate, Magnesium Oxide and Citric Acid, Metronidazole Oral
- Volunteers
- 81 people
- Sponsor
- McMaster University
COVID-19
Prophylactic Benefit of Hydroxychloroquine in COVID-19 Cases With Mild to Moderate Symptoms and in Healthcare Workers With High Exposure Risk
Few studies have reported the efficacy of HCQ in reducing the viral load and improving the severity of symptoms in hospitalized COVID-19 cases with serious respiratory infection.
- Trial name
- PREVENT (NCT04371926)
- Testing
- Hydroxychloroquine Sulfate
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Chronic Ankle Instability, CAI
Ankle Brace vs Functional Taping In Adolescents With Chronic Ankle Instability
The aim of this study was to compare the effects of an ankle brace, functional taping, and no prophylactic method on maximum inversion angle, inversion velocity, peroneus longus reaction time, and subjective perception of…
- Trial name
- NCT07762352
- Testing
- Ankle Brace, Functional Taping
- Where
- Portugal
- Volunteers
- 14 people
- Sponsor
- Escola Superior de Saude do Alcoitao
Scoliosis
Effectiveness of Bracing in Preventing Scoliosis in Children With Spinal Cord Injury
The purpose of this study is to determine whether full-time high dose prophylactic bracing (23 hours or more per day) is more effective than low dose bracing (12 hours or less per day) in preventing or delaying spinal curve…
- Trial name
- NCT00256672
- Testing
- Thoraco-Lumbar-Sacral-Orthoses (TLSO) / Flex-Foam
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- Shriners Hospitals for Children
Duchenne Muscular Dystrophy, Cardiomyopathies
The Preventive Efficacy of Carvedilol on Cardiac Dysfunction in Duchenne Muscular Dystrophy
Purpose This cardiac dysfunction in patients with Duchenne muscular dystrophy is associated with minor cardiac damage as indicated by elevation of plasma cardiac troponin I (cTnI).
- Trial name
- NCT00606775
- Testing
- Carvedilol
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Suzuka Hospital
Tooth Diseases, Caries,Dental
Dental Practitioners KAP Regarding Caries Preventive Measures in Cairo and Riyadah
The study aims to evaluate the knowledge, attitude, and practice of dental practitioners from Cairo and Riyadh regarding caries preventive measures.
- Trial name
- NCT05792800
- Where
- Egypt
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Cairo University
Philadelphia Chromosome Positive Acute Lymphocytic Leukemia, Tyrosine Kinase Inhibitor
Effect of Prophylactic TKI Therapy Post-transplants on Ph+ ALL Undergoing Allo-HSCT With MRD Positive Pre-transplants
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) in early first complete remission improves the long-term outcomes for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).
- Conditions
- Philadelphia Chromosome Positive Acute Lymphocytic Leukemia, Tyrosine Kinase Inhibitor, Minimal Residual Disease, Allogeneic Hematopoietic Stem Cell Transplantation
- Trial name
- NCT03624530
- Testing
- Tyrosine kinase inhibitor (TKIs)
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Tuberculosis, Pulmonary, Mycobacterium Tuberculosis Infection
Clinic-based Versus Hotspot-focused Active TB Case Finding
This five-year study will evaluate two strategies for conducting tuberculosis (TB) active case finding (ACF) and linkage to TB treatment or TB preventive therapy (TPT) in peri-urban Uganda.
- Trial name
- CHASE-TB (NCT05285202)
- Testing
- Active TB case finding with linkage to preventive therapy (ACF/TPT)
- Where
- Uganda
- Volunteers
- 146,539 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Short Message Service (SMS), Incentives
Leveraging Community Health Workers and a Digital Health System to Improve the Timeliness of Child Well Visits
The goal of this cluster-randomized type 1 effectiveness implementation hybrid trial is to evaluate whether a community health worker led, integrated digital health intervention (Huduma Kwa Wakati; "Timely Services" in Kiswahili)…
- Conditions
- Short Message Service (SMS), Incentives, Knowledge, Attitudes, Practice, Preventive Services
- Trial name
- MINT-II/HKW (NCT06024317)
- Testing
- Huduma Kwa Wakati - Knowledge Intervention, Huduma Kwa Wakati - Reminders, Huduma Kwa Wakati - Incentives
- Where
- Tanzania
- Volunteers
- 800 people
- Sponsor
- University of South Carolina