Clinical trials: Prophylaxis
HIV
Integrated Care Delivery of HIV Prevention and Treatment in AGYW in Zambia
The study team will test a multilevel package of interventions to connect adolescent girls and young women (AGYW) with a source of regular care to provide a sustainable platform for successful implementation of regular human…
- Trial name
- NCT03995953
- Testing
- SHIELD intervention (Support for HIV Integrated Education, Linkages to care, and Destigmatization), Integrated wellness care (IWC) clinics
- Where
- Zambia
- Volunteers
- 2,150 people
- Sponsor
- RTI International
Obesity Prevention
Activity at Ventilation Threshold on Appetite and Food Intake in Boys
The investigators hypothesize exercise increases short term appetite and food intake, and interferes with satiety and satiations to a preload in normal weight, overweight and obese boys.
- Trial name
- VeT (NCT01196351)
- Testing
- Dietary Supplement: water with noncalorie sweetener, Activity: With noncalorie sweetener or glucose
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Toronto
HIV/AIDS
A Mobile Phone Game to Prevent HIV Among Young Africans
This project will test the feasibility of an electronic game to prevent HIV among African preadolescents, delivered via inexpensive Android smart phones.
- Trial name
- NCT03054051
- Testing
- Tumaini Mobile Phone Game
- Where
- Kenya
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Emory University
Tobacco Cessation, Media Use
Adolescent Smoking Cessation in Pediatric Primary Care
This is a study of the effectiveness of adolescent smoking cessation interventions in pediatric primary care settings. Our specific aims are to: 1.
- Trial name
- Smokebusters (NCT01312480)
- Testing
- 5A's Model, Media Use Assessment
- Where
- United States
- Volunteers
- 10,967 people, healthy volunteers welcome
- Sponsor
- American Academy of Pediatrics
Cerebrovascular Disease
Individualized Antithrombotic Therapy for Patients With Ischemic Cerebrovascular Disease
To investigate the therapeutic effect of individualized treatment of antiplatelet in secondary prevention of ischemic stroke.
- Trial name
- NCT03471169
- Testing
- Desirable TEG, Undesirable TEG
- Where
- China
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Congenital Bleeding Disorder, Haemophilia A
Evaluation of Safety and Efficacy, Including Pharmacokinetics, of NNC 0129-0000-1003 When Administered for Treatment and Prophylaxis of Bleeding in Subjects With Haemophilia A
This trial is conducted globally. The aim of the trial is to evaluate the safety and efficacy, including pharmacokinetics (the exposure of the trial drug in the body) of NNC 0129-0000-1003 (N8-GP) in subjects with Haemophilia A.
- Trial name
- pathfinder™2 (NCT01480180)
- Testing
- turoctocog alfa pegol
- Where
- 93 sites in United States, Australia and 22 more
- Volunteers
- 186 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Nutritional Intervention to Prevent Diabetes
Type 1 Diabetes (T1D) is an autoimmune disease. This means that the immune system (the part of the body which helps fight infections) mistakenly attacks and destroys the cells that produce insulin (islet cells found in the…
- Trial name
- TN06 (NCT00333554)
- Testing
- DHA Treatment
- Where
- 9 sites in United States
- Volunteers
- 99 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
HIV, Pre-exposure Prophylaxis
Life Steps for PrEP for Youth
This is a formative study, designed to provide information required to tailor Life-Steps for Pre-Exposure Prophylaxis (PrEP), an evidence-based cognitive behavioral adherence intervention, to enhance PrEP uptake and adherence in…
- Conditions
- HIV, Pre-exposure Prophylaxis, Medication Adherence
- Trial name
- LSPY (NCT03805451)
- Testing
- Life Steps for PrEP for Youth
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fenway Community Health
Hemophilia A
BAX 855 PK-guided Dosing
1. To compare the efficacy and safety of pharmacokinetic (PK)-guided treatment with BAX 855 targeting FVIII trough levels of 1-3% and approximately 10% (8-12%) 2.
- Trial name
- PROPEL (NCT02585960)
- Testing
- PEGylated Recombinant Factor VIII
- Where
- 83 sites in United States, Australia and 20 more
- Volunteers
- 135 people
- Sponsor
- Baxalta now part of Shire
Education, Nursing
The Effect of Mobile Augmented Reality Application on Nursing Students' Knowledge Skills and Motivation
The aim of this study was to examine the effects of a mobile augmented reality application on nursing students' knowledge, skills, and motivation regarding pressure injuries.
- Trial name
- NCT06675760
- Testing
- The intervention group
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Izmir University of Economics
HIV Infections
A Study of Zidovudine/Lamivudine and Either Nevirapine or Nelfinavir for Reduction of Mother-to-child HIV Transmission During Breastfeeding
The purpose of the study is to demonstrate that a regimen using highly active antiretroviral therapy (HAART) to maximally suppress maternal viral load in the late antenatal period and during the first six months of lactation is…
- Trial name
- KiBS (NCT00146380)
- Testing
- Zidovudine/Lamivudine and either Nevirapine or Nelfinavir, Breastfeeding for 6 months postpartum
- Where
- Kenya
- Volunteers
- 520 people
- Sponsor
- Centers for Disease Control and Prevention
Suicide, Suicide, Attempted
Suicide Prevention and Intervention in Spain: the SURVIVE Study
Suicide is one of the leading causes of avoidable death worldwide. Gathering population-representative data on the incidence of suicidal behavior, as well as developing effective secondary prevention strategies are imperative…
- Conditions
- Suicide, Suicide, Attempted, Depression
- Trial name
- SURVIVE (NCT04343703)
- Testing
- Telephone-based management, iFightDepression for Suicide, Treatment as Usual
- Where
- 8 sites in Spain
- Volunteers
- 1,742 people
- Sponsor
- Parc de Salut Mar
Suicide Prevention, User Experience
User Evaluation of Zelfmoord1813.be and Its Related Websites
Monitoring the availability and accessibility of suicide prevention information in Flanders remains crucial. In 2022, 1,024 people died by suicide in Flanders, and approximately 10,000 individuals required emergency care…
- Trial name
- NCT07071922
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University Ghent
HIV Infections, Pregnancy
A Study of Nevirapine for the Prevention of HIV Transmission From Mothers to Their Babies
The purpose of this study is to see if giving the anti-HIV drug nevirapine (NVP) to HIV-positive pregnant women and their babies can help reduce the chance that a mother will give HIV to her baby during delivery.
- Trial name
- NCT00000869
- Testing
- Nevirapine
- Where
- 72 sites in United States, Puerto Rico
- Volunteers
- 2,009 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anaesthesia, Toxicity
Sensitivity of ECG on Detection of Three Different Intravascular Applied Test Doses of Bupivacaine and Epinephrine
The purpose of this prospective randomised study is to investigate electrocardiographic alterations after intravascular injection of three different test solutions of bupivacaine and epinephrine in anaesthetised children up to 16…
- Trial name
- NCT01091766
- Testing
- intravenous injection of test solution
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Role, Nurses
Clarification of Nurses' Expected Role in Health Promotion
The purpose of this study is to implement and evaluate ROLE-AP, a multi-component program to clarify primary care nurses' expected role in health promotion.
- Trial name
- ROLE-AP (NCT04726696)
- Testing
- ROLE-AP programme
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Radius Fractures
Young Goalkeeper's Fracture: Radiographic Findings
The aim of this project is to evaluate retrospectively goalkeeper's fractures in children using the children fracture classification and to evaluate the distal radius tilt angle of the growth plate on plain radiographs of the…
- Trial name
- Goalkeeper (NCT02840188)
- Testing
- Radius tilt angle
- Where
- Switzerland
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Eating Disorders in Adolescence
The Peer-Delivered Body Project for Young Women in High School
This study will evaluate the impact of the Body Project (a dissonance-based program designed to address body image concerns and prevent eating disorders) on key eating disorder risk factors and relevant social and self-constructs…
- Trial name
- NCT04263155
- Testing
- The Body Project
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Surgical Wound Infection
Efficacy of Diluted Betadine vs Antibiotic Installation Before Surgical Wound Closure in Prevention of Post Cardiac Surgery Wound Infection
1. Infection control and health-care-associated infections and Safety of medical service providers 2. Evidence based management of common medical and surgical problems
- Trial name
- NCT05276687
- Testing
- Betadine, Vancomycin
- Volunteers
- 80 people
- Sponsor
- Assiut University
HIV/AIDS
Assessing the Impact of an Educational HIV Prevention Intervention in Zambia
In Zambia, 13% of the 15 to 49 year old population lives with HIV. The highest number of new HIV infections is among young people.
- Trial name
- NCT03316040
- Testing
- JIC
- Where
- 3 sites in United States, Zambia
- Volunteers
- 8,270 people, healthy volunteers welcome
- Sponsor
- Columbia University
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