Clinical trials: Prophylaxis
GVHD in the Setting of Haplo-HSCT
ATG-F VS ATG for the Prevention of GVHD
Anti-thymocyte globulin (ATG) preparative regimen in the setting of haploidentical stem cell transplantation (haplo-HSCT) is vital for inducing immune tolerance.The study aims to compare the efficacy and safety of ATG-F vs ATG…
- Trial name
- NCT03631563
- Testing
- Immunosuppressive Agent
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University
Problematic Alcohol Use
Self-help Internet-based Relapse Prevention for Problematic Alcohol Use
The purpose of this study is to observe and evaluate the use of a relapse prevention program over time among internet help-seekers.
- Trial name
- eChangeNAT (NCT02283593)
- Testing
- eChange.se
- Where
- Sweden
- Volunteers
- 4,165 people
- Sponsor
- Karolinska Institutet
Allergy, Seasonal Allergic Rhinitis
Pilot Study of Allergy Immunotherapy and Prevention of Viral Respiratory Infections
The objective of this study is to determine whether there is a relationship between interferon-gamma levels and the incidence of viral respiratory infections in allergic children treated with allergy immunotherapy as compared to…
- Conditions
- Allergy, Seasonal Allergic Rhinitis, Perennial Allergic Rhinitis
- Trial name
- NCT00405899
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- West Penn Allegheny Health System
Childhood Obesity
The Optimising Family Engagement in HENRY (OFTEN) Study
This study will test whether parent engagement (recruitment, attendance) in a Childhood obesity prevention programme (HENRY) can be improved in local authorities randomised to receive an Optimisation intervention (in addition to…
- Trial name
- OFTEN (NCT02675699)
- Testing
- Optimisation + HENRY, HENRY as standard
- Where
- United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Colorectal Cancer
Translation of Colorectal Cancer Screening Guidelines to Practice: A System Intervention
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States. Results from randomized clinical trials and intervention studies have suggested that implementation of a CRC screening program for…
- Trial name
- NCT00122187
- Testing
- Electronic Consult System
- Where
- 9 sites in United States
- Volunteers
- 8 people
- Sponsor
- US Department of Veterans Affairs
Obesity, Adolescent, Eating, Healthy
Prevention of Eating Habits Associated With Obesity
This study evaluates the effectiveness of a Wise Intervention based on a values alignment approach to improve obesity-related eating habits in Spanish adolescents.
- Trial name
- NCT05865444
- Testing
- Values alignment wise intervention, Educational traditional intervention
- Where
- Spain
- Volunteers
- 591 people, healthy volunteers welcome
- Sponsor
- University of Deusto
Diabetes Mellitus, Type 2
A Comprehensive Community Approach for Diabetes Prevention and Care for a Vulnerable Population in Galveston
To improve diabetes self-management outcomes, patients with type 2 diabetes (n=150 - aged 13-84) recruited from St. Vincent Clinic (SVC) and Teen Health Center Inc., Clinics will be randomized using block randomization to receive…
- Trial name
- NCT05097534
- Testing
- iDSMES, Standard of Care
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- The University of Texas Medical Branch, Galveston
GVHD
Vorinostat for Graft-versus-host Disease (GVHD) Prevention in Non-Malignant Adolescent and Young Adults (AYA) Population
This is a single-arm, open label, phase 2 study to determine the safety and efficacy of vorinostat without serotherapy as GVHD prophylaxis when combined with either tacrolimus and methotrexate or post-transplant cyclophosphamide…
- Trial name
- NCT06995521
- Testing
- Vorinostat
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Sung Won Choi
Sickle Cell Disease, Stroke
Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II
The overall goal of this proposal is to conduct a partial double-blind randomized Phase III clinical trial for primary stroke prevention in children with sickle cell anemia (SCA) in sub-Saharan Africa.
- Trial name
- SPRING (NCT02560935)
- Testing
- Hydroxyurea (Moderate Dose), Hydroxyurea (Low Dose)
- Where
- 3 sites in Nigeria
- Volunteers
- 440 people
- Sponsor
- Vanderbilt University Medical Center
Sports Physical Therapy
Effect of Injury Prevention Program on Cricketers
The main aim of the study is to prevent the injuries during cricket.Total 60 players were included in the study. 20 players were in warm up group,20 players were in cool down group and 20 players in control group.Base line…
- Trial name
- NCT04017715
- Testing
- Experimental: warm up, Experimental: cool down, No intervention: control
- Where
- Pakistan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Sinusitis
Efficacy of Azithromycin Prophylaxis in Preventing Recurrent Acute Sinusitis in Children
The purpose of this study is to evaluate efficacy of azithromycin prophylaxis in preventing recurrent acute sinusitis in children.
- Trial name
- NCT00944515
- Testing
- azithromycin
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Diabetes, Neuropathic Foot
A Comparison of Insoles Used to Prevent Neuropathic Diabetic Foot Ulceration
Importance of the topic: Lower extremity amputation is a costly complication of diabetes for both the NHS and the patient. Amputation may be avoided if the preceding foot ulceration can be prevented.
- Trial name
- NCT00999635
- Testing
- Insole
- Where
- 2 sites in United Kingdom
- Volunteers
- 119 people
- Sponsor
- University of Plymouth
Retinopathy of Prematurity
Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study)
Phase 2, open-label, randomized, multi-center studies in infants and premature infants are necessary to determine treatment and preventative strategies for ROP.
- Trial name
- SPIPROP (NCT02344225)
- Testing
- Caffeine citrate, Ibuprofen, Ketorolac
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- State University of New York - Downstate Medical Center
Bronchopulmonary Dysplasia, Lung Diseases
Inhaled NO in Prevention of Chronic Lung Disease
To test the hypothesis that low-dose inhaled nitric oxide administered to preterm infants who continue to require mechanical ventilation at 14 days of age will reduce the incidence of chronic lung disease.
- Trial name
- NCT00000548
- Testing
- mechanical ventilation
- Sponsor
- University of California, San Francisco
HIV, HIV Infections
Evaluation of an Integrated Economic Strengthening and HIV Prevention Program for Vulnerable Youth in South Africa
This study evaluates whether the integration of an Economic Strengthening program with an HIV-prevention education program produce synergistic effects on economic and health outcomes for South African youth ages 14-17 years old.
- Trial name
- ASPIRES (NCT02888678)
- Testing
- Economic Strengthening (Impumelelo), HIV Prevention Education (Vhutshilo 2.2)
- Where
- South Africa
- Volunteers
- 1,773 people, healthy volunteers welcome
- Sponsor
- FHI 360
Knowledge, Attitudes, Practice, Risk Behavior
The Effect of a Safety Video on Ski and Snowboard School Program Participants in Calgary, Alberta
The main objective of the study is to investigate if a video intervention can help increase knowledge, decrease risky behaviours on the hill, and reduce injury risk in students who participate in ski and snowboard school…
- Conditions
- Knowledge, Attitudes, Practice, Risk Behavior, Injuries
- Trial name
- NCT03184779
- Testing
- Ski and Snowboard Safety Video
- Volunteers
- 2,348 people, healthy volunteers welcome
- Sponsor
- Sport Injury Prevention Research Centre
Breast Cancer
Randomized Study Versus Placebo for the Prevention of Neurotoxicity Induced by Weekly PACLITAXEL
This study recommends the use of OnLife dietary supplement, which will be followed by a few day before the initiation of PACLITAXEL, for the prevention of PACLITAXEL induced neuropathy.
- Trial name
- NEUROTAX (NCT05695313)
- Testing
- OnLife®
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Georges Francois Leclerc
Dental Plaque
Dental Office Prevention Strategies for Children
The overall goal of this study is to improve the standard of care in treating young children who often suffer from chronic caries (dental decay).
- Trial name
- NCT02004990
- Testing
- Single cleansing procedure of 10% Povidone Iodine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Prevention of Meningococcus C Infections
Evaluation of Vaccinal and Natural Immunity Against Meningococcus C
Meningococcus C vaccine was first used in France to prevent epidemics. It was a success in Puy-de-Dôme, Landes, Pyrénées Atlantiques and Hautes Pyrénées.
- Trial name
- NCT02844088
- Testing
- Meningococcus C conjugate vaccine
- Where
- France
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Chemotherapy-induced Nausea and Vomiting
Study of the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Fosaprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Children (MK-0517-029)
The purpose of this study was to determine the appropriate dosing regimen of fosaprepitant, when administered with ondansetron (with or without dexamethasone), for the prevention of CINV in children from birth to <17 years of…
- Trial name
- NCT01697579
- Testing
- Fosaprepitant, Ondansetron, 5-hydroxytryptamine 3 antagonist
- Volunteers
- 240 people
- Sponsor
- Merck Sharp & Dohme LLC
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