Clinical trials: Prospective Studies
Autism Spectrum Disorder (ASD, Prospective Study
Prospective Clinical Study on Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Childhood Autism
This clinical study aims to evaluate whether a nasal spray containing exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSC-EXOs) can safely and effectively improve core symptoms in children aged 3-7 years…
- Trial name
- EXO-ASD (NCT07243561)
- Testing
- hUC-MSC-Exos Nasal Spray
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Dongfang People's Hospital
Uterine Fibroid, Uterine Sarcoma
A Prospective Validation Study of Radiomics in the Differential Diagnosis of Uterine Leiomyoma and Uterine Sarcoma
In our previous study, based on the multi-center clinical big data collected from January 2012 to January 2025, we have completed the construction of a multimodal early warning model for the malignant transformation of uterine…
- Conditions
- Uterine Fibroid, Uterine Sarcoma, AI (Artificial Intelligence), Radiomic
- Trial name
- NCT07269535
- Testing
- No intervention (observational study)
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Paediatric Surgery, Anaemia
South African Paediatric Surgical Outcomes Study 2
Preoperative anaemia has been shown to be associated with worse outcomes after surgery in both adults and children. Limited research has been done on how common preoperative iron-deficiency anaemia (IDA) is in children and how…
- Conditions
- Paediatric Surgery, Anaemia, Iron Deficiency Anemia, Iron
- Trial name
- SAPSOS2 (NCT05681871)
- Testing
- Ferrous gluconate syrup or ferrous fumarate/folic acid tablets
- Where
- 2 sites in South Africa
- Volunteers
- 755 people
- Sponsor
- University of Cape Town
Primary Biliary Cholangitis (PBC), Long-term Outcomes
PBC Long-term Outcomes Study
Primary biliary cholangitis (PBC) is an autoimmune liver disease predominantly affecting middle-aged women. While historically it was deemed rare, advancements in specific auto-antibody tests have led to increased recognition of…
- Conditions
- Primary Biliary Cholangitis (PBC), Long-term Outcomes, Prognosis, Multicenter Prospective Study
- Trial name
- NCT07149675
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Beijing Friendship Hospital
Paediatric Surgery, Perioperative/Postoperative Complications
An African, Multi-centre Evaluation of Patient Care and Clinical Outcomes for Paediatric Patients Undergoing Surgery
Access to safe surgery is a basic human right. This is highlighted by the work of the Lancet Commission on Global Surgery. There is a large burden of surgical disease in the paediatric surgical population with a large unmet need.
- Conditions
- Paediatric Surgery, Perioperative/Postoperative Complications, Perioperative Outcomes, Hospital Mortality
- Trial name
- ASOS-Paeds (NCT05061407)
- Where
- 2 sites in South Africa, Sudan
- Volunteers
- 8,625 people
- Sponsor
- University of KwaZulu
Basilar Invagination, Prospective Study
A Prospective Study of Surgical Treatment Strategies for Goal B Type Basilar Invagination
The etiology of Goal B type basilar invagination (BI) is still not clear, and it may be related to platybasia and short slope. There is no unified standard surgical strategy for Goal B type BI, and different surgical strategies…
- Conditions
- Basilar Invagination, Prospective Study, Surgical Outcome
- Trial name
- NCT05849363
- Testing
- Posterior fossa decompression, Posterior Compression-Distraction-Reduction-Fixation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
We Conducted This Prospective Randomized Comparative Study to Compare Between Outcome of Laparoscopic and Open Orchiopexy of High Inguina
Laparoscopic Versus Open Orchiopexy in High Inguinal Undescended Testis, Prospective Randomized Clinical Trial
We conducted this prospective randomized comparative study to compare between outcome of laparoscopic and open orchiopexy of high inguinal.
- Trial name
- NCT05845515
- Testing
- laparoscopic orchiopexy
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- South Valley University
Nutrition Supporting, Hirschsprung Disease
Nutrition Support for Hirschsprung Disease
A multi-center, prospective,randomized, non-blind, controlled study was conducted to investigate the effects of different pre-operative nutritional support modes on perioperative nutritional status, surgical treatment success…
- Conditions
- Nutrition Supporting, Hirschsprung Disease, Infants, Prospective Study
- Trial name
- NCT04598841
- Testing
- supplement nutritional supporting
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Tongji Hospital
Colonic Cancer, Rectal Cancer
Chinese Colorectal Cancer Database
1. To establish the Chinese people's own clinical data database of colorectal cancer, reflecting the law and characteristics of colorectal cancer patients in China. 2.
- Conditions
- Colonic Cancer, Rectal Cancer, Prospective Studies
- Trial name
- CCCD (NCT05434026)
- Where
- China
- Volunteers
- 200,000 people
- Sponsor
- Beijing Friendship Hospital
Prospective Cross-sectional Study
Reduced ER-QOL in Families After Congenital Cataract Surgery
Children after congenital cataract surgery experience a lower quality of life and reduced functional vision. Their families have also been seriously affected.
- Trial name
- NCT04824755
- Testing
- Yune Zhao
- Where
- China
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Yune Zhao
Child, Cerebral Palsy
Prevention of Hip Displacement in Children With Cerebral Palsy in Denmark
Children with cerebral palsy have an increased risk of hip dislocation, which is a painful and severe complication of cerebral palsy.
- Conditions
- Child, Cerebral Palsy, Radiography, Hip Dislocation
- Trial name
- NCT04403178
- Testing
- Radiographic examination with a Migration of > 40 %
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Mette Røn Kristensen
Prospective Study, Ulcerative Colitis in Remission
A Multicenter Prospective Cohort Study on the Clinical Prognosis of Ulcerative Colitis
Mucosal healing or histological remission is an important target for the treatment of inflammatory bowel disease. In this study, patients with mucosal healing are defined as a control group, observing their clinical outcomes for…
- Trial name
- NCT03698812
- Testing
- Colonoscope
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Tonsillectomy, Prospective Studies
Tonsil Surgery in Sweden: A National Quality Register
For the purpose of quality assurance, the Swedish Association for Otorhinolaryngology and Head and Neck surgery has developed several national registers concerning ear, nose and throat care.
- Conditions
- Tonsillectomy, Prospective Studies, Registries, Postoperative Complications
- Trial name
- NTSRS (NCT02829515)
- Testing
- tonsil surgery with or without concomitant adenoidectomy
- Where
- Sweden
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Joacim Stalfors
Prospective Studies
Detect Novel Pathogens and Characterize Emerging Infections
Infectious disease is the single biggest cause of death worldwide. New infectious agents,such as the Severe Acute Respiratory Syndrome coronavirus and new strains of influenza continually emerge and require new investigations to…
- Trial name
- NP (NCT01979705)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- Singapore General Hospital
Prospective, Single-blind
Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children.
In high-income societies the use of health care and medication is steadily increasing. Children have high morbidity, many visits at the general practitioner, an increasing number of hospitalisations, and an increasing use of…
- Conditions
- Prospective, Single-blind, Clinical, Trial
- Trial name
- NCT01694108
- Testing
- BCG-vaccine (SSI)
- Where
- 3 sites in Denmark
- Volunteers
- 4,262 people
- Sponsor
- Lone Graff Stensballe
Carbon Dioxide, Endovascular Abdominal Aortic Aneurym Repair
Prospective, Non-Randomized Evaluation of Carbon Dioxide Gas as a Contrast Agent in Comparison With Iodinated Contrast in Endovascular Aneurysm Repair
Endovascular repair of infrarenal abdominal aortic aneurysms (AAA) requires a contrast agent to identify the vascular anatomy and placement of the stent graft.
- Conditions
- Carbon Dioxide, Endovascular Abdominal Aortic Aneurym Repair, Prospective, Angiogram
- Trial name
- NCT00520416
- Testing
- Carbon dioxide angiogram
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California
Prospective Study , Questionaires
Neurocognitive Outcome in Children Who Suffered From Idiopathic Increased Intracranial Hypertension (IIH)
15 patients, Ages 8-17 who were diagnosed in the recent years with Idiopathic increased intracarnial hypertension (IIH) went through a battery of neurocognitive tests to establish whether there was any affect of the disease on…
- Trial name
- NCT02857335
- Testing
- neurocognitive tests
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center