Clinical trials: Prospective Studies
Highly Sensitized Prospective Kidney Transplant Recipients
Daratumumab and Belatacept for Desensitization
Some kidney transplant candidates have a very low chance of getting a kidney transplant because their immune systems are "highly sensitized" to most kidney donors.
- Trial name
- ATTAIN (NCT04827979)
- Testing
- daratumumab, belatacept, Bone marrow aspiration
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Autism Spectrum Disorder (ASD, Prospective Study
Prospective Clinical Study on Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Childhood Autism
This clinical study aims to evaluate whether a nasal spray containing exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSC-EXOs) can safely and effectively improve core symptoms in children aged 3-7 years…
- Trial name
- EXO-ASD (NCT07243561)
- Testing
- hUC-MSC-Exos Nasal Spray
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Dongfang People's Hospital
Diabetic Retinopathy, Non Proliferative Diabetic Retinopathy
Randomized, Controlled Study to Investigate the 12-month Efficacy and Safety of Resveratrol Vitamin Supplements in Patients With Non-proliferative Diabetic Retinopathy Without Center Involved Diabetic Macular Edema (REVOLUTION Study)
This randomized, controlled study aims to investigate the efficacy and safety of resveratrol-containing vitamin supplements in patients with non-proliferative diabetic retinopathy (NPDR) without center-involved diabetic macular…
- Conditions
- Diabetic Retinopathy, Non Proliferative Diabetic Retinopathy, Prospective Study
- Trial name
- REVOLUTION (NCT07868458)
- Testing
- Resveratrol-Containing Vitamin Supplement
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
Uterine Fibroid, Uterine Sarcoma
A Prospective Validation Study of Radiomics in the Differential Diagnosis of Uterine Leiomyoma and Uterine Sarcoma
In our previous study, based on the multi-center clinical big data collected from January 2012 to January 2025, we have completed the construction of a multimodal early warning model for the malignant transformation of uterine…
- Conditions
- Uterine Fibroid, Uterine Sarcoma, AI (Artificial Intelligence), Radiomic
- Trial name
- NCT07269535
- Testing
- No intervention (observational study)
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Prospective Study , Questionaires, Outcomes
Prospective Study To Assess The Outcomes Of Nitrous Oxide Cryoablation For Treatment Of Duodenal Adenomas In Patients With Hereditary Conditions Such As FAP, HNPCC
To learn how well nitrous oxide cryoballoon ablation, a procedure that uses extreme cold to destroy abnormal tissue, works in treating flat duodenal adenomas (abnormal growths in the small intestine) in people with FAP or Lynch…
- Conditions
- Prospective Study , Questionaires, Outcomes, Nitrous Oxide, Cryoablation
- Trial name
- NCT07859514
- Testing
- Esophagogastroduodenoscopy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Postoperative Care, Complications of Surgical Procedures or Medical Care
Prevalence of Post Anesthesia Care Unit Complications and Associated Factors
The post-anesthesia care unit (PACU) is a crucial component of the surgical process, providing patients with vital support and monitoring as they recover from anesthesia.
- Conditions
- Postoperative Care, Complications of Surgical Procedures or Medical Care, Inpatients, Ethiopia
- Trial name
- NCT06815510
- Testing
- Questionnaire and Physical Exam
- Where
- 4 sites in Ethiopia, Spain
- Volunteers
- 1,778 people
- Sponsor
- Ángel Becerra-Bolaños, MD PhD
Longitudinal Studies, Prospective Studies
Clinical Time and Temporal Dynamics Study (CLIN-TIME)
TH-CLINICAL-TIME is a prospective, longitudinal observational study evaluating how changes in clinical measurements over time may help researchers better understand patient health trajectories and clinically meaningful outcomes.
- Conditions
- Longitudinal Studies, Prospective Studies, Biomarkers, Predictive Value of Tests
- Trial name
- CLIN-TIME (NCT07812831)
- Testing
- No Study-Assigned Intervention
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Prospective Observational Study, Gemcitabine
Prospective Observational Study of Outcomes After Gemcitabine, Docetaxel, Melphalan, and Carboplatin With Autologous Stem Cell Transplantation in Pediatric Relapsed/Refractory Germ Cell Tumors
To collect information about treatment outcomes in pediatric and adolescent patients with relapsed/refractory germ cells tumors who receive GemDMC with an ASCT.
- Conditions
- Prospective Observational Study, Gemcitabine, Docetaxel, Melphalan
- Trial name
- NCT07662018
- Testing
- Gemcitabine (GEM), Docetaxel, Melphalan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Prospective Study
Physical Activity During Radiation Therapy for Lung Cancer
The primary objective of this trial is to evaluate patterns of physical activity during radiation therapy for lung cancer and to estimate the within-patient change in physical activity between Week 1 and Week 5 of radiation…
- Trial name
- APART-LUNG (NCT07380815)
- Where
- 7 sites in Denmark, Georgia and 2 more
- Volunteers
- 20 people
- Sponsor
- University Hospital Schleswig-Holstein
Highly Sensitized Prospective Kidney Transplant Recipients
Carfilzomib and Belatacept for Desensitization
Some kidney transplant candidates have a very low chance of getting a kidney transplant because their immune systems are "highly sensitized" to most kidney donors.
- Trial name
- ADAPT (NCT05017545)
- Testing
- carfilzomib, belatacept, Bone marrow aspiration
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Environmental Exposure, Assisted Reproductive Technology
Environmental and Behavioral Factors in Infertility and ART Outcomes
This large-scale study aims to understand how everyday environment and lifestyle may affect the success of fertility treatments like IVF.
- Conditions
- Environmental Exposure, Assisted Reproductive Technology, Prospective Study
- Trial name
- NCT07384676
- Testing
- plastic products, None exposure
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Labor, Induced, Labor, Obstetric
Maternal Informing on Labor Induction: Impact on Childbirth Experience
The aim of this study is to explore the information provided to mothers about labor induction and its connection to their childbirth experience.
- Conditions
- Labor, Induced, Labor, Obstetric, Pregnancy, Humans
- Trial name
- NCT07272785
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Turku University Hospital
CAD-CAM, Prospective Study
Clinical Evaluation of Additive and Subtractive Onlay Restorations
The goal of this clinical trial is to learn whether onlay restorations produced by additive manufacturing [three-dimensional (3D) printing] and subtractive manufacturing [Computer-Aided Design/Computer-Aided Manufacturing…
- Conditions
- CAD-CAM, Prospective Study, 3D Printing, Clinical Assessment
- Trial name
- CIP-ONLAY (NCT07195201)
- Testing
- 3D Printed Onlay Restoration, CAD/CAM Onlay Restoration
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Ayse Tugba Erturk Avunduk
Paediatric Surgery, Anaemia
South African Paediatric Surgical Outcomes Study 2
Preoperative anaemia has been shown to be associated with worse outcomes after surgery in both adults and children. Limited research has been done on how common preoperative iron-deficiency anaemia (IDA) is in children and how…
- Conditions
- Paediatric Surgery, Anaemia, Iron Deficiency Anemia, Iron
- Trial name
- SAPSOS2 (NCT05681871)
- Testing
- Ferrous gluconate syrup or ferrous fumarate/folic acid tablets
- Where
- 2 sites in South Africa
- Volunteers
- 755 people
- Sponsor
- University of Cape Town
Primary Biliary Cholangitis (PBC), Long-term Outcomes
PBC Long-term Outcomes Study
Primary biliary cholangitis (PBC) is an autoimmune liver disease predominantly affecting middle-aged women. While historically it was deemed rare, advancements in specific auto-antibody tests have led to increased recognition of…
- Conditions
- Primary Biliary Cholangitis (PBC), Long-term Outcomes, Prognosis, Multicenter Prospective Study
- Trial name
- NCT07149675
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Beijing Friendship Hospital
Hemodynamics;In-stent Stenosis;Transcranial Doppler;Intracranial Aneurysm;Flow Diverter; Prospective Cohort Study
Hemodynamic Study of In-Stent Stenosis(I) After Flow Diverter(F) Based on 3D-DSA(D) Combined With TCCD(T)
DTFI is a single-center, prospective cohort study aimed at evaluating the hemodynamics of in-stent stenosis after flow diverter implantation, seeking to identify the threshold effect of blood flow in stenosis.
- Trial name
- DTFI (NCT06448949)
- Testing
- Flow Diverter Implantation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhujiang Hospital
Older Adults (65 Years and Older), Fitness Testing
Health-related Physical Fitness and Executive Function in Older Adults: A Prospective Study
This study aims to explore the relationship between health-related physical fitness and behavioural and electrophysiological aspects of cool and hot executive function in older adults through a year prospective study design.
- Conditions
- Older Adults (65 Years and Older), Fitness Testing, Executive Function (Cognition), Prospective Study
- Trial name
- NCT07048561
- Testing
- observation alone
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Osseointegration Failure of Dental Implant, Periimplantitis
Prospective Longitudinal Clinical Study for the Evaluation of Peri-implant Tissue and Osseointegration After Rehabilitation With Osseointegrated Implants
The success of rehabilitation with osseointegrated implants is associated with numerous factors, including patient characteristics, installed implants, proper planning, and the prosthetic connections used.
- Conditions
- Osseointegration Failure of Dental Implant, Periimplantitis, Peri-Implant Tissues, Peri-Implant Health
- Trial name
- Dental Implant (NCT06967649)
- Testing
- TITANIUM IMPLANT
- Where
- Brazil
- Volunteers
- 350 people
- Sponsor
- Universidade Federal Fluminense
Prospective, Multicenter, Randomized, Controlled, and Superior Efficiency
Clinical Trial of Safety and Efficacy of Intracranial Laser Balloon Dilation Catheter in Patients With Symptomatic Intracranial Atherosclerotic Stenosis: A Prospective, Multi-center, Randomized Comparison
Experimental group：Name of Medical Apparatus ：Intracranial Laser Balloon Dilation Catheter and Laser Generator Manufacturer：Hangzhou Juzheng Medical Technology limited company
- Trial name
- Laser balloon (NCT06950242)
- Testing
- Balloon dilation treatment for intracranial arterial stenosis in order to improve intracranial blood supply., Boston Scientific Corporation
- Where
- China
- Volunteers
- 128 people
- Sponsor
- The First People's Hospital of Changzhou
Paediatric Surgery, Perioperative/Postoperative Complications
An African, Multi-centre Evaluation of Patient Care and Clinical Outcomes for Paediatric Patients Undergoing Surgery
Access to safe surgery is a basic human right. This is highlighted by the work of the Lancet Commission on Global Surgery. There is a large burden of surgical disease in the paediatric surgical population with a large unmet need.
- Conditions
- Paediatric Surgery, Perioperative/Postoperative Complications, Perioperative Outcomes, Hospital Mortality
- Trial name
- ASOS-Paeds (NCT05061407)
- Where
- 2 sites in South Africa, Sudan
- Volunteers
- 8,625 people
- Sponsor
- University of KwaZulu