Clinical trials: Pulmonary Failure
Bronchiolitis, Bronchiolitis, Viral
Nasal and Bronchial Absorption Sampling in RSV Bronchiolitis
This study will compare the novel methods of NS and BS with the standard technique of nasophayngeal aspiration (NPA) and routine ETT suction.
- Conditions
- Bronchiolitis, Bronchiolitis, Viral, RSV Infection, Respiratory Failure
- Trial name
- RSV-SAM (NCT03062917)
- Testing
- Nasal and Bronchial Sampling
- Where
- United Kingdom
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Congenital Diaphragmatic Hernia, Acute Kidney Injury
Incidence of Acute Kidney Injury and Risk Factors in Newborns With Congenital Diaphragmatic Hernia
The main aim of this project is to elucidate the incidence of acute kidney injury (AKI) in newborns with congenital diaphragmatic hernia during stay in the Pediatric intensive care unit. (PICU).
- Conditions
- Congenital Diaphragmatic Hernia, Acute Kidney Injury, Multiple Organ Failure, Pulmonary Hypertension
- Trial name
- NCT06050525
- Where
- Sweden
- Volunteers
- 109 people
- Sponsor
- Karolinska Institutet
Respiratory Failure, Respiratory Distress Syndrome
Ventilator Induced Diaphragm Dysfunction in Pediatric Critically Ill Patients (VIDD)
evaluation of diaphragmatic disfunction eventually occurred in pediatric patient undergoing mechanical ventilation therapy
- Conditions
- Respiratory Failure, Respiratory Distress Syndrome, Mechanical Ventilation Complication
- Trial name
- VIDD (NCT03768232)
- Testing
- ultrasound asessment
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Cancer, Respiratory Failure
Multi-Disciplinary Treatment on the Anthropomorphism of Large Language Models
This retrospective clinical trial aims to better explore the potential of large language models in medicine by comparing the effectiveness of MDT consultations conducted by human doctors with those conducted by large language…
- Conditions
- Cancer, Respiratory Failure, Heart Diseases, Infections
- Trial name
- MDTALLM (NCT06627985)
- Testing
- GPT-4o, GPT-4o mini, MedicalGPT
- Where
- China
- Volunteers
- 300 people
- Sponsor
- North Sichuan Medical College
Congenital Diaphragmatic Hernia, Persistent Pulmonary Hypertension of the Newborn
Milrinone in Congenital Diaphragmatic Hernia
Infants with congenital diaphragmatic hernia (CDH) usually have pulmonary hypoplasia and persistent pulmonary hypertension of the newborn (PPHN) leading to hypoxemic respiratory failure (HRF).
- Conditions
- Congenital Diaphragmatic Hernia, Persistent Pulmonary Hypertension of the Newborn, Hypoxemic Respiratory Failure, Pulmonary Hypoplasia
- Trial name
- NCT02951130
- Testing
- Milrinone
- Where
- 19 sites in United States
- Volunteers
- 66 people
- Sponsor
- NICHD Neonatal Research Network
COVID-19, Acute Respiratory Failure
Lung Ultrasound for COVID-19 Initial Triage and Monitoring
The QUICK study main aim is to assess the predictive value at Day 1, of a model built on lung ultrasound (LUS) and clinical data, both recorded at hospital admission of COVID-19 patients.
- Conditions
- COVID-19, Acute Respiratory Failure, Triage, Lung Ultrasound
- Trial name
- QUICK (NCT04474236)
- Testing
- thoracic lung ultrasound
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Toulouse
Neonatal Disease
Neonatologist-performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy to Prevent Extubation Failure
The objective of the study is to evaluate the role of neonatologist-performed lung ultrasound (NPLUS) after weaning from invasive mechanical ventilation and extubation.
- Trial name
- NCT06469580
- Testing
- NPLUS (neonatologist performed lung ultrasound)
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Acute Respiratory Failure
Continuous Positive Airway Pressure and Oxygen Concentration on Measurement of Rapid Shallow Breathing Index
To compare the rapid shallow breathing index (RSBI) values, the incidence of adverse reactions, and the predictive accuracy measured under 5 different ventilator strategies in the same patient group.
- Trial name
- NCT00632320
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Extubation
Electrical Impedence Tomography With ENLIGHT2100
Children with acute respiratory failure often need a breathing tube attached to a breathing machine, called a mechanical ventilator, to assist their breathing until they can recover.
- Trial name
- NCT05098834
- Testing
- ENLIGHT 2100 ventilatory electrical impedance tomograph
- Where
- United States
- Sponsor
- Duke University
Respiratory Distress Syndrome
Comparative Effectiveness Study of Bubble CPAP Devices in the NICU
Multiple different devices are available to provide Bubble CPAP to preterm and newborn infants. The most significant difference between these devices is the size of the bubble produced by the exhalation limb.
- Trial name
- NCT02392806
- Testing
- Bubble CPAP- BabiPlus, Respiralogics, Bubble CPAP- B&B Bubbler, B&B Medical devices
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Marya Strand, MD
Ventilatory Failure
Comparison of Two Different NCPAP Methods in Preterm Infants With Respiratory Distress Syndrome
is to compare introduction of two different NCPAP methods in terms of mechanical ventilation (MV) need (non-invasive respiratory support failure) and surfactant need within the first 72 hours of life in preterm infants with…
- Trial name
- (NCPAP) (NCT03400670)
- Testing
- ventilator NCPAP
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Acute Respiratory Failure With Hypoxia
pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure
This is a trial of a new way of treating patients with respiratory failure. The investigators propose to deliver a multi-centre clinical trial to determine whether veno-venous extracorporeal carbon dioxide removal (VV-ECCO2R) and…
- Trial name
- REST (NCT02654327)
- Testing
- VV-ECCO2R to enable lower tidal volume mechanical ventilation
- Where
- United Kingdom
- Volunteers
- 1,120 people
- Sponsor
- Belfast Health and Social Care Trust
Bronchiolitis, Respiratory Failure (Pediatric Patients)
Nurse-led High-flow Nasal Cannula Weaning Protocol in Pediatric Intensive Care Unit
Bronchiolitis is a leading cause of pediatric hospital admissions. Despite its limited clinical benefits, the use of HFNC in children with bronchiolitis is increasing.
- Conditions
- Bronchiolitis, Respiratory Failure (Pediatric Patients), High Flow Nasal Cannula
- Trial name
- NCT06621641
- Testing
- The new HFNC weaning protocol
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Lung Transplant Failure and Rejection
Long Term Follow up of the LTOG Cohort
The purpose of the study is to follow participants who enrolled in the Lung Transplant Outcomes Group. Clinical data, functional assessments, and surveys will be collected to determine long term graft function and functional…
- Trial name
- LTOG (NCT04787822)
- Where
- 10 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- University of Pennsylvania
Bronchopulmonary Dysplasia
Inhaled Treatment for Bronchopulmonary Dysplasia
The primary objective of this study is to provide expanded access of S-nitrosylation therapy for the treatment of bronchopulmonary dysplasia
- Trial name
- NCT04619602
- Testing
- GSNO
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
Multicystic Dysplastic Kidney, Polycystic Kidney Disease
Amnioinfusion for Fetal Renal Failure
The goal of this clinical trial is to learn if serial amnioinfusions can improve the chances of survival for fetuses with severe kidney problems that cause low amniotic fluid (anhydramnios).
- Conditions
- Multicystic Dysplastic Kidney, Polycystic Kidney Disease, Fetal Renal Anomaly, Anhydramnios
- Trial name
- NCT06728228
- Testing
- Amnioinfusion
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Fetal Care Center, PLLC
Lung Cancer, Ventricular Failure
Right Ventricular Inflammation After Lung Resection
The purpose of this study is explore the impact of lung cancer surgery on inflammation and function of the right side of the heart.
- Trial name
- NCT03523611
- Testing
- Lung Resection
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Glasgow
Chronic Obstructive Pulmonary Disease, Neuromuscular Disease
Telemedicine and Ventilator Titration in Chronic Respiratory Patients Initiating Non-invasive Ventilation
The critical nature of respiratory diseases, the continuously increasing prevalence of these conditions, and the subjective perception of patients vis-à-vis their pulmonary function and health status underscore the importance of…
- Conditions
- Chronic Obstructive Pulmonary Disease, Neuromuscular Disease, Chest Wall Disorders, Obesity Hypoventilation Syndrome
- Trial name
- TeleMotiNIV (NCT01560741)
- Testing
- Telemonitoring tools, Usual Care
- Where
- Portugal
- Volunteers
- 128 people
- Sponsor
- Hospital Sao Joao
COVID-19, Acute Hypoxemic Respiratory Failure
Helmet Non-Invasive Ventilation for COVID-19 Patients
Study hypothesis: Non-invasive positive pressure ventilation delivered by helmet will reduce 28-day all-cause mortality in patients with suspected or confirmed severe COVID-19 pneumonia and acute hypoxemic respiratory failure
- Trial name
- Helmet-COVID (NCT04477668)
- Testing
- Helmet non-invasive ventilation
- Where
- Saudi Arabia
- Volunteers
- 322 people
- Sponsor
- King Abdullah International Medical Research Center
Acute on Chronic Systolic Congestive Heart Failure
Reversible Pulmonary Artery Banding as Simplified Management of End-stage Dilated Left Ventriculopathy in Early Life
The purpose of this study is to: 1) Remodel and restore left ventricular geometry and function. 2) Avoid the need for mechanical circulatory support (MCS) and/or cardiac transplantation (CT).
- Trial name
- NCT02652676
- Testing
- Reversible Pulmonary Artery Banding, GORE-TEX DualMesh EMERGE PLUS Biomaterial
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Loma Linda University