Clinical trials: Radiologically Isolated Syndrome
Multiple Sclerosis, Neuromyelitis Optica
The Italian Multiple Sclerosis and Related Disorders Register
The Italian Multiple Sclerosis and Related Disorders Register (Registro Italiano Sclerosi Multipla e Patologie Correlate - RISM) is an observational cohort study that aims to create an organised multicentre structure to collect…
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica, Demyelinating Diseases of the Central Nervous System, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease
- Trial name
- RISM (NCT07636876)
- Where
- Italy
- Volunteers
- 96,000 people
- Sponsor
- Fondazione Italiana Sclerosi Multipla
Clinically Isolated Syndrome, Radiologically Isolated Syndrome
Isoelectric Focusing of Tears in Children With Radiologically Isolated or Clinically Isolated Syndrome
The main gold of this study is to lead a multicentric, prospective study, to evaluate the diagnostic quality of tears in children with clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) during a…
- Conditions
- Clinically Isolated Syndrome, Radiologically Isolated Syndrome, Multiple Sclerosis in Children
- Trial name
- OBIT (NCT03979391)
- Testing
- Tear collection and lumbar punction
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Lille Catholic University
Multiple Sclerosis, Radiologically Isolated Syndrome
Epstein Barr Virus Infection in Patients With Radiologically Isolated Syndrome
The clinical course of RRMS patients is variable. Among RIS-Consortium international cohorts, one third of RIS patients progressed to MS at 5 years and 52.2% at 10 years.
- Conditions
- Multiple Sclerosis, Radiologically Isolated Syndrome, Epstein-Barr Virus
- Trial name
- EBV-RIS (NCT05815108)
- Testing
- NO INTERVENTION
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Multiple Sclerosis, Radiologically Isolated Syndrome
Prognostic Value of Three New Biomarkers of Multiple Sclerosis in Patients With Radiologically Isolated Syndrome
To look at the prognostic value of new biomarkers in CSF and serum for characterisation of multiple sclerosis
- Trial name
- T-RIS (NCT03357887)
- Testing
- Analysis of cerebrospinal fluid and serum
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Radiologically Isolated Syndrome, Multiple Sclerosis
Stratification of Risks of Conversion of Radiologically Isolated Syndromes (RIS) by Identifying Biomarkers in Serum and Cerebrospinal Fluid.
Radiologically isolated syndrome (RIS) often precedes Multiple Sclerosis (MS) but some patients have no symptoms. This study aims to use biological samples and magnetic resonance imaging (MRI) data from four large cohorts of…
- Trial name
- ProBioRIS (NCT06395662)
- Testing
- Observational
- Where
- 3 sites in United States, France
- Volunteers
- 320 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Radiologically Isolated Syndrome, Epstein-Barr Virus Infections
Environmental Risk Factors in Multiple Sclerosis Development: Epidemiological Study of EBV Infection and Vitamin D Deficiency in RIS Patients
This is an ancillary study using samples collected in the ProBioRIS cohort (NCT06395662). The aim of the project is to highlight new biomarker candidates to assess the risk of conversion to clinically definite multiple sclerosis…
- Trial name
- RIS - EBVD (NCT07256431)
- Testing
- Antibiody titration
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Multiple Sclerosis, Radiologically Isolated Syndrome
RIS International Cohort
The Radiologically Isolated Syndrome (RIS) corresponds to the discovery of white matter (WM) abnormalities suggestive of multiple sclerosis (MS) by their location, size, and appearance, on the brain or spinal cord Magnetic…
- Trial name
- NCT05388331
- Testing
- No intervention
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire de Nice