Clinical trials: Randomised Clinical Trial
İnguinal Hernia
Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Caudal Epidural Block
The goal of This prospective, randomized, double-blind comparative study is to compare the efficacy of dexamethasone and dexmedetomidine as adjuvants to bupivacaine 0.125% in caudal epidural block for pediatrics undergoing…
- Trial name
- NCT07056244
- Testing
- Dexmedetomidine, Dexamethasone
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Twin Pregnancy With Antenatal Problem
An Open Randomised Trial of the Arabin Pessary to Prevent Pre-term Birth in Twin Pregnancy
This study aims to determine whether the Arabin cervical pessary prevents preterm birth in women with a twin pregnancy and a short cervix.
- Trial name
- STOPPIT-2 (NCT02235181)
- Testing
- Arabin Cervical Pessary
- Where
- 57 sites in Belgium, United Kingdom
- Volunteers
- 2,228 people
- Sponsor
- University of Edinburgh
Active Immunisation for Chikungunya Virus Infection
A Seamless Phase II/III, Observer-blind, to Evaluate Immunogenicity and Safety of Chikungunya Virus Vaccine in Healthy Subjects 12-65Years of Age.
A Seamless Phase II/III, Observer-blind, Multi-centre, Randomized Clinical Trial to Evaluate Immunogenicity and Safety of BBV87, an Inactivated Chikungunya Virus Vaccine in Healthy Subjects 12-65 Years of Age
- Trial name
- CHIKV/II-III (NCT07555392)
- Testing
- BBV87 Chikungunya vaccine
- Where
- 10 sites in India
- Volunteers
- 1,000 people
- Sponsor
- Bharat Biotech International Limited
Impacted Canine
Closed Window vs. Open Window Technique in Management of Palatally Impacted Canines
In this investigation the investigators would like to find out which of two commonly used techniques of management of palatally impacted canines: closed-window (CWT) or open-window (OWT), produces more favorable outcome.
- Trial name
- NCT02582645
- Testing
- open window technique, closed window technique
- Where
- 3 sites in Belgium, Czechia and 1 more
- Volunteers
- 100 people
- Sponsor
- University Hospital Olomouc
Malaria, Anemia
Uganda Housing Modification Study
To explore housing modification as a malaria control intervention, and to assess the degree to which it may offer protection in moderate to high malaria endemicity settings, we propose a two-phase study evaluating epidemiological…
- Trial name
- UHMS (NCT04622241)
- Testing
- Eave Tubes, Eave Ribbons, Full House Screening
- Where
- Uganda
- Volunteers
- 2,422 people, healthy volunteers welcome
- Sponsor
- Infectious Diseases Research Collaboration, Uganda
Malaria, Anemia
Evaluation of a Comprehensive School Health Programme in Zambia
In Zambia, the health and well-being of children aged 5 to 14 has often been overlooked, leading to various health challenges affecting their development and education.
- Conditions
- Malaria, Anemia, Diarrhea
- Trial name
- NCT06560853
- Testing
- Comprehensive School Health Programme, Deworming and vitamin A supplementation delivery
- Where
- 6 sites in Zambia
- Volunteers
- 28,700 people, healthy volunteers welcome
- Sponsor
- London School of Economics and Political Science
Polycystic Ovary Syndrome (PCOS)
A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS)
This is a multi-centre, multi-national, double-blinded, placebo-controlled, parallel, randomised Phase II clinical trial to evaluate the efficacy, tolerability, and safety of a fixed dose combination of Spironolactone…
- Trial name
- SPIOMET4HEALTH (NCT05394142)
- Testing
- Pioglitazone, Spironolactone, Metformin
- Where
- 7 sites in Austria, Denmark and 4 more
- Volunteers
- 364 people
- Sponsor
- Fundació Sant Joan de Déu
Reading Ability
Omega 3/6 Fatty Acids for Reading in Children
The primary objective was to assess whether supplementation of Omega 3/6 fatty acids improves mainstream schoolchildren's reading ability.
- Trial name
- NCT02557477
- Testing
- Omega 3/6 fatty acids
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Göteborg University
HIV Infections
Reducing HIV in Adolescents
The purpose of this study is to assess the impact of a cash-incentivised prevention intervention on reducing HIV incidence rates in high-school learners in rural KwaZulu-Natal.
- Trial name
- RHIVA (NCT01187979)
- Testing
- Cash incentives, Life skills curriculum
- Where
- South Africa
- Volunteers
- 3,217 people, healthy volunteers welcome
- Sponsor
- Centre for the AIDS Programme of Research in South Africa
Acute and Chronic Wounds
Is Pressurized Irrigation an Effective Alternative to Swabbing for Wound Cleansing?
The study is to examine the effectiveness of cleansing wound with pressurized irrigation method compared with conventional practice of swabbing on the wound healing and infection of acute and chronic wound, and to evaluate the…
- Trial name
- NCT01885273
- Testing
- Pressurized irrigation method, Swabbing wound cleansing method
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Spasticity, Muscle, Cerebral Palsy
Effect of Session Frequency of rESWT on Gastrocnemius Muscle Spasticity in Children With Spastic Type Cerebral Palsy
Spasticity, defined as a velocity dependent increase in tonic stretch reflexes, is one of the most prominent motor problems that occur in patients with cerebral palsy (CP).
- Conditions
- Spasticity, Muscle, Cerebral Palsy, Child; Spastic
- Trial name
- NCT04574622
- Testing
- radial Extracorporeal Shockwave Therapy
- Where
- Indonesia
- Volunteers
- 14 people
- Sponsor
- Rizky Kusuma Wardhani
Dental Anxiety
Comparative Clinical Study Between Virtual Reality Hypnosis and Nitrous Oxide Inhalation for Dental Anxie
The vicious circle of dental anxiety impacts major aspects of a child's quality of life. Hypnosis using distraction is one of the most common non-pharmalogical techniques in behavior and pain management in pediatric dentistry.
- Trial name
- HYPNOSEDENT (NCT05167331)
- Testing
- Nitrous Oxide inhalation, Dispositif de RV - HYPNO VR
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Liver Disease
Comparison and Outcomes of Endoscopic Ultrasound Liver Biopsies Versus Percutaneous Liver Biopsies
Histopathological examination of liver tissue is used to determine the etiology and extent of liver disease. In order for a clinician to make a better-informed decision regarding a patient with liver disease, the liver biopsy…
- Trial name
- NCT04751045
- Testing
- EUS liver biopsy
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Missouri-Columbia
Childhood Obesity, Physical Activity
Development and Feasibility of an Intervention to Increase Physical Activity Among Young Children
The aim of this study is to develop, implement, and evaluate a novel intervention to increase physical activity and reduce sedentary behaviour among pre-school children, with the ultimate goal of reducing obesity among this age…
- Trial name
- NCT05754359
- Testing
- I'm an Active Hero (IAAH) Intervention Program
- Where
- Saudi Arabia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Retinoschisis
The AXIS Study: the Efficacy of Acetazolamide for the Treatment of Cystoid Fluid Collections in Retinoschisis
X-linked retinoschisis (XLRS) is a rare hereditary eye disease that causes irreversible vision loss in boys and young men. This disease occurs in 1 in 10,000-30,000.
- Trial name
- AXIS (NCT06114537)
- Testing
- Acetazolamide
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Temporomandibular Joint Disorders
Intra-articular Injection in Arthroscopic Management of Temporomandibular Diseases
The aim of this study is to evaluate the efficacy of intra-articular injection of platelet rich plasma versus hyaluronic acid following diagnostic arthroscopy in the management of patients suffering from degenerative…
- Trial name
- NCT04936945
- Testing
- Temporomandibular joint arthroscopy plus intra-articular injection
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Retinopathy of Prematurity
Effect of Vitamin E for Prevention of Retinopathy of Prematurity: A Randomized Clinical Trial.
The retinopathy of prematurity (ROP) is a public health problem, the main causes of ROP are prematurity, use of oxygen, malnutrition and oxidative stress.
- Trial name
- NCT03274596
- Testing
- Vitamin E
- Volunteers
- 90 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Suicide Awareness, Suicidal Ideation
"Youth Aware of Mental Health" in Galicia
The goal of this interventional study is to assess the effectiveness of the universal suicide prevention program "Youth Aware of Mental Health" in 3rd-year secondary education students in Galicia.
- Conditions
- Suicide Awareness, Suicidal Ideation, Suicide, Attempted, Depressive Symptoms
- Trial name
- YAM (NCT06251037)
- Testing
- Youth Aware of Mental Health in Galicia
- Where
- 68 sites in Spain
- Volunteers
- 4,453 people, healthy volunteers welcome
- Sponsor
- Fundacin Biomedica Galicia Sur
Autism Spectrum Disorder
Effectiveness of Aerobic Exercises on the Autistic Children
Autism spectrum disorder (ASD) is a neurodevelopmental disorder manifesting stereotypic behaviors and problem in communication and social interaction.
- Trial name
- NCT05067361
- Testing
- Aerobic Exercise, Ball Exercises
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- University of Faisalabad
Osteoarthritis
The HIHO Study: Hospital Inpatient vs Home Rehabilitation After Total Knee Replacement
Total knee replacement (TKR) surgery is a common and highly effective treatment option for alleviating the pain and disability caused by chronic arthritis.
- Trial name
- HIHO (NCT01583153)
- Testing
- Hospital Inpatient Rehabilitation, Hybrid Home Programme (HO)
- Where
- 3 sites in Australia
- Volunteers
- 165 people
- Sponsor
- Mark Buhagiar
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