Clinical trials: Randomised Controlled Trial
Cow Milk Allergy, Food Allergy
Effectiveness and Safety of Milk Ladders in Children with IgE-Mediated Cow's Milk Protein Allergy
Cow's milk protein allergy (CMPA) is one of the most common food allergies in early childhood. The first-line treatment of CMPA is the elimination of cow's milk proteins (CMPs) from the child's or maternal diet.
- Trial name
- NCT06664918
- Testing
- oral food challenge (OFC)
- Where
- 2 sites in Poland
- Volunteers
- 92 people
- Sponsor
- Medical University of Warsaw
Rectal Cancer
Magnetic Resonance Tumour Regression Grade (mrTRG) as a Novel Biomarker - Phase III Non CTIMP Trial
Open to patients undergoing any pre-operative treatment for locally advanced rectal cancer, TRIGGER is the only phase III clinical trial in the UK offering watch and wait.
- Trial name
- TRIGGER (NCT02704520)
- Testing
- High resolution MRI scan, mrTRG assessment
- Where
- 10 sites in United Kingdom
- Volunteers
- 441 people
- Sponsor
- Imperial College London
Child Development, Socioeconomic Factors
Study Protocol: Cognitive, Emotional and Social Stimulation Programme for Low-SES Children.
Latin America and the Caribbean exhibit high rates of poverty and social exclusion, where a significant portion of the population faces challenges in meeting basic needs.
- Trial name
- Activa-Mente (NCT07281482)
- Testing
- Cognitive and emotional stimulation, Random activities, Training for parents and teachers
- Where
- 2 sites in Colombia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Joan Deus Yela
Termination of Pregnancy Second Trimester
Misoprostol for Second Trimester Termination of Pregnancy
To compare the efficacy of two different dose regimens of misoprostol administered vaginally in combination with mifepristone in second trimester termination of (non)viable pregnancy.
- Trial name
- MIMIS (NCT00945997)
- Testing
- misoprostol
- Where
- Netherlands
- Volunteers
- 176 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Orthodontic Appliance Complication
Control of Pain From Braces With Patient Advice Sheets
To compare the analgesic property of acupressure with NSAIDs (Ibuprofen) in controlling pain following orthodontic treatment. This will be achieved by assessing the effectiveness of acupressure in controlling pain and discomfort…
- Trial name
- COPPAS (NCT03159520)
- Testing
- Advice sheet
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Dundee
Attention Deficit Hyperactivity Disorder, ADHD
Omega-3 Polyunsaturated Fatty Acids in Youth With ADHD
N-3 polyunsaturated fatty acids(N-3 PUFAs) is important in balancing the immune function and crucial for the developing brain. Deficiency in n-3 PUFAs might be linked to the poor cognitive performances resulting in inattention…
- Trial name
- NCT03542643
- Testing
- n-3 Polyunsaturated fatty acid
- Where
- Taiwan
- Volunteers
- 105 people
- Sponsor
- China Medical University Hospital
Resilience, Depressive Symptom
Musical Training to Enhance Resilience of Underprivileged School-aged Children
This is a multi-centre randomised controlled trial aims to examine the effects of a group-based gamified instrumental musical training in enhancing resilience (primary outcome), reducing psychological distress (depressive…
- Conditions
- Resilience, Depressive Symptom, Anxiety
- Trial name
- NCT07165925
- Testing
- Gamified music training
- Where
- Hong Kong
- Volunteers
- 174 people
- Sponsor
- Chinese University of Hong Kong
Asthma
Laminar Airflow in Severe Asthma for Exacerbation Reduction
To ascertain whether home-based nocturnal TLA usage over a 12 month period can reduce exacerbations and improve asthma control and quality of life as compared to placebo, whilst being cost-effective and acceptable to adults with…
- Trial name
- LASER (NCT03058497)
- Testing
- Temperature-Controlled Laminar Airflow Device (Airsonett®)
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Fetal Intrauterine Distress First Noted During Labor and or Delivery in Liveborn Infant, Team Based on Their Existing Guidelines and the Woman Consents to Have EFM and EFM is
Use of Decision Support in the Management of Labour
In women judged to require continuous electronic fetal heart rate monitoring (EFM) during their labour, does the addition of decision support software to aid the interpretation of the intrapartum cardiotocogram (CTG) reduce the…
- Conditions
- Fetal Intrauterine Distress First Noted During Labor and or Delivery in Liveborn Infant, Team Based on Their Existing Guidelines and the Woman Consents to Have EFM and EFM is, Possible
- Trial name
- INFANT (NCT02010710)
- Testing
- INFANT software
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 47,062 people
- Sponsor
- University College, London
Alcohol Consumption, Violence
Violence Brief Intervention Pilot v1.1
This study is a randomised controlled trial of a new brief intervention with young (16-29) adult male patients who have a facial injury sustained as a result of interpersonal violence (fighting or assaults).
- Conditions
- Alcohol Consumption, Violence, Facial Injuries
- Trial name
- NCT02394990
- Testing
- Violence Brief Intervention, ABI
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- NHS Greater Glasgow and Clyde
Injuries
Effectiveness of Dental Trauma Educational Poster to Secondary Students
to investigate the effectiveness of the educational poster regarding knowledge of dental trauma for the secondary school students
- Trial name
- NCT01809457
- Testing
- educational poster
- Where
- Hong Kong
- Volunteers
- 671 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Juvenile Dermatomyositis
Five-year Actively Controlled Clinical Trial in New Onset Juvenile Dermatomyositis
This is a 5-year project, involving 185 partners from 46 countries ((110 in 21 European Union (EU) States and 75 in 25 extra-EU States)), with a randomised clinical trials (RCT) in juvenile dermatomyositis (JDM): 5-year phase III…
- Trial name
- PRINTOJDMTR (NCT00323960)
- Testing
- 3 MPDN pulse + PDN, 3 MPDN pulse + PDN + CSA, 3 MPDN pulse + PDN + MTX
- Where
- Italy
- Volunteers
- 139 people
- Sponsor
- Istituto Giannina Gaslini
Ophthalmology, Low Vision Aids
The Efficacy of an Artificial Intelligence Platform to Adapt Visual Aids for Patients With Low Vision: a Randomised Controlled Trial
According to the WHO's definition of visual impairment, as of 2018, there were approximately 1.3 billion people with visual impairment in the world, and only 10% of countries can provide assisting services for the rehabilitation…
- Conditions
- Ophthalmology, Low Vision Aids, Artificial Intelligence
- Trial name
- AI (NCT04919837)
- Testing
- Low vision aids
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
Compliance, Patient
The Effectiveness of Virtual Appointments on Compliance With Twin Block Wear
The investigators aim to determine the effect of virtual appointments on compliance with Twin Block wear. Patients satisfying the inclusion criteria requiring a Twin Block appliance will be requested to participate in the study.
- Trial name
- NCT06411847
- Testing
- Virtual appointments
- Where
- 2 sites in Ireland
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Dental Caries
Evaluation of Prefabricated CAD/CAM PEEK Crowns Used in Primary Molars
Fifty healthy cooperative children will be randomly allocated to two groups. Group I (test group) will receive CAD/CAM PEEK crowns, while group II (control group) will receive SSC.
- Trial name
- NCT06583759
- Testing
- Full coverage Crowns
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Pneumonia
Hospitalised Pneumonia With Extended Treatment (HOPE) Study
An intervention study to determine if a longer duration of antibiotics (compared to shorter duration) improves the short and long term clinical outcomes of children hospitalised for pneumonia
- Trial name
- HOPE (NCT02783859)
- Testing
- Amoxicillin-clavulanic Acid
- Where
- 5 sites in Australia, Malaysia and 1 more
- Volunteers
- 314 people
- Sponsor
- Menzies School of Health Research
Neonatal Hypoglycemia, Metabolic Complication
Pasteurised Donor Human Milk Supplementation for Term Babies
PRESENT is a multi-center randomised controlled trial that aims to assess whether access to pasteurized donor human milk as supplementary nutrition in the first five days of life for term infants born to women with diabetes in…
- Conditions
- Neonatal Hypoglycemia, Metabolic Complication, Cows Milk Allergy, Hospital Length of Stay
- Trial name
- PRESENT (NCT06993103)
- Testing
- Standard care Cow's milk based formula, Dietary Supplement: PDHM Pasteurised Donor Human Milk
- Where
- 4 sites in Australia
- Volunteers
- 1,444 people
- Sponsor
- The University of Queensland
Genitourinary Syndrome of Menopause
RCT of Laser Therapy for GSM
The aim of the current study is to assess whether the CO2-laser results in superior alleviation of GSM symptoms compare to Er:YAG-laser.
- Trial name
- NCT03288883
- Testing
- Photothermal Non-ablative Erbium:YAG-laser, Fractional Microablative CO2-laser
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Irreversible Pulpitis, Extremely Deep Caries
Outcome Following Use of Different Concentrations of NaOCl as Wound Lavage and Hemostatic Agent in Partial Pulpotomy
The aim of this randomised control trial is to compare the effect of different concentrations of NaOCl on outcome of partial pulpotomy in teeth with clinical signs indicative of irreversible pulpitis.
- Conditions
- Irreversible Pulpitis, Extremely Deep Caries, Partial Pulpotomy
- Trial name
- NCT06433245
- Testing
- effect of 3% and 5% sodium hypochlorite on outcome of partial pulpotomy in teeth with clinical signs indicative of irreversible pulpitis.
- Where
- India
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Skin Condition, Cleft Lip and Palate
Online Psychosocial Support for Young People With a Visible Difference: A Randomised Control Study
A visible difference can have a profound impact in a society with a massive emphasis on appearance and "looks". A vulnerable group is adolescents with a condition affecting their appearance as a result of injuries (burns…
- Conditions
- Skin Condition, Cleft Lip and Palate, Burns, Other Conditions Leading to a Visible Difference
- Trial name
- UNGFaceIT (NCT03165331)
- Testing
- Ung Face IT
- Where
- Norway
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
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