Clinical trials: Randomised Controlled Trial
Psychological Distress, PTSD
Feasibility and Acceptability of BRIGHT
Refugees and asylum seekers (RAS) face numerous stressors and adversities which put them at risk for developing mental health problems. However, access to adequate mental health care in host countries is limited.
- Conditions
- Psychological Distress, PTSD, Trauma, Psychological
- Trial name
- NCT06397105
- Testing
- Problem Management Plus
- Where
- Switzerland
- Volunteers
- 64 people
- Sponsor
- University of Zurich
Stillbirth, Perinatal Death
A Feasibility Randomised Control Trial to Evaluate Early Perinatal Bereavement Counselling for Parents Who Have Experienced a Perinatal Death
The goal of this feasibility randomised control trial is to determine if a trial to evaluate perinatal bereavement counselling for parents who have experienced a perinatal death is feasible.
- Conditions
- Stillbirth, Perinatal Death, Psychological, Grief
- Trial name
- PEARL-C (NCT07494760)
- Testing
- Bereavement Counselling, Usual bereavement care
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Bacterial Pneumonia, Viral Pneumonia
Inhaled Corticosteroids in U-5 Children With Acute Respiratory Infection in Uganda: A Randomised Trial
The purpose of this study is to find out whether adjunct treatment with inhaled corticosteroids lead to faster improvement and reduce mortality of children under 5 years of age admitted to hospital with ALRI.
- Conditions
- Bacterial Pneumonia, Viral Pneumonia, Acute Asthma
- Trial name
- ICS (NCT01868113)
- Testing
- Inhaled corticosteroid
- Where
- Uganda
- Volunteers
- 1,010 people
- Sponsor
- Makerere University
Tuberculosis
Increasing Notifications of Tuberculosis From Private Practitioners
Tuberculosis (TB) is the third leading cause of death in Indonesia. Disturbingly, the prevalence survey showed that over half of TB cases in Indonesia are not notified.
- Trial name
- INSTEP2 (NCT04187313)
- Testing
- INSTEP2 intervention package
- Where
- Indonesia
- Volunteers
- 105 people
- Sponsor
- Universitas Padjadjaran
Hepatitis C
Link Hepatitis C Notifications to Treatment in Tasmania
This project will utilise the notification process as a point of intervention to work with primary practitioners (GP) by contacting them directly when a notification of hepatitis C exposure is received by the Tasmanian department…
- Trial name
- NCT04510246
- Testing
- Enhanced case management
- Where
- Australia
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Macfarlane Burnet Institute for Medical Research and Public Health Ltd
Bronchial Asthma
Effect of High Dose Ciclesonide on Asthma Control
The aim of the trial is to investigate asthma control with 160 to 640 mcg ciclesonide/day. Asthma control will be assessed by the Asthma Control Questionnaire (ACQ).
- Trial name
- CONTRAST (NCT01455194)
- Testing
- Ciclesonide
- Where
- 30 sites in Argentina, Brazil and 3 more
- Volunteers
- 520 people
- Sponsor
- AstraZeneca
Zirconia Crowns
Custom-made Zirconia Crowns Versus Prefabricated Zirconia Crowns in Young Permanent Molars
This study aims to compare the clinical performance of Prefabricated Zirconia Crowns (PZCs) with that of Custom-made Zirconia Crowns (CZCs) using enhanced clinical protocols.
- Trial name
- NCT07704151
- Testing
- Prefabricated Zirconia Crown, Custom-made Zirconia Crowns
- Where
- Jordan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Hand Hygiene
Fit Plus: Assessing the Impact of a School-based Intervention on Toilet Quality
This study will assess the impact of a school-based water, sanitation, and hygiene management intervention on toilet use and pupil handwashing in the Philippines.
- Trial name
- NCT03204175
- Testing
- FIT Plus, Comparator arm
- Where
- Philippines
- Volunteers
- 8,687 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Hand Hygiene
Randomised Controlled Trial (RCT) of 6 Versus 3 Steps for Hand Hygiene
The aim is to compare the effectiveness of the 6 step hand rub technique versus 3 step hand rub technique in hand coverage and in reducing bacterial contamination on the hands of healthcare workers in practice.
- Trial name
- SHoRT (NCT02396836)
- Testing
- 6 step technique, 3 step technique
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Glasgow Caledonian University
Autism Spectrum Disorder
Development and Evaluation of a Parent-led Intervention Module for Early Autism Spectrum Disorder (PRIME-ASD) in Odisha, India: Protocol for a Multiphase Mixed-methods Study Including an Open-label Randomised Controlled Trial
Many families of young children with autism in India wait a long time for a diagnosis and specialist therapy, and receive little structured guidance on how to help their child at home.
- Trial name
- NCT07858383
- Testing
- Behavioral: PRIME-ASD (Parent-led Intervention Module for Early Autism Spectrum Disorder), Behavioral: PRIME-ASD; Other: Treatment as usual
- Volunteers
- 188 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Obesity, Childhood, Diet Modification
A Trial to Improve the Healthiness of Packed Lunches in Primary School Aged Children
Public Health England's (PHE) Behavioural Insights Team are leading and fully funding a randomised controlled research trial in collaboration with Derby City Council's Public Health Team and the Health and Social Care Research…
- Trial name
- NCT03104777
- Testing
- Behaviourally Informed Intervention Materials
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Public Health England
Diabetes Mellitus
Trial of Motivational Interviewing in Adolescents With Diabetes
The management of diabetes in adolescence presents significant difficulties due to psychological and physiological factors. Blood glucose control deteriorates in this age group and poor management threatens long-term health.
- Trial name
- NCT00326573
- Testing
- Motivational Interviewing
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Chronic Liver Disease
Efficacy and Safety of Sodium Benzoate in the Management of Hyperammonemia in Infants, Children and Adolescent With Chronic Liver Disease.
Subject will be randomize in two groups. Group A will receive drug packets containing 2.5 gm sodium benzoate and 5 gm powdered table sugar for 5days.Since the dosage of Sodium Benzoate is Sta t250mg/Kg and then 250mg/Kg in next…
- Trial name
- NCT04022941
- Testing
- Sodium Benzoate, Powdered table sugar as palcebo
- Where
- India
- Volunteers
- 108 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Defect of Articular Cartilage
Protected Versus Early Weight Bearing Post Microfracture Surgery
To test using a randomised control trial, whether conservative rehabilitation and protected weight bearing versus early weight bearing and accelerated rehabilitation affects patient outcomes post microfracture surgery of the knee.
- Trial name
- NCT02542566
- Testing
- Physiotherapy rehabilitation
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Hypertension
Study on Impact of Patient-Held Guidelines on Blood Pressure
While patient held guidelines for the management of chronic diseases have been employed in some countries. There is little evidence of their effectiveness in improving patient outcomes.
- Trial name
- NCT00148434
- Testing
- Patient-held guideline for hypertension
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Ashgrove Research Practice
Neutropenia, Febrile, Pediatric Cancer
Early Termination of Empirical Antibiotics in Febrile Neutropenia in Children With Cancer
The study is a nationwide, multicenter, open label, randomized controlled trial. A target population of 220 children in treatment for cancer with neutropenic fever and a neutrophil count below 0.5 × 10⁹ cells/L with expected…
- Trial name
- NCT04637464
- Testing
- Early termination of empirical antibiotics
- Where
- 3 sites in Denmark
- Volunteers
- 93 people
- Sponsor
- Kjeld Schmiegelow
Tic Disorders
Efficacy of Amoxicilline/Clavulanic Acid in Patients Affected by Tic Disorder Colonized by Group A Streptococcus
This study is an extension of the European Multicentre Tics In Children Studies (EMTICS) COURSE study for which a separate study protocol exists; Aim of this clinical trial is to study the efficacy of treatment with antibiotics…
- Trial name
- AntibioTICS (NCT01860300)
- Testing
- Amoxicillin-Potassium Clavulanate Combination
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- University of Roma La Sapienza
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Microscopic Polyangiitis
Rituximab Vasculitis Maintenance Study
Rituximab is now established as an effective drug for anti-neutrophil cytoplasmic antibody (ANCA) vasculitis following major European and US trials reported in 2010. After a time, its effect wears off and the disease can return.
- Conditions
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Microscopic Polyangiitis, Wegener Granulomatosis
- Trial name
- RITAZAREM (NCT01697267)
- Testing
- Rituximab, Azathioprine
- Where
- 38 sites in United States, Australia and 8 more
- Volunteers
- 188 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Antimicrobial Stewardship, Urinary Tract Infections
Nurse-led Antimicrobial Stewardship Intervention to Increase Antibiotic Appropriateness in Residential Aged Care Facilities
The study will explore the impact of a nurse-led bundled antimicrobial stewardship intervention on the appropriateness of antimicrobial use in residential aged care facilities.
- Conditions
- Antimicrobial Stewardship, Urinary Tract Infections, Respiratory Tract Infections, Skin and Soft Tissue Infections
- Trial name
- NCT03941509
- Testing
- Antimicrobial stewardship
- Where
- Australia
- Volunteers
- 700 people
- Sponsor
- Bayside Health
Rehabilitation
Early Rehabilitation in Critical Illness Survivors
Background: Few studies showed that early rehabilitation on the Intensive Care Unit (ICU) results in a better functional outcome at hospital discharge and reduced hospital stay.
- Trial name
- ER (NCT02754505)
- Testing
- Early rehabilitation, Usual care
- Where
- Austria
- Volunteers
- 53 people
- Sponsor
- Danube Hospital
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