Clinical trials: Randomised Controlled Trial
Insomnia
Comparison of the Effects of Support and Non-support Online CBT-I
Insomnia is the most prevalent sleep problem in children and adolescents and it has been found to predict the development of mental health problems in young adulthood.
- Trial name
- NCT05011929
- Testing
- Cognitive behavioral therapy
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Myopia
S.T.O.P.® Technology Contact Lenses Versus Dual-focus Contact Lenses for Slowing Down Myopia Progression in Children
To compare the rate of myopia progression of contact lenses utilising S.T.O.P.® technology against MiSight® contact lenses.
- Trial name
- NCT05243836
- Testing
- S.T.O.P® F2, S.T.O.P® DT, MiSight®
- Where
- 7 sites in China, India and 1 more
- Volunteers
- 441 people
- Sponsor
- nthalmic Pty Ltd
Healthy
Evaluating a Digital Single-session Intervention for Adolescent Mental Health in New Zealand
Currently, one in five rangatahi (young people) in Aotearoa report difficulty accessing support for their mental health concerns.
- Trial name
- NCT06896071
- Testing
- Project SOLVE, Project Success
- Where
- New Zealand
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Waikato
Asthma
RCT of a Written Action Plan vs. Usual Care in Children With Acute Asthma
The objective of the proposed large, high-intensity, randomised controlled trial is to evaluate the real-life effectiveness of providing a written action plan to asthmatic children discharged from the emergency department (ED) or…
- Trial name
- NCT00381355
- Testing
- Written Action Plan for Acute Asthma
- Where
- Canada
- Volunteers
- 218 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Ductus Arteriosus, Patent, Very Low Birth Weight Infants
Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies
The purpose of the study is to determine the safety and efficacy of ibuprofen, compared with indomethacin, in the treatment for the closure of the patent ductus arteriosus in premature babies born under 29 weeks gestation
- Trial name
- NCT00470743
- Testing
- Ibuprofen, Indomethacin
- Where
- Singapore
- Sponsor
- KK Women's and Children's Hospital
Breast Cancer, Lymphedema
Vitamin E and Pentoxifylline in Treating Women With Lymphedema After Radiation Therapy for Breast Cancer
RATIONALE: Vitamin E and pentoxifylline may be effective in decreasing lymphedema in women who have received radiation therapy for breast cancer.
- Trial name
- NCT00022204
- Testing
- vitamin E, pentoxifylline, quality-of-life assessment
- Where
- United Kingdom
- Sponsor
- Royal Marsden NHS Foundation Trust
Anal Fissure Chronic, Anal Fissure
Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial
The study compares the efficacy and safety of a Propionibacterium extract gel with 0.4% glyceryl trinitrate ointment in the treatment of chronic anal fissure.
- Trial name
- NCT05616455
- Testing
- Propionibacterium Acnes, glyceryl trinitrate
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Treviso Regional Hospital
Skin Wound
To Evaluate The Skin Closure Time, Parents' Satisfaction, Post Operative Mental Health, Wound Cosmesis and Wound Complication Of Skin Closure Using Adhesive Glue, Adhesive Tape And Suture In Paediatric Surgery Patients
This study is a randomised controlled trial to evaluate the skin closure time, parents' satisfaction, post operative mental health, wound cosmesis and wound complication of skin closure using adhesive glue, adhesive tape and…
- Trial name
- NCT06713772
- Testing
- Dermabond Mini, 0.36ml, Ethicon Johnson and Johnson, Somerville, New Jersey, USA, Steri-StripsTM (3M, St. Paul, Minnesota, USA, Monosyn, B.Braun, 118 Pfieffewiesen, Melsungen, Germany
- Where
- Malaysia
- Volunteers
- 90 people
- Sponsor
- National University of Malaysia
Trichuriasis, Ascariasis
Efficacy, Safety and Acceptability of Ivermectin ODT in PSAC
This study is a single-blind randomized controlled dose-ranging trial aiming at providing evidence on the on the optimal dose of co-administered ivermectin and albendazole in terms of efficacy, safety and acceptability in…
- Conditions
- Trichuriasis, Ascariasis, Hookworm Infections
- Trial name
- Iverped (NCT06184399)
- Testing
- Ivermectin 1.5 mg ODT, Ivermectin 3 mg Oral Tablet, Albendazole 400 mg Oral Tablet
- Where
- Tanzania
- Volunteers
- 260 people
- Sponsor
- Jennifer Keiser
Infant, Premature
Nasogastric Tube in Premature Babies - Pain and Treatment
Does sucrose or pacifier influence pain in premature babies when a nasogastric tube is inserted?
- Trial name
- NCT00218946
- Testing
- Sucrose, Pacifier, sterile water
- Where
- Norway
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Dermatochalasis, Blepharoptosis
Vibration-Assisted Anaesthesia
Aim of study is to investigate whether a small, non-invasive vibrating device applied to the forehead during local anaesthetic administration reduces the pain of the injection.
- Trial name
- NCT00793988
- Testing
- Vibration-assisted anaesthesia, Switched-off vibrating device
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Acute Watery Diarrhea
Bacillus Clausii Versus Multistrain Probiotics for Acute Watery Diarrhea in Children
This randomized controlled trial will compare Bacillus clausii (Enterogermina) and a multistrain probiotic preparation (Ecotec) in children aged 1-5 years with acute watery diarrhea.
- Trial name
- NCT07660367
- Testing
- Enterogermina, Ecotec
- Where
- Pakistan
- Volunteers
- 138 people
- Sponsor
- Children Hospital and Institute of Child Health, Lahore
Depression and Self-Harm
RCT of the Clinical and Cost Effectiveness of Cognitive Behaviour Therapy (CBT) Delivered Remotely Versus Treatment as Usual in Adolescents and Young Adults With Depression Who Repeatedly Self-harm
A randomized controlled trial to test the whether remote delivery of cognitive based therapy (CBT) is clinically and cost effective when compared to treatment as usual in adolescents and young adults with depression who self-harm.
- Trial name
- eDASH (NCT02377011)
- Testing
- Problem solving cognitive behaviour therapy (PS CBT)
- Where
- 4 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Nottingham
Pelvic Organ Prolapse
A Study of the Effects of Physiotherapy to Prevent Pelvic Organ Prolapse
Pelvic organ prolapse is a problem experienced by women where a bulge comes down in the vagina, and may even drop down outside the vagina.
- Trial name
- PREVPROL (NCT01171846)
- Testing
- Pelvic Floor Muscle training
- Where
- 3 sites in New Zealand, United Kingdom
- Volunteers
- 337 people
- Sponsor
- Glasgow Caledonian University
Food Allergy in Infants, Nut Allergy
The TreEat Study- Can Early Introduction of Tree Nuts Prevent Tree Nut Allergy in Infants With Peanut Allergy
Early and regular ingestion of the common allergens, peanut and egg has been shown to be an effective allergy prevention strategy. It is not clear whether this is also true of tree nut allergy.
- Trial name
- TreEat (NCT04801823)
- Testing
- Home introduction, Multi Nut oral food challenge
- Where
- Australia
- Volunteers
- 212 people
- Sponsor
- Murdoch Childrens Research Institute
Epidural Anesthesia, Infection
The Effect of Combined General-epidural vs General Anaesthesia on Postoperative Gastrointestinal Surgery
Sixty neonates and infants will be enrolled and randomised into two groups of n=30 each . For their surgical procedures, one group general (GA) anaesthesia the second group will receive a combined general and epidural anaesthesia…
- Conditions
- Epidural Anesthesia, Infection, Infant, Newborn, Diseases
- Trial name
- NCT03056261
- Testing
- Combined general and epidural, General anaesthesia
- Volunteers
- 60 people
- Sponsor
- Bnai Zion Medical Center
Twin; Complicating Pregnancy, Microwave Ablation
Microwave Ablation vs Radiofrequency Ablation in the Management of Complicated Monochorionic Pregnancies：A RCT Study
Complicated pregnancies refer some special complications, including twin to twin transfusion syndrome(TTTS), twin reverse arterial perfusion(TRAP), selective intrauterine fetal growth restriction(sIUGR), twin anemia-polycythemia…
- Trial name
- MWAvsRFA (NCT04014452)
- Testing
- Microwave ablation, Radiofrequency ablation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Pain, Acute, Anxiety
The Effect of VR on Pain, Anxiety And Fear During Venipuncture in Children
The use of non-pharmacological applications such as virtual reality,and bubbles are recommended in intravenous interventions. There are very few studies evaluating the effect of non-pharmacological applications in intravenous…
- Conditions
- Pain, Acute, Anxiety, Fear
- Trial name
- VR (NCT06527092)
- Testing
- Virtual Reality, Bubbles
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Ege University
Gastric Cancer (Diagnosis)
Two-component Radiology-guided Autonomous Cascade Engine (TRACE)
This study employed a prospective, randomised crossover trial design to evaluate the clinical utility of the TRACE artificial intelligence system for gastric cancer T-staging.
- Trial name
- TRACE (NCT07651644)
- Testing
- Utilizing the TRACE model to assist radiologists in T-staging, washout period
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Liaoning Cancer Hospital & Institute
Breast Cancer
Phase II Neoadjuvant ER+/PgR + Arimidex +/- Iressa Study
The purpose of this study is to compare the changes in a proliferation biomarker in subjects receiving Anastrozole or Anastrozole/ZD1839 combination.
- Trial name
- NCT00255463
- Testing
- Anastrazole, Gefitinib
- Where
- 34 sites in Czechia, France and 5 more
- Volunteers
- 185 people
- Sponsor
- AstraZeneca
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