Clinical trials: Randomised Controlled Trial
Visceral Leishmaniasis, Kala Azar
Efficacy, Acceptability and Cost-effectiveness of Long Lasting Insecticide Nets (LLIN) in the Prevention of Kala Azar
A cluster-randomized vector control trial in Bihar, India, and neighboring Nepal, will test the efficacy of long-lasting impregnated bednets (LLINs, Permanets) for reducing visceral leishmaniasis incidence.
- Trial name
- KALANET (NCT00318721)
- Testing
- Long Lasting Impregnated Nets (LLIN)
- Where
- 2 sites in India, Nepal
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Premature Birth, Late-onset Invasive Infection
Speed of Increasing Milk Feeds Trial
Survival of preterm infants has increased greatly over the years, so a major aim now is to improve the long term outlook for these babies and to avoid serious complications.
- Conditions
- Premature Birth, Late-onset Invasive Infection, Necrotizing Enterocolitis
- Trial name
- SIFT (NCT01727609)
- Testing
- Milk feed (breast milk or formula milk)
- Where
- 57 sites in Ireland, United Kingdom
- Volunteers
- 2,804 people
- Sponsor
- University of Oxford
Asthma
Self-management Intervention to Improve Adolescents' Asthma Control
Approximately 1.1 million children and young people in the United Kingdom (UK) are living with asthma, making it the most common chronic disease in children in the UK.
- Trial name
- MAIS (NCT03536416)
- Testing
- My Asthma in School
- Where
- United Kingdom
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Trigeminal Neuralgia
Comparision Efficacy of Carbamazepine & Oxcarbazepine in the Treatment of Trigeminal Neuralgia- a Randomised Clinical Trial
Trigeminal neuralgia is a neuropathic facial pain condition, characterized by unilateral paroxysmal pain which can be described as stabbing or electric shock like, in the distribution of one or more divisions of trigeminal nerve…
- Trial name
- NCT04996199
- Testing
- Oxcarbazepine, Carbamazepine
- Where
- 2 sites in India
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Strength, Stress
Effects of Root Extract Ashwagandha (KSM-66) on Perception of Recovery and Muscle Strength in Adolescents Aged 11 to 19 Engaged in Grassroots Football
This study will test whether six weeks of ashwagandha (KSM-66 root extract), helps teenage footballers recover and improve strength.
- Conditions
- Strength, Stress, Exercise Adaptation, Sleep
- Trial name
- NCT07890935
- Testing
- Ashwagandha
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sports Performance and Applied Research in Trials and Analysis
Antibiotic Prophylaxis, Colorectal Surgery
Colo-Pro_2: Bolus-continuous Infusion Cefuroxime Prophylaxis for the Prevention of Infections After Colorectal Surgery
After a surgical operation patients may have an infection in the operation wound, the bladder, kidneys or lungs. To stop these infections patients are given a dose of antibiotic before their operation.
- Trial name
- NCT05609240
- Testing
- Cefuroxime
- Where
- 3 sites in United Kingdom
- Volunteers
- 180 people
- Sponsor
- University of Leeds
Malaria
Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria
Acute kidney injury is a common complication of severe Plasmodium knowlesi malaria, and an important contributor to mortality. The exact pathogenic mechanisms of AKI in knowlesi malaria are not known, however it is hypothesised…
- Trial name
- PACKNOW (NCT03056391)
- Testing
- Paracetamol
- Where
- 4 sites in Malaysia
- Volunteers
- 360 people
- Sponsor
- Menzies School of Health Research
Severe Acute Malnutrition
A Trial of n-3 PUFA-Enriched Ready to Use Therapeutic Food for Childhood Severe Malnutrition
The investigators will perform a randomised controlled trial of the provision of food designed for rehabilitation of malnourished children that is supplemented with n-3 fatty acids compared to usual composition.
- Trial name
- Njugu Plus (NCT01593969)
- Testing
- RUTF/Flax Oil, RUTF/Flax Oil plus additional Fish Oil, Standard RUTF
- Where
- Kenya
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Apnoeic Oxygenation
Apnoeic Oxygenation by Nasal Cannula During Airway Management in Children Undergoing General Anaesthesia.
Airway management is a core clinical skill in anaesthesia. Pre-oxygenation prior to induction of anaesthesia is standard practice to prevent desaturation.
- Trial name
- NCT03271827
- Testing
- Apnoeic oxygenation
- Volunteers
- 30 people
- Sponsor
- University of Birmingham
Type 2 Diabetes, Chronic Disease
PRE-STARt Intervention - Trial of an Interactive Family Based Lifestyle Programme
To investigate whether the interactive family based lifestyle programme leads to behaviour change at 6 months with the primary outcome being increased levels of moderate to vigorous physical activity (MVPA).
- Conditions
- Type 2 Diabetes, Chronic Disease, Obesity
- Trial name
- NCT02845791
- Testing
- Interactive Lifestyle programme workshop
- Where
- United Kingdom
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Scoliosis Idiopathic
Self Correction Exercises for Idiopathic Scoliosis Among Adolescents. A Randomised Controlled Trial
Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity with an unknown cause that affects adolescents aged 10 or older.
- Trial name
- NCT03779581
- Testing
- Self Correction exercises, orthotic devices
- Where
- Saudi Arabia
- Volunteers
- 108 people
- Sponsor
- Majmaah University
Influenza
ADITEC FLU STUDY: Understanding the Genetic Basis for Immune Responses
Infants and young children do not respond as well as adults to the flu vaccines currently available in the UK. Fluad, is a different type of influenza vaccine that has been available in the European continent for the last decade…
- Trial name
- NCT01682369
- Testing
- TIV (Aggripal), ATIV (Fluad)
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Human Immunodeficiency Virus
Reduction of EArly mortaLITY in HIV-infected Adults and Children Starting Antiretroviral Therapy
A randomised controlled trial to investigate three methods to reduce early mortality in adults, adolescents and children aged 5 years or older starting antiretroviral therapy (ART) with severe immuno-deficiency.
- Trial name
- REALITY (NCT01825031)
- Testing
- Raltegravir, Fluconazole, Azithromycin
- Where
- 8 sites in Kenya, Malawi and 2 more
- Volunteers
- 1,805 people
- Sponsor
- Anna Griffiths, MRC
Brain Injuries
Manual-Based Vocational Rehabilitation Program for Patients With Acquired Brain Injury
An acquired brain injury (ABI) is a complex injury often followed by a broad range of cognitive, physical, emotional, and behavioral disabilities.
- Trial name
- NCT03086031
- Testing
- Program -based vocational rehabilitation intervention, Conventional vocational rehabilitation (controls)
- Volunteers
- 84 people
- Sponsor
- Brain Injury Center BOMI, Roskilde, Denmark
Malaria
Restricting the Use of Artesunate Plus Amodiaquine Combination Therapy to Malaria Cases Confirmed by a Dipstick Test: A Cluster Randomised Control Trial
Effective use of Rapid Diagnostic Test (RDT) and artemisinin-based combination therapy (ACT) depends on the accuracy and safety of RDT based treatment practices and on factors related to the health delivery system.
- Trial name
- RDT-ACT (NCT00832754)
- Testing
- RDT, Clinical Judgement as basis for treatment of malaria with ACT
- Where
- Ghana
- Volunteers
- 3,063 people
- Sponsor
- Kintampo Health Research Centre, Ghana
Neonatal Hypoglycemia, Metabolic Complication
Pasteurised Donor Human Milk Supplementation for Term Babies
PRESENT is a multi-center randomised controlled trial that aims to assess whether access to pasteurized donor human milk as supplementary nutrition in the first five days of life for term infants born to women with diabetes in…
- Conditions
- Neonatal Hypoglycemia, Metabolic Complication, Cows Milk Allergy, Hospital Length of Stay
- Trial name
- PRESENT (NCT06993103)
- Testing
- Standard care Cow's milk based formula, Dietary Supplement: PDHM Pasteurised Donor Human Milk
- Where
- 4 sites in Australia
- Volunteers
- 1,444 people
- Sponsor
- The University of Queensland
Preterm Infant, Birth, Preterm
Aeration, Breathing, Clamping Study 3
Delayed cord clamping (DCC) in preterm infants results in a decrease in mortality and a trend towards fewer intraventricular haemorrhages.
- Trial name
- ABC3 (NCT03808051)
- Testing
- Physiological-based cord clamping, Time-based cord clamping
- Where
- 10 sites in Netherlands
- Volunteers
- 689 people
- Sponsor
- Leiden University Medical Center
Patent Ductus Arteriosus
Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus
The purpose of this pilot trial is to study efficacy and safety of simultaneous intravenous (iv) ibuprofen/indomethacin and paracetamol medications in the closure of patent ductus arteriosus (PDA) in preterm infants.
- Trial name
- PAI (NCT03648437)
- Testing
- Paracetamol 10Mg/mL, 0.45% Sodium Chloride, Ibuprofen
- Where
- 4 sites in Finland
- Volunteers
- 22 people
- Sponsor
- University of Oulu
Lupus Nephritis, Systemic Lupus Erythematosus (SLE)
Induction Therapy for Lupus Nephritis With no Added Oral Steroids: A Trial Comparing Oral Corticosteroids Plus Mycophenolate Mofetil (MMF) Versus Obinutuzumab and MMF
This is a randomised, open label, controlled non-inferiority phase III multicentre trial. As primary objective, the study aims to demonstrate that a regimen free of additional oral corticosteroids but with obinutuzumab (and MMF)…
- Trial name
- OBILUP (NCT04702256)
- Testing
- Obinutuzumab administration, Administration of Methylprednisolone + Prednisone + Mycophenolate mofetil, Administration of methylprednisolone, paracetamol and dexchlorpheniramine
- Where
- France
- Volunteers
- 196 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Child Abuse
Effect E-learning Program About Child Maltreatment
The purpose of this study is to determine whether the e-learning program about the recognition of child maltreatment is effective in nurses on the A\&E department compared to a control group.
- Trial name
- NCT00844571
- Testing
- E-learning program
- Volunteers
- 38 people
- Sponsor
- UMC Utrecht
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