Clinical trials: Randomised Controlled Trial
COVID-19
Intranasal Heparin Treatment to Reduce Transmission Among Household Contacts of COVID 19 Positive Adults and Children
Coronavirus-induced disease 2019 (COVID-19) is an infection caused by a virus whose full name is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- INHERIT (NCT05204550)
- Testing
- unfractionated heparin, 0.9%sodium chloride
- Where
- Australia
- Volunteers
- 506 people
- Sponsor
- Murdoch Childrens Research Institute
Parenting
The Incredible Years Parents and Babies Program in Denmark
The purpose of the pilot study is to examine the effects of the Incredible Years Baby Programme (IY baby) offered as a universal intervention compared to Usual Care (UC) for parents with infants aged 0-12 months.
- Trial name
- NCT01931917
- Testing
- Incredible Years Parents and Babies Program, Usual Care
- Where
- Denmark
- Volunteers
- 112 people
- Sponsor
- VIVE - The Danish Center for Social Science Research
Nutrition, Healthy
Testing the Veggie Brek Intervention
This programme of work aims to investigate the feasibility and acceptability to both children and nursery staff of offering vegetables to children at breakfast time at nursery.
- Trial name
- NCT05217550
- Testing
- Veggie Brek
- Where
- United Kingdom
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Pelvic Organ Prolapse
Multi-centre Randomised Controlled Trial of Pelvic Floor Muscle Training for Prolapse
The aim of this study is to determine the effectiveness and cost-effectiveness of pelvic floor muscle training in the management of pelvic organ prolapse in women.
- Trial name
- POPPY (NCT00476892)
- Testing
- Pelvic Floor Muscle Training
- Where
- 28 sites in Australia, Ireland and 2 more
- Volunteers
- 448 people
- Sponsor
- Glasgow Caledonian University
Acute Respiratory Distress Syndrome (ARDS)
Dexamethasone Treatment for Sepsis-associated Acute Respiratory Distress Syndrome: a Multicenter, Randomised, Double-blinded, Controlled Trial
Acute respiratory distress syndrome (ARDS) is a major cause of acute hypoxemic respiratory failure in critically ill patients and is associated with substantial mortality.
- Trial name
- DEFEND (NCT07576660)
- Testing
- Dexamethasone
- Where
- 2 sites in China
- Volunteers
- 1,704 people
- Sponsor
- Southeast University, China
Vitamin A Deficiency, Maternal Mortality
Trial of the Impact of Vitamin A on Maternal Mortality
Main objectives: To evaluate the impact of weekly vitamin A supplementation (VAS) to women of reproductive age (15-45 years) on maternal mortality in rural Ghana, and to compare this with the impact on overall mortality.
- Conditions
- Vitamin A Deficiency, Maternal Mortality, Maternal Morbidity
- Trial name
- ObaapaVitA (NCT00211341)
- Testing
- Vitamin A
- Where
- Ghana
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Tobacco Prevention
Effectiveness of an Online Quiz in Promoting Tobacco-Related Knowledge, Attitudes, and Behaviours Among Primary Students
The goal of this modified pilot RCT is to evaluate the effects of the intervention (online platform) on tobacco-related knowledge, attitudes and intentions on smoking among local primary 5-6 school students.
- Trial name
- NCT06913166
- Testing
- Online quiz competition
- Where
- Hong Kong
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Female Genital Schistosomiasis
A Phase III Trial to Evaluate the Safety and Efficacy of Anti-inflammatory Drugs in Addition to Praziquantel in Girls and Women With Female Genital Schistosomiasis
Female Genital Schistosomiasis (FGS) is a neglected complication of Schistosoma haematobium infection affecting an estimated 56 million women and girls globally, with a high burden in sub-Saharan Africa.
- Trial name
- WINGS-4-FGS (NCT07915518)
- Testing
- Praziquantel 80, Prednisolone, Diclofenac
- Where
- 4 sites in Côte d’Ivoire, Democratic Republic of the Congo and 2 more
- Volunteers
- 800 people
- Sponsor
- Brian Ngwira
Stammering
Pilot: Group Therapy for Children Who Stammer
The aim of the study is to answer the question: Is a large-scale research study of the effectiveness of group speech and language therapy (SALT) for young people who stammer possible? The study will look at the issues involved in…
- Trial name
- NCT00945113
- Testing
- One-week speech therapy group
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Role, Nurses
Clarification of Nurses' Expected Role in Health Promotion
The purpose of this study is to implement and evaluate ROLE-AP, a multi-component program to clarify primary care nurses' expected role in health promotion.
- Trial name
- ROLE-AP (NCT04726696)
- Testing
- ROLE-AP programme
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Rotator Cuff Tear
Treatment of Small Acute Cuff Tears, a Randomized Study
The purpose of this project is to compare operative repair of traumatically torn rotator cuff tendon with physiotherapy in a randomized prospective study.
- Trial name
- NCT02059473
- Testing
- Rotator cuff repair, Physiotherapy
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- University Hospital, Linkoeping
Body Weight, Nutrition Processes
Effectiveness Evaluation of Three Strategies of Promotion of Healthy Dietary and Physical Activity Behaviours to Prevent Weight Excess Among Teenagers
The aim of this study is to compare the effectiveness of three public health intervention strategies to reduce weight excess and obesity prevalence among teenagers within the frame of a public health program aiming at promoting…
- Conditions
- Body Weight, Nutrition Processes, Prevention
- Trial name
- PRALIMAP (NCT00814554)
- Testing
- Educational strategy, Screening strategy, Environmental strategy
- Where
- France
- Volunteers
- 5,458 people
- Sponsor
- University of Nancy
Intestinal Parasitic Infections, Anaemia
Impact of Hand Hygiene Activities on the Prevention of Intestinal Parasitic Infections and Anaemia Among School Children
Impact exerted by intestinal parasitic infections is much higher in developing countries. School-aged children are at higher risk from the burden of disease, because they specially have many parasitic infections.
- Trial name
- NCT01619254
- Testing
- Hand washing with soap and hand finger nail clipping
- Where
- Ethiopia
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- Mekelle University
Parental Anxiety, Children's Safety
Randomised Controlled Trial to Investigate the Effect of Parental Presence at Intensive Care Unit to Ward Transfer Bedside Rounds on Parental Anxiety and Children's Safety
The investigators shall conduct a randomized controlled trial to investigate the effect of parental presence at transfer rounds on parental anxiety and patient safety following transfer from the Pediatric Cardiac Intensive Care…
- Trial name
- NCT01883739
- Testing
- Parental Presence at Handover Rounds
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Coronary Artery Disease
Programme to Optimise Risk Factors in Patients Waiting for Coronary Artery Bypass Surgery
The time spent waiting for heart surgery can be extremely stressful. This programme aims to address this by providing a home-based, nurse-led support and education programme.
- Trial name
- NCT00124371
- Testing
- a nurse led home-based education and support programme
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Diarrhea, Respiratory Tract Infections (RTI)
Impact Evaluation of Accelerating Climate-Resilient Water, Sanitation and Hygiene Services for Schools and Healthcare Facilities in Karamoja
Karamoja, in north-eastern Uganda, is among the most water-insecure regions in sub-Saharan Africa. Only 24 per cent of households can access the WHO-recommended 20 litres of water per person per day.
- Conditions
- Diarrhea, Respiratory Tract Infections (RTI), Menstrual Hygiene, Absenteeism
- Trial name
- NCT07823231
- Testing
- Climate-resilient school WASH infrastructure package, WASH and menstrual health capacity building and social and behaviour change package
- Where
- Uganda
- Volunteers
- 16,380 people, healthy volunteers welcome
- Sponsor
- Elijah Kipchumba
Narcolepsy Type 1
Temporal Interference Stimulation of Hypothalamus in Patients With Narcolepsy Type 1
Narcolepsy type 1 (NT1) is a chronic brain disorder caused by selective loss or dysfunction of orexin (hypocretin) neurons in the lateral hypothalamus, for which current pharmacological treatments offer limited efficacy.
- Trial name
- TINY (NCT07727239)
- Testing
- Active Temporal Interference Stimulation
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Xijing Hospital
Fractured Hip
Does Early Ambulation After Hip Fracture Surgery Accelerate Recovery?
Hip fractures are a significant problem for healthcare providers due to the increasing incidence of fractures in an ageing population.
- Trial name
- NCT00224367
- Testing
- time to first ambulation
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Bayside Health
Snake Bites
Improving Safety of Antivenom in People Bitten by Snakes
A study to increase the safety of polyvalent antivenom involving 1000 patients in three centres: low dose adrenaline, promethazine, \& hydrocortisone (alone and in combination) to prevent acute adverse reactions to antivenom in…
- Trial name
- NCT00270777
- Testing
- adrenaline, promethazine, hydrocortisone
- Where
- Sri Lanka
- Volunteers
- 1,000 people
- Sponsor
- University of Kelaniya
Pneumonia
Vitamin-D Supplementation: Impact on Severe Pneumonia Among Under-five Children
Background: Burden: Pneumonia is the leading cause of morbidity and mortality in under-five children, particularly in developing countries.
- Trial name
- Vitamin-D (NCT02185196)
- Testing
- Vitamin D3
- Where
- Bangladesh
- Volunteers
- 197 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
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