Clinical trials: Randomised Controlled Trial
Malaria,Falciparum
A Study to Test Experimental Blood Stage Malaria Vaccine in Burkina Faso.
This is a Phase IIb randomised controlled trial of the safety, immunogenicity and efficacy of the blood-stage malaria vaccine candidates RH5.1 in Matrix-MTM and RH5.2-VLP in Matrix-MTM in infants aged 5-17 months in Burkina Faso
- Trial name
- NCT05790889
- Testing
- Rabies vaccine, RH5.1 10μg adjuvated with 50μg Matrix-M, RH5.2 5μg adjuvated with 50μg Matrix-M
- Where
- Burkina Faso
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Medical Education, Point of Care Ultrasound (POCUS)
Video-Based Versus Bedside eFAST Training in Final-Year Medical Students
This study compared two methods of teaching the Extended Focused Assessment with Sonography for Trauma (eFAST) examination to final-year medical students.
- Conditions
- Medical Education, Point of Care Ultrasound (POCUS), eFast
- Trial name
- NCT07790497
- Testing
- Standardized Video-Based eFAST Training, Instructor-Led Bedside eFAST Training
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gorkem Alper Solakoglu
Brain Injuries
Manual-Based Vocational Rehabilitation Program for Patients With Acquired Brain Injury
An acquired brain injury (ABI) is a complex injury often followed by a broad range of cognitive, physical, emotional, and behavioral disabilities.
- Trial name
- NCT03086031
- Testing
- Program -based vocational rehabilitation intervention, Conventional vocational rehabilitation (controls)
- Volunteers
- 84 people
- Sponsor
- Brain Injury Center BOMI, Roskilde, Denmark
Colon Cancer
The Impact of Palm Date Intake on Colon Health Biomarkers
This aim of this study is to investigate the prebiotic potential of date fruits in healthy human volunteers compared to a control diet. Each arm was 21 days in duration, separated by a 14 days washout period.
- Trial name
- AJWA (NCT02288611)
- Testing
- Date fruit - Ajwa variety, Maltodextrin/Dextrose
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Reading
Duchenne Muscular Dystrophy
Tamoxifen in Duchenne Muscular Dystrophy
A randomised, double blind, placebo controlled, 48-week clinical trial with a core population (group A) of 79 ambulant 6.5 to 12 years old Duchenne's muscular dystrophy (DMD) patients that are under stable standard treatment of…
- Trial name
- TAMDMD (NCT03354039)
- Testing
- Tamoxifen
- Where
- 11 sites in France, Germany and 4 more
- Volunteers
- 93 people
- Sponsor
- University Hospital, Basel, Switzerland
Brain Concussion, Post-Concussion Syndrome
Early Intervention Programme for Young Patients (Aged 15 - 30 Years) With Symptoms Following Concussion.
Background: Five - 15 % of patients with concussion continue to experience impairing physical, cognitive and emotional symptoms longer than 3 months post-injury.
- Trial name
- NCT02337101
- Testing
- Enhanced Usual Care (EUC), EUC + Early intervention programme
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Aarhus
Antenatal Care
Strategies to Increase Antenatal Iron and Folic Acid Supplementation and Malaria Prophylaxis
Pregnancy increases the risk of malaria and nutritional deficiency. Despite some progress in ANC access over the past years, coverage of antenatal iron and folic acid supplementation (AIFAS) and intermittent preventive treatment…
- Trial name
- AIFASMaP (NCT04250428)
- Testing
- Demand intervention, Supply intervention
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Centre Suisse de Recherches Scientifiques en Cote d'Ivoire
Adolescent Idiopathic Scoliosis, Patient Engagement
Designing Multimedia Patient Education for Adolescent Idiopathic Scoliosis
The goal of this triple-masked three-armed feasibility randomised controlled trial is to compare patient education materials for participants with adolescent idiopathic scoliosis.
- Trial name
- PEMAIS (NCT06090344)
- Testing
- Traditional video format, Evidence-informed video format
- Where
- Ireland
- Volunteers
- 46 people
- Sponsor
- University College Dublin
Cannabis Use Disorder
Cannabidiol: a Novel Intervention for Cannabis Use Problems?
The purpose of this trial is to investigate a novel treatment for cannabis dependence: cannabidiol. Between 96 and 168 young people who want to quit cannabis and meet criteria for moderate cannabis use disorder (DSM-5) will be…
- Trial name
- NCT02044809
- Testing
- Cannabidiol
- Where
- United Kingdom
- Volunteers
- 82 people
- Sponsor
- University College, London
Autism
Autism - Children's Improvisational Music Therapy Evaluation
The goal of this clinical trial is to evaluate the effectiveness of individual sessions of improvisational music therapy for autistic children aged 7 - 11.
- Trial name
- CHIME (NCT06016621)
- Testing
- Improvisational Music Therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 240 people
- Sponsor
- Prof Simon Baron-Cohen
Marfan Syndrome
The Oxford Marfan Trial
The primary objective of the trial is to estimate the effects of allocation to irbesartan, or doxycycline, or a combination of both irbesartan and doxycycline, compared with placebo, on measures of elastic function of the aorta…
- Trial name
- NCT01949233
- Testing
- Irbesartan 150-300mg capsules daily for 6 months, Doxycycline 100-200mg capsules daily for 6 months
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people
- Sponsor
- University of Oxford
Knee Osteoarthritis
Bespoke vs Standard Instrumentation in TKR
Total knee replacement (TKR) is an established treatment for knee osteoarthritis and leads to a satisfactory outcome in over 75% of patients.
- Trial name
- NCT02845206
- Testing
- Patient specific cutting blocks, Conventional cutting blocks
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- NHS Lothian
Hypertension
The Impact of Yoga on Blood Pressure and Quality of Life in Patients With Hypertension
The purpose of this study is to determine the effects of yoga on blood pressure and quality of life in patients in primary health care diagnosed with hypertension within the last year.
- Trial name
- YHIP (NCT01302535)
- Testing
- Yoga group with supervision (trainer), Yoga at home
- Where
- Sweden
- Volunteers
- 83 people
- Sponsor
- Region Skane
Renal Transplantation
Fibrin Sealant in Renal Transplantation
Background: Post-operative wound complications arise in as many as 50% of kidney transplant recipients. Fibrin sealants have been used in many areas of surgery in attempt to reduce the accumulation of post-operative fluid…
- Trial name
- NCT00910052
- Testing
- Tisseelä fibrin sealant
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Hennepin County Medical Center, Minneapolis
Infection, Catheter-Related, Central Line-associated Bloodstream Infection (CLABSI)
Ethanol-lock Therapy for the Prevention of Non-tunneled Catheter-related Infection in Pediatric Patients
Central venous catheter (CVC) infection is a common complication in pediatric patients, resulting in prolonged length of stay in hospital, requiring antibiotics, invasive procedures and increase morbidity and mortality.
- Conditions
- Infection, Catheter-Related, Central Line-associated Bloodstream Infection (CLABSI), Pediatric
- Trial name
- E-LockPed (NCT03253887)
- Testing
- Ethanol-lock
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Moderate Acute Malnutrition (MAM)
Comparison of Four Different Supplementary Foods in the Treatment of Moderate Acute Malnutrition (MAM) in Children in Sierra Leone: a Cluster-randomised, Controlled Clinical Effectiveness Trial
The objective of this study is to test and compare the effectiveness and cost-effectiveness of four supplementary foods for the treatment of moderate acute malnutrition (MAM) in normal programmatic settings in Sierra Leone.
- Trial name
- NCT02077907
- Testing
- Super Cereal Plus (SC+), Super Cereal (SC), fortified oil, sugar, Plumpy Sup
- Volunteers
- 1,147 people, healthy volunteers welcome
- Sponsor
- Tufts University
Peripheral Artery Disease
Effects of Message Content on Intention to Quit Smoking
Message framing involves "the presentation of choice alternatives, either in a positive or negative manner" (Huber, Neale, \& Northcraft, 1987; p.137).
- Trial name
- NCT02138032
- Testing
- Gains Framed Message, Loss Framed Message
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Stirling
Narcolepsy Type 1
Temporal Interference Stimulation of Hypothalamus in Patients With Narcolepsy Type 1
Narcolepsy type 1 (NT1) is a chronic brain disorder caused by selective loss or dysfunction of orexin (hypocretin) neurons in the lateral hypothalamus, for which current pharmacological treatments offer limited efficacy.
- Trial name
- TINY (NCT07727239)
- Testing
- Active Temporal Interference Stimulation
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Xijing Hospital
Depression
School-based IPT-G for Adolescents With Depression in Nepal: a Pilot Realist C-RCT
Globally a third of adolescents are at risk of depression with negative consequences for their health and development. Most of the world's adolescents live in low- and middle-income countries (LMICs) where access to treatment for…
- Trial name
- SAATHI-2 (NCT06017700)
- Testing
- Interpersonal Psychotherapy Group, Enhanced Usual Care
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Transcultural Psychosocial Organization Nepal
Speech and Language Therapy
Parent-based Intervention for Language Delayed 2 to 3 Year Olds
The aim of the study is to evaluate the impact of parent based intervention on the language of 2 to 3 year old children from socially disadvantaged populations with a clinical diagnosis of primary language delay.
- Trial name
- NCT03083236
- Testing
- Standard PBI, Enhanced
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Solent NHS Trust
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