Clinical trials: Randomised Controlled Trial
Difficulty Writing
Effectiveness of the Occupational Therapy Handwriting Intervention Guideline on Children
This study aims to evaluate the effectiveness of the Occupational Therapy Handwriting Interventions Guidelines (OTHIG) in enhancing handwriting performance among children.
- Trial name
- NCT05217394
- Testing
- OTHIG
- Where
- 4 sites in Malaysia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Pain Score Reduction, Effectiveness of Acetaminophen
Effectiveness Of Intravenous Vs Rectal Acetaminophen For Pain Management In Post Operative Neonates
This randomized controlled trial aims to evaluate the effectiveness of intravenous (IV) versus rectal acetaminophen for postoperative pain management in neonates.
- Conditions
- Pain Score Reduction, Effectiveness of Acetaminophen, Postoperative Pain Management in Neonates, Rescue Analgesia
- Trial name
- NCT06638086
- Testing
- Acetaminophen Suppositories, Acetaminophen Injection
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Rawalpindi Medical College
Violence, Physical, Violence
Preventing Violence Against Children in Schools Study
To date, no interventions to prevent violence in refugee camp schools have ever been rigorously evaluated. The primary objective of this project is to test the effectiveness of the Empateach intervention to prevent physical…
- Conditions
- Violence, Physical, Violence, Child Abuse, Violence Against Children
- Trial name
- PVACS (NCT03745573)
- Testing
- Empateach
- Volunteers
- 2,120 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Hemorrhage
Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage
CRASH 2 is a large pragmatic randomised placebo controlled trial of the effects of the early administration of the antifibrinolytic agent tranexamic acid on death, vascular events and transfusion requirements.
- Trial name
- NCT00375258
- Testing
- Tranexamic acid, Sodium Chloride 0.9%
- Where
- United Kingdom
- Volunteers
- 20,211 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Steroid-refractory Acute Graft-versus-host Disease
Trial of Efficacy and Safety of MC0518 Versus Best Available Therapy in Participants With Steroid-Refractory Acute Graft Versus Host Disease
The purpose of this trial is the comparative evaluation of overall response rate (ORR) in paediatric participants with steroid-refractory acute graft-versus-host disease (SR-aGvHD) at Visit Day 28 after treatment with MC0518 or…
- Trial name
- BALDER (NCT06075706)
- Testing
- MC0518, BAT
- Where
- 36 sites in France, Germany and 3 more
- Volunteers
- 49 people
- Sponsor
- medac GmbH
Infant Sleep Problems, Circadian Rhythm
Chrononutrition in Preterm Infants: a Randomised Controlled Trial of Time-matched Breast Milk Feeding and Its Effects on Sleep and Circadian Development
This study investigates whether the timing of feeding expressed breast milk influences infant sleep and circadian (day-night) development in preterm infants.
- Conditions
- Infant Sleep Problems, Circadian Rhythm, Neurodevelopment
- Trial name
- NCT07533578
- Testing
- Chronobiologically Timed Feeding of Expressed Breast Milk, Usual Feeding Practice (Untimed Expressed Breast Milk)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Luzerner Kantonsspital
Obesity, Overweight
FutureShape Family
The number of adults and children living with obesity is increasing worldwide. Once childhood obesity has developed, more than 80% of children carry the obesity into adulthood, with a high risk of cardiometabolic disease, poor…
- Trial name
- NCT07872904
- Testing
- Family Care, Standard Care, Semaglutide (administered by PDS290 pen-injector)
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Signe Torekov
Preterm Infant, Hypothermia, Newborn
Early Kangaroo Mother Care in Gambian Hospitalised Unstable Neonates
The mortality effect of kangaroo mother care in stable newborns <2000g is well established but mortality effect in unstable newborns is not conclusively known.
- Conditions
- Preterm Infant, Hypothermia, Newborn, Death, Kangaroo Mother Care
- Trial name
- eKMC (NCT03555981)
- Testing
- Early Kangaroo Mother Care, Standard care
- Where
- The Gambia
- Volunteers
- 279 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Health Care Workers
Hand Hygiene Intervention Study
Infections acquired by patients in hospitals are a major cause of illness and death worldwide, and particularly so in hospitals with very limited resources.
- Trial name
- HAND (NCT01933087)
- Testing
- Hand hygiene promotion
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Hematologic Cancer, Leukaemia
Digitalized Exercise Fit Tool Intervention for Adolescents With Blood Cancer
The goal of this clinical trial is to learn if a digitalised Exercise Fit Tool (EFT) mobile application can promote physical activity in adolescents aged 12-18 years who have completed treatment for hematologic cancer (e.g.…
- Conditions
- Hematologic Cancer, Leukaemia, Lymphoma, Physical Activity
- Trial name
- NCT07621887
- Testing
- Digitalized Exercise Fit Tool Intervention, Usual Care
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Back Pain
Injection Treatment of Corticosteroid to Pelvic Ligament Insertions on Women With Longlasting Backpain After Pregnancy
To evaluate the pain relief effect of locally injected corticosteroid treatment in women with long-lasting low back pain beginning in pregnancy.
- Trial name
- NCT00757016
- Testing
- Triamcinolone, Saline solution
- Where
- Sweden
- Volunteers
- 38 people
- Sponsor
- Sundsvall Hospital
Thrombocytopenia, Transfusion
Study Comparing Platelet Transfusion Volumes in Premature Babies
Platelet transfusions can help clotting but may also have risks. Currently when babies get platelet transfusions they get as much as three times (per kilogram of body weight) as much as adults do.
- Trial name
- PlaNeT-3 (NCT06095648)
- Testing
- Dose of platelet transfusion
- Where
- Ireland
- Volunteers
- 370 people
- Sponsor
- University College Dublin
Malnutrition
Effects of Fortified Complementary Foods on Vitamin A Status and Body Pool Size in Ghanaian Infants.
This study tried to prove that children given food supplements containing vitamin A would have better liver vitamin A stores than children given food supplements without vitamin A over a 5 month period.
- Trial name
- vitapool (NCT01751009)
- Testing
- Vitamin A supplements, Sprinkles without Vitamin A
- Where
- Ghana
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Kintampo Health Research Centre, Ghana
Dental Anxiety
Effectiveness of Auricular Acupuncture in Reducing Dental Anxiety and Pain Perception During Orthodontic Extractions Among Adolescents
This prospective, randomised, double-blinded cross-over study aims to compare the effectiveness of auricular acupuncture (AA) with placebo sham acupuncture (PSA) in reducing dental anxiety, pain perception and physiological…
- Trial name
- NCT06434844
- Testing
- Auricular acupunctures
- Where
- Hong Kong
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Sickle Cell Disease
Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphine
The use of oral ibuprofen combined with Opioid (Morphine or Diamorphine) administered through patient controlled analgesia (PCA) will be clinically effective for acute pain crisis in adults with sickle cell disease (SCD).
- Trial name
- SWIM (NCT00880373)
- Testing
- Ibuprofen, Diamorphine or Morphine
- Where
- 2 sites in United Kingdom
- Volunteers
- 320 people
- Sponsor
- London North West Healthcare NHS Trust
Speech and Language Therapy
Parent-based Intervention for Language Delayed 2 to 3 Year Olds
The aim of the study is to evaluate the impact of parent based intervention on the language of 2 to 3 year old children from socially disadvantaged populations with a clinical diagnosis of primary language delay.
- Trial name
- NCT03083236
- Testing
- Standard PBI, Enhanced
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Solent NHS Trust
Urinary Catheterization, Device
Positioning Device for Female Urinary Catheterization
In female patients, the dorsal recumbent position is required to visualize the urethral meatus. In female patients, direct visualization of the urethral meatus after providing a suitable position is very important for successful…
- Conditions
- Urinary Catheterization, Device, Nursing, Positioning (Prone, Right Lateral and Semi-Elevated Supine Position)
- Trial name
- NCT07327671
- Testing
- dorsal recumbent positioning device
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Ankle Sprain
Ketoprofen Gel vs Placebo in Children With Ankle Sprain
The aim of this study is to analyse the effect of ketoprofen gel in children presented with ankle sprain to the emergency department.
- Trial name
- NCT02491736
- Testing
- Ketoprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Akdeniz University
Malaria, Anaemia
Efficacy of Three Novel Bi-treated Long Lasting Insecticidal Nets
The massive scale-up of Long Lasting Insecticidal Nets (LLIN) has led to a major reduction in malaria burden (up to 50%) in many sub-Saharan African countries.
- Trial name
- NCT03554616
- Testing
- Chlorfenapyr LLIN, pyriproxyfen LLIN, Piperonyl butoxide LLIN
- Where
- Tanzania
- Volunteers
- 4,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Cerebral Palsy, Parents
The Effect of Parent-based Occupational Therapy
Background/Aims Parents of children with cerebral palsy face higher levels of stress, anxiety and depression, sadness, exhaustion and burnout.
- Trial name
- NCT05728593
- Testing
- parent-based occupational therapy, Standard occupational therapy intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Hacettepe University
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