Clinical trials: Randomised Controlled Trial
Neonatal Seizure
The Effect of AI-assisted cEEG Diagnosis on the Administration of Antiseizure Medication in Neonatal Seizures
This is a prospective randomised clinical trial study to test an artificial intelligence (AI)-assisted continuous electroencephalogram(cEEG) diagnostic tool for optimizing the administration of antiseizure medication (ASM) in…
- Trial name
- NCT05036395
- Testing
- The routine assessment protocol and AI-assisted cEEG Diagnostic tool, The routine assessment protocol
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Children's Hospital of Fudan University
Severe Malaria, Severe Anemia
PDMC Implementation Trial in Kenya
The goal of this implementation trial is to evaluate at least two alternative delivery strategies and adherence support for malaria chemoprevention with dihydroartemisinin-piperaquine in the post-discharge management of children…
- Trial name
- PDMC-SL (NCT06624631)
- Testing
- SMS reminders; adherence support strategy a, Community Health Promoters (CHP) home visits; adherence support strategy b, No reminders; adherence support strategy c
- Where
- Kenya
- Volunteers
- 600 people
- Sponsor
- Liverpool School of Tropical Medicine
Malaria, Mosquito-Borne Disease
Evaluation of the Protective Efficacy of a Spatial Repellent to Reduce Malaria Prevalence in Uganda
A cluster-randomized double-blinded control trial will be conducted in Uganda to demonstrate and quantify the protective efficacy (PE) of Mossie-GO, an active spatial repellent system disseminating transfluthrin, in reducing the…
- Trial name
- Mossie-GO (NCT06232954)
- Testing
- Mossie-Go containing treated transfluthrin disc, Mossie-Go containing untreated blank disc
- Where
- Uganda
- Volunteers
- 5,600 people, healthy volunteers welcome
- Sponsor
- Africa Power Limited
Serum 25-hydroxyvitamin D Concentrations (25OHD)
Dietary Requirement for Vitamin D in Adolescents Aged 14-18 Years
It is known that low vitamin D status is a very common problem in the UK. It is also known that a lack of vitamin D availability has potentially serious health implications, especially with respect to bone and muscle function.
- Trial name
- NCT02150122
- Testing
- Vitamin D3
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Nocturnal Enuresis
A New Check-list Method for Nocturnal Enuresis
The study is aimed to demonstrate the benefits of newly formed written check-list of behavioral instructions and investigate its effects on parent's awareness, consciousness and motivation toward MNE.
- Trial name
- NCT03510975
- Testing
- desmopressin melt form 120 μg, Verbal behavioral therapy, Behavioral therapy with written check-list
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
Back Pain, Low Back Pain
Low Back and Neck Pain in Nursing Students at The University of The West Indies
The purpose of this study is to identify the prevalence of neck and low back pain in nursing students enrolled at the University of the West Indies, Mona; to assess their knowledge, attitude and practice of good spine health and…
- Conditions
- Back Pain, Low Back Pain, Musculoskeletal Pain, Neck Pain
- Trial name
- NCT07167888
- Testing
- Clinical Control Group (Group A), Spine Exercise Program (Group B)
- Where
- Jamaica
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Anesthesia
Gaze Training on Task Performance Regional Anaesthesia
Regional anaesthesia is the performance of spinal, epidural or peripheral nerve blocks to allow patients to undergo surgery awake and to provide post-operative pain relief.
- Trial name
- NCT04426227
- Testing
- Gaze training, Discovery learning
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Reading Ability
Omega 3/6 Fatty Acids for Reading in Children
The primary objective was to assess whether supplementation of Omega 3/6 fatty acids improves mainstream schoolchildren's reading ability.
- Trial name
- NCT02557477
- Testing
- Omega 3/6 fatty acids
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Retention, Compliance
Evaluation of Tailored Electronic Reminders on Compliance With Removable Orthodontic Retention
Participants will be recruited for inclusion at a routine adjustment appointment prior to planned removal of the appliances. Following removal of the appliances, consenting participants will be randomly allocated to one of two…
- Conditions
- Retention, Compliance, Orthodontic, Periodontal Health
- Trial name
- NCT03224481
- Testing
- Electronic reminder
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Vitamin D Deficiency
Effect of Oral Daily Supplementation With 400 IU Vs 200 IU of Vitamin D in Term Healthy Neonates
The purpose of the study is to evaluate the effect of daily oral supplementation with vitamin D on serum Vitamin D levels in term healthy newborns.
- Trial name
- NCT02186028
- Testing
- Vitamin D
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Lady Hardinge Medical College
Autism Spectrum Disorder
Development and Evaluation of a Parent-led Intervention Module for Early Autism Spectrum Disorder (PRIME-ASD) in Odisha, India: Protocol for a Multiphase Mixed-methods Study Including an Open-label Randomised Controlled Trial
Many families of young children with autism in India wait a long time for a diagnosis and specialist therapy, and receive little structured guidance on how to help their child at home.
- Trial name
- NCT07858383
- Testing
- Behavioral: PRIME-ASD (Parent-led Intervention Module for Early Autism Spectrum Disorder), Behavioral: PRIME-ASD; Other: Treatment as usual
- Volunteers
- 188 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
COVID-19
Shaping Care Home COVID-19 Testing Policy
The goal of this interventional study is to investigate whether continued use of regular asymptomatic testing in staff is a feasible, effective and cost-effective strategy to reduce the impact of COVID-19 in care homes.
- Trial name
- VIVALDI-CT (NCT05639205)
- Testing
- Lateral Flow Device
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University College, London
Graft Versus Host Disease, Nonneoplastic Condition
T-Lymphocyte Infusion or Standard Therapy in Treating Patients at Risk of Cytomegalovirus Infection After a Donor Stem Cell Transplant
RATIONALE: An infusion of cytomegalovirus-specific T lymphocytes may prevent or reduce cytomegalovirus infection during the first year after a donor stem cell transplant.
- Trial name
- NCT00986557
- Testing
- adoptive immunotherapy, alemtuzumab, in vitro-treated peripheral blood lymphocyte therapy
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- University Hospital Birmingham
Infant Development, Pain, Procedural
Parental Touch Trial (Petal)
This is a two centre two-arm randomised controlled interventional trial. We aim to determine whether parental touch prior to a painful clinical procedure provides effective analgesia in neonates.
- Conditions
- Infant Development, Pain, Procedural, Parents
- Trial name
- Petal (NCT04901611)
- Testing
- Parental touch
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Paediatric Neuroimaging Research Group
Depression
A Mobile Phone Self-Monitoring Tool to Increase Emotional Self-Awareness and Reduce Depression in Young People
The mobiletype program is a mental health assessment and monitoring tool that runs on mobile phones. The program assesses the general mental health of young people in real-time and transmits this data to a website to be reviewed…
- Trial name
- mobiletype (NCT00794222)
- Testing
- Mobile Tracking Young People's Experiences (mobiletype)
- Where
- Australia
- Volunteers
- 118 people
- Sponsor
- Murdoch Childrens Research Institute
Acute Myocardial Infarction
A Trial of a Home Based Walking Program as an Alternate Program for Non Attenders at Cardiac Rehabilitation
The purpose of this study is to investigate if a home-based walking program is an acceptable alternative for those who choose not to attend formal cardiac rehabilitation programs and if such a program has an effect on coronary…
- Trial name
- CRU-SHAL (NCT00219830)
- Testing
- home-based walking program
- Where
- United Kingdom
- Sponsor
- Queen's University, Belfast
Malaria
Evaluating ATSBs for Malaria Reduction in Kenya
The effectiveness of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) in western Kenya are threatened by insecticide resistance and vector behaviour changes toward early evening and outdoor biting malaria…
- Trial name
- NCT05219565
- Testing
- Attractive Targeted Sugar Bait (ATSB)
- Where
- 9 sites in Kenya
- Volunteers
- 2,962 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Brain and Central Nervous System Tumors
Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00053872
- Testing
- cisplatin, lomustine, vincristine sulfate
- Where
- 8 sites in Belgium, France and 6 more
- Volunteers
- 316 people
- Sponsor
- University of Leicester
Hepatitis C
Link Hepatitis C Notifications to Treatment in Tasmania
This project will utilise the notification process as a point of intervention to work with primary practitioners (GP) by contacting them directly when a notification of hepatitis C exposure is received by the Tasmanian department…
- Trial name
- NCT04510246
- Testing
- Enhanced case management
- Where
- Australia
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Macfarlane Burnet Institute for Medical Research and Public Health Ltd
Post Operative Pain
CAUDAL BUPIVACAINE VERSUS INTRAVENOUS MORPHINE ON TIME TO FIRST ANALGESIC REQUIREMENT
Pain is a subjective sensation which in children can only be experienced and most times not expressed. Pain management in children thus falls short of their adult counterparts.
- Trial name
- CaBuMorph (NCT02456142)
- Testing
- caudal bupivacaine, intravenous morphine
- Where
- Uganda
- Volunteers
- 70 people
- Sponsor
- Makerere University