Clinical trials: Randomised Controlled Trial
Gestational Diabetes
Ursodeoxycholic Acid vs Metformin in Gestational Diabetes Mellitus
GUARD is a Clinical Trial that wants to explore the impact of UDCA compared to metformin in the treatment of GDM. The trial wants to recruit 158 women who are overweight or obese who have been diagnosed with GDM, and require…
- Trial name
- GUARD (NCT04407650)
- Testing
- Metformin, Ursodeoxycholic Acid
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- King's College London
Attention Deficit Hyperactivity Disorder, ADHD
Omega-3 Polyunsaturated Fatty Acids in Youth With ADHD
N-3 polyunsaturated fatty acids(N-3 PUFAs) is important in balancing the immune function and crucial for the developing brain. Deficiency in n-3 PUFAs might be linked to the poor cognitive performances resulting in inattention…
- Trial name
- NCT03542643
- Testing
- n-3 Polyunsaturated fatty acid
- Where
- Taiwan
- Volunteers
- 105 people
- Sponsor
- China Medical University Hospital
Catheter-related Infections
CATCH - Catheter Infections in Children
Most children admitted to paediatric intensive care units (PICU) need to have medicines given to them into their veins using a narrow tube, so they do not need repeated injections. This tube is called a central venous catheter.
- Trial name
- NCT01029717
- Testing
- Standard polyurethane Central Venous Catheter, Antibiotic impregnated polyurethane CVC (minocycline and rifampicin), Heparin bonded polyurethane CVC
- Where
- United Kingdom
- Volunteers
- 1,859 people
- Sponsor
- Institute of Child Health
Reproductive Health, Herpesvirus Infection
Cups or Cash for Girls Trial to Reduce Sexual and Reproductive Harm and School Dropout
A 4-armed cluster randomised controlled trial conducted among secondary schoolgirls in Siaya, western Kenya, where clusters are the unit of allocation and schoolgirls the unit of measurement.
- Conditions
- Reproductive Health, Herpesvirus Infection, HIV Infections, Woman Abuse
- Trial name
- CCg (NCT03051789)
- Testing
- Menstrual Cup, Cash transfer, Cups and Cash
- Where
- Kenya
- Volunteers
- 4,138 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Virtual Reality, Anxiety
Effect of VR and Music on Fetal Well-Being and Anxiety During Nonstress Test
Music and virtual reality (VR) have been utilized in the medical field and are known to reduce anxiety and stress. However, a limited number of studies have investigated the effects of music and VR on women undergoing non-stress…
- Conditions
- Virtual Reality, Anxiety, Pregnancy, Randomised Controlled Trial
- Trial name
- NCT07082790
- Testing
- Music intervention, Virtual Reality Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bilecik Seyh Edebali Universitesi
Body Image
The Impact of Playing Super U on Pre-adolescents' Body Image
Body image concerns can have serious physical and psychological consequences on young people, including anxiety, depression, risk taking behaviours, eating disorders and suicidal ideation.
- Trial name
- NCT05669053
- Testing
- Super U Story intervention, Alternative Roblox game, Online word search
- Where
- United Kingdom
- Volunteers
- 2,941 people, healthy volunteers welcome
- Sponsor
- University of the West of England
Iodine Deficiency Disorders
RCT of Iodine-containing MNPs vs Oral Iodized Oil to Prevent Iodine Deficiency in Weaning Infants
In this study, two intervention strategies to address iodine deficiency and prevent iodine deficiency disorders in breast-fed weaning infants will be evaluated in a mild to moderate iodine-deficient population in Zamboanga del…
- Trial name
- NCT02421653
- Testing
- MNP90, MNP45, IODISED OIL
- Volunteers
- healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Osteogenesis Imperfecta
Whole Body Vibration Training in Children With Osteogenesis Imperfecta and Limited Mobility
Children with osteogenesis imperfecta (OI) have impaired bone strength, fractures, weak muscles and limited mobility. Mild to moderate forms of OI (type 1 and 4) may benefit from muscle training that leads to secondary…
- Trial name
- NCT03029312
- Testing
- Galileo M
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Coronary Artery Disease
Programme to Optimise Risk Factors in Patients Waiting for Coronary Artery Bypass Surgery
The time spent waiting for heart surgery can be extremely stressful. This programme aims to address this by providing a home-based, nurse-led support and education programme.
- Trial name
- NCT00124371
- Testing
- a nurse led home-based education and support programme
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Rare Disorders, Rare Diseases
AI-assisted Rare Disease Diagnosis
A multicentre randomised controlled trial evaluating whether a rare-disease diagnostic large language model can improve diagnostic quality, efficiency, and health-economic outcomes for physicians managing patients with suspected…
- Trial name
- NCT07650799
- Testing
- AI system
- Where
- 12 sites in China
- Volunteers
- 1,056 people
- Sponsor
- Peking Union Medical College Hospital
Cerebral Palsy, Post-operative Pain
The Post-Operative Pain in Cerebral Palsy (POPPIES) Trial
Cerebral palsy is common. It affects approximately 3 per 1000 children. Hip displacement due to muscle tightness (spasticity) occurs in up to half of the more severely affected children, and many of these children require major…
- Trial name
- POPPIES (NCT01437644)
- Testing
- botulinum toxin intramuscular injection
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Antimicrobial Stewardship, Urinary Tract Infections
Nurse-led Antimicrobial Stewardship Intervention to Increase Antibiotic Appropriateness in Residential Aged Care Facilities
The study will explore the impact of a nurse-led bundled antimicrobial stewardship intervention on the appropriateness of antimicrobial use in residential aged care facilities.
- Conditions
- Antimicrobial Stewardship, Urinary Tract Infections, Respiratory Tract Infections, Skin and Soft Tissue Infections
- Trial name
- NCT03941509
- Testing
- Antimicrobial stewardship
- Where
- Australia
- Volunteers
- 700 people
- Sponsor
- Bayside Health
Overweight and Obesity
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS9531 Injection in Adolescents With Obesity
The aim of this trial is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS9531 injection compared with placebo in adolescents with obesity
- Trial name
- NCT07559136
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Conditions or Focus of Study, Pressure Injury Prevention
AI-Supported E-Learning for Pressure Injury Prevention
Brief Summary Pressure injuries are damage to the skin and underlying tissue that may occur in patients who stay in bed for long periods, have limited mobility or use medical devices. These injuries are often preventable.
- Conditions
- Conditions or Focus of Study, Pressure Injury Prevention, Pressure Ulcer Prevention, Nursing Education
- Trial name
- NCT07658209
- Testing
- Face-to-Face Pressure Injury Prevention Education, AI-Supported Modular E-Learning Programme
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Kilis 7 Aralik University
Urinary Incontinence, Stress
Transvaginal Tape (TVT) Secur Versus TVT Randomised Controlled Trial (RCT)
This randomized multi-centre trial will recruit women with stress urinary incontinence who need surgical treatment for their condition.
- Trial name
- NCT00685217
- Testing
- TVT Secur (Gynecare), TVT (Gynecare)
- Where
- 4 sites in Canada
- Volunteers
- 74 people
- Sponsor
- University of Calgary
Eosinophilic Asthma
Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment
This study evaluates the efficacy and safety of benralizumab as an add-on therapy in uncontrolled eosinophilic asthma participants treated with medium-dose ICS-LABA compared to the conventional treatment step of escalation of…
- Trial name
- BRISOTE (NCT06750289)
- Testing
- ICS-LABA, benralizumab
- Where
- 86 sites in United States, Bulgaria and 11 more
- Volunteers
- 130 people
- Sponsor
- AstraZeneca
Gastric Residual Volume
Feasibility of 1 Hour Clear Fluid Fasting Prior to Paediatric GA
The study is aim to investigate the appropriate fasting time for clear fluid in paediatric patients who plan for elective minor surgery.
- Trial name
- NCT03952260
- Testing
- Fasting time for clear fluid prior to anaesthesia
- Where
- Malaysia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ma Tai Jiun
Child Maltreatment
Evaluating the Effectiveness of Keeping Safe - a School Based Intervention Aimed at Preventing Abuse
This study evaluates the effectiveness of Keeping Safe, a whole school preventative education intervention in improving children's knowledge and understanding to keep safe in situations of abuse.
- Trial name
- NCT02961010
- Testing
- Keeping Safe
- Where
- United Kingdom
- Volunteers
- 6,300 people, healthy volunteers welcome
- Sponsor
- National Society for the Prevention of Cruelty to Children
Asthma
Evaluation of Tiotropium 2.5 and 5 mcg Once Daily Delivered Via the Respimat® Inhaler Compared to Placebo in 1 to 5 Year Old Patients With Persistent Asthma
The primary objective of this trial is to evaluate the safety and efficacy of two doses of tiotropium inhalation solution delivered via the Respimat® inhaler once daily in the afternoon in patients (1 to 5 years old) with…
- Trial name
- NCT01634113
- Testing
- tiotropium-bromide
- Where
- 33 sites in United States, Belgium and 9 more
- Volunteers
- 102 people
- Sponsor
- Boehringer Ingelheim
Smoking Cessation
Mobile EMA-based Peer Counselling for Youth Smokers
This pilot trial aims to examine the feasibility, acceptability, and preliminary effectiveness of EMA-based peer counseling for youth smokers.
- Trial name
- NCT05732220
- Testing
- EMA assessment, EMA-based cessation counselling, Usual peer counselling
- Where
- Hong Kong
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
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