Clinical trials: Randomized Controlled Trial (RCT)
Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD)
Social Skills Group Training ("KONTAKT") for Children and Adolescent With High-functioning Autism Spectrum Disorders
This trial investigates the behavioral effects of manualized social skills training (KONTAKT) in children´s and adolescents with high-functioning autism spectrum disorder with psychiatric comorbidity in a RCT, multicenter study.
- Conditions
- Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD), Anxiety, Depression
- Trial name
- KONTAKT-RCT (NCT01854346)
- Testing
- Social skills group training, KONTAKT
- Where
- Sweden
- Volunteers
- 296 people
- Sponsor
- Karolinska Institutet
Urinary Tract Infections
Oral vs Initial Intravenous Antibiotic Treatment of Urinary Tract Infections in Children: a RCT
The main objectives of the study are 1. to compare the efficacy of oral vs initial iv antibiotic treatment in children with a first episode of UTI 2.
- Trial name
- NCT00161330
- Testing
- oral amoxicilline/clavulanic acid, iv ceftriaxone
- Volunteers
- 440 people
- Sponsor
- University of Padova
Low Back Pain
Effect of Pilates Core Stabilization in Adjunct With Plyometric Shoulder Training on Low Back Pain in Fast Bowlers(RCT)
This RCT will seek to determine both the Pilates core stabilization and plyometric shoulder training on LBP in fast bowlers. The research problem will emphasize the absence of detailed rehabilitation protocols that address the…
- Trial name
- NCT06901804
- Testing
- Experimental Group (training and stabilization), Control Group (physiotherapy and exercise)
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Superior University
Oral Health
Cluster RCT on the Effect of the Topics Number in Oral Health Educational Video Among Preschool Children.
Purpose: This cluster randomized controlled trials study aims to investigate whether different number of topics delivered through educational video affect the oral health status, knowledge, attitude and practice of preschool…
- Trial name
- NCT06073392
- Testing
- Educational video
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Child Abuse, Child Neglect
Fostering Healthy Futures for Teens: An RCT
This study will implement and evaluate a mentoring program designed to promote positive youth development and reduce adverse outcomes among maltreated adolescents with open child welfare cases.
- Conditions
- Child Abuse, Child Neglect, Risk Behavior, Delinquency
- Trial name
- FHF-T (NCT03707366)
- Testing
- FHF-T
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- University of Denver
Pain, Acute, Infant, Newborn
The Influence of Skin-to-skin Contact on Cortical Activity During Painful Procedures on Preterm Infants in the NICU
The aim of this study is to examine the effect of SSC compared to sucrose on pain induced activity in the preterm infant brain using: a) series of low intensity experimental stimuli (PinPrick);and b) medically required heel…
- Conditions
- Pain, Acute, Infant, Newborn, Electroencephalography
- Trial name
- iCAPmini (NCT03745963)
- Testing
- Skin-to-skin contact, 24% oral sucrose
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- IWK Health Centre
Preterm Infant, Growth Delay
The Milk, Growth and Microbiota Study
Late preterm infants, who are born at 34, 35 or 36 weeks gestation, often have difficulty feeding, establishing growth, and fighting off infection.
- Conditions
- Preterm Infant, Growth Delay, Microbial Colonization, Breastfeeding
- Trial name
- MGM (NCT03220282)
- Testing
- Donor milk, Preterm infant formula
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of California, San Francisco
Heat Cramps, Heat Rash
Testing Interventions to Mitigate the Health Impact of Heatwaves on Primary School Children in Climate-vulnerable Districts of Bangladesh.
The goal of this clinical trial is to assess the impact of implementing a combination of heat education and school-based physical infrastructure interventions in reducing heat related illnesses and improving educational outcomes…
- Conditions
- Heat Cramps, Heat Rash, Heat Exhaustion, Heat Stress
- Trial name
- NCT07877935
- Testing
- Solar reflective paint, Bamboo ceiling with polyethylene foam, Heat education toolkit
- Where
- 2 sites in Bangladesh
- Volunteers
- 2,875 people, healthy volunteers welcome
- Sponsor
- BRAC University
Multiple Sclerosis
TELEMS: Feasibility of Remote Patient Visits in MS
This trials randomizes patients with multiple sclerosis (MS, pwMS) to a remote visit (via phone or videochat) or a regular outpatient visit. Outcomes include satisfaction on the patients' and doctor's side.
- Trial name
- TELEMSRCT (NCT04838990)
- Testing
- EDSS, Discussion of symptoms, Patient reported outcome (MSIS)
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
ACL Reconstruction
A Multi-centre, Double-blind RCT to Investigate the Effect of Alendronate on Knee Function Following ACLR
Anterior cruciate ligament (ACL) is the key ligament connecting the femur to tibia that helps stabilising the knee joint. ACL tear is common.
- Trial name
- NCT05527548
- Testing
- Alendronate (ALN)
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Chronic Ankle Instability, Ankle Ligament Injury
Dilute Epinephrine vs Tourniquet for Visualization in Ankle Arthroscopy: A RCT
This multicenter, prospective randomized controlled trial investigates the effect of dilute epinephrine irrigation versus tourniquet use on visual field clarity (VFC) during ankle arthroscopy.
- Conditions
- Chronic Ankle Instability, Ankle Ligament Injury, Ankle Arthroscopy
- Trial name
- NCT07349407
- Testing
- Epinephrine group, Tourniquet group
- Volunteers
- 88 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
VLBW - Very Low Birth Weight Infant
Feeding Study in VLBW Premature Infants
A multi-center, single-blind, randomized, controlled, parallel-designed, prospective trial to compare growth between preterm infants fed one of three study human milk fortifiers added to human milk
- Trial name
- NCT05744193
- Testing
- Exempt Infant Formula
- Where
- 6 sites in United States
- Volunteers
- 22 people
- Sponsor
- Mead Johnson Nutrition
Orthopedic Disorder, Anterior Cruciate Ligament Injuries
Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT
The choice of autograft for ACL reconstruction continues to be debated. To date, there has only be one completed randomized controlled trial with quad tendon to BTB and the tendon included a bone plug.
- Trial name
- NCT05461326
- Testing
- Quad tendon, BTB
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Autism Spectrum Disorder, Suspected Autism
Caregiver Training to Support Children With Social Communication Challenges
"More Than Words® - The Hanen Program® for Parents of Autistic Children or Children Who May Benefit from Social Communication Support" is a family-focused intervention program delivered by a speech-language pathologist (SLP).
- Conditions
- Autism Spectrum Disorder, Suspected Autism, Social Communication Challenges
- Trial name
- NCT06909279
- Testing
- The Hanen Centre's More Than Words® program
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Western University, Canada
Stress
Early Interventions for Primary Care Patients With Stress-related Ill-health: a Non-inferiority RCT
Stress-related ill-health is rated one of the largest health challenges in the western world. The most empirically supported treatment for stress-related disorders is cognitive behaviour therapy (CBT), but accessibility is low…
- Trial name
- NCT04820283
- Testing
- Care manager intervention (nurse), CBT
- Where
- Sweden
- Volunteers
- 172 people
- Sponsor
- Karolinska Institutet
Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic
Feasibility Study Assessing the Effect of Carbidopa/Levodopa Ratio on Orthostatic Hypotension in Multiple System Atrophy - Parkinsonian Type and Parkinson Disease.
This study is aimed at patients with multi-system atrophy - parkinsonian type (P-MSA) or Parkinson's disease (PD) receiving dopaminergic drugs and suffering from orthostatic hypotension (OH).
- Conditions
- Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic, Parkinson Disease
- Trial name
- CARBIDOH (NCT06831500)
- Testing
- Administration of Carbidopa/levodopa
- Where
- 2 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Julien Bally
Visual Snow Syndrome
MBCT-vision VSS RCT
Visual Snow Syndrome (VSS) is a neurological condition with bran network dysregulation involving the visual pathway. This is a research trial comparing the effect of an 8-week mindfulness-based intervention via a group-learning…
- Trial name
- NCT06018103
- Testing
- MBCT-vision
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Class III Malocclusion
Treatment of Skeletal Class III Malocclusion Using Orthodontic Removable Traction Appliance
This experimental study aims to evaluate the efficiency of the orthodontic removable traction appliance in the treatment of skeletal class III malocclusion.
- Trial name
- NCT03172442
- Testing
- Vacuum plate, Rapid maxillary expander, Class III elastics
- Where
- Syria
- Volunteers
- 22 people
- Sponsor
- Damascus University
Child Development
Effectiveness of a Baby App for Enhancing Infant Mental Well-being (RCT)
This RCT aims to design and develop a developmental guidance program delivered by a smartphone app "Happy Baby HK" and evaluate its effectiveness for enhancing the mental well-being of recently born infants in Hong Kong.
- Trial name
- NCT06163560
- Testing
- Smartphone app "Happy Baby HK", Family Health Service parenting booklet
- Where
- Hong Kong
- Volunteers
- 586 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pregnancy Complications, Preterm Birth
Group Antenatal/Postnatal Care in Rwanda
The focus of this work is to improve antenatal care (ANC) and postnatal care (PNC) at the health center level in five districts in Rwanda (Bugesera, Burera, Nyamasheke, Nyarugenge, and Rubavu).
- Conditions
- Pregnancy Complications, Preterm Birth, Preterm Labor, Stillbirth
- Trial name
- PTBi Rwanda (NCT03154177)
- Testing
- Group ANC/PNC, Ultrasound+Pregnancy Testing
- Where
- 2 sites in Rwanda
- Volunteers
- 26,381 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco