Clinical trials: Randomized Controlled Trial (RCT)
Eosinophilic Esophagitis
EoE RCT Fluticasone and Omeprazole vs Fluticasone Alone
The purpose of this study is to evaluate the efficacy of combination therapy with omeprazole and swallowed fluticasone vs fluticasone therapy and placebo in the treatment of Eosinophilic Esophagitis (EoE) in children and adults.
- Trial name
- NCT03781596
- Testing
- Retrospective evaluation of endoscopy prior to study drug, Symptom Survey, Medication Compliance Phone Call
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Claire Daniels
Post-traumatic Stress Disorder
Effectiveness of a Brief Intensive Trauma Treatment for Adolescents With (s)PTSD: a Multi-center RCT
The primary objective of this study is to examine the effectiveness of a Brief Intensive Trauma Treatment (BITT) for adolescents with (s)PTSD.
- Trial name
- NCT06143982
- Testing
- Brief Intensive Trauma Treatment
- Where
- 3 sites in Bonaire, Saint Eustatius and Saba , Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cognitive Function, Mood Disorders
RCT on the Neurobehavioral Effects of Fruits and Vegetables in Shanghai Children
This project proposal outlines a randomized-controlled trial (RCT) aimed at evaluating the effects of increased fruit and vegetable (F\&V) intake on cognitive performance, attention, and mood in Chinese children aged 7-11…
- Conditions
- Cognitive Function, Mood Disorders, Attention-deficit
- Trial name
- NCT06560359
- Testing
- F&V, No F&V
- Where
- China
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Fudan University
Suture Techniques, Training Effectiveness
Online vs. In-Person Suturing Training: A Non-Inferiority Randomized Controlled Trial in a Low-Resource Setting
The goal of this clinical trial is to assess whether online suturing training is non-inferior to in-person training in developing suturing skills among medical students at Yarmouk University in a low-resource setting.
- Conditions
- Suture Techniques, Training Effectiveness, Online Education, Student Education
- Trial name
- RCT (NCT07038525)
- Testing
- Suturing training
- Where
- Jordan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Diala Burjak
Chronic Ankle Instability, Ankle Ligament Injury
Dilute Epinephrine vs Tourniquet for Visualization in Ankle Arthroscopy: A RCT
This multicenter, prospective randomized controlled trial investigates the effect of dilute epinephrine irrigation versus tourniquet use on visual field clarity (VFC) during ankle arthroscopy.
- Conditions
- Chronic Ankle Instability, Ankle Ligament Injury, Ankle Arthroscopy
- Trial name
- NCT07349407
- Testing
- Epinephrine group, Tourniquet group
- Volunteers
- 88 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Child Development, Mother-Infant Interaction
Mother-infant Bonding During COVID-19
This study will assess whether the promotion of emotional exchange between mother and infant during the first four months of life improves primarily mother-child early relational health (ERH) and secondarily child…
- Conditions
- Child Development, Mother-Infant Interaction, Relation, Parent-Child
- Trial name
- NCT04531618
- Testing
- Emotional Exchange (EE), Newborn Care (NC)
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Columbia University
ACL Reconstruction
A Multi-centre, Double-blind RCT to Investigate the Effect of Alendronate on Knee Function Following ACLR
Anterior cruciate ligament (ACL) is the key ligament connecting the femur to tibia that helps stabilising the knee joint. ACL tear is common.
- Trial name
- NCT05527548
- Testing
- Alendronate (ALN)
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Acute Malnutrition in Infancy, Acute Malnutrition in Childhood
ComPAS Low-WAZ RCT Mali
Admissions criteria which treat children with only low mid-upper arm circumference (MUAC) or children with low weight-for-height z-score (WHZ) are not aligned with the evidence on which children are at risk of mortality.
- Conditions
- Acute Malnutrition in Infancy, Acute Malnutrition in Childhood, Underweight
- Trial name
- NCT05248516
- Testing
- Simplified dose of ready-to-use therapeutic food (RUTF), Standard dose of ready-to-use therapeutic food (RUTF), No nutritional treatment
- Where
- 11 sites in Mali
- Volunteers
- 1,500 people
- Sponsor
- International Rescue Committee
Kidney Transplant Rejection, Kidney Transplant Failure
The smartNTx Trial:Telemedical Management Versus Standard Aftercare in Kidney Transplant Recipients (KTR)
The smartNTx trial: Prospective, randomized controlled trial (RCT) to investigate additional interventional telemedical management versus standard aftercare in kidney transplant recipients (KTR).
- Trial name
- smartNTx (NCT05897047)
- Testing
- Additional interventional telemedical management
- Where
- 2 sites in Germany
- Volunteers
- 391 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Patent Ductus Arteriosus After Premature Birth
Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCT
Background: Among preterm infants, those born at a gestational age less than 26 weeks are considered the most vulnerable with a high risk of short- and long-term health problems that include chronic lung disease, brain bleeds…
- Trial name
- SMART-PDA (NCT05011149)
- Testing
- Ibuprofen
- Where
- 9 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- IWK Health Centre
Perineal Injury
Designed Protocol of Care for Postpartum Perineal Trauma
the study is intended to test the effect of designed protocol of care that include perineal ice-gel pad application, performance of pelvic floor exercises (Kegel exercises) and perineal warm compresses application on the outcomes…
- Trial name
- NCT05268276
- Testing
- 1-perineal ice-gel pad application, 2-performance of pelvic floor exercises (Kegel exercises), 3- perineal warm compresses application
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Asmaa Abdallah Ahmed Hussein
Smoking (Tobacco) Addiction, Young Adult
Designing a Smoking Intervention for Youth Smokers
This study aims to develop a typology-based intervention delivered by smoking cessation (SC) counsellors to prevent smoking relapse in ex-smokers who recently quit.
- Conditions
- Smoking (Tobacco) Addiction, Young Adult, RCT
- Trial name
- NCT07178899
- Testing
- typology-based intervention, Routine Treatment
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Anxiety, Fear
Effectiveness of Multisensoral Nature-based Intervention in Hospitalized Children During Venous Blood Sampling
This randomized controlled trial (RCT) study aims to evaluate the effectiveness of multisensoral nature-based intervention compare to standard care in relieving anxiety, fear and pain in hospitalized child aged 5 to 9 years and…
- Conditions
- Anxiety, Fear, Pain, Satifaction
- Trial name
- NCT05494684
- Testing
- Multisensoral Nature-based Intervention
- Where
- Finland
- Volunteers
- 106 people
- Sponsor
- University of Oulu
Acute Renal Colic
Diclofenac IM Versus Tramadol IV in Acute Renal Colic, RCT
Patients presented with acute pain from renal colic, the standard of care are prescribed NSAIDs, most common drug used is intramuscular (IM) Diclofenac injected at the gluteal muscle.
- Trial name
- NCT06231043
- Testing
- Diclofenac/Tramadol
- Where
- Thailand
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Lampang Hospital
Edentulism Nos
Accuracy of 3D Printed Complete Dentures Using Two Impression Techniques: RCT
the aim of this crossover randomized controlled clinical trial is comparing retention of 3D printed maxillary complete dentures produced from thermoplastic impression trays and conventional acrylic impression trays.
- Trial name
- NCT04982510
- Testing
- complete denture
- Where
- Egypt
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cairo University
Myopia, Progressive
Crossover RCT of TAMER Lenses in Myopia Control
This study is a prospective, randomized, crossover clinical trial with a planned proposed enrollment of 120 Chinese male and female subjects aged 6-12 years without systemic or ocular diseases to follow up their cycloplegic…
- Trial name
- NCT06329986
- Testing
- TAMER Lens Spectacle, SV lenses
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Hospital
Hospital-at-Home Education as Implementation Tool - RCT
To enhance implementation of Hospital-at-home (HaH) in Scandinavia, the Nordic Digital Health \& Education (NorDigHE) project has developed a comprehensive virtual education on HaH for clinical staff.
- Trial name
- HAH-EDUCATION (NCT07166653)
- Testing
- HaH education
- Where
- 3 sites in Denmark, Norway and 1 more
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Substance Use Disorders (SUD)
Substance-focused SBI as a Complement to Internet-based Psychiatric Treatment: RCT
Objectives: This study evaluates the efficacy of eScreen for internet psychiatry patients treated for major depressive disorder, panic anxiety and social phobia.
- Trial name
- eScreeniPsy (NCT01885026)
- Testing
- eScreen, Assessment only of alcohol and drug use., Internet-based treatment for depression or anxiety
- Where
- Sweden
- Volunteers
- 93 people
- Sponsor
- Karolinska Institutet
Attention-deficit/Hyperactivity Disorder
Toolkit for School Behavior Modification in Children With Attention-Deficit/Hyperactivity Disorder (ADHD)
The purpose of this study is to examine the efficacy of the ADHD-Toolkit (a toolkit for school behaviour modification in primary school children with ADHD-behaviours) in terms of general improvement in ADHD symptoms, specific…
- Trial name
- NCT01330849
- Testing
- ADHD Toolkit, Waiting List Control group
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Vomiting in Infants and/or Children, Nausea
RCT of Olanzapine for Control of CIV in Children Receiving Highly Emetogenic Chemotherapy
Chemotherapy-induced nausea and vomiting (CINV) are among the most bothersome symptoms during cancer treatment according to children and their parents.
- Conditions
- Vomiting in Infants and/or Children, Nausea, Hematopoietic System--Cancer, Oncology
- Trial name
- NCT03118986
- Testing
- Olanzapine
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 161 people
- Sponsor
- The Hospital for Sick Children