Clinical trials: Recurrent
Hemophilia A
An Open Label Study to Determine the Safety and Efficacy of Replacement Factor VIII Protein (Known as rFVIIIFc) in Previously Untreated Males With Severe Hemophilia A
The primary objective of the study was to evaluate the safety of rFVIIIFc (BIIB031) in previously untreated participants (PUPs) with severe hemophilia A.
- Trial name
- NCT02234323
- Testing
- rFVIIIFc
- Where
- 71 sites in United States, Australia and 12 more
- Volunteers
- 108 people
- Sponsor
- Bioverativ, a Sanofi company
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
ABT-751 in Treating Young Patients With Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy, such as ABT-751, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Kidney Cancer
- Trial name
- NCT00036959
- Testing
- ABT-751
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cushing Disease
The Factors Associated With the Recurrence in Patients With Cushing Disease
Cushing syndrome refers the manifestations induced by chronic glucocorticoid excess and may arise from various causes. Iatrogenic Cushing syndrome accounts for most patients, when they are given exogenous glucocorticoid…
- Trial name
- NCT02233335
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- National Taiwan University Hospital
Multiple Sclerosis
Preventive Use of COrticosteroids During the Post-Partum in Relapsing MS Patients (COPP-MS)
Multiple Sclerosis (MS) is most prevalent among women of childbearing age. The post-partum (PP) period is a critical phase in MS patients, during which a recrudescence of disease activity is expected.
- Trial name
- COPP-MS (NCT03917589)
- Where
- 5 sites in France
- Volunteers
- 350 people
- Sponsor
- Rennes University Hospital
Anxiety Disorder, Depression
Combination Chemotherapy Plus Fluoxetine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer
This trial is designed to test the efficacy of fluoxetine to improve patient's quality of life during chemotherapy. An innovative application of a selective serotonin reuptake inhibitor may modulate the effects of fatigue…
- Conditions
- Anxiety Disorder, Depression, Fatigue, Lung Cancer
- Trial name
- NCT00005850
- Testing
- cisplatin, fluoxetine, gemcitabine hydrochloride
- Where
- 43 sites in United States, Puerto Rico
- Volunteers
- 21 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Head Cancer Neck
IReC-Bio and IReC Registry
IReC is the world's first centre for recurrent head and neck cancers. We have the ambitious aim to create a centre of international excellence and set international standards in the curative treatment of recurrent head and neck…
- Trial name
- IReC-Bio (NCT05885490)
- Volunteers
- 10,000,000 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Recurrent Shoulder Dislocations
Arthroscopic Rotator Interval Closure in Shoulder Instability Repair
Study Title: Arthroscopic rotator interval closure in shoulder instability repair - a prospective study Objective: To evaluate the effect of arthroscopic rotator interval closure (ARIC) on patients with recurrent shoulder…
- Trial name
- NCT00901797
- Testing
- Arthroscopic Bankart repair, ABR+ARIC
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Clostridium Difficile Infections
Molecular Epidemiology of Clostridium Difficile Infections in Children
Objectives: 1. Describe the molecular epidemiology of Clostridium Difficile infection in children in the Chicago area. 2. Determine the clinical spectrum and risk factors for Clostridium Difficile infection secondary to…
- Trial name
- NCT01957761
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Tonsil Disease, Tonsillitis
Intracapsular Tonsillectomy in Adults
Comparing the classical extracapsular tonsillectomy (TE) performed with electrosurgery to intracapsular approaches (SIPT) by coblation or microdebrider. The patient group is adults with recurrent or chronic tonsillitis
- Conditions
- Tonsil Disease, Tonsillitis, Tonsillitis Acute, Tonsillitis Chronic
- Trial name
- NCT03654742
- Testing
- tonsillectomy
- Where
- Finland
- Volunteers
- 167 people
- Sponsor
- Turku University Hospital
Unspecified Childhood Solid Tumor, Protocol Specific
Irofulven in Treating Children With Recurrent or Refractory Solid Tumors
Phase I trial to study the effectiveness of irofulven in treating children with recurrent or refractory solid tumors. Drugs used in chemotherapy use different ways to stop tumor cells so they stop growing or die.
- Trial name
- NCT00003370
- Testing
- irofulven
- Where
- 56 sites in United States, Australia and 1 more
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Relapsed and Refractory CD5 Hematological Tumors
CD5 CART for the Treatment of Relapsed and Refractory CD5 Hematological Tumors
This is an investigator-initiated dose-finding clinical study with the primary objective of evaluating the safety of CD5CART in the treatment of subjects with relapsed and refractory CD5 hematological malignancies and to explore…
- Trial name
- NCT07234110
- Testing
- Fully human CD5 chimeric antigen receptor T cell injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Ependymoma
Immunotherapy for Recurrent Ependymomas in Children Using Tumor Antigen Peptides With Imiquimod
The purpose of this study is to see if vaccination with HLA-A2 restricted peptides, combined with the immunoadjuvant imiquimod is safe and can induce immune responses in children with recurrent ependymomas.
- Trial name
- NCT01795313
- Testing
- HLA-A2 restricted synthetic tumor antigen, Imiquimod, enzyme-linked immunosorbent assay
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- James Felker
Acute Pancreatitis
The Effect of Dietary Fat Content on the Recurrence of Pancreatitis
This trial aims to test the effects of two different diets on the recurrence of acute pancreatitis, and acute pancreatitis associated mortality.
- Trial name
- EFFORT (NCT04761523)
- Testing
- Dietary intervention: reduced fat diet, Dietary intervention: standard healthy diet
- Where
- Hungary
- Volunteers
- 384 people
- Sponsor
- University of Pecs
Anaplastic Astrocytoma, Anaplastic Ependymoma
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease.
- Conditions
- Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Ganglioglioma, Anaplastic Meningioma
- Trial name
- NCT03434262
- Testing
- Gemcitabine, ribociclib, sonidegib
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- St. Jude Children's Research Hospital
Recurrent Childhood Soft Tissue Sarcoma, Recurrent Ewing Sarcoma
Trabectedin and Irinotecan for Refractory Pediatric Sarcomas
The purpose of the study is to evaluate patients with refractory childhood sarcomas, who have been treated with a combination therapy of trabectedin and irinotecan (within compassionate use), to determine, if this is a promising…
- Conditions
- Recurrent Childhood Soft Tissue Sarcoma, Recurrent Ewing Sarcoma, Recurrent Rhabdomyosarcoma
- Trial name
- TrIPReSarc (NCT02509234)
- Testing
- Combined chemotherapy with trabectedin followed by irinotecan
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Refractory or Recurrent Hypermutated Malignancies, Biallelic Mismatch Repair Deficiency (bMMRD) Positive Patients
Pilot Study of Nivolumab in Pediatric Patients With Hypermutant Cancers
This is an open-label, single arm, multi-center, pilot study of Nivolumab in pediatric patients with recurrent or refractory hypermutant malignancies aged 12 months to 18 years of age.
- Trial name
- NCT02992964
- Testing
- Nivolumab
- Where
- 10 sites in United States, Australia and 3 more
- Volunteers
- 11 people
- Sponsor
- The Hospital for Sick Children
Ovarian Cancer, Primary Peritoneal Cavity Cancer
Gemcitabine Plus Cisplatin in Treating Patients With Ovarian Epithelial Cancer or Primary Peritoneal Cancer That Is Recurrent or Has Not Responded to Platinum-based Chemotherapy
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00006028
- Testing
- cisplatin, gemcitabine hydrochloride
- Where
- 31 sites in United States, Norway
- Sponsor
- Gynecologic Oncology Group
Recurrent Solid Tumor, Recurrent Ewing Sarcoma
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma
The phase I portion of this study is designed for children or adolescents and young adults (AYA) with a diagnosis of a solid tumor that has recurred (come back after treatment) or is refractory (never completely went away).
- Conditions
- Recurrent Solid Tumor, Recurrent Ewing Sarcoma, Recurrent Hepatoblastoma, Recurrent Malignant Germ Cell Tumor
- Trial name
- NCT04901702
- Testing
- Onivyde, Talazoparib, Temozolomide
- Where
- 10 sites in United States, Canada
- Volunteers
- 90 people
- Sponsor
- St. Jude Children's Research Hospital
Histiocytosis,Langerhans-Cell
A Single-Arm,Multicenter Phase, Phase II Clinical Trial of Adebrelimab Combined With Trametinib in the Treatment of Refractory Recurrent Langerhans Cell Histiocytosis in Children and Adolescents
Based on clinical observation data from two previously enrolled cases, the adezbelimab combined with trametinib regimen showed good safety in pediatric refractory relapsed LCH, with good drug tolerance.
- Trial name
- NCT07890701
- Testing
- treated group
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Colorectal Cancer
Aspirin and/or Folic Acid in Preventing Recurrent Colorectal Polyps
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of aspirin and/or folic acid may be effective in preventing recurrent polyps in patients who have…
- Trial name
- NCT00033319
- Testing
- folic acid, acetylsalicylic acid
- Where
- 32 sites in United Kingdom
- Sponsor
- Queen's Medical Center
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