Clinical trials: Recurrent Respiratory Papillomatosis
Recurrent Respiratory Papillomatosis
4-valent HPV Vaccine to Treat Recurrent Respiratory Papillomatosis in Children
Recurrent respiratory papillomatosis in children caused by HPV 6,11 can be a life threatening condition resulting in surgical interventions.
- Trial name
- NCT01995721
- Testing
- 4-valent HPV vaccine
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- National Institute of Child Health, Hungary
Laryngeal Papilloma, Recurrent
Optiflow vs. Convential Anesthesia During Pediatric Laryngeal Papilloma Removal
This is a randomized cross over study of high flow oxygen delivery via nasal cannula vs. conventional tubeless anesthesia for patients undergoing dubulking surgery for laryngeal papilloma.
- Trial name
- NCT05215249
- Testing
- Transnasal humidified high-flow oxygen delivery
- Sponsor
- Massachusetts Eye and Ear Infirmary
Recurrent Respiratory Papillomatosis (RRP), Juvenile-onset Recurrent Respiratory Papillomatosis
Zopapogene Imadenovec for the Treatment of Recurrent Respiratory Papillomatosis in Children
Recurrent respiratory papillomatosis (RRP) is a rare disease in which wart-like growths caused by human papillomavirus (HPV) types 6 or 11 form in the airway.
- Conditions
- Recurrent Respiratory Papillomatosis (RRP), Juvenile-onset Recurrent Respiratory Papillomatosis, Papillomavirus Infections
- Trial name
- NCT07901738
- Testing
- Zopapogene imadenovec-drba
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Precigen, Inc
Lung Cancer, Malignant Mesothelioma
Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease
RATIONALE: Diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells.
- Conditions
- Lung Cancer, Malignant Mesothelioma, Metastatic Cancer, Nonmalignant Neoplasm
- Trial name
- NCT00733252
- Testing
- bronchoscopic and lung imaging studies, diagnostic bronchoscopy, histopathologic examination
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Recurrent Respiratory Papillomatosis
Use of Cidofovir for Recurrent Respiratory Papillomatosis
Recurrent respiratory papillomatosis (RRP) is the most common benign neoplasm of the larynx in the pediatric population. The impact of the disease on patients and families can be tremendous due to the need for frequent treatment.
- Trial name
- NCT00205374
- Testing
- Cidofovir
- Volunteers
- 19 people
- Sponsor
- University of Wisconsin, Madison
Recurrent Respiratory Papillomatosis, Human Papilloma Virus
Airway Intervention Registry (AIR): Recurrent Respiratory Papillomatosis (RRP)
Recurrent Respiratory Papillomatosis (RRP) causes wart-like growths in the airway which can make it difficult to breathe, speak and carry out normal everyday activities.
- Trial name
- AIR:RRP (NCT03465280)
- Testing
- Microdebrider, Cold-steel surgery (forceps), Carbon dioxide laser
- Where
- 48 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Recurrent Respiratory Papillomatosis
Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis
Juvenile onset recurrent respiratory papillomatosis (JORRP) is a rare, difficult to treat, benign tumor of the pediatric airway.
- Trial name
- NCT01058317
- Testing
- Propranolol
- Sponsor
- Massachusetts Eye and Ear Infirmary
Recurrent Respiratory Papillomatosis
Multi-Center, Randomized Trial of the Pulsed Dye Laser for JORRP
The purpose of this study is to determine whether the 585-nm pulse dye laser can decrease the time interval between surgeries and improve voice outcomes in children with severe RRP.
- Trial name
- NCT00550914
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Recurrent Respiratory Papillomatosis
Bevacizumab Versus Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis
The aim of this study is to compare the efficacy of intralesional bevacizumab, a monoclonal antibody against vascular endothelial growth factor, versus the antiviral drug cidofovir in patients with recurrent respiratory…
- Trial name
- NCT02555800
- Testing
- Bevacizumab, Cidofovir
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Centro de Investigación en. Enfermedades Infecciosas, Mexico
Juvenile Recurrent Respiratory Papillomatosis
Juvenile Recurrent Respiratory Papillomatosis: Establishment of a French National Cohort (PRR : National Cohort " REPA ")
Recurrent respiratory papillomatosis (RRP) is a rare disease. However, it is the most common benign laryngeal tumor in children. To date, no epidemiological data are available in France.
- Trial name
- REPA (NCT06000527)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Imagine Institute
Recurrent Respiratory Papillomatosis, Extra Oesophageal Reflux
Recurrent Respiratory Papillomatosis and Extraesophageal Reflux
The purpose of the study was to determine, whether patients with recurrent respiratory papillomatosis (RRP) suffer from extra oesophageal reflux more often than patients with laryngeal cyst (control group).
- Conditions
- Recurrent Respiratory Papillomatosis, Extra Oesophageal Reflux, Laryngeal Cyst
- Trial name
- NCT02592902
- Testing
- Surgical collection of histology specimen, Performance of immunohistochemical analysis
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Ostrava
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Recurrent Laryngeal Papillomatosis, Human Papilloma Virus
Human Papillomatosis Genotyping of Children in Thailand
The purpose of the present study was to identify risk factors for more severe juvenile Recurrent Respiratory Papillomatosis (RRP) through prospective evaluation of a pediatric population in Thailand by the employing a protocol…
- Trial name
- NCT01304966
- Testing
- biopsy
- Where
- 2 sites in Thailand
- Volunteers
- 15 people
- Sponsor
- Queen Sirikit National Institute of Child Health
Recurrent Respiratory Papillomatosis
Study of Celebrex (Celecoxib) in Patients With Recurrent Respiratory Papillomatosis
This is a randomized double blind controlled study to determine if celebrex (celecoxib), a selective COX-2 inhibitor, can decrease the rate of recurrence in adult and pediatric patients with recurrent respiratory papillomatosis.
- Trial name
- NCT00571701
- Testing
- celebrex (celecoxib)
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Recurrent Respiratory Papillomatosis
Pembrolizumab for HPV-associated Recurrent Respiratory Papilloma Patients
This research study is evaluating an immune modulatory agent as a possible treatment for patients with Recurrent Respiratory Papillomatosis (RRP) with significant disease involving the larynx, trachea, and/or lungs.
- Trial name
- NCT02632344
- Testing
- Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Papilloma, Recurrent Respiratory Papillomatosis
A Trial Study of SGN-00101 in Treating Pediatric Patients With Recurrent Respiratory Papillomatosis
Recurrent Respiratory Papillomatosis (RRP) causes wart-like lesions along the throat area and can obstruct the airway or become malignant. The cause has been related to specific types of Human Papillomavirus (HPV).
- Trial name
- NCT00038714
- Testing
- SGN-00101
- Where
- 8 sites in United States
- Volunteers
- 27 people
- Sponsor
- Nventa Biopharmaceuticals Corporation