Clinical trials: Reflux
Asthma
A Randomized, Double-Blind, Placebo-Controlled Study of Gastroesophageal Reflux Disease Therapy.
Asthma and gastroesophageal reflux disease (GERD) are common disorders, which although are not usually lethal, both have high morbidity, and high healthcare costs.
- Trial name
- NCT00237068
- Testing
- Lansoprazole; Solutab
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Emory University
Idiopathic Pulmonary Fibrosis, Gastroesophageal Reflux
Treatment of IPF With Laparoscopic Anti-Reflux Surgery
This study will test the hypothesis that treatment with laparoscopic anti-reflux surgery in subjects with idiopathic pulmonary fibrosis (IPF) and abnormal gastroesophageal reflux (GER) will slow the decline of forced vital…
- Trial name
- WRAP-IPF (NCT01982968)
- Testing
- Surgery
- Where
- 5 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of California, San Francisco
Gastrointestinal Disorder, Functional, Regurgitation, Gastric
Transition to Infant Formula Feeding on Gastrointestinal Regurgitation (TIGER) Study
To compare the frequency of regurgitation and other digestive outcomes between infants who receive an infant formula based on whole goat milk and an infant formula based on cow milk proteins during the transition period from…
- Conditions
- Gastrointestinal Disorder, Functional, Regurgitation, Gastric, Colic, Infantile, Constipation - Functional
- Trial name
- TIGER (NCT05363553)
- Testing
- Infant formula based on whole goat milk, infant formula based on cow milk proteins
- Where
- Thailand
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Dairy Goat Co-operative (N.Z.) Limited
Gastro Esophageal Reflux
Effect of Right Lateral Position on Ventilated Preterm Neonates
Objective: to evaluate the effect of right lateral positioning in comparison with supine positioning on tracheal aspirate pepsin levels as a marker of aspiration of gastric contents in ventilated preterm neonates.
- Trial name
- NCT03258528
- Testing
- positioning
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Gastroesophageal Reflux
Study Evaluating Pantoprazole in Children With GERD
The purpose of this study is to characterize the PK profile, safety and tolerability of single and multiple doses of pantoprazole in children aged 1 through 11 years with endoscopically proven GERD.
- Trial name
- NCT00141817
- Testing
- pantoprazole for approximately 9 weeks.
- Where
- 23 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Non-acid Reflux Disease
Prospective Evaluation of Symptom Resolution in Acid Versus Non-acid Reflux Disease Following Anti-reflux Surgery
Gastroesophageal reflux disease (GERD) is a common ailment affecting a significant portion of the US population. With the advent and increased use of esophageal impedance monitoring, both acid and nonacid reflux disease can be…
- Trial name
- NCT01241149
- Testing
- anti-reflux surgery
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- United States Naval Medical Center, Portsmouth
Gastroesophageal Reflux Disease (GERD)
A Study of Single and Multiple Doses of Rabeprazole in Pediatric Patients With Gastroesophageal Reflux Disease (GERD) 1 to 11 Months Old, Inclusive
The purpose of the study is to evaluate the pharmacokinetics (how the drug is absorbed in the body, how it is distributed within the body and removed from the body over time), pharmacodynamics (how the study medication affects…
- Trial name
- NCT00747526
- Testing
- Rabeprazole sodium 5 mg, Rabeprazole sodium 10 mg
- Where
- 20 sites in United States, Belgium and 3 more
- Volunteers
- 51 people
- Sponsor
- Janssen Research & Development, LLC
Gastroesophageal Reflux
Study Evaluating Pantoprazole Sodium Enteric-Coated Spheroid Suspension In Infants With Presumed GERD
The purpose of this study is to characterize the pharmacokinetic (PK) and pharmacodynamic (PD) profiles to determine the safety and tolerability of single and multiple doses of pantoprazole in infants aged 1 through 11 months.
- Trial name
- NCT00259012
- Testing
- pantoprazole sodium enteric-coated spheroid suspension
- Where
- 31 sites in United States, Australia and 6 more
- Volunteers
- 67 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Gastreoesophageal Reflux Disease
Pharmacokinetics of Enteral Omeprazole Suspension in Patients With Cerebral Palsy and Mental Retardation
Gastroesophageal reflux disease and reflux-esophagitis are a major chronic problem in most children with cerebral palsy and mental retardation.
- Trial name
- NCT00426595
- Testing
- Administration of omeprazole suspension, omeprazole administered as a multi-unit-pellet system
- Where
- Belgium
- Volunteers
- 14 people
- Sponsor
- University Hospital, Ghent
Bile Duct Stricture
Suspended Overlength Biliary Stents Preventing Duodenobiliary Reflux in Patients With Biliary Stricture
Endoscopic insertion of plastic or metal stents in bile duct under endoscopic retrograde cholangiopancreatography is a well established treatment of distal malignant biliary obstruction.Biliary stents are widely used to relieve…
- Trial name
- NCT03310554
- Testing
- 26cm suspended overlength biliary stents, 30cm suspended overlength biliary stents, ordinary plastic biliary stents
- Where
- China
- Volunteers
- 117 people
- Sponsor
- Peking University Third Hospital
Gastroesophageal Reflux
Study Evaluating the Efficacy and Safety of Pantoprazole in Infants With Symptomatic Gastroesophageal Reflux Disease (GERD)
To assess the efficacy of pantoprazole for the treatment of infants with symptomatic Gastroesophageal Reflux Disease (GERD).
- Trial name
- NCT00365300
- Testing
- pantoprazole
- Where
- 38 sites in United States
- Volunteers
- 129 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Bile Duct Stricture
Intraintestinal Extended Biliary Stents Preventing Duodenobiliary Reflux in Patients With Biliary Stricture
Metal or plastic biliary stents placement under Endoscopic Retrograde Cholangiopancreatography(ERCP) is a well-established treatment for patients with benign biliary obstruction to relieve jaundice, a palliative treatment for…
- Trial name
- NCT04550819
- Testing
- intraintestinal extended biliary stents, ordinary plastic biliary stents
- Where
- China
- Volunteers
- 724 people
- Sponsor
- Peking University Third Hospital
Gastro Esophageal Reflux, Gastric Ulcer
Comparison Between Two Types of Sedation for Elective Upper Endoscopy Procedures
Sedation is defined as the act of administrating a sedative drug to produce a state of calm or sleep. Sedation is commonly given to a patient in hospital settings to provide a tolerable and pleasant experience by relieving…
- Conditions
- Gastro Esophageal Reflux, Gastric Ulcer, Sedation Complication
- Trial name
- NCT04410211
- Testing
- Sevoflurane, Midazolam injection
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Gastric Ulcer, Duodenal Ulcer, and Reflux Esophagitis
Drug Use Surveillance of Vonoprazan for "Gastric Ulcer, Duodenal Ulcer, and Reflux Esophagitis"
The purpose of this survey is to evaluate the safety and effectiveness of vonoprazan tablets in patients with gastric ulcer, duodenal ulcer, and reflux esophagitis in the routine clinical setting.
- Trial name
- NCT03214952
- Testing
- Vonoprazan
- Where
- Japan
- Volunteers
- 3,183 people
- Sponsor
- Takeda
Esophageal Atresia, Esophagitis
Management of Esophagitis Following Repair of Esophageal Atresia
The goal of this study is to prospectively evaluate the impact of antacid therapy on esophagitis in children with repaired esophageal atresia.
- Trial name
- NCT03619408
- Testing
- Antacids
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Gastro-Esophageal Reflux, Fundoplication
Health, Economic Analysis and Clinical Aspects of Patients With Neurological Disabilities in Enteral Nutrition With Dedicated Formula. The Role of Nissen's Fundoplication in the Management of Gastroesophageal Reflux
Nutritional difficulties are common in children with neurodisabilities and can be associated with malnutrition and gastrointestinal diseases, such as gastro-esophageal reflux disease (GERD) and constipation.
- Trial name
- NCT05068089
- Testing
- Nissen fundoplication, Enteral nutrition
- Where
- Italy
- Volunteers
- 360 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Functional Gastrointestinal Disorders, Infant Conditions
Prevalence of FGIDs and Probiotics Study
This is a study to evaluate the prevalence of FGIDs in infants using the Thai version of Rome IV diagnostic questionnaire for functional gastrointestinal disorders in infants and evaluate the efficacy of Limosilactobacillus…
- Trial name
- PROOF (NCT06309199)
- Testing
- Biogaia
- Where
- Thailand
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Gastroesophageal Reflux Disease (GERD)
A Study of the Safety and Effectiveness of Rabeprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Pediatric Patients
The purpose of the study is to access the effectiveness and safety of oral rabeprazole in the treatment of acid-related disorders in pediatric patients, focusing specifically on the manifestation of GERD (symptomatic and erosive…
- Trial name
- NCT00787891
- Testing
- rabeprazole
- Volunteers
- 127 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.