Clinical trials: Reflux
Gastroesophageal Reflux Disease
Anthropometric Measures and Severity of Gastroesophageal Reflux Disease
evaluate the impact of different anthropometric measures on clinical and endoscopic severity of GERD and its relation to serum leptin.
- Trial name
- NCT01954667
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Gastroesophageal Reflux Disease
Diagnosis and Response to Treatment Using a Reliable Gastroesophageal Reflux Disease (GERD) Questionnaire: An In Clinical Practice Study
The purpose of the study is to determine the applicability and utility of Gerd Q in the diagnosis of GERD and in the assessment of treatment response.
- Trial name
- GQS (NCT00963144)
- Where
- 2 sites in Malaysia
- Volunteers
- 250 people
- Sponsor
- AstraZeneca
Proton Pump Inhibitors, Gastroesophageal Reflux Disease
Should I Continue Taking My Acid Reflux Medication? Development and Pilot Testing of a Patient Decision Aid
BACKGROUND: Proton pump inhibitors (PPIs) treat problems such as gastroesophageal reflux disease (GERD). In many patients with mild or moderate GERD, PPIs should be used for 1-2 months but are often continued longer…
- Trial name
- NCT02558049
- Testing
- Decision aid
- Where
- 3 sites in Canada
- Volunteers
- 12 people
- Sponsor
- University of Ottawa
Esophagogastric Cancer
A Study of Tooth Erosion in People With Esophagogastric Cancer
The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer…
- Trial name
- NCT05612048
- Testing
- Survey, Intra-oral camera, Optional Salvia sample
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Gastroesophageal Reflux Disease (GERD), Laryngopharyngeal Reflux (LPR)
Transoral Incisionless Fundoplication (TIF) for Laryngopharyngeal Reflux (LPR) Patients
In this research study the investigators want to learn more about the effectiveness of an endoscopic procedure (an endoscope is a lighted tube that is placed down the participants esophagus, through the participants mouth) which…
- Conditions
- Gastroesophageal Reflux Disease (GERD), Laryngopharyngeal Reflux (LPR), Reflux Disease, Gastro-Esophageal, Motility Disorder
- Trial name
- TIF-LPR (NCT05579587)
- Testing
- Transoral Incisionless Fundoplication
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Cystic Fibrosis
The Prevalence and Significance of Gastro-oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation
Gastro-oesophageal reflux (GOR) has been found to be prevalent in children with cystic fibrosis (CF)and may further worsen lung damage via reflex bronchospasm or pulmonary aspiration.
- Trial name
- NCT00164021
- Testing
- Physiotherapy, exercise, percutaneous gastrostomy feeds, Anti-reflux pharmacotherapy
- Where
- Australia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Gastroesophageal Reflux Disease With Hiatal Hernia, Paraesophageal Hernia
Follow-up of Patients Operated Upon for Type II-IV Hiatal Hernia
Surgical therapy for gastroesophageal reflux disease (GERD) and hiatal hernia (HH) can achieve outcomes that afford the patient lifelong satisfaction.
- Trial name
- NCT01606449
- Testing
- Surgical Therapy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Bologna
GERD (Gastroesophageal Reflux Disease)
Evaluating Medication Adherence of Patients With Gastroesophageal Reflux Disease With Support of the Smartphone Application GERDCare
Adherence to GERD treatment, including medication, diet, and lifestyle, is essential for symptom control and complication prevention, yet adherence rates remain low due to various demographic and clinical factors.
- Trial name
- AppGERD (NCT07125521)
- Testing
- GERCCare mobile app
- Where
- Vietnam
- Volunteers
- 380 people
- Sponsor
- Institute of Gastroenterology and Hepatology, Vietnam
Gastroesophageal Reflux Disease (GERD), Neurology
Combined Scalp and Ear Acupuncture in Patients With Proton Pump Inhibitor- Dependent Gastroesophageal Reflux Disease
According to the statistics of the National Health Insurance Administration Ministry of Health and Welfare, the number of patients about gastroesophageal reflux disease (GERD) has increased from 610,000 to over 760,000 in the…
- Trial name
- NCT04660019
- Testing
- Scalp and auricular acupuncture, Seed acupressure
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Taipei Medical University WanFang Hospital
Gastroesophageal Reflux
Laparoscopic Nissen Versus Anterior Partial Fundoplication
The most widely used operative technique for gastroesophageal reflux is total fundoplication where the gastric fundus is sutured around the distal esophagus like a wrap.
- Trial name
- NCT01669330
- Testing
- Nissen fundoplication, Laparoscopic antireflux surgery ad modum Watson
- Where
- 4 sites in Sweden
- Volunteers
- 72 people
- Sponsor
- Region Skane
GERD
CYP2C19 Genetic Polymorphism on the Accuracy of Proton-Pump Inhibitor Testing
Background/Aim: To evaluate the optimal dosage of rabeprazole for proton-pump inhibitor (PPI) testing of gastroesophageal reflux disease (GERD) and to test the influence of cytochrome P (CYP) 2C19 polymorphism in a population…
- Trial name
- NCT00354757
- Testing
- rabeprazole
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Gastroesophageal Reflux Disease
Narrow-band Imaging, Autofluorescence Imaging and Gastroesophageal Reflux Disease
Aim of this study is to compare the efficacy of narrow band imaging (NBI) and autofluorescence imaging (AFI) to distinguish subtle mucosal change related to acid reflux that is not visible in standard white light imaging (WLI)…
- Trial name
- NCT01504971
- Testing
- symptom questionaire, pH monitoring, Tri-modal imaging endoscopy
- Where
- China
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
GERD
A Prospective Blinded Randomized Study Comparing Laparoscopic Sleeve Gastrectomy and Laparoscopic Roux-en-y Gastric Bypass and Their Effect on Gastro-Esophageal Reflux Disease Using 24 Horus pH Monitoring
Obesity has become a significant health problem in Canada. It is known to be a risk factor for many diseases, including Gastro-Esophageal Reflux Disease (GERD).
- Trial name
- GERD (NCT02142998)
- Testing
- 24 pH monitoring, Esophageal Manometry:
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Gastroesophageal Reflux
Thresholds of Straight Leg Raise Maneuver During High-Resolution-Manometry
High resolution manometry (HRM) is a key test in the preoperative assessment of patients with gastro-esophageal reflux disease (GERD) who are potential candidates for antireflux surgery.
- Trial name
- NCT04813029
- Testing
- Straight leg raise maneuver
- Where
- Italy
- Volunteers
- 336 people
- Sponsor
- University of Milan
Obese Adults
Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity
This study will assess whether a single subcutaneous dose of tirzepatide 7.5 mg , compared with saline placebo, increases total esophageal acid exposure time during a 96-hour wireless pH recording beginning about 48 hours after…
- Trial name
- NCT07893457
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pulmonary Aspiration of Gastric Contents, Emergency Surgery
Gastric Ultrasound for Airway Management in Emergency Patients
This prospective observational cohort study evaluates the association between gastric residual content and volume, assessed by point-of-care gastric ultrasound (PoCUS), and the choice of airway management technique (Rapid…
- Conditions
- Pulmonary Aspiration of Gastric Contents, Emergency Surgery, Gastric Residual Volume, Airway Management
- Trial name
- NCT07640165
- Testing
- Preoperative Gastric Point-of-Care Ultrasound (PoCUS)
- Where
- Indonesia
- Volunteers
- 43 people
- Sponsor
- Universitas Indonesia
Chronic Obstructive Pulmonary Disease, Bronchiectasis
The Prevalence of Gastro-oesophageal Reflux in Chronic Lung Disease
Gastric reflux into the oesophagus may further lung damage in respiratory disease. The proportion of adults with chronic lung disease and gastric reflux is unknown.
- Trial name
- NCT00697177
- Where
- Australia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Erosive Esophagitis, Heartburn
A Study to Evaluate Vonoprazan Concentrations in Breast Milk of Healthy Lactating Women Receiving Vonoprazan 20 mg Once Daily or Vonoprazan 20 mg Twice Daily
The primary objective is to determine the pharmacokinetics (PK) of vonoprazan in breast milk of healthy lactating women who have received vonoprazan administered once daily or vonoprazan 20 mg administered twice daily for 4…
- Conditions
- Erosive Esophagitis, Heartburn, Symptomatic Nonerosive Gasroesophageal Reflux Disease, Helicobacter Pylori Infection
- Trial name
- NCT06391177
- Testing
- Vonoprazan
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Phathom Pharmaceuticals, Inc.
Vesicoureteral Reflux
Determination of Voiding Patterns of Children With Vesicoureteral Reflux
Determine if the pattern of voiding differs in children with vesicoureteral reflux (VUR) compared to those who do not have VUR.
- Trial name
- NCT00186199
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Stanford University
Chest Pain, Gastroesophageal Reflux
Chest Pain Pilot Study
The purpose of this study is to compare the efficacy of Nexium® with placebo in relief of acid related pain or discomfort in the chest.
- Trial name
- NCT00251901
- Testing
- Esomeprazole
- Where
- 80 sites in Canada, Denmark and 4 more
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
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