Clinical trials: Refractive Disorders
Myopia
Combined Atropine With Orthokeratology in Childhood Myopia Control (AOK) -A Randomized Controlled Trial
This study aims to compare effects in retardation of myopia progression of combined ortho-k and 0.01% atropine therapy with those of ortho-k alone.Myopia control methods mainly focus on optical and pharmaceutical interventions .
- Trial name
- NCT02955927
- Testing
- 0.01% atropine eye drops, ortho-k
- Where
- Hong Kong
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Myopia
Comparison of Efficacy Between Two Myopia Control Lenses
This is a one-year, mono-centre, randomize, double-masked, monocular cross-over clinical trial designed to test and compare the efficacy of the new lens design in slowing down the increase of axial length and controlling myopia…
- Trial name
- NCT06148870
- Testing
- Myopia Control Lens-1 (MCL1), Myopia Control Lens-2 (MCL2)
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Essilor International
Myopia, Progressive
Myopia Progression With Freeform Myopia Control Spectacles
This is a prospective, randomized clinical trial. There will be a total of 180 participants randomized into three groups, Group 1 - 60 participants will wear the commercial peripheral plus myopia control lens (CML).
- Trial name
- NCT06927388
- Testing
- freeform myopia control spectacles, Commercial myopia control spectacle lens (CML)
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia
CHAMP: Study of NVK-002 in Children With Myopia
Stage 1: To evaluate the safety and efficacy of 2 concentrations of NVK-002 compared to Vehicle (placebo) for slowing the progression of myopia in children over a 3 year treatment period.
- Trial name
- NCT03350620
- Testing
- NVK-002 Concentration 1, NVK-002 Concentration 2
- Where
- 26 sites in United States, Hungary and 4 more
- Volunteers
- 670 people
- Sponsor
- Vyluma, Inc.
Myopia
Influence of Rodenstock Spectacle Lenses on Myopia Progression.
The prevalence of myopia in Singapore is among the highest in the world, with 65 percent of our children being myopic by Primary 6, and 83 percent of young adults being myopic.
- Trial name
- NCT06816446
- Testing
- Myopia control spectacle lens, Single-vision lens
- Where
- Singapore
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Rodenstock GmbH
Myopia
Defocus-Enhanced vs. Single Vision Spectacles in Myopia Control Visual Function Training
The purpose of this study is to compare the effectiveness of vision function training using defocus-enhanced spectacles (DIMS) versus single vision spectacles combined with vision function training in controlling myopia…
- Trial name
- NCT06821074
- Testing
- Defocus-enhanced spectacles, Single vision spectacles
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Visionly Plus Eye Hospital
Myopia, Conjunctivitis
Zanzibar Arts for Children's Eyesight Pilot Trial
In Zanzibar, around 22,000 children (4% of those aged 6 to 12) need treatment for eye issues like conjunctivitis or require glasses. A 2017 study found that 42% of rural children needing glasses didn't have them.
- Conditions
- Myopia, Conjunctivitis, Hyperopia
- Trial name
- ZANZI-ACEII (NCT06469697)
- Testing
- School music broadcast, Community music broadcast
- Where
- Tanzania
- Volunteers
- 1,295 people
- Sponsor
- Queen's University, Belfast
Healthy, Myopia
Ocular Imaging With Spectral Domain Optical Coherence Tomography
The purpose of this study is to analyze macular retinal thickness and macular volume using the spectral domain - optical coherence tomography (SD-OCT) in normal eyes and in eyes with various ocular diseases.
- Conditions
- Healthy, Myopia, Hypermetropia
- Trial name
- NCT00926549
- Testing
- Spectral domain-OCT (Cirrus™ HD-OCT, Carl Zeiss Meditec AG)
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Myopia
Evaluation of Stenfilcon A Versus Etafilcon A
Evaluation of two contact lenses
- Trial name
- NCT01809834
- Testing
- Etafilcon A, Stenfilcon A
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- CooperVision, Inc.
Myopia
Combination Effect of Optical Defocus and Low Dose Atropine in Myopia Control
The purpose of the study is to investigate the combination effect of optical defocus and low dose atropine on myopia control in schoolchildren.
- Trial name
- NCT06358755
- Testing
- Defocus Incorporated Multiple Segments lenses, single vision spectacle lenses, Low dose atropine
- Where
- Hong Kong
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Myopia, Progressive
Efficacy and Safety of Low-concentration Atropine for Myopia Control in Chinese Children and Adolescents
To investigate the efficacy and safety of three low-concentration atropine sulfate eye drops (0.01%, 0.025% and 0.05%) in controlling the progression of myopia in Chinese children and adolescents through a two-year clinical trial.
- Trial name
- LAMC (NCT05597163)
- Testing
- low concentration atropine (0.01%), low concentration atropine (0.025%), low concentration atropine (0.05%)
- Volunteers
- 588 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia
Four Week Performance Comparison Between Two Commercially Available Silicone Hydrogel Lenses
The purpose of this study is to compare the performance of two commercially marketed contact lenses when worn for up to 4 weeks in a daily wear modality.
- Trial name
- NCT01300767
- Testing
- Lotrafilcon B contact lens (AIR OPTIX® AQUA), Balafilcon A contact lens (PureVision® 2), Contact lens solution (Clear Care®)
- Volunteers
- 75 people
- Sponsor
- CIBA VISION
Myopia
Exploratory Study on the Effectiveness of Myopia Control Lenses in Slowing Myopia Progression in Young Children
This study will be a mono-center, single-arm, unmasked study evaluating the effectiveness of test lens in slowing myopia progression in children aged 6 to 8 years.
- Trial name
- NCT06857864
- Testing
- Test myopia control lenses (BSL)
- Where
- Singapore
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Essilor International
Myopia
Myopia Progression and the Effect of 7-Methylxanthine
7-methylxanthine has been shown to increase the concentration and thickness of collagen fibrils in rabbit sclera. Deficient collagen in the sclera may be the cause of progression of childhood myopia.
- Trial name
- NCT00263471
- Testing
- 7-methylxanthine
- Volunteers
- 90 people
- Sponsor
- Trier Research Laboratories
Congenital Cataract, Pediatric Cataract
Five-Year Visual Function and Refractive Outcomes After Congenital Cataract Surgery
This prospective multicenter observational study aims to evaluate the 5-year visual function and refractive outcomes in children undergoing surgery for congenital cataract.
- Trial name
- NCT07070037
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Jin Yang
Myopia
Myopia Control Efficacy of Second-generation DIMS Spectacle Lenses on Fast Progressing Myopes - Auxiliary Group
The purpose of this study is to examine the efficacy and performance of the Defocus Incorporated Multiple Segments (DIMS) and a variant of DIMS (D2) spectacle lenses on controlling myopia progression in fast progressing myopic…
- Trial name
- NCT05888805
- Testing
- DIMS spectacle lens
- Where
- Hong Kong
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Astigmatism, Myopia
Evaluation of Two Daily Disposable Contact Lenses for Wearers With Astigmatism
The purpose of this trial is to compare the performance of two contact lenses for contact lens wearers with astigmatism.
- Trial name
- NCT01207466
- Testing
- Nelfilcon A investigational contact lens, Nelfilcon A commercial contact lens
- Volunteers
- 95 people
- Sponsor
- CIBA VISION
Myopia, Hyperopia
Daily Disposable Performance of 1•DAY ACUVUE® TruEye™ and 1•DAY ACUVUE® MOIST® With LACREON® TECHNOLOGY
This study is an observational registry of patients who have recently been prescribed 1•DAY ACUVUE® TruEye® or 1•DAY ACUVUE® MOIST® Brand Contact Lenses with LACREON® TECHNOLOGY.
- Trial name
- TEMPO (NCT01467557)
- Testing
- narafilcon B daily disposable soft contact lenses, etafilcon A daily disposable soft contact lenses
- Where
- 37 sites in United States
- Volunteers
- 1,171 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Myopia, Cornea
Euclid Phoenix Lens Design Trial 2
Lens wettability and subjective comfort of Euclid orthokeratology lenses with and without an enhanced coating will be compared in 50 children. Axial elongation will be monitored in pediatric patients who qualify and consent.
- Trial name
- NCT06392607
- Testing
- Euclid orthokeratology (standard coating), Euclid orthokeratology (enhanced coating)
- Where
- 5 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Euclid Systems Corporation
Myopia
Non-dispense Comfort Comparison of Two Silicone Hydrogel Lenses
The purpose of this study is to compare subjective responses to two contact lenses after 15 minutes of wear.
- Trial name
- NCT00808834
- Testing
- Lotrafilcon A contact lens, Senofilcon A contact lens
- Volunteers
- 196 people
- Sponsor
- CIBA VISION