Clinical trials: Regression
Malaria, Anemia
Intermittent Preventive Treatment With Antimalarials in Kenyan Infants
The purpose of the study is to see whether antimalarial drugs administered at the time of routine infant vaccinations prevents malaria and anemia in the first year of life.
- Trial name
- NCT00111163
- Testing
- sulfadoxine-pyrimethamine with artesunate, amodiaquine with artesunate, chlorproguanil-dapsone
- Where
- Kenya
- Volunteers
- 1,516 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Drug Hypersensitivity
Predictive Models for Betalactam Allergy
Background: ß-lactam (BL) antibiotics represent the main cause of allergic reactions to drugs, inducing both immediate and non-immediate reactions.
- Trial name
- NCT03076749
- Testing
- Creating models for the diagnosis of BL allergy
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Montpellier
White Spot Lesion
Evaluation of Remin Pro Forte Versus Remin Pro on Treatment of White Spot Lesions Post Orthodontic Treatment
randomized clinical trial to evaluate caries regression, the change in colour and mineral content of the demineralized enamel after treatment with Remin Pro Forte paste (fluoride, hydroxyapatite, xylitol, ginger, and curcuma) and…
- Trial name
- NCT04017884
- Testing
- Remin Pro Forte, Remin Pro
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Retinopathy
Anesthesia for Retinopathy of Prematurity
Premature infants experience more respiratory problems after surgical procedures. The investigators aimed to compare general anesthesia with sedation on the need for post-operative mechanical ventilation in infants undergoing…
- Trial name
- NCT01955135
- Testing
- Ketamine, Sevoflurane, propofol
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Sphincter (Anal); Perineal Rupture, Obstetric
Development and Validation of a Logistic Regression Algorithm to Predict the Risk of Obstetric Anal Sphincter Injury.
An obstetric anal sphincter injury (OASI) occurs during the final stage of a vaginal delivery. This tissue laceration, even if adequately sutured, poses a substantial threat to bowel continence in women.1,2 In a recent…
- Trial name
- NCT05218837
- Testing
- Vaginal birth
- Where
- Sweden
- Volunteers
- 800,000 people
- Sponsor
- Maria Gyhagen
Sickle Cell Disease, Virtual Reality
Role of Virtual Reality (VR) in Patients With Sickle Cell Disease (SCD)
Patients with sickle cell disease (SCD) and cancer often have complicated courses while hospitalized and often deal with pain, anxiety and depression.
- Conditions
- Sickle Cell Disease, Virtual Reality, Anxiety, Depression
- Trial name
- NCT03387033
- Testing
- Relaxation response and virtual reality (VR) session
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Duke University
Emergency Treatment, Telephone Hotlines
Decreasing ED Utilization by Nudging Patients to Call Their Providers
In the present study, patients will be sent a message shortly after completing a medical procedure that informs or reminds them that they can reach out to Geisinger, and how to do it, if they have any medical issues or concerns.
- Trial name
- NCT04567849
- Testing
- message, provider, tele-nurse
- Where
- United States
- Volunteers
- 11,546 people
- Sponsor
- Geisinger Clinic
Autism
Efficacy and Safety of Lenalidomide for Treatment of Autistic Spectrum Disorders
The purpose of this study is to determine if lenalidomide (Revlimid®)reduces proinflammatory cytokines including TNF-alpha and may actually alter the clinical course of autism for some children.
- Trial name
- NCT00996931
- Testing
- lenalidomide
- Volunteers
- 6 people
- Sponsor
- Sutter Medical Foundation
Preoperative Anxiety
Comparing Virtual Reality (VR) to Non-VR for Decreasing Preoperative/Procedural Anxiety
The primary objective of the study is to utilize the modified Yale Preoperative Anxiety scale (mYPAS), a validated preoperative/procedural anxiety score, to measure preoperative anxiety via distraction in pediatric oncology…
- Trial name
- NCT05094141
- Testing
- Virtual reality
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Patient Satisfaction, Cesarean Section
Decreasing Patient Dissatisfaction With Unplanned Cesarean Sections
Patient satisfaction after an unplanned cesarean section was studied and in the previous study it was noted that there were common themes that lead to patient dissatisfaction.
- Trial name
- NCT02472327
- Testing
- Pre-operative support
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Albany Medical College
Extubation
Modified Deep Extubation vs. Standard Awake Extubation
The proposed study is to compare a modified DE technique, which is regularly used for low-risk patients by staff anesthesiologists at our institution, to a standard awake extubation.
- Trial name
- mDE (NCT06318715)
- Testing
- modified deep extubation (mDE), standard awake extubation
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Allergy, Peanut
Efficacy and Safety of QGE031 (Ligelizumab) in Patients With Peanut Allergy
This was a 52-week, Phase 3 multi-center, randomized, double-blind and placebo-controlled study to assess the safety and clinical efficacy of two dosing regimens of ligelizumab (240 mg and 120 mg) SC q4w (subcutaneous injection…
- Trial name
- NCT04984876
- Testing
- ligelizumab
- Where
- 55 sites in United States, Australia and 8 more
- Volunteers
- 211 people
- Sponsor
- Novartis Pharmaceuticals
Strabismus
The Effect of Dexmedetomidine on Decreasing Emergence Agitation and Delirium in Pediatric Patients Undergoing Strabismus Surgery
Postoperative agitation in children is a well-documented clinical phenomenon with incidence ranging from 10% to 67%. Recently, dexmedetomidine has been investigated extensively in the pediatric population and there is now…
- Trial name
- NCT01512355
- Testing
- Dexmedetomidine
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Yonsei University
Rett Syndrome
Safety and Preliminary Efficacy of TSHA-102 Gene Therapy in Pediatric Females Aged >2 to <4 Years With Rett Syndrome
The primary objectives of this study are to evaluate the safety, tolerability and preliminary efficacy of a single intrathecal (IT) dose of TSHA-102 in pediatric females with typical Rett syndrome.
- Trial name
- ASPIRE (NCT07480564)
- Testing
- TSHA-102
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- Taysha Gene Therapies, Inc.
Catheterization, Pain
Efficacy of Art Intervention on Decreasing Pain and Anxiety During Intravenous Cannulation
Peripheral Intravenous Cannulation (PIVC), one of the most common therapeutic procedures in medical care, can be difficult even for experienced medical practitioners.
- Conditions
- Catheterization, Pain, Anxiety, Art
- Trial name
- NCT04714255
- Testing
- Trace Image and Coloring for Kids-Book (TICK-B)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Witten/Herdecke
Ventilator Associated Pneumonia, Nosocomial Infections in Children
Decreasing Antibiotic Use in Infants With Suspected Ventilator-associated Infection
This is a prospective study with three specific aims: (1) To convene a consensus conference to develop a guideline for antibiotic use in infants (age < 3 yrs) with suspected ventilator-associated infection; (2) To evaluate…
- Conditions
- Ventilator Associated Pneumonia, Nosocomial Infections in Children, Microbial Colonization
- Trial name
- VAIN2 (NCT03041207)
- Testing
- Development and implementation of an antibiotic guideline
- Where
- 23 sites in United States, Canada
- Volunteers
- 555 people
- Sponsor
- Virginia Commonwealth University
Stress, Complete Psychological Check Up
Cognition and Health in Adolescents, Mindfulness as Prevention of Stress.
The purpose of this study is to determine whether mindfulness is useful as primary prevention for psychological health in highschool students, primarily related to stress, and whether mindfulness can improve cognitive function.
- Conditions
- Stress, Complete Psychological Check Up, Sleep, Cognition - Other
- Trial name
- CHAMPS (NCT01457222)
- Testing
- Mindfulness intervention, Music relaxation
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Region Skane
Physical Inactivity, Sedentary Behavior
Children- Sit Less, Move More (C-SLAMM): Increasing Physical Activity and Decreasing Sedentary Behaviour in Children
The Children Sit Less, Move More (C-SLAMM) study aims to test the feasibility and potential effect of a multi-component school and home-based pilot cluster randomized control trial on reducing sedentary behavior and increasing…
- Conditions
- Physical Inactivity, Sedentary Behavior, Health Behavior, Child Behavior
- Trial name
- NCT05854355
- Testing
- C-SLAMM Study
- Where
- United Kingdom
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Hepatitis B, Chronic
Development and Validation of Models to Predict Functional Cure in Patients With CHB After Peg-IFN Based Therapy
Hepatitis B virus (HBV) infection is prevalent across the world. Functional cure is the optimal endpoint of antiviral therapy for chronic hepatitis B virus (HBV) infection.
- Trial name
- NCT06196632
- Testing
- Peginterferon-α; Nucleoside analogs
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Qilu Hospital of Shandong University
Diarrhoea
Racecadotril Versus Standard Treatment in Decreasing the Duration of Acute Diarrhoea in Children
Acute watery diarrhea is defined as the passage of 3 or more loose or liquid stools per day for 3 or more days but less than 14 days, including patients with mild to moderate dehydration per WHO classification.
- Trial name
- ERADICATE (NCT06529497)
- Testing
- Racecadotril
- Where
- Pakistan
- Volunteers
- 260 people
- Sponsor
- Benazir Bhutto Hospital, Rawalpindi